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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Louisa Dunmall

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Sarbia N, Lopez E, Tsai YT, Buckley PR, Gievers DM, Portillo M, Ferreira R, Chard LS et al. ( 2025 ) . 896 Oncolytic vaccinia virus-mediated immunotherapy increases survival and reduces tumour growth by turning immunologically ‘cold’ oestrogen receptor-positive breast tumours ‘hot’ . Conference: Regular and Young Investigator Award Abstractsa1015 - a1016 .
Ji Y, Wang Z, Cheng Z, Lu S, Lemoine NR, Baleeiro R, Dunmall LSC, Wang Y ( 2025 ) . Ectopic HLA-II Expression in ESCC: Exploration of Its Relationship with Neoantigen Burden and Patient Survival . Cells vol. 14 , ( 17 )
Qian X, Ning W, Yang J, Dunmall LC, Pandha HS, Shang G, Guo Y, Zhang D et al. ( 2025 ) . The oncolytic adenovirus Ad-TD-nsIL12 in primary or progressive pediatric IDH wild-type diffuse intrinsic pontine glioma results of two phase I clinical trials . Nature Communications vol. 16 , ( 1 )
Jia Y, Wang Y, Zhao G, Yang Y, Yan W, Wang R, Han B, Wang L et al. ( 2025 ) . Novel oncolytic vaccinia virus armed with interleukin-27 is a potential therapeutic agent for the treatment of murine pancreatic cancer . Journal for ImmunoTherapy of Cancer vol. 13 , ( 5 )
Zhao Z, Cutmore LC, Baleeiro RB, Hartlebury JJ, Brown N, Chard-Dunmall L, Lemoine N, Wang Y et al. ( 2025 ) . The Combination of Oncolytic Virus and Antibody Blockade of TGF-β Enhances the Efficacy of αvβ6-Targeting CAR T Cells Against Pancreatic Cancer in an Immunocompetent Model . Cancers vol. 17 , ( 9 )
Wang C, Cheng Z, Miao J, Xue X, Dong Y, Zhao L, Guo H, Wang J et al. ( 2025 ) . Genomic-transcriptomic analysis identifies the Syrian hamster as a superior animal model for human diseases . BMC Genomics vol. 26 , ( 1 )
Chen L, Wang P, Di Gioia C, Yuan M, Zhang Z, Miao J, Yan W, Zhao G et al. ( 2025 ) . A novel oncolytic Vaccinia virus armed with IL-12 augments antitumor immune responses leading to durable regression in murine models of lung cancer . Frontiers in Immunology vol. 15 ,
Ning W, Qian X, Dunmall LC, Liu F, Guo Y, Li S, Song D, Liu D et al. ( 2024 ) . Non-secreting IL12 expressing oncolytic adenovirus Ad-TD-nsIL12 in recurrent high-grade glioma: a phase I trial . Nature Communications vol. 15 , ( 1 )
Jiang G, Wang Z, Cheng Z, Wang W, Lu S, Zhang Z, Anene CA, Khan F et al. ( 2024 ) . The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma . Nature Communications vol. 15 , ( 1 )
Qian X, Ning W, Dunmall LC, Qu Y, Wang Y, Zhang H ( 2024 ) . Treatment of intracranial inflammatory myofibroblastic tumor with PD-L1 inhibitor and novel oncolytic adenovirus Ad-TD-nsIL12: a case report and literature review . Frontiers in Immunology vol. 15 ,
Qian X, Ning W, Guo Y, Li S, Song D, Liu D, Ma L, Chen Y et al. ( 2024 ) . Initial results from phase I trial of a novel oncolytic adenovirus Ad-TD-nsIL12 in recurrent glioblastoma connecting to ventricular system . Journal of Clinical Oncology vol. 42 , ( 16_suppl ) 2057 - 2057 .
Wang L, Zhang L, Dunmall LC, Wang YY, Fan Z, Cheng Z, Wang Y ( 2024 ) . The dilemmas and possible solutions for CAR-T cell therapy application in solid tumors . Cancer Letters vol. 591 ,
Yan W, Dunmall LSC, Lemoine NR, Wang Y, Wang Y, Wang P ( 2023 ) . The capability of heterogeneous γδ T cells in cancer treatment . Frontiers in Immunology vol. 14 ,
Zhou W, Miao J, Cheng Z, Wang Z, Wang J, Guo H, Wang P, Lu S et al. ( 2023 ) . Hypoxia-regulated secretion of IL-12 enhances antitumor activity and safety of CD19 CAR-T cells in the treatment of DLBCL . Molecular Therapy Oncology vol. 30 , 216 - 226 .
Baleeiro RB, Liu P, Dunmall LSC, Di Gioia C, Nagano A, Cutmore L, Wang J, Chelala C et al. ( 2023 ) . Personalized neoantigen viro-immunotherapy platform for triple-negative breast cancer . Journal for ImmunoTherapy of Cancer vol. 11 , ( 8 )
Wang L, Wang X, Wu Y, Wang J, Zhou W, Wang J, Guo H, Zhang N et al. ( 2023 ) . A novel microenvironment regulated system CAR-T (MRS.CAR-T) for immunotherapeutic treatment of esophageal squamous carcinoma . Cancer Letters vol. 568 ,
Jia Y, Wang Y, Dunmall LSC, Lemoine NR, Wang P, Wang Y ( 2023 ) . Syrian hamster as an ideal animal model for evaluation of cancer immunotherapy . Frontiers in Immunology vol. 14 ,
Wang L, Wu Y, Wang X, Wang J, Zhou W, Wang J, Guo H, Wu Y et al. ( 2023 ) . A Novel Microenvironment Regulated System CAR-T (MRS.CAR-T) for Immunotherapeutic Treatment of Esophageal Squamous Carcinoma . MOLECULAR THERAPY . vol. 31 , 645 - 646 .
Baleeiro R, Liu P, Chard LS, Di Gioia C, Nagano A, Cutmore L, Wang J, Chelala C et al. ( 2023 ) . Emerging Data from the Use of TILT-123, an Oncolytic Adenovirus Armed with TNFa and IL-2 in Patients with Solid Tumors . MOLECULAR THERAPY . vol. 31 , 154 - 154 .
Zhao Y, Dunmall LSC, Cheng Z, Wang Y, Si L ( 2022 ) . Natural products targeting glycolysis in cancer . Frontiers in Pharmacology vol. 13 ,
Zhang N, Wu Y, Wu Y, Wang L, Chen J, Wang X, Dunmall LSC, Cheng Z et al. ( 2022 ) . Ferroptosis-Related Genes Are Potential Therapeutic Targets and the Model of These Genes Influences Overall Survival of NSCLC Patients . Cells vol. 11 , ( 14 )
Lan T, Wang Y, Miao J, Guo H, Wang Z, Wang J, Zhang C, Yang P et al. ( 2022 ) . Deoxythymidylate Kinase as a Promising Marker for Predicting Prognosis and Immune Cell Infiltration of Pan-cancer . Frontiers in Molecular Biosciences vol. 9 ,
Wang Z, Cheng Z, Lu S, Dunmall LSC, Wang J, Guo Y, Wang Y ( 2022 ) . Characterization of the Intra-tumoral B Cell Immunoglobulin Repertoire Is of Prognostic Value for Esophageal Squamous Cell Carcinoma . Frontiers in Immunology vol. 13 ,
Sun Y, Zhang Z, Zhang C, Zhang N, Wang P, Chu Y, Dunmall LSC, Lemoine NR et al. ( 2022 ) . An effective therapeutic regime for treatment of glioma using oncolytic vaccinia virus expressing IL-21 in combination with immune checkpoint inhibition . Molecular Therapy Oncology vol. 26 , 105 - 119 .
Wang L, Dunmall LSC, Cheng Z, Wang Y ( 2022 ) . Remodeling the tumor microenvironment by oncolytic viruses: beyond oncolysis of tumor cells for cancer treatment . Journal for ImmunoTherapy of Cancer vol. 10 , ( 5 )
Xu L, Wang J, Zhang D, Song L, Wu H, Wang J, Miao J, Guo H et al. ( 2022 ) . The two-faced role of ATF2 on cisplatin response in gastric cancer depends on p53 context . Cell & Bioscience vol. 12 , ( 1 )
Baleeiro RB, Bouwens CJ, Liu P, Di Gioia C, Dunmall LSC, Nagano A, Gangeswaran R, Chelala C et al. ( 2022 ) . MHC class II molecules on pancreatic cancer cells indicate a potential for neo-antigen-based immunotherapy . OncoImmunology vol. 11 , ( 1 )
Baleeiro RB, Dunmall LSC, Liu P, Lu S, Lone Y, Lemoine NR, Wang Y ( 2022 ) . Optimized Anchor-Modified Peptides Targeting Mutated RAS Are Promising Candidates for Immunotherapy . Frontiers in Immunology vol. 13 ,
Cao D, Song Q, Li J, Dunmall LSC, Jiang Y, Qin B, Wang J, Guo H et al. ( 2022 ) . Redirecting anti-Vaccinia virus T cell immunity for cancer treatment by AAV-mediated delivery of the VV B8R gene . Molecular Therapy Oncology vol. 25 , 264 - 275 .
Lu S, Zhang Z, Du P, Chard LS, Yan W, El Khouri M, Wang Z, Zhang Z et al. ( 2021 ) . Correction: A Virus-infected, Reprogrammed Somatic Cell–derived Tumor Cell (VIReST) Vaccination Regime can Prevent Initiation and Progression of Pancreatic Cancer . Clinical Cancer Research vol. 27 , ( 9 ) 2663 - 2663 .
Lan T, Xue X, Dunmall LC, Miao J, Wang Y ( 2021 ) . Patient-derived xenograft: a developing tool for screening biomarkers and potential therapeutic targets for human esophageal cancers . Aging vol. 13 , ( 8 ) 12273 - 12293 .
Marelli G, Dunmall LSC, Yuan M, Di Gioia C, Miao J, Cheng Z, Zhang Z, Liu P et al. ( 2021 ) . A systemically deliverable Vaccinia virus with increased capacity for intertumoral and intratumoral spread effectively treats pancreatic cancer . Journal for ImmunoTherapy of Cancer vol. 9 , ( 1 )
Wang N, Wang J, Zhang Z, Cao H, Yan W, Chu Y, Dunmall LSC, Wang Y ( 2020 ) . A novel vaccinia virus enhances anti-tumor efficacy and promotes a long-term anti-tumor response in a murine model of colorectal cancer . Molecular Therapy Oncology vol. 20 , 71 - 81 .
Zhang Z, Zhang C, Miao J, Wang Z, Wang Z, Cheng Z, Wang P, Dunmall LSC et al. ( 2020 ) . A Tumor-Targeted Replicating Oncolytic Adenovirus Ad-TD-nsIL12 as a Promising Therapeutic Agent for Human Esophageal Squamous Cell Carcinoma . Cells vol. 9 , ( 11 )
Miao J-X, Wang J-Y, Li H-Z, Guo H-R, Dunmall LSC, Zhang Z-X, Cheng Z-G, Gao D-L et al. ( 2020 ) . Promising xenograft animal model recapitulating the features of human pancreatic cancer . World Journal of Gastroenterology vol. 26 , ( 32 ) 4802 - 4816 .
Zhang Z, Lu S, Dunmall LSC, Wang Z, Cheng Z, Zhang Z, Yan W, Chu Y et al. ( 2020 ) . Treatment and Prevention of Lung Cancer Using a Virus-Infected Reprogrammed Somatic Cell-Derived Tumor Cell Vaccination (VIReST) Regime . Frontiers in Immunology vol. 11 ,
( 2020 ) . Correction: A new oncolytic Vaccinia virus augments antitumor immune responses to prevent tumor recurrence and metastasis after surgery . Journal for ImmunoTherapy of Cancer vol. 8 , ( 1 )
Ahmed J, Chard LS, Yuan M, Wang J, Howells A, Li Y, Li H, Zhang Z et al. ( 2020 ) . A new oncolytic V accinia virus augments antitumor immune responses to prevent tumor recurrence and metastasis after surgery . Journal for ImmunoTherapy of Cancer vol. 8 , ( 1 )
Ferguson MS, Chard Dunmall LS, Gangeswaran R, Marelli G, Tysome JR, Burns E, Whitehead MA, Aksoy E et al. ( 2020 ) . Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus . Molecular Therapy vol. 28 , ( 5 ) 1263 - 1275 .
Lu S, Zhang Z, Du P, Chard LS, Yan W, Khouri ME, Wang Z, Zhang Z et al. ( 2020 ) . A Virus-Infected, Reprogrammed Somatic Cell–Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer . Clinical Cancer Research vol. 26 , ( 2 ) 465 - 476 .
Miao J, Chard LS, Wang Z, Wang Y ( 2019 ) . Syrian Hamster as an Animal Model for the Study on Infectious Diseases . Frontiers in Immunology vol. 10 ,
Wang P, Li X, Wang J, Gao D, Li Y, Li H, Chu Y, Zhang Z et al. ( 2018 ) . Author Correction: Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent . Nature Communications vol. 9 , ( 1 )
Wang P, Li X, Wang J, Gao D, Li Y, Li H, Chu Y, Zhang Z et al. ( 2017 ) . Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent . Nat Commun vol. 8 , ( 1 ) 1395 - 1395 .
Yuan M, Wang P, Chard LS, Lemoine NR, Wang Y ( 2016 ) . A Simple and Efficient Approach to Construct Mutant Vaccinia Virus Vectors . Journal of Visualized Experiments ( 116 )
Yuan M, Wang P, Chard LS, Lemoine NR, Wang Y ( 2016 ) . A Simple and Efficient Approach to Construct Mutant Vaccinia Virus Vectors . Journal of Visualized Experiments ( 116 )
Yuan M, Gao X, Chard LS, Ali Z, Ahmed J, Li Y, Liu P, Lemoine NR et al. ( 2015 ) . A marker-free system for highly efficient construction of vaccinia virus vectors using CRISPR Cas9 . Molecular Therapy — Methods & Clinical Development vol. 2 ,
Chard LS, Lemoine NR, Wang Y ( 2015 ) . New role of Interleukin-10 in enhancing the antitumor efficacy of oncolytic vaccinia virus for treatment of pancreatic cancer . OncoImmunology vol. 4 , ( 9 )
Ahmed J, Yuan M, Li Y, Chu Y, Zhang Z, Gao D, Chard LS, Alusi G et al. ( 2015 ) . 420. A Promising Neo-Adjuvant Immuno-Therapeutic Agent for Preventing Cancer Recurrence and Metastasis After Surgery . Molecular Therapy . vol. 23 ,
Yuan M, Zhang W, Wang J, Al Yaghchi C, Ahmed J, Chard L, Lemoine NR, Wang Y ( 2015 ) . Efficiently Editing the Vaccinia Virus Genome by Using the CRISPR-Cas9 System . Journal of Virology vol. 89 , ( 9 ) 5176 - 5179 .
Chard LS, Maniati E, Wang P, Zhang Z, Gao D, Wang J, Cao F, Ahmed J et al. ( 2015 ) . A Vaccinia Virus Armed with Interleukin-10 Is a Promising Therapeutic Agent for Treatment of Murine Pancreatic Cancer . Clinical Cancer Research vol. 21 , ( 2 ) 405 - 416 .
Hiley CT, Chard L, Tysome J, Briat A, Lemoine NR, Wang Y ( 2012 ) . Abstract A37: Increased efficacy of oncolytic vaccinia virus, an emerging therapy for pancreatic adenocarcinoma, due to intratumoral hypoxia and vascular endothelial growth factor A . Conference: Therapya37 - a37 .
Ahmed J, Yuan M, Li Y, Chu Y, Shi H, Chard L, Alusi G, Lemoine N et al. ( 2014 ) . A Novel Tumour Selective Oncolytic Vaccinia Virus Lacking the N1L Gene Enhances the Anti-Tumour Immune Response When Used as an Anticancer Therapeutic . MOLECULAR THERAPY . vol. 22 , S248 - S249 .
Hiley CT, Chard LS, Gangeswaran R, Tysome JR, Briat A, Lemoine NR, Wang Y ( 2013 ) . Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway . J Virol vol. 87 , ( 5 ) 2781 - 2790 .
Chard LS, Maniati E, Wang P, Hughes J, Wang J, Denes B, Fodor I, Hagemann T et al. ( 2013 ) . A Vaccinia Virus Armed with Interleukin-10 That Dampens Host Immunity to the Vctor but Not to Tumor Is a Promising Therapeutic Agent for Pancreatic Cancer . MOLECULAR THERAPY . vol. 21 , S196 - S196 .
Tysome JR, Li X, Wang S, Wang P, Gao D, Du P, Chen D, Gangeswaran R et al. ( 2012 ) . A novel therapeutic regimen to eradicate established solid tumors with an effective induction of tumor-specific immunity . Clin Cancer Res vol. 18 , ( 24 ) 6679 - 6689 .
Wang P, Jiang G, Chard L, Wang J, Gao D, Cao H, Lemoine NR, Wang Y ( 2012 ) . A Rationally Designed Oncolytic Adenovirus, Ad-TD-IL-12, Cures Pancreatic Cancer in the Immunocompetent Syrian Hamster . MOLECULAR THERAPY . vol. 20 , S131 - S131 .
Hiley CT, Chard L, Lemoine N ( 2011 ) . A novel replication-selective vaccinia virus vector to express diagnostic or therapeutic genes in hypoxic environments . HUMAN GENE THERAPY vol. 22 , ( 10 ) A99 - A100 .
Chard LS, Bailey DS, Dash P, Barrett T ( 2008 ) . Full genome sequences of two virulent strains of peste-des-petits ruminants virus, the Côte d'Ivoire 1989 and Nigeria 1976 strains . Virus Res vol. 136 , ( 1-2 ) 192 - 197 .
Bailey D, Chard LS, Dash P ( 2007 ) . Reverse genetics for peste-des-petits-ruminants virus (PPRV): promoter and protein specificities . Virus Res vol. 126 , ( 1-2 ) 250 - 255 .
Bordeleau M-E, Mori A, Oberer M, Chard LS, Higa T, Belsham GJ, Tanaka J ( 2006 ) . Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A . Nat Chem Biol vol. 2 , ( 4 ) 213 - 220 .
Chard LS, Bordeleau M-E, Pelletier J ( 2006 ) . Hepatitis C virus-related internal ribosome entry sites are found in multiple genera of the family Picornaviridae . J Gen Virol vol. 87 , ( Pt 4 ) 927 - 936 .
Chard LS, Kaku Y, Jones B ( 2006 ) . Functional analyses of RNA structures shared between the internal ribosome entry sites of hepatitis C virus and the picornavirus porcine teschovirus 1 Talfan . J Virol vol. 80 , ( 3 ) 1271 - 1279 .
Pisarev AV, Chard LS, Kaku Y, Johns HL, Shatsky IN ( 2004 ) . Functional and structural similarities between the internal ribosome entry sites of hepatitis C virus and porcine teschovirus, a picornavirus . J Virol vol. 78 , ( 9 ) 4487 - 4497 .
Kaku Y, Chard LS, Inoue T ( 2002 ) . Unique characteristics of a picornavirus internal ribosome entry site from the porcine teschovirus-1 talfan . J Virol vol. 76 , ( 22 ) 11721 - 11728 .
Cheng Z, Zhang D, Chen J, Wu Y, Liu X, Si L, Zhang Z, Zhang N et al. . A novel viral protein translation mechanism reveals mitochondria as a target for antiviral drug development .
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