Publications: DR Lucy Norling

Margraf A, Chen J, Christoforou M, Claria-Ribas P, Henriques Schneider A, Cecconello C, Bu W, Imbert PRC et al. ( 2025 ) . Formyl-peptide receptor type 2 activation mitigates heart and lung damage in inflammatory arthritis . EMBO Molecular Medicine vol. 17 , ( 5 ) 1153 - 1183 .

Thomas BL, Montero‐Melendez T, Oggero S, Kaneva MK, Chambers D, Pinto AL, Nerviani A, Lucchesi D et al. ( 2024 ) . Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis . Arthritis & Rheumatology vol. 76 , ( 12 ) 1705 - 1718 .

Hussain MT, Austin-Williams S, Wright TD, Dhawan UK, Pinto AL, Cooper D, Norling LV ( 2024 ) . β1-Integrin-Mediated Uptake of Chondrocyte Extracellular Vesicles Regulates Chondrocyte Homeostasis . International Journal of Molecular Sciences vol. 25 , ( 9 ) 4756 - 4756 .

Norling LV, Cooper D ( 2023 ) . Being old and female is an inflammatory combination . Journal of Leukocyte Biology vol. 114 , ( 4 ) 299 - 300 .

Chen J, Austin-Williams S, O'Riordan CE, Claria-Ribas P, Sugimoto MA, Norling LV, Thiemermann C, Perretti M ( 2023 ) . Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction . Journal of Innate Immunity vol. 15 , ( 1 ) 548 - 561 .

Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN et al. ( 2023 ) . Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis . JCI Insight vol. 8 , ( 3 ) Article e168728 ,

Norling LV, Halade GV ( 2022 ) . Helpful inflammation turned harmful in non-communicable diseases . Current Opinion in Pharmacology vol. 67 , Article 102317 , 102317 - 102317 .

Qin CX, Norling LV, Vecchio EA, Brennan EP, May LT, Wootten D, Godson C, Perretti M et al. ( 2022 ) . Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35 . British Journal of Pharmacology vol. 179 , ( 19 ) 4617 - 4639 .

Oggero S, Godec T, van Gorp R, Pinto AL, Schurgers LJ, Reutelingsperger C, Sever P, Norling LV et al. ( 2022 ) . Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients . Journal of Hypertension vol. 40 , ( 8 ) 1522 - 1529 .

Cecconello C, Clària Ribas P, Norling LV ( 2022 ) . Resolving acute inflammation; what happens when inflammation goes haywire? How can it get back in line? . Diet, Inflammation, and Health , Elsevier

Iqbal AJ, Krautter F, Blacksell IA, Wright RD, Austin‐Williams SN, Voisin M, Hussain MT, Law HL et al. ( 2021 ) . Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent manner . The FASEB Journal vol. 36 , ( 1 )

Austin-Williams S, Hussain MT, Oggero S, Norling LV ( 2021 ) . Enhancing extracellular vesicles for therapeutic treatment of arthritic joints . Free Radical Biology and Medicine vol. 175 , 80 - 94 .

Chen J, Norling LV, Garrido Mesa J, Silva MDP, Burton SE, Reutelingsperger C, Perretti M, Cooper D ( 2021 ) . Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis . Proceedings of the National Academy of Sciences vol. 118 , ( 38 ) Article e2020385118 ,

Oggero S, de Gaetano M, Marcone S, Fitzsimons S, Pinto AL, Ikramova D, Barry M, Burke D et al. ( 2021 ) . Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity . Journal of Extracellular Vesicles vol. 10 , ( 6 ) Article 12084 ,

Chen J, Norling LV, Cooper D ( 2021 ) . Cardiac Dysfunction in Rheumatoid Arthritis: The Role of Inflammation . Cells vol. 10 , ( 4 ) 881 - 881 .

Brouwers H, Jónasdóttir HS, Kuipers ME, Kwekkeboom JC, Auger JL, Gonzalez-Torres M, López-Vicario C, Clària J et al. ( 2020 ) . Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid . The Journal of Immunology vol. 205 , ( 10 ) 2840 - 2849 .

Souza PR, Walker ME, Goulding NJ, Dalli J, Perretti M, Norling LV ( 2020 ) . The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections . Frontiers in Immunology vol. 11 , Article 573019 ,

Hussain MT, Iqbal AJ, Norling LV ( 2020 ) . The Role and Impact of Extracellular Vesicles in the Modulation and Delivery of Cytokines during Autoimmunity . International Journal of Molecular Sciences vol. 21 , ( 19 ) 7096 - 7096 .

Norling LV, Perretti M ( 2020 ) . Proresolving lipid mediators enhance PMN-mediated bacterial clearance . Proceedings of the National Academy of Sciences vol. 117 , ( 17 ) 9148 - 9150 .

Law HL, Wright RD, Iqbal AJ, Norling LV, Cooper D ( 2020 ) . A Pro-resolving Role for Galectin-1 in Acute Inflammation . Frontiers in Pharmacology vol. 11 , Article 274 ,

Padovan MG, Norling LV ( 2020 ) . Pro-resolving lipid mediators in sepsis and critical illness . Current Opinion in Clinical Nutrition & Metabolic Care vol. 23 , ( 2 ) 76 - 81 .

Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin M-B, Vinci C et al. ( 2020 ) . Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody . Frontiers in Immunology vol. 11 , Article 10 ,

Oggero S, Austin-Williams S, Norling LV ( 2019 ) . The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue Repair . Frontiers in Pharmacology vol. 10 , Article 1479 ,

Oggero S, de Gaetano M, Marcone S, Barry M, Montero-Melendez T, Cooper D, Norling LV, Brennan EP et al. ( 2019 ) . Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque responses .

Oggero S, Van Gorp R, Cooper D, Norling L, Schurgers L, Reutelinsperger C, Perretti M ( 2019 ) . Monocyte and not Neutrophil derived microvesicles are able to activate endothelial cells and smooth muscle cells and to enhance recruitment of PMN in a Flow Chamber based assay . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION . vol. 49 , 198 - 199 .

Oggero S, Van Gorp R, Norling LV, Schurgers L, Reutelingsperger C, Perretti M ( 2019 ) . Stimulation of monocyte-platelet aggregation drives formation of microvesicle subsets to promote vascular inflammation . BRITISH JOURNAL OF PHARMACOLOGY . vol. 176 , 3032 - 3033 .

Topping LM, Vinci C, Rhys H, Norling L, Nissim A ( 2018 ) . OP0260 Targeting neutrophil microvesicles to damaged cartilage using antibodies to post-translationally modified collagen ii . Annals of the Rheumatic Diseases . vol. 77 , 179 - 179 .

Thomas BL, Jones HR, Norling LV, Headland SE, Pitzalis C, Dell'Accio F, Perretti M ( 2018 ) . Neutrophil extracellular vesicles have a cartilage protective effect during inflammatory arthritis . Osteoarthritis and Cartilage . vol. 26 , S125 - S126 .

Rhys HI, Dell'Accio F, Pitzalis C, Moore A, Norling LV, Perretti M ( 2018 ) . Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages . EBioMedicine vol. 29 , 60 - 69 .

Oggero S, Norling L, Perretti M ( 2018 ) . Microvesicles in cardiovascular inflammation: markers or mediators of cardiovascular diseases? . Proceedings for Annual Meeting of The Japanese Pharmacological Society vol. WCP2018 , ( 0 )

Perretti M, Norling LV ( 2017 ) . Actions of SPM in regulating host responses in arthritis . Molecular Aspects of Medicine vol. 58 , 57 - 64 .

( 2017 ) . Nutrition, Immunity, and Infection . CRC Press

Topping LM, Rhys H, Norling L, Nissim A ( 2017 ) . FRI0011 Targeting neutrophil microvesicles to damaged cartilage using antibodies to post translationally modified collagen ii . Annals of the Rheumatic Diseases . vol. 76 , 483 - 484 .

Piovezan AP, Batisti AP, Benevides MLACS, Turnes BL, Martins DF, Kanis L, Duarte ECW, Cavalheiro AJ et al. ( 2017 ) . Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways . Journal of Ethnopharmacology vol. 204 , 179 - 188 .

Norling LV, Ly L, Dalli J ( 2017 ) . Resolving inflammation by using nutrition therapy . Current Opinion in Clinical Nutrition & Metabolic Care vol. 20 , ( 2 ) 145 - 152 .

Ross EA, Naylor AJ, O'Neil JD, Crowley T, Ridley ML, Crowe J, Smallie T, Tang TJ et al. ( 2017 ) . Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression . Annals of the Rheumatic Diseases vol. 76 , ( 3 ) 612 - 619 .

Perretti M, Cooper D, Dalli J, Norling LV ( 2017 ) . Immune resolution mechanisms in inflammatory arthritis . Nature Reviews Rheumatology vol. 13 , ( 2 ) 87 - 99 .

Wright RD, Souza PR, Flak MB, Thedchanamoorthy P, Norling LV, Cooper D ( 2016 ) . Galectin-3–null mice display defective neutrophil clearance during acute inflammation . Journal of Leukocyte Biology vol. 101 , ( 3 ) 717 - 726 .

Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M, Serhan CN ( 2016 ) . Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation . The Journal of Immunology vol. 197 , ( 6 ) 2362 - 2368 .

Souza PR, Norling LV ( 2016 ) . Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritis . European Journal of Pharmacology vol. 785 , 165 - 173 .

Norling L, Headland S, Dalli J, Arnardottir H, Jones H, Haworth O, Serhan C, Perretti M ( 2016 ) . SAT0026 Pro-Resolving and Cartilage-Protective Actions of Resolvin D1 in Inflammatory Arthritis . Annals of the Rheumatic Diseases . vol. 75 , 673 - 673 .

Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN et al. ( 2016 ) . Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis . JCI Insight vol. 1 , ( 5 )

Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A et al. ( 2015 ) . Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis . Science Translational Medicine vol. 7 , ( 315 )

Canova DF, Pavlov AM, Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB et al. ( 2015 ) . Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response . Journal of Controlled Release vol. 217 , 284 - 292 .

Headland SE, Norling LV ( 2015 ) . The resolution of inflammation: Principles and challenges . Seminars in Immunology vol. 27 , ( 3 ) 149 - 160 .

Headland S, Norling L, Kim A, Jones H, Jan L, Perretti M ( 2015 ) . Neutrophil‐Derived Microvesicles Migrate into Cell‐Impenetrable Cartilage to Protect the Joint During Inflammatory Arthritis . The FASEB Journal vol. 29 , ( S1 ) Article 285.11 ,

Ross EA, Smallie T, Naylor AJ, Desanti GE, Crowe J, O'Neil JD, Turner JD, Yemm A et al. ( 2015 ) . A8.1 Tristetraprolin is a novel therapeutic target for rheumatoid arthritis . Annals of the Rheumatic Diseases . vol. 74 , A81 - A81 .

Burgmaier M, Schutters K, Willems B, van der Vorst EPC, Kusters D, Chatrou M, Norling L, Biessen EAL et al. ( 2014 ) . AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE^−/− mice . Journal of Cellular and Molecular Medicine vol. 18 , ( 10 ) 2117 - 2124 .

Montero-Melendez T, Madeira MFM, Norling LV, Alsam A, Curtis MA, da Silva TA, Perretti M ( 2014 ) . Association between Periodontal Disease and Inflammatory Arthritis Reveals Modulatory Functions by Melanocortin Receptor Type 3 . The American Journal of Pathology vol. 184 , ( 8 ) 2333 - 2341 .

Cash JL, Norling LV, Perretti M ( 2014 ) . Resolution of inflammation: targeting GPCRs that interact with lipids and peptides . Drug Discovery Today vol. 19 , ( 8 ) 1186 - 1192 .

Headland SE, Jones HR, D'Sa ASV, Perretti M, Norling LV ( 2014 ) . Cutting-Edge Analysis of Extracellular Microparticles using ImageStreamX Imaging Flow Cytometry . Scientific Reports vol. 4 , ( 1 ) Article 5237 ,

Headland S, Norling L, Patel H, Dalli J, Kelly S, Pitzalis C, Dell'Accio F, Perretti M ( 2014 ) . A novel mechanism for protecting the arthritic joint: microparticles deliver Annexin A1 into cartilage (146.8) . The FASEB Journal . vol. 28 ,

Norling L, Headland S, Dalli J, Serhan C, Perretti M ( 2014 ) . Resolvin D1 protects from neutrophil mediated joint destruction in inflammatory arthritis (146.5) . The FASEB Journal . vol. 28 ,

Dalli J, Norling LV, Montero‐Melendez T, Canova DF, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ et al. ( 2013 ) . Microparticle alpha‐2‐macroglobulin enhances pro‐resolving responses and promotes survival in sepsis . EMBO Molecular Medicine vol. 6 , ( 1 ) 27 - 42 .

Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M, Perretti M ( 2013 ) . Heterogeneity in Neutrophil Microparticles Reveals Distinct Proteome and Functional Properties . Molecular & Cellular Proteomics vol. 12 , ( 8 ) 2205 - 2219 .

Norling LV, Dalli J ( 2013 ) . Microparticles are novel effectors of immunity . Current Opinion in Pharmacology vol. 13 , ( 4 ) 570 - 575 .

Norling LV, Perretti M ( 2013 ) . The role of omega-3 derived resolvins in arthritis . Current Opinion in Pharmacology vol. 13 , ( 3 ) 476 - 481 .

Norling LV, Perretti M ( 2013 ) . Control of Myeloid Cell Trafficking in Resolution . Journal of Innate Immunity vol. 5 , ( 4 ) 367 - 376 .

Perretti M, Dalli J, Norling LV, Melendez TM, Hinds C ( 2013 ) . Neutrophil Microparticles are heterogenous in content and function . The FASEB Journal . vol. 27 ,

Norling LV, Perretti M ( 2013 ) . Omega‐3 derived Resolvin D1 reduces the severity of inflammatory arthritis . The FASEB Journal . vol. 27 ,

Gil-Villa AM, Norling LV, Serhan CN, Cordero D, Rojas M, Cadavid A ( 2012 ) . Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma . Prostaglandins, Leukotrienes and Essential Fatty Acids vol. 87 , ( 4-5 ) 127 - 134 .

Yazid S, Norling LV, Flower RJ ( 2012 ) . Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system . Prostaglandins & Other Lipid Mediators vol. 98 , ( 3-4 ) 94 - 100 .

Norling LV, Dalli J, Flower RJ, Serhan CN, Perretti M ( 2012 ) . Resolvin D1 Limits Polymorphonuclear Leukocyte Recruitment to Inflammatory Loci . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 32 , ( 8 ) 1970 - 1978 .

Norling LV, Dalli J, Flower RJ, Serhan CN, Perretti M ( 2012 ) . Resolvin D1 limits PMN recruitment to inflammatory loci: receptor dependent bioactions . The FASEB Journal . vol. 26 ,

Norling L, Dalli J, Flower R, Serhan C, Perretti M ( 2012 ) . RESOLVIN D1 LIMITS PMN RECRUITMENT TO INFLAMMATORY LOCI: RECEPTOR DEPENDENT BIOACTIONS . RHEUMATOLOGY . vol. 51 , 47 - 48 .

Norling LV, Spite M, Yang R, Flower RJ, Perretti M, Serhan CN ( 2011 ) . Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing . The Journal of Immunology vol. 186 , ( 10 ) 5543 - 5547 .

Norling LV, Spite M, Yang R, Flower RJ, Perretti M, Serhan CN ( 2011 ) . Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing . JOURNAL OF IMMUNOLOGY vol. 186 , ( 10 ) 5543 - 5547 .

Norling LV, Dalli J, Serhan CN, Perretti M ( 2011 ) . RESOLVIN D1 LIMITS PMN RECRUITMENT TO INFLAMMATORY LOCI: RECEPTOR DEPENDENT BIOACTIONS . INFLAMMATION RESEARCH . vol. 60 , 60 - 60 .

Canaider ( 2010 ) . Human RCAN3 gene expression and cell growth in endothelial cells . International Journal of Molecular Medicine vol. 26 , ( 6 )

Norling LV, Serhan CN ( 2010 ) . Profiling in resolving inflammatory exudates identifies novel anti‐inflammatory and pro‐resolving mediators and signals for termination . Journal of Internal Medicine vol. 268 , ( 1 ) 15 - 24 .

Norling LV, Leoni G, Cooper D, Perretti M ( 2010 ) . Cell Adhesion Molecules . Fundamentals of Inflammation , Cambridge University Press

Norling LV, Dalli J, Flower RJ, Serhan CN, Perretti M ( 2010 ) . Resolvin D1 limits PMN recruitment to inflammatory loci: receptor dependent bioactions . FASEB JOURNAL vol. 24 ,

Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D, Perretti M ( 2010 ) . Human RCAN3 gene expression and cell growth in endothelial cells . INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE vol. 26 , ( 6 ) 913 - 918 .

Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M et al. ( 2009 ) . Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis . NATURE vol. 461 , ( 7268 ) 1287 - U125 .

Norling LV, Perretti M, Cooper D ( 2009 ) . Endogenous galectins and the control of the host inflammatory response . J ENDOCRINOL vol. 201 , ( 2 ) 169 - 184 .

Piqueras L, Sanz MJ, Perretti M, Morcillo E, Norling L, Mitchell JA, Li Y, Bishop-Bailey D ( 2009 ) . Activation of PPARβ/δ inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release . Journal of Leukocyte Biology vol. 86 , ( 1 ) 115 - 122 .

Dalli J, Norling LV, Renshaw D, Cooper D, Leung K-Y, Perretti M ( 2008 ) . Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles . Blood vol. 112 , ( 6 ) 2512 - 2519 .

Cooper D, Norling LV, Perretti M ( 2008 ) . Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow . J LEUKOCYTE BIOL vol. 83 , ( 6 ) 1459 - 1466 .

Dasgupta B, Dalli J, Norling L, Pederzoli-Ribeil M, Hollywood J, D'Acquisto F, Perretti M ( 2008 ) . Altered expression of annexin 1 and its receptor in neutrophils of patients with giant cell arteritis (GCA) and ANCA associated vasculitis (AAV) . RHEUMATOLOGY . vol. 47 , II99 - II99 .

Harrington LS, Evans RJ, Wray J, Norling L, Swales KE, Vial C, Ali F, Carrier MJ et al. ( 2007 ) . Purinergic 2X1 Receptors Mediate Endothelial Dependent Vasodilation to ATP . Molecular Pharmacology vol. 72 , ( 5 ) 1132 - 1136 .

Norling LV, Sampaio ALF, Cooper D, Perretti M ( 2007 ) . Inhibitory control of endothelial galectin‐1 on<i>in vitro</i>and<i>in vivo</i>lymphocyte trafficking . The FASEB Journal vol. 22 , ( 3 ) 682 - 690 .

Norling LV, Cooper D, Perretti M ( 2006 ) . Endogenous Galectn‐1 inhibits lymphocyte‐endothelial cell interactions as determined by small interference RNA . The FASEB Journal . vol. 20 ,