Publications: DR Mangesh Thorat
Sinha A, Jurrius P, Schelt A-SV, Darwish O, Annio G, Shifa B, Peterson Z, Jeffery H et al.
(
2025
)
.
Abstract P4-05-19: Magnetic Resonance Elastography: A Novel Imaging tool to predict response in patients undergoing Neo-Adjuvant Chemotherapy for Breast Cancer
.
Clinical Cancer Research
vol.
31
,
(
12_Supplement
)
Thorat MA
(
2025
)
.
An aspirin a day keeps cancer at bay
.
BJC Reports
vol.
3
,
(
1
)
Article
23
,
Tondare A, Thorat MA
(
2025
)
.
De-escalation of axillary interventions in the management of breast cancer patients following neoadjuvant systemic treatment
.
Translational Breast Cancer Research
vol.
6
,
14
-
14
.
Thorat MA
(
2025
)
.
COMETgazing - interesting insights, lessons for clinical practice and a call for more precision using the biomarkerSCOPE
.
Oncotarget
vol.
16
,
(
1
)
138
-
139
.
Sinha AP, Jurrius P, van Schelt A-S, Darwish O, Shifa B, Annio G, Peterson Z, Jeffery H et al.
(
2025
)
.
Tumor Biomechanics Quantified Using MR Elastography to Predict Response to Neoadjuvant Chemotherapy in Individuals with Breast Cancer
.
Radiology: Imaging Cancer
vol.
7
,
(
2
)
Article
e240138
,
Irakleidis F, Warren M, Sidlauskas K, Hall P, Hawkesford K, Phillips M, Thorat M, Angelis V
(
2025
)
.
P437: Discrepancies in the assessment of oestrogen and progesterone receptor status using immunohistochemistry and OncotypeDX; reclassification to triple negative breast cancer and implications in treatment
.
The Breast
vol.
80
,
Article
104249
,
104249
-
104249
.
Agha R, Mathew G, Rashid R, Kerwan A, Al-Jabir A, Sohrabi C, Franchi T, Nicola M et al.
(
2025
)
.
Revised Strengthening the reporting of cohort, cross-sectional and case-control studies in surgery (STROCSS) Guideline: An update for the age of Artificial Intelligence
.
Premier Journal of Science
Madathil JP, Sureka S, Spyrou I, Denoiseux C, Thorat MA
(
2024
)
.
Axillary imaging to assess response to neoadjuvant chemotherapy in breast cancer and guide de-escalation of axillary surgery: a single-institution retrospective study
.
European Journal of Surgical Oncology
vol.
50
,
Article
109426
,
109426
-
109426
.
Thorat MA
(
2024
)
.
Differences in Sentinel Node Biopsy and Targeted Axillary Dissection Following Neoadjuvant Chemotherapy
.
JAMA Oncology
vol.
10
,
(
12
)
1728
-
1728
.
Chougle Q, Hamed H, Thorat M, Kothari A
(
2024
)
.
MENOPRE – A Randomised Controlled trial comparing the use of Meshes versus No meshes in pre-pectoral direct to implant immediate breast reconstruction
.
European Journal of Surgical Oncology
vol.
50
,
Article
108882
,
108882
-
108882
.
Thorat MA, Cuzick J, Chan AT
(
2024
)
.
Aspirin vs Placebo as Adjuvant Therapy for Breast Cancer
.
JAMA
vol.
332
,
(
13
)
1111
-
1111
.
Aggarwal A, Badve SS, Cuzick J, Madabhushi A, Thorat MA
(
2024
)
.
171P A computational pathology collagen signature predictive of tamoxifen benefit in ductal carcinoma in situ: Results from a cohort within the UK/ANZ DCIS randomized trial
.
Annals of Oncology
vol.
35
,
S284
-
S284
.
Li H, Aggarwal A, Toro P, Fu P, Badve SS, Cuzick J, Madabhushi A, Thorat MA
(
2024
)
.
A prognostic and predictive computational pathology immune signature for ductal carcinoma in situ: retrospective results from a cohort within the UK/ANZ DCIS trial
.
The Lancet Digital Health
vol.
6
,
(
8
)
e562
-
e569
.
Garg N, Thorat MA
(
2024
)
.
A nomogram for predicting axillary node pathologic complete response—A necessary component of the path toward true axillary de‐escalation but needs a clear definition of the research question and a robust study design
.
Cancer
vol.
130
,
(
20
)
3549
-
3550
.
Sinha A, Peterson Z, Shifa B, Jeffery H, Jurrius P, Allen S, Lee E, Azmat M et al.
(
2024
)
.
Cerenkov luminescence imaging and flexible autoradiography for specimen margin assessment during breast-conserving cancer surgery
.
Radiology Advances
vol.
1
,
(
2
)
Article
umae015
,
Garg N, Thorat M, Hamed H, Kothari A
(
2024
)
.
Abstract PO3-23-07: Evaluation of the role of axillary ultrasound to estimate axillary nodal burden to guide de-escalation of upfront axillary surgery in node positive early breast cancer patients
.
Cancer Research
vol.
84
,
(
9_Supplement
)
Sinha A, Jeffery H, Peterson Z, Shifa B, Jurrius P, Allen S, Lee E, Azmat M et al.
(
2024
)
.
Cerenkov Luminescence Imaging and flexible autoradiography – A first-in-human novel imaging study for intra-operative margin assessment in women undergoing breast-conserving surgery for cancer
.
European Journal of Surgical Oncology
vol.
50
,
Article
108143
,
108143
-
108143
.
Sinha A, Jurrius P, Darwish O, Shifa B, Peterson Z, Jeffery H, Walsh K, Metafa A et al.
(
2024
)
.
Predicting response to neoadjuvant chemotherapy in breast cancer by biomechanics quantified with magnetic resonance elastography
.
European Journal of Surgical Oncology
vol.
50
,
Article
108145
,
108145
-
108145
.
Garg N, Thorat MA, Kothari AS
(
2024
)
.
The SOUND Randomized Clinical Trial Results
.
JAMA Oncology
vol.
10
,
(
5
)
676
-
676
.
Sinha A, Jeffery H, Peterson Z, Shifa B, Jurrius P, Allen S, Lee E, Azmat M et al.
(
2024
)
.
Cerenkov Luminescence Imaging and Flexible AutoRadiography – a first-in-human novel imaging study for intra-operative margin assessment in women undergoing breast-conserving surgery for cancer
.
European Journal of Cancer
vol.
200
,
Article
113758
,
113758
-
113758
.
Garg N, Thorat M, Kothari A
(
2024
)
.
Do the results of the SOUND trial necessitate a paradigm shift in our approach to axillary staging in patients undergoing a mastectomy for DCIS?
.
European Journal of Cancer
vol.
200
,
Article
113791
,
113791
-
113791
.
Sinha A, Jurrius P, Darwish O, Shifa B, Peterson Z, Jeffery H, Welsh K, Metafa A et al.
(
2024
)
.
Predicting response to neoadjuvant chemotherapy in breast cancer by biomechanics quantified with Magnetic Resonance Elastography
.
European Journal of Cancer
vol.
200
,
Article
113817
,
113817
-
113817
.
Chougle Q, Chandra A, Thorat M, Hamed H, Kothari A
(
2024
)
.
Audit on the use of core biopsy imprint cytology in a one stop Breast clinic
.
European Journal of Surgical Oncology
vol.
50
,
(
2
)
Article
107468
,
107468
-
107468
.
Mathew G, Sohrabi C, Franchi T, Nicola M, Kerwan A, Agha R
(
2023
)
.
Preferred reporting of case series in surgery (PROCESS) 2023 guidelines
.
International Journal of Surgery
Garg N, Thorat MA
(
2023
)
.
Letter to the Editor: Cost‐Efficacy Analysis of Use of Frozen Section Histology for Margin Assessment During Breast Conservation Surgery in Breast Cancer Patients
.
World Journal of Surgery
vol.
47
,
(
12
)
3451
-
3452
.
Thorat MA
(
2023
)
.
Multiclonality of ER expression in DCIS - Implications for clinical practice and future research
.
Oncotarget
vol.
14
,
(
1
)
719
-
720
.
McDermott KT, Noake C, Wolff R, Bauld L, Espina C, Foucaud J, Steindorf K, Thorat MA et al.
(
2023
)
.
Digital interventions to moderate physical inactivity and/or nutrition in young people: a Cancer Prevention Europe overview of systematic reviews
.
Frontiers in Digital Health
vol.
5
,
Article
1185586
,
McDermott KT, Noake C, Wolff R, Espina C, Foucaud J, Steindorf K, Schüz J, Thorat MA et al.
(
2023
)
.
Digital interventions to moderate alcohol consumption in young people: a Cancer Prevention Europe overview of systematic reviews
.
Frontiers in Digital Health
vol.
5
,
Article
1178407
,
Sohrabi C, Mathew G, Maria N, Kerwan A, Franchi T, Agha RA
(
2023
)
.
The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines
.
International Journal of Surgery
vol.
109
,
(
5
)
1136
-
1140
.
Garg N, Thorat MA, Deshpande A
(
2023
)
.
P236 Immediate breast reconstruction as a day case procedure and impact of COVID-19 pandemic
.
The Breast
vol.
68
,
S109
-
S109
.
Li H, Madabhushi A, Badve S, Cuzick J, Thorat MA
(
2023
)
.
P240 Computerized Quantification of Tumor Infiltrating Lymphocyte (TIL) as a prognostic and predictive factor in ductal carcinoma in situ: Results from the UK/ANZ DCIS randomized trial
.
The Breast
vol.
68
,
S111
-
S111
.
Garg N, Thorat MA
(
2023
)
.
HER2 expression should be routinely evaluated in DCIS to avoid under or overtreatment!
.
Oncoscience
vol.
10
,
1
-
3
.
Li H, Madabhushi A, Badve S, Cuzick J, Thorat MA
(
2023
)
.
Computerized Quantification of Tumor Infiltrating Lymphocyte (TIL) as a prognostic and predictive factor in ductal carcinoma in situ: Results from the UK/ANZ DCIS randomized trial
.
BREAST
.
vol.
68
,
S111
-
S111
.
Garg N, Thorat MA, Deshpande A
(
2023
)
.
Immediate breast reconstruction as a day case procedure and impact of COVID-19 pandemic
.
BREAST
.
vol.
68
,
S109
-
S109
.
Mathew G, Agha R, Albrecht J, Goel P, Mukherjee I, Pai P, D'Cruz AK, Nixon IJ et al.
(
2021
)
.
STROCSS 2021: Strengthening the reporting of cohort, cross-sectional and case-control studies in surgery
.
Annals of Medicine and Surgery
vol.
72
,
Article
103026
,
103026
-
103026
.
(
2021
)
.
Mammographic density, endocrine therapy and breast cancer risk: a prognostic and predictive biomarker review
.
Cochrane Database of Systematic Reviews
vol.
2021
,
(
10
)
Hall LH, Thorneloe R, Rodriguez-Lopez R, Grice A, Thorat MA, Bradbury K, Kamble MW, Okoli GN et al.
(
2021
)
.
Delivering brief physical activity interventions in primary care: a systematic review
.
British Journal of General Practice
vol.
72
,
(
716
)
e209
-
e216
.
Thorat MA, Levey PM, Jones JL, Pinder SE, Bundred NJ, Fentiman IS, Cuzick J
(
2021
)
.
Prognostic and Predictive Value of HER2 Expression in Ductal Carcinoma <i>In Situ</i>: Results from the UK/ANZ DCIS Randomized Trial
.
Clinical Cancer Research
vol.
27
,
(
19
)
5317
-
5324
.
Lloyd KE, Hall LH, Ziegler L, Smith SG, Adamson V, Ainsworth S, Akerlund M, Baker I et al.
(
2021
)
.
Breast cancer worry in higher-risk women offered preventive therapy: a UK multicentre prospective study
.
Breast Cancer Research and Treatment
vol.
188
,
(
3
)
703
-
712
.
Thorat MA, Levey PM, Jones JL, Pinder SE, Bundred NJ, Fentiman IS, Cuzick J
(
2021
)
.
Prognostic Value of ER and PgR Expression and the Impact of Multi-clonal Expression for Recurrence in Ductal Carcinoma <i>in situ</i>: Results from the UK/ANZ DCIS Trial
.
Clinical Cancer Research
vol.
27
,
(
10
)
2861
-
2867
.
Li H, Fu P, Toro P, Madabhushi A, Thorat M
(
2021
)
.
Computerized Quantification of Tumor Infiltrating Lymphocyte (TIL) Density on H&E Images is Associated with Recurrence Risk in Ductal Carcinoma in Situ (DCIS)
.
LABORATORY INVESTIGATION
.
vol.
101
,
121
-
122
.
Agha RA, Sohrabi C, Mathew G, Franchi T, Kerwan A, O’Neill N, Thoma A, Beamish AJ et al.
(
2020
)
.
The PROCESS 2020 Guideline: Updating Consensus Preferred Reporting Of CasE Series in Surgery (PROCESS) Guidelines
.
International Journal of Surgery
vol.
84
,
231
-
235
.
Agha RA, Franchi T, Sohrabi C, Mathew G, Kerwan A, Thoma A, Beamish AJ, Noureldin A et al.
(
2020
)
.
The SCARE 2020 Guideline: Updating Consensus Surgical CAse REport (SCARE) Guidelines
.
International Journal of Surgery
vol.
84
,
226
-
230
.
Thorat MA, Balasubramanian R
(
2020
)
.
Breast cancer prevention in high-risk women
.
Best Practice & Research Clinical Obstetrics & Gynaecology
vol.
65
,
18
-
31
.
Li H, Bera K, Gilmore H, Zhang Z, Cuzick J, Thorat MA, Madabhushi A
(
2020
)
.
Abstract P5-06-15: Computer extracted features of nuclear shape, orientation disorder and texture from H&E Whole slide images are associated with disease-free survival in ductal carcinoma in situ (DCIS)
.
Cancer Research
.
vol.
80
,
Agha R, Abdall-Razak A, Crossley E, Dowlut N, Iosifidis C, Mathew G, Beamishaj, Bashashati M et al.
(
2019
)
.
STROCSS 2019 Guideline: Strengthening the reporting of cohort studies in surgery
.
International Journal of Surgery
vol.
72
,
156
-
165
.
Li H, Whitney J, Bera K, Gilmore H, Thorat MA, Badve S, Madabhushi A
(
2019
)
.
Quantitative nuclear histomorphometric features are predictive of Oncotype DX risk categories in ductal carcinoma in situ: preliminary findings
.
Breast Cancer Research
vol.
21
,
(
1
)
Article
114
,
Dowling RJO, Sparano JA, Goodwin PJ, Bidard F-C, Cescon DW, Chandarlapaty S, Deasy JO, Dowsett M et al.
(
2019
)
.
Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 2: Approaches to Predict and Identify Late Recurrence, Research Directions
.
JNCI Cancer Spectrum
vol.
3
,
(
4
)
Article
pkz049
,
Dowling RJO, Kalinsky K, Hayes DF, Bidard F-C, Cescon DW, Chandarlapaty S, Deasy JO, Dowsett M et al.
(
2019
)
.
Toronto Workshop on Late Recurrence in Estrogen Receptor–Positive Breast Cancer: Part 1: Late Recurrence: Current Understanding, Clinical Considerations
.
JNCI Cancer Spectrum
vol.
3
,
(
4
)
Article
pkz050
,
Espina C, Bauld L, Bonanni B, Brenner H, Brown K, Dillner J, Kampman E, Nilbert M et al.
(
2019
)
.
WITHDRAWAL—Administrative Duplicate Publication: The essential role of prevention in reducing the cancer burden in Europe: a commentary from Cancer Prevention Europe
.
Tumori Journal
vol.
106
,
(
5
)
NP2
-
NP4
.
Thorat MA
(
2019
)
.
Liquid biopsy for cancer diagnosis and screening – The promise and challenges
.
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
vol.
56
,
(
4
)
420
-
423
.
Allen N, Allen M, Ahmed K, Gomm J, Nelan R, Nagano A, Chelala C, Gadaleta E et al.
(
2019
)
.
Abstract P5-18-08: Defining molecular signatures to personalise management of patients with early breast cancer
.
Cancer Research
.
vol.
79
,
Thorneloe RJ, Horne R, Side L, Wolf MS, Smith SG, Adamson V, Ainsworth S, Akerlund M et al.
(
2019
)
.
Beliefs About Medication and Uptake of Preventive Therapy in Women at Increased Risk of Breast Cancer: Results From a Multicenter Prospective Study
.
Clinical Breast Cancer
vol.
19
,
(
1
)
e116
-
e126
.
Agha RA, Borrelli MR, Farwana R, Koshy K, Fowler AJ, Orgill DP, Zhu H, Alsawadi A et al.
(
2018
)
.
The PROCESS 2018 statement: Updating Consensus Preferred Reporting Of CasE Series in Surgery (PROCESS) guidelines
.
International Journal of Surgery
vol.
60
,
279
-
282
.
Agha RA, Borrelli MR, Farwana R, Koshy K, Fowler AJ, Orgill DP, Zhu H, Alsawadi A et al.
(
2018
)
.
The SCARE 2018 statement: Updating consensus Surgical CAse REport (SCARE) guidelines
.
International Journal of Surgery
vol.
60
,
132
-
136
.
(
2018
)
.
Mammographic density, endocrine therapy and breast cancer risk: a prognostic and predictive biomarker review
.
Cochrane Database of Systematic Reviews
Thorat MA
(
2018
)
.
Aspirin
.
Reference Module in Biomedical Sciences
,
Elsevier
Thorat MA
(
2018
)
.
Aspirin and Cancer
.
Encyclopedia of Cancer Third Edition Volumes 1 3
,
vol.
1
,
Agha RA, Fowler AJ, Saeta A, Barai I, Rajmohan S, Orgill DP, Afifi R, Al-Ahmadi R et al.
(
2017
)
.
Erratum to “Erratum to “The SCARE guidelines: Consensus-based surgical case report guidelines” [Int. J. Surg. 34 (2016) 180–186]” [Int. J. Surg. 36 (2016) 396]
.
International Journal of Surgery
vol.
47
,
151
-
151
.
Agha RA, Borrelli MR, Vella-Baldacchino M, Thavayogan R, Orgill DP, Pagano D, Pai PS, Basu S et al.
(
2017
)
.
The STROCSS statement: Strengthening the Reporting of Cohort Studies in Surgery
.
International Journal of Surgery
vol.
46
,
198
-
202
.
Thorat MA, Cuzick J
(
2017
)
.
Preventing invasive breast cancer using endocrine therapy
.
The Breast
vol.
34
,
S47
-
S54
.
Cuzick J
(
2017
)
.
Preventing invasive breast cancer using endocrine therapy
.
The Breast
vol.
32
,
S7
-
S8
.
Thorat MA, Wagner S, Jones LJ, Levey PM, Bulka K, Hoff R, Sangale Z, Flake DD et al.
(
2017
)
.
Abstract P1-09-06: Prognostic and predictive relevance of cell cycle progression (CCP) score in ductal carcinoma <i>in situ</i>: Results from the UK/ANZ DCIS trial
.
Cancer Research
.
vol.
77
,
Oke A, Knox J, Tan J, Aigret B, Schmid P, Coleman RE, Cuzick J, Thorat MA
(
2017
)
.
Barriers to recruitment from primary care into a trial in secondary care settings: experience from the feasibility study of IBIS-3 trial
.
TRIALS
.
vol.
18
,
Ussi AE, Rebolj M, Thorat MA, Bietrix F, Fauvel A, Hajdúch M, Hill C, Walker I et al.
(
2016
)
.
Assessing opportunities for coordinated <scp>R</scp>&<scp>D</scp> in early cancer detection and management in <scp>E</scp>urope
.
International Journal of Cancer
vol.
140
,
(
7
)
1700
-
1701
.
Agha RA, Fowler AJ, Saeta A, Barai I, Rajmohan S, Orgill DP, Afifi R, Al-Ahmadi R et al.
(
2016
)
.
Erratum to “The SCARE guidelines: Consensus-based surgical case report guidelines” [Int. J. Surg. 34 (2016) 180–186]
.
International Journal of Surgery
vol.
36
,
396
-
396
.
Agha RA, Fowler AJ, Rajmohan S, Barai I, Orgill DP, Afifi R, Alahmadi R, Albrecht J et al.
(
2016
)
.
Preferred reporting of case series in surgery; the PROCESS guidelines
.
International Journal of Surgery
vol.
36
,
319
-
323
.
Agha RA, Fowler AJ, Saeta A, Barai I, Rajmohan S, Orgill DP, Afifi R, Al-Ahmadi R et al.
(
2016
)
.
The SCARE Statement: Consensus-based surgical case report guidelines
.
International Journal of Surgery
vol.
34
,
180
-
186
.
Guerrieri-Gonzaga A, Sestak I, Lazzeroni M, Serrano D, Rotmensz N, Cazzaniga M, Varricchio C, Thorat MA et al.
(
2016
)
.
Abstract 1788: Benefit of low-dose tamoxifen in a large, single-institution cohort of high-risk ER-positive DCIS
.
Cancer Research
.
vol.
76
,
1788
-
1788
.
Thorat MA
(
2016
)
.
Individualised benefit–harm balance of aspirin as primary prevention measure – a good proof-of-concept, but could have been better…
.
BMC Medicine
vol.
14
,
(
1
)
Article
101
,
Thorat MA
(
2016
)
.
A major flaw in “Awareness of breast cancer and barriers to breast screening uptake in Bangladesh: A population based survey”
.
Maturitas
vol.
88
,
45
-
45
.
Thorat MA, Wagner S, Jones LJ, Levey PM, Bulka K, Hoff R, Sangale Z, II FDD et al.
(
2016
)
.
Prognostic and predictive relevance of HER2 status in ductal carcinoma in situ: Results from the UK/ANZ DCIS trial
.
CANCER RESEARCH
.
vol.
76
,
Thorat MA, Jones LJ, Levey PM, Elia G, Evagora CA, Bundred NJ, Fentiman IS, Forbes JF et al.
(
2016
)
.
Prognostic role and impact of multi-clonal ER and PgR expression in ductal carcinoma in situ: Results from the UK/ANZ DCIS trial
.
CANCER RESEARCH
.
vol.
76
,
Cuzick J, Cuschieri K, Denton K, Hopkins M, Thorat MA, Wright C, Cubie H, Moore C et al.
(
2015
)
.
Performance of the Xpert HPV assay in women attending for cervical screening
.
Papillomavirus Research
vol.
1
,
32
-
37
.
DeCensi A
(
2015
)
.
Barriers to preventive therapy for breast and other major cancers and strategies to improve uptake
.
ecancermedicalscience
vol.
9
,
Cuzick J, Sestak I, Thorat MA
(
2015
)
.
Impact of preventive therapy on the risk of breast cancer among women with benign breast disease
.
The Breast
vol.
24
,
S51
-
S55
.
Thorat MA
(
2015
)
.
Sentinel lymph node assessment in breast cancer patients receiving neo‐adjuvant chemotherapy: to biopsy before or after?
.
International Journal of Cancer
vol.
138
,
(
2
)
267
-
270
.
Cuzick J, Thorat M
(
2015
)
.
PG 6.02 Preventing invasive breast cancer in women at high risk based on benign/in situ pathology
.
The Breast
.
vol.
24
,
S11
-
S11
.
Thorat MA, Cuzick J
(
2015
)
.
Reply to the letter to the editor ‘The harms of low-dose aspirin prophylaxis are overstated’ by P. Elwood and G. Morgan
.
Annals of Oncology
vol.
26
,
(
2
)
442
-
443
.
Cuzick J, Thorat MA, Bosetti C, Brown PH, Burn J, Cook NR, Ford LG, Jacobs EJ et al.
(
2015
)
.
Estimates of benefits and harms of prophylactic use of aspirin in the general population
.
Annals of Oncology
vol.
26
,
(
1
)
47
-
57
.
Cuzick J, Thorat MA, Bosetti C, Brown PH, Burn J, Cook NR, Ford LG, Jacobs EJ et al.
(
2015
)
.
Estimates of benefits and harms of prophylactic use of aspirin in the general population
.
Annals of oncology : official journal of the European Society for Medical Oncology
vol.
26
,
(
1
)
47
-
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vol.
347
,
(
26
)
2170
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2171
.
Sinha A, Jurrius P, Darwish O, Shida B, Peterson Z, Jeffery H, Welsh K, Metafa A et al.
.
Predicting response to neoadjuvant chemotherapy in breast cancer by biomechanics quantified with Magnetic Resonance Elastography
.
ISMRM Annual Meeting
.
Conference:
2024 ISMRM & ISMRT Annual Meeting
from:
04/05/2024
to:
09/05/2024
,