Publications: DR Pedro Casado-Izquierdo

Kaya F, Bewicke-Copley F, Miettinen JJ, Casado P, Leddy E, Deniz Ö, Lavallée V-P, Philippe C et al. ( 2025 ) . DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes . Leukemia vol. 39 , ( 6 ) 1526 - 1531 .

Casado P, Marfa S, Hadi MM, Gerdes H, Martin-Guerrero SM, Miraki-Moud F, Rajeeve V, Cutillas PR ( 2025 ) . Phosphoproteomics identifies determinants of PAK inhibitor sensitivity in leukaemia cells . Cell Communication and Signaling vol. 23 , ( 1 )

Dembitz V, Lawson H, Burt R, Natani S, Philippe C, James SC, Atkinson S, Durko J et al. ( 2024 ) . Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation . Leukemia vol. 38 , ( 11 ) 2395 - 2409 .

Grey W, Atkinson S, Rix B, Casado P, Ariza‐McNaughton L, Hawley C, Sopoena ML, Bridge KS et al. ( 2023 ) . The CKS1/CKS2 Proteostasis Axis Is Crucial to Maintain Hematopoietic Stem Cell Function . HemaSphere vol. 7 , ( 3 )

Casado P, Rio-Machin A, Miettinen JJ, Bewicke-Copley F, Rouault-Pierre K, Krizsan S, Parsons A, Rajeeve V et al. ( 2023 ) . Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes . Signal Transduction and Targeted Therapy vol. 8 , ( 1 )

Casado P, Cutillas PR ( 2023 ) . Proteomic Characterization of Acute Myeloid Leukemia for Precision Medicine . Molecular & Cellular Proteomics vol. 22 , ( 4 )

Grey W, Rio-Machin A, Casado P, Grönroos E, Ali S, Miettinen JJ, Bewicke-Copley F, Parsons A et al. ( 2022 ) . CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia . Science Translational Medicine vol. 14 , ( 650 ) eabn3248 - eabn3248 .

Grey W, Rio‐Machin A, Casado‐Izquierdo P, Gronroos E, Ali S, Miettinen J, Bewicke‐Copley F, Parsons A et al. ( 2022 ) . P405: INHIBITION OF CKS1‐DEPENDENT PROTEOSTASIS REVEALS VULNERABILITIES IN LEUKAEMIC STEM CELLS WITH CONCOMITANT PROTECTION OF HEALTHY HAEMATOPOIETIC STEM CELLS . HemaSphere vol. 6 , 305 - 306 .

Hijazi M, Casado P, Akhtar N, Alvarez-Teijeiro S, Rajeeve V, Cutillas PR ( 2022 ) . eEF2K Activity Determines Synergy to Cotreatment of Cancer Cells With PI3K and MEK Inhibitors . Molecular & Cellular Proteomics vol. 21 , ( 6 )

Pedicona F, Casado P, Hijazi M, Gribben JG, Rouault-Pierre K, Cutillas PR ( 2022 ) . Targeting the lysine-specific demethylase 1 rewires kinase networks and primes leukemia cells for kinase inhibitor treatment . Science Signaling vol. 15 , ( 730 )

Grey W, Rio-Machin A, Casado-Izquierdo P, Gronroos E, Ali S, Miettinen J, Copley FB, Parsons A et al. ( 2022 ) . 3094 – INHIBITION OF CKS1-DEPENDENT PROTEOSTASIS REVEALS VULNERABILITIES IN LEUKAEMIC STEM CELLS WITH CONCOMITANT PROTECTION OF HEALTHY HAEMATOPOIESIS . Experimental Hematology vol. 111 , s91 - s92 .

Grey W, Rio-Machin A, Casado-Izquierdo P, Gronroos E, Ali S, Miettinen J, Parsons A, Swanton C et al. ( 2022 ) . INHIBITION OF CKS1-DEPENDENT PROTEOSTASIS REVEALS VULNERABILITIES IN LEUKAEMIC STEM CELLS WITH CONCOMITANT PROTECTION OF HEALTHY HAEMATOPOIESIS . EXPERIMENTAL HEMATOLOGY . vol. 111 , S91 - S91 .

Newport E, Pedrosa AR, Lees D, Dukinfield M, Carter E, Gomez‐Escudero J, Casado P, Rajeeve V et al. ( 2021 ) . Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth . The Journal of Pathology vol. 256 , ( 2 ) 235 - 247 .

Casado P, Hijazi M, Gerdes H, Cutillas PR ( 2021 ) . Implementation of Clinical Phosphoproteomics and Proteomics for Personalized Medicine . Clinical Proteomics , vol. 2420 , Springer Nature

Nobre LV, Basanta CC, Pedicona SF, Dokal AD, Arruda A, Smith R, Greenhalgh C, Patella F et al. ( 2021 ) . Abstract LBA013: Phosphoproteomics reveals active drug targets on pathways of resistance and predicts response to midostaurin plus chemotherapy in FLT3 mutant-positive acute myeloid leukemia . Molecular Cancer Therapeutics . vol. 20 , lba013 - lba013 .

Davidson K, Grevitt P, Contreras-Gerenas MF, Bridge KS, Hermida M, Shah KM, Mardakheh FK, Stubbs M et al. ( 2021 ) . Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes . Cell Death & Disease vol. 12 , ( 11 )

Nobre LMVV, Pedicona SF, Dokal A, Arruda A, Smith R, Greenhalgh C, Patella F, Casado-Izquierdo P et al. ( 2021 ) . Proteomics and Phospho-Proteomics Reveal Predictive Signatures of Response and Mechanisms of Resistance to Midostaurin Plus Chemotherapy in FLT3 Mutant Positive Acute Myeloid Leukemia . Blood vol. 138 , ( Supplement 1 )

Dokal AD, Arruda A, Smith R, Greenhalgh C, Patella F, Casado-Izquierdo PM, Wrench B, Theaker J et al. ( 2021 ) . Predictive phosphoproteomic signatures for midostaurin plus chemotherapy response in FLT3 mutant positive acute myeloid leukaemia . Journal of Clinical Oncology vol. 39 , ( 15_suppl ) 7019 - 7019 .

Gualtieri A, Kyprianou N, Gregory LC, Vignola ML, Nicholson JG, Tan R, Inoue S-I, Scagliotti V et al. ( 2021 ) . Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans . Nature Communications vol. 12 , ( 1 )

Gerdes H, Casado P, Dokal A, Hijazi M, Akhtar N, Osuntola R, Rajeeve V, Fitzgibbon J et al. ( 2021 ) . Drug ranking using machine learning systematically predicts the efficacy of anti-cancer drugs . Nature Communications vol. 12 , ( 1 )

Martín-Guerrero SM, Alonso P, Iglesias A, Cimadevila M, Brea J, Loza MI, Casado P, Martín-Oliva D et al. ( 2021 ) . His452Tyr polymorphism in the human 5-HT2A receptor affects clozapine-induced signaling networks revealed by quantitative phosphoproteomics . Biochemical Pharmacology vol. 185 ,

Martín-Guerrero SM, Casado P, Hijazi M, Rajeeve V, Plaza-Díaz J, Abadía-Molina F, Navascués J, Cuadros MA et al. ( 2020 ) . PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability . Biochemical Journal vol. 477 , ( 23 ) 4491 - 4513 .

Rio-Machin A, Casado-Izquierdo P, Miettinen J, Bewicke-Copley F, Khan N, Demeulemeester J, Krizsán S, Zheng J et al. ( 2020 ) . Integration of Deep Multi-Omics Profiling Veals New Insights into the Biology of Poor-Risk Acute Myeloid Leukemia . Blood vol. 136 , ( Supplement 1 ) 39 - 40 .

Fernández‐Varo G, Perramón M, Carvajal S, Oró D, Casals E, Boix L, Oller L, Macías‐Muñoz L et al. ( 2020 ) . Bespoken Nanoceria: An Effective Treatment in Experimental Hepatocellular Carcinoma . Hepatology vol. 72 , ( 4 ) 1267 - 1282 .

Kostaras E, Kaserer T, Lazaro G, Heuss SF, Hussain A, Casado P, Hayes A, Yandim C et al. ( 2020 ) . A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity . British Journal of Cancer vol. 123 , ( 4 ) 542 - 555 .

Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J et al. ( 2020 ) . Cancer associated fibroblast FAK regulates malignant cell metabolism . Nature Communications vol. 11 , ( 1 )

Carvajal S, Perramón M, Casals G, Oró D, Ribera J, Morales-Ruiz M, Casals E, Casado P et al. ( 2019 ) . Cerium Oxide Nanoparticles Protect against Oxidant Injury and Interfere with Oxidative Mediated Kinase Signaling in Human-Derived Hepatocytes . International Journal of Molecular Sciences vol. 20 , ( 23 )

Grey W, Casado-Izquierdo P, Cutillas P, Bonnet D ( 2019 ) . Combination Therapy Targeting CKS1-Dependent Protein Degradation Reduces AML Burden Whilst Protecting Normal Haematopoietic Stem Cellsfrom Cytarabine Toxicity . Blood vol. 134 , ( Supplement_1 )

Martín-Guerrero SM, Casado P, Muñoz-Gámez JA, Carrasco M-C, Navascués J, Cuadros MA, López-Giménez JF, Cutillas PR et al. ( 2019 ) . Poly(ADP-Ribose) Polymerase-1 inhibition potentiates cell death and phosphorylation of DNA damage response proteins in oxidative stressed retinal cells . Experimental Eye Research vol. 188 ,

Angulo-Urarte A, Casado P, Castillo SD, Kobialka P, Kotini MP, Figueiredo AM, Castel P, Rajeeve V et al. ( 2018 ) . Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility . Nature Communications vol. 9 , ( 1 )

Álvarez-Teijeiro S, García-Inclán C, Villaronga MÁ, Casado P, Hermida-Prado F, Granda-Díaz R, Rodrigo JP, Calvo F et al. ( 2018 ) . Factors Secreted by Cancer-Associated Fibroblasts that Sustain Cancer Stem Properties in Head and Neck Squamous Carcinoma Cells as Potential Therapeutic Targets . Cancers vol. 10 , ( 9 )

Casado P, Wilkes EH, Miraki-Moud F, Hadi MM, Rio-Machin A, Rajeeve V, Pike R, Iqbal S et al. ( 2018 ) . Proteomic and genomic integration identifies kinase and differentiation determinants of kinase inhibitor sensitivity in leukemia cells . Leukemia vol. 32 , ( 8 ) 1818 - 1822 .

Corominas MP, Restoy SC, Casals G, Oró D, Ribera J, Casals E, Casado-Izquierdo P, Varo GF et al. ( 2018 ) . THU-028 Cerium oxide nanoparticles protect against oxidant mediated injury and recover kinase activity of multiple pathways in human-derived hepatocellular carcinoma cells . Journal of Hepatology . vol. 68 ,

Wilkes EH, Casado P, Rajeeve V, Cutillas PR ( 2017 ) . Kinase activity ranking using phosphoproteomics data (KARP) quantifies the contribution of protein kinases to the regulation of cell viability* . Molecular & Cellular Proteomics vol. 16 , ( 9 ) 1694 - 1704 .

Warrick N, Miraki-Moud F, Aicher A, McNaughton LA, Casado-Izquierdo P, Nagano A, Carroll R, Bonnet D et al. ( 2017 ) . Adipocyte Induced Antagonism of ALL Growth Highlights a Novel Inhibitory Niche and Potential Therapeutic Opportunity . BLOOD . vol. 130 ,

Casado-Izquierdo P, Wilkes EH, Miraki-Moud F, Hadi MM, Rio-Machin A, Rajeeve V, Pike R, Sameena I et al. ( 2017 ) . PHOSPHOPROTEOMICS AND MASS CYTOMETRY SIGNATURES OF PRIMARY AML CELL DIFFERENTIATION ARE ASSOCIATED WITH SENSITIVITY TO KINASE INHIBITORS . HAEMATOLOGICA . vol. 102 , 203 - 203 .

Casado P, Hijazi M, Britton D, Cutillas PR ( 2016 ) . Impact of phosphoproteomics in the translation of kinase‐targeted therapies . Proteomics vol. 17 , ( 6 )

Dermit M, Casado P, Rajeeve V, Wilkes EH, Foxler DE, Campbell H, Critchlow S, Sharp TV et al. ( 2016 ) . Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition . Oncogene vol. 36 , ( 19 ) 2762 - 2774 .

Bouchekioua-Bouzaghou K, Lenihan C, Shia A, Wilkes E, Casado-Izquierdo P, Cutillas P, Schmid P ( 2016 ) . Abstract 2819: Characterization of the mechanisms of early and later stages of resistance to the selective CDK4/6 inhibitor palbociclib . Cancer Research . vol. 76 , 2819 - 2819 .

Lenihan C, Bouchekioua-Bouzaghou K, Shia A, Wilkes E, Casado-Izquierdo1 P, Cutillas P, Schmid P ( 2016 ) . Abstract P3-06-02: Characterization of resistance to the selective CDK4/6 inhibitor palbociclib in ER positive breast cancer . Cancer Research . vol. 76 ,

Terfve CDA, Wilkes EH, Casado P, Cutillas PR, Saez-Rodriguez J ( 2015 ) . Large-scale models of signal propagation in human cells derived from discovery phosphoproteomic data . Nature Communications vol. 6 , ( 1 )

Carretero L, Llavona P, López-Hernández A, Casado P, Cutillas PR, de la Peña P, Barros F, Domínguez P ( 2015 ) . ERK and RSK are necessary for TRH-induced inhibition of r-ERG potassium currents in rat pituitary GH3 cells . Cellular Signalling vol. 27 , ( 9 ) 1720 - 1730 .

Wilkes EH, Casado P, Cutillas PR ( 2014 ) . Approaches for measuring signalling plasticity in the context of resistance to targeted cancer therapies . Biochemical Society Transactions vol. 42 , ( 4 ) 791 - 797 .

Casado P, Bilanges B, Rajeeve V, Vanhaesebroeck B, Cutillas PR ( 2014 ) . Environmental Stress Affects the Activity of Metabolic and Growth Factor Signaling Networks and Induces Autophagy Markers in MCF7 Breast Cancer Cells* . Molecular & Cellular Proteomics vol. 13 , ( 3 ) 836 - 848 .

Cabal-Hierro L, Noelia A, Iglesias J, A. PM, Ugarte-Gil L, Pedro C, Fernández-García B, Darnay BG et al. ( 2013 ) . A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1 . Oncotarget vol. 5 , ( 1 ) 224 - 236 .

Casado P, Alcolea MP, Iorio F, Rodríguez-Prados J-C, Vanhaesebroeck B, Saez-Rodriguez J, Joel S, Cutillas PR ( 2013 ) . Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors . Genome Biology vol. 14 , ( 4 )

Casado P, Rodriguez-Prados J-C, Cosulich SC, Guichard S, Vanhaesebroeck B, Joel S, Cutillas PR ( 2013 ) . Kinase-Substrate Enrichment Analysis Provides Insights into the Heterogeneity of Signaling Pathway Activation in Leukemia Cells . Science Signaling vol. 6 , ( 268 )

Beltran L, Casado P, Rodríguez-Prados J-C, Cutillas PR ( 2012 ) . Global profiling of protein kinase activities in cancer cells by mass spectrometry . Journal of Proteomics vol. 77 , 492 - 503 .

Alcolea MP, Casado P, Rodríguez-Prados J-C, Vanhaesebroeck B, Cutillas PR ( 2012 ) . Phosphoproteomic Analysis of Leukemia Cells under Basal and Drug-treated Conditions Identifies Markers of Kinase Pathway Activation and Mechanisms of Resistance* . Molecular & Cellular Proteomics vol. 11 , ( 8 ) 453 - 466 .

Montoya A, Beltran L, Casado P, Rodríguez-Prados J-C, Cutillas PR ( 2011 ) . Characterization of a TiO2 enrichment method for label-free quantitative phosphoproteomics . Methods vol. 54 , ( 4 ) 370 - 378 .

Casado P, Cutillas PR ( 2010 ) . A Self-validating Quantitative Mass Spectrometry Method for Assessing the Accuracy of High-content Phosphoproteomic Experiments* . Molecular & Cellular Proteomics vol. 10 , ( 1 )

Fernandez-Garcia B, Casado P, Prado MA, Ugarte-Gil LJ, Artime N, Cabal-Hierro L, Calvo E, López JA et al. ( 2010 ) . Proteomic Analysis of Annexin A2 Phosphorylation Induced by Microtubule Interfering Agents and Kinesin Spindle Protein Inhibitors . Journal of Proteome Research vol. 9 , ( 9 ) 4649 - 4660 .

Casado P, Prado MA, Zuazua-Villar P, del Valle E, Artime N, Cabal-Hierro L, Rupérez P, Burlingame AL et al. ( 2008 ) . Microtubule interfering agents and KSP inhibitors induce the phosphorylation of the nuclear protein p54nrb, an event linked to G2/M arrest . Journal of Proteomics vol. 71 , ( 6 ) 592 - 600 .

Prado MA, Casado P, Zuazua‐Villar P, del Valle E, Artime N, Cabal‐Hierro L, Martínez‐Campa CM, Lazo PS et al. ( 2007 ) . Phosphorylation of human eukaryotic elongation factor 1Bγ is regulated by paclitaxel . Proteomics vol. 7 , ( 18 ) 3299 - 3304 .

Casado P, Zuazua-Villar P, Prado MA, del Valle E, Iglesias JM, Martínez-Campa C, Lazo PS, Ramos S ( 2007 ) . Characterization of HSP27 phosphorylation induced by microtubule interfering agents: Implication of p38 signalling pathway . Archives of Biochemistry and Biophysics vol. 461 , ( 1 ) 123 - 129 .

Casado P, Zuazua-Villar P, del Valle E, Martínez-Campa C, Lazo PS, Ramos S ( 2006 ) . Vincristine regulates the phosphorylation of the antiapoptotic protein HSP27 in breast cancer cells . Cancer Letters vol. 247 , ( 2 ) 273 - 282 .

Martínez-Campa C, Casado P, Rodríguez R, Zuazua P, García-Pedrero JM, Lazo PS, Ramos S ( 2006 ) . Effect of Vinca alkaloids on ERα levels and Estradiol-induced responses in MCF-7 cells . Breast Cancer Research and Treatment vol. 98 , ( 1 )

Grey W, Rio-Machin A, Casado-Izquierdo P, Miettinen JJ, Copley F, Parsons A, Heckman CA, Cutillas P et al. . CKS1-dependent proteostatic regulation has dual roles combating acute myeloid leukemia whilst protecting normal hematopoiesis .

Kaya F, Bewicke-Copley F, Miettinen JJ, Casado P, Leddy E, Deniz Ö, Lavallée V-P, Philippe C et al. . DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes .

Casado P, Rio-Machin A, Miettinen JJ, Bewicke-Copley F, Rouault-Pierre K, Krizsan S, Parsons A, Rajeeve V et al. . Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes .

Dembitz V, Lawson H, Burt R, Philippe C, James SC, Atkinson S, Durko J, Wang LM et al. . SCD inhibition preferentially eradicates AML displaying high de novo fatty acid desaturation and synergizes with chemotherapy .

Davidson K, Grevitt P, G. MFC, Bridge KS, Hermida M, Shah KM, Mardakheh FK, Stubbs M et al. . Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes .