Publications: DR Adam Brentnall

Wei X, Mansour L, Oxley S, Fierheller CT, Kalra A, Sia J, Ganesan S, Sideris M et al. ( 2025 ) . Defining Lifetime Risk Thresholds for Breast Cancer Surgical Prevention . JAMA Oncology

Rebolj M, Brentnall AR, Geppert J, Kouppa N, Shinkins B, Freeman K, Stinton C, Randell MJ et al. ( 2025 ) . LATE-STAGE OUTCOMES AS SURROGATES FOR MORTALITY IN CANCER SCREENING TRIALS: \nA SYSTEMATIC REVIEW AND META-ANALYSIS . Cancer Epidemiology, Biomarkers & Prevention

Hutton G, Li SJ, Quaife SL, Brentnall A, Cookson J, Jenkins J, Hudson S, Webb S et al. ( 2025 ) . Understanding barriers to breast screening: an online survey of non-attenders as part of a service evaluation in the breast screening programme in England . BMC Public Health vol. 25 , ( 1 ) Article 2509 ,

Mathews CS, Sargent A, Cuschieri K, Rebolj M, Brentnall AR, Mackie A, Mills C, Martinelli C et al. ( 2025 ) . HPValidate—human papillomavirus testing with DNA and mRNA assays on self-collected samples in cervical screening: comparison of test characteristics on three self-sampling devices . British Journal of Cancer

Cullimore V, Newhouse R, Baker-Rand H, Brentnall AR, Chu K, Denton K, McWilliams L, Sargent A et al. ( 2025 ) . Postnatal instead of normally-timed cervical screening (PINCS-1): a protocol for a feasibility study of paired-sample cervical screening and urine self-sampling at 6 weeks and 12 weeks postnatal in the UK . BMJ Open vol. 15 , ( 5 ) e092701 - e092701 .

Chaudhry T, Tum P, Tam HZ, Brentnall A, Smethurst H, Kielmann K, Kunst H, Hargreaves S et al. ( 2025 ) . COVER-ME: developing and evaluating community-based interventions to promote vaccine uptake for COVID-19 and influenza in East London minority ethnicity (ME) and underserved individuals - protocol for a pilot randomised controlled trial . BMJ Open vol. 15 , ( 3 ) e092568 - e092568 .

Swanton C, Bachtiar V, Mathews C, Brentnall AR, Lowenhoff I, Waller J, Bomb M, McPhail S et al. ( 2025 ) . NHS-Galleri trial: Enriched enrolment approaches and sociodemographic characteristics of enrolled participants . Clinical Trials vol. 22 , ( 2 ) 227 - 238 .

Cullimore V, Newhouse R, Baker-Rand H, Brentnall AR, Chu K, Denton K, McWilliams L, Sargent A et al. ( 2024 ) . PINCS-1: protocol for a feasibility study investigating the acceptability and accuracy of cervical screening and self-sampling in women at 6-weeks postnatal .

Manchanda R, Wei X, Sun L, Slade E, Fierheller C, Oxley S, Kalra A, Sia J et al. ( 2024 ) . Cost-effectiveness analysis of cancer susceptibility gene-specific prevention strategies for ovarian and breast cancer . Gynecologic Oncology . vol. 190 , S159 - S160 .

Sasieni P, Brentnall AR ( 2024 ) . More efficient, smaller multicancer screening trials . JNCI: Journal of the National Cancer Institute vol. 117 , ( 3 ) 450 - 455 .

Hill H, Roadevin C, Duffy S, Mandrik O, Brentnall A ( 2024 ) . Cost-Effectiveness of AI for Risk-Stratified Breast Cancer Screening . JAMA Network Open vol. 7 , ( 9 ) e2431715 - e2431715 .

Chaudhry T, Tum P, Tam ZH, Brentnall A, Smethurst H, Kielmann K, Kunst H, Hargreaves S et al. ( 2024 ) . COVER-ME: Developing and Evaluating community-based interventions to promote vaccine uptake in East London minority ethnicity (ME) populations; underserved migrants and persons with low income: protocol for a pilot randomised controlled trial .

Faheem M, Tam HZ, Nojoum M, Suaris T, Jahan N, Lloyd T, Johnson L, Aggarwal S et al. ( 2024 ) . Role of Supplemental Breast MRI in Screening Women with Mammographically Dense Breasts: A Systematic Review and Meta-analysis . Journal of Breast Imaging vol. 6 , ( 4 ) 355 - 377 .

Law R, Krupa K, Brentnall A, Tam HZ, Rusby JE ( 2024 ) . CANCER-RELATED ANXIETY AND PERCEIVED BREAST CANCER RISK IN PARTICIPANTS OF A RANDOMISED PILOT STUDY OF LIFESTYLE INTERVENTION TO REDUCE BREAST CANCER RISK (PIONEER) . European Journal of Surgical Oncology vol. 50 , Article 108080 , 108080 - 108080 .

Law R, Krupa K, Brentnall A, Tam HZ, Rusby JE ( 2024 ) . Pilot of lifestyle intervention to reduce breast cancer risk (PIONEER): A randomised study . European Journal of Surgical Oncology vol. 50 , Article 108169 , 108169 - 108169 .

Rebolj M, Brentnall AR, Cuschieri K ( 2024 ) . Predictable changes in the accuracy of human papillomavirus tests after vaccination: review with implications for performance monitoring in cervical screening . British Journal of Cancer vol. 130 , ( 11 ) 1733 - 1743 .

Gilham C, Nedjai B, Scibior‐Bentkowska D, Reuter C, Banwait R, Brentnall AR, Cuzick J, Peto J et al. ( 2024 ) . Long‐term prediction by DNA methylation of high‐grade cervical intraepithelial neoplasia: Results of the ARTISTIC cohort . International Journal of Cancer vol. 155 , ( 1 ) 81 - 92 .

Manchanda R, Evans DG, Antoniou AC, Brentnall A ( 2024 ) . Penetrance estimates of hereditary cancers in a population setting using UK Biobank data . BJC Reports vol. 2 , ( 1 ) Article 24 ,

Wei X, Sun L, Slade E, Fierheller C, Oxley S, Kalra A, Sia J, Sideris M et al. ( 2024 ) . 443 Cost-effectiveness analysis of cancer susceptibility gene-specific prevention strategies for ovarian and breast cancer . Oral Sessions . Conference: ESGO 2024 Congress AbstractsA40 - A41 .

Wei X, Sun L, Slade E, Fierheller CT, Oxley S, Kalra A, Sia J, Sideris M et al. ( 2024 ) . Cost-Effectiveness of Gene-Specific Prevention Strategies for Ovarian and Breast Cancer . JAMA Network Open vol. 7 , ( 2 ) e2355324 - e2355324 .

Santeramo R, Damiani C, Wei J, Montana G, Brentnall AR ( 2024 ) . Are better AI algorithms for breast cancer detection also better at predicting risk? A paired case–control study . Breast Cancer Research vol. 26 , ( 1 ) Article 25 ,

Pegington M, Zhen Tam H, Brentnall A, Sestak I, Adams J, Blake GM, Gareth Evans D, Howell A et al. ( 2024 ) . Body composition changes during breast cancer preventive treatment with anastrozole: Findings from the IBIS-II trial . Preventive Medicine Reports vol. 38 , Article 102620 , 102620 - 102620 .

Brentnall AR, Cuschieri K, Sargent A, Berkhof J, Rebolj M ( 2024 ) . Staged design recommendations for validating relative sensitivity of self-sample human papillomavirus tests for cervical screening . Journal of Clinical Epidemiology vol. 166 , Article 111227 , 111227 - 111227 .

Cuzick J, Chu K, Keevil B, Brentnall AR, Howell A, Zdenkowski N, Bonanni B, Loibl S et al. ( 2024 ) . Effect of baseline oestradiol serum concentration on the efficacy of anastrozole for preventing breast cancer in postmenopausal women at high risk: a case-control study of the IBIS-II prevention trial . The Lancet Oncology vol. 25 , ( 1 ) 108 - 116 .

Slade E, Berg L, Dworzynski K, Manchanda R ( 2024 ) . Ovarian cancer: Identifying and managing familial and genetic risk - Summary of new NICE guidance . BMJ

Wei X, Sun L, Slade E, Oxley S, Kalra A, Sia J, Sideris M, Fierheller C et al. ( 2023 ) . EE675 Cost-Effectiveness Analysis of Cancer Susceptibility Gene-Specific Prevention and Surveillance Strategies for Ovarian and Breast Cancer . Value in Health . vol. 26 , S183 - S184 .

Brentnall AR, Atakpa EC, Hill H, Santeramo R, Damiani C, Cuzick J, Montana G, Duffy SW ( 2023 ) . An optimization framework to guide the choice of thresholds for risk-based cancer screening . npj Digital Medicine vol. 6 , ( 1 ) Article 223 ,

Atakpa EC, Buist DSM, Aiello Bowles EJ, Cuzick J, Brentnall AR ( 2023 ) . Development and evaluation of a method to assess breast cancer risk using a longitudinal history of mammographic density: a cohort study . Breast Cancer Research vol. 25 , ( 1 ) Article 147 ,

Swanton C, Bachtiar V, Mathews C, Brentnall AR, Lowenhoff I, Waller J, Bomb M, McPhail S et al. ( 2023 ) . 1239P NHS-Galleri trial enrolment approaches and participant sociodemographic diversity . Annals of Oncology vol. 34 , S723 - S723 .

Roberts E, van Veen EM, Byers H, Barnett-Griness O, Gronich N, Lejbkowicz F, Pinchev M, Smith MJ et al. ( 2023 ) . Breast cancer polygenic risk scores derived in White European populations are not calibrated for women of Ashkenazi Jewish descent . Genetics in Medicine vol. 25 , ( 10 ) Article 100963 , 100963 - 100963 .

Wei X, Oxley S, Sideris M, Kalra A, Brentnall A, Sun L, Yang L, Legood R et al. ( 2023 ) . Quality of life after risk-reducing surgery for breast and ovarian cancer prevention: a systematic review and meta-analysis . American Journal of Obstetrics and Gynecology vol. 229 , ( 4 ) 388 - 409.e4 .

Roberts E, van Veen EM, Byers H, Barnett-Griness O, Gronich N, Lejbkowicz F, Pinchev M, Smith MJ et al. ( 2023 ) . Breast cancer polygenic risk scores derived in White European populations are not calibrated for women of Ashkenazi Jewish descent . Genetics in Medicine vol. 25 , ( 9 ) Article 100846 , 100846 - 100846 .

Shepherd JM, Ross J, Anton L, Rourke C, Brentnall AR, Tarning J, White NJ, Thiemermann C et al. ( 2023 ) . Safety and efficacy of artesunate treatment in severely injured patients with traumatic hemorrhage. The TOP-ART randomized clinical trial . Intensive Care Medicine vol. 49 , ( 8 ) 922 - 933 .

Damiani C, Kalliatakis G, Sreenivas M, Al-Attar M, Rose J, Pudney C, Lane EF, Cuzick J et al. ( 2023 ) . Evaluation of an AI Model to Assess Future Breast Cancer Risk . Radiology vol. 307 , ( 5 ) Article e222679 ,

Faheem M, Thompson EW, Aggarwal S, Ullah MZ, Brentnall A ( 2023 ) . Role of breast MRI in screening women with dense breasts: A systematic review . European Journal of Surgical Oncology vol. 49 , ( 5 ) e219 - e219 .

Gareth Evans D, McWilliams L, Astley S, Brentnall AR, Cuzick J, Dobrashian R, Duffy SW, Gorman LS et al. ( 2023 ) . Correction To: Quantifying the effects of risk-stratified breast cancer screening when delivered in real time as routine practice versus usual screening: the BC-Predict non-randomised controlled study (NCT04359420) . British Journal of Cancer vol. 128 , ( 11 ) 2140 - 2140 .

Brentnall AR, Mathews C, Beare S, Ching J, Sleeth M, Sasieni P ( 2023 ) . Dynamic data-enabled stratified sampling for trial invitations with application in NHS-Galleri . Clinical Trials vol. 20 , ( 4 ) 425 - 433 .

Gareth Evans D, McWilliams L, Astley S, Brentnall AR, Cuzick J, Dobrashian R, Duffy SW, Gorman LS et al. ( 2023 ) . Quantifying the effects of risk-stratified breast cancer screening when delivered in real time as routine practice versus usual screening: the BC-Predict non-randomised controlled study (NCT04359420) . British Journal of Cancer vol. 128 , ( 11 ) 2063 - 2071 .

Atakpa EC, Cuzick J, Duffy SW, Evans DG, Howell SJ, Brentnall AR ( 2023 ) . Abstract PD14-01: PD14-01 A model to assess the utility of risk-based screening algorithms . Cancer Research vol. 83 , ( 5_Supplement )

Oxley S, Kalra A, Sideris M, Itzkowitz N, Evans O, Atakpa EC, Brentnall AR, Dworschak N et al. ( 2023 ) . Impact of Multiple COVID-19 Waves on Gynaecological Cancer Services in the UK . Cancers vol. 15 , ( 4 ) 1273 - 1273 .

Paige JS, Lee CI, Wang P-C, Hsu W, Brentnall AR, Hoyt AC, Naeim A, Elmore JG ( 2023 ) . Variability Among Breast Cancer Risk Classification Models When Applied at the Level of the Individual Woman . Journal of General Internal Medicine

Pegington M, Harvie M, Harkness EF, Brentnall A, Malcomson L, Southworth J, Fox J, Howell A et al. ( 2023 ) . Obesity at age 20 and weight gain during adulthood increase risk of total and premature all-cause mortality: findings from women attending breast screening in Manchester . BMC Women's Health vol. 23 , ( 1 ) Article 17 ,

Doorbar JA, Mathews CS, Denton K, Rebolj M, Brentnall AR ( 2022 ) . Supporting the implementation of new healthcare technologies by investigating generalisability of pilot studies using area-level statistics . BMC Health Services Research vol. 22 , ( 1 ) Article 1412 ,

Crocker-Buque T, Myles J, Brentnall A, Gabe R, Duffy S, Williams S, Tiberi S ( 2022 ) . Using ISARIC 4C mortality score to predict dynamic changes in mortality risk in COVID-19 patients during hospital admission . PLOS ONE vol. 17 , ( 10 ) e0274158 - e0274158 .

Evans DGR, van Veen EM, Harkness EF, Brentnall AR, Astley SM, Byers H, Woodward ER, Sampson S et al. ( 2022 ) . Breast cancer risk stratification in women of screening age: Incremental effects of adding mammographic density, polygenic risk, and a gene panel . Genetics in Medicine vol. 24 , ( 7 ) 1485 - 1494 .

Brentnall AR, Rebolj M ( 2022 ) . Comments on: “Meta‐analysis of agreement/concordance statistics in studies comparing self‐ vs clinician‐collected samples for HPV testing in cervical cancer screening” . International Journal of Cancer vol. 151 , ( 3 ) 481 - 483 .

Atakpa EC, Thorat MA, Cuzick J, Brentnall AR ( 2021 ) . Mammographic density, endocrine therapy and breast cancer risk: a prognostic and predictive biomarker review . Cochrane Database of Systematic Reviews vol. 2021 , ( 10 )

Evans DG, van Veen EM, Byers H, Roberts E, Howell A, Howell SJ, Harkness EF, Brentnall A et al. ( 2021 ) . The importance of ethnicity: Are breast cancer polygenic risk scores ready for women who are not of White European origin? . International Journal of Cancer vol. 150 , ( 1 ) 73 - 79 .

Atakpa EC, Brentnall AR, Astley S, Cuzick J, Evans DG, Warren RML, Howell A, Harvie M ( 2021 ) . The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study . Cancers vol. 13 , ( 13 ) 3245 - 3245 .

Leventea E, Harkness EF, Brentnall AR, Howell A, Evans DG, Harvie M ( 2021 ) . Is Breast Cancer Risk Associated with Menopausal Hormone Therapy Modified by Current or Early Adulthood BMI or Age of First Pregnancy? . Cancers vol. 13 , ( 11 ) 2710 - 2710 .

Crocker-Buque T, Williams S, Brentnall AR, Gabe R, Duffy S, Prowle JR, Orkin C, Kunst H et al. ( 2021 ) . The Barts Health NHS Trust COVID-19 cohort: characteristics, outcomes and risk scoring of patients in East London . The International Journal of Tuberculosis and Lung Disease vol. 25 , ( 5 ) 358 - 366 .

Belaya JA, Zakharova NA, Brentnall AR ( 2021 ) . Realisation of mammography screening in Khanty-Mansiysk Autonomous State – Yugra . Tumors of female reproductive system vol. 16 , ( 3 ) 32 - 36 .

Ramírez AT, Sánchez GI, Nedjai B, Agudelo MC, Brentnall AR, Cuschieri K, Castañeda KM, Cuzick J et al. ( 2020 ) . Effective methylation triage of <scp>HPV</scp> positive women with abnormal cytology in a middle‐income country . International Journal of Cancer vol. 148 , ( 6 ) 1383 - 1393 .

Brentnall AR, Duffy SW ( 2020 ) . Calculating, Using and Improving Individual Breast Cancer Risk Estimates . Breast MRI for High-risk Screening , Springer International Publishing

Brentnall AR, Warren R, Harkness EF, Astley SM, Wiseman J, Fox J, Fox L, Eriksson M et al. ( 2020 ) . Mammographic density change in a cohort of premenopausal women receiving tamoxifen for breast cancer prevention over 5 years . Breast Cancer Research vol. 22 , ( 1 ) Article 101 ,

Manchanda R, Sun L, Patel S, Evans O, Wilschut J, De Freitas Lopes AC, Gaba F, Brentnall A et al. ( 2020 ) . Economic Evaluation of Population-Based BRCA1/BRCA2 Mutation Testing across Multiple Countries and Health Systems . Cancers vol. 12 , ( 7 ) 1929 - 1929 .

French DP, Astley S, Brentnall AR, Cuzick J, Dobrashian R, Duffy SW, Gorman LS, Harkness EF et al. ( 2020 ) . What are the benefits and harms of risk stratified screening as part of the NHS breast screening Programme? Study protocol for a multi-site non-randomised comparison of BC-predict versus usual screening (NCT04359420) . BMC Cancer vol. 20 , ( 1 ) Article 570 ,

Renehan AG, Pegington M, Harvie MN, Sperrin M, Astley SM, Brentnall AR, Howell A, Cuzick J et al. ( 2020 ) . Young adulthood body mass index, adult weight gain and breast cancer risk: the PROCAS Study (United Kingdom) . British Journal of Cancer vol. 122 , ( 10 ) 1552 - 1561 .

Law RSL, Pitches C, Krupa K, Brentnall A, Rusby J ( 2020 ) . Abstract OT3-15-01: Pilot of lifestyle InterventiON to reducE brEast cancer Risk (PIONEER): A randomised study . Cancer Research vol. 80 , ( 4_Supplement )

Wang C, Brentnall AR, Mainprize J, Yaffe M, Cuzick J, Harvey JA ( 2020 ) . External validation of a mammographic texture marker for breast cancer risk in a case–control study . Journal of Medical Imaging vol. 7 , ( 01 ) 1 - 1 .

Bright CJ, Brentnall AR, Wooldrage K, Myles J, Sasieni P, Duffy SW ( 2020 ) . Errors in determination of net survival: cause-specific and relative survival settings . British Journal of Cancer vol. 122 , ( 7 ) 1094 - 1101 .

Moore KM, Desai A, Delgado BDL, Trabulo SMD, Reader C, Brown NF, Murray ER, Brentnall A et al. ( 2020 ) . Integrin αvβ6-specific therapy for pancreatic cancer developed from foot-and-mouth-disease virus . Theranostics vol. 10 , ( 7 ) 2930 - 2942 .

Sun L, Brentnall A, Patel S, Buist DSM, Bowles EJA, Evans DGR, Eccles D, Hopper J et al. ( 2019 ) . A Cost-effectiveness Analysis of Multigene Testing for All Patients With Breast Cancer . JAMA Oncology vol. 5 , ( 12 ) 1718 - 1718 .

Sun L, Brentnall A, Patel S, Buist D, Bowles E, Evans DG, Eccles D, Hopper J et al. ( 2019 ) . Should we offer multi-gene testing to all patients with breast cancer: a cost-effectiveness analysis . Oral Communication 4 – Gynaecological Cancer . Conference: ESGO Annual Meeting AbstractsA31 - A32 .

Manchanda R, Sun L, Patel S, Wilschut J, Lopes Carolina de Freitas A, Brentnall A, Duffy S, Cui B et al. ( 2019 ) . 10 Global economic evaluation of population-based BRCA1/BRCA2 mutation testing . Plenary sessions . Conference: IGCS Annual 2019 Meeting AbstractsA6 - A7 .

Sun L, Brentnall A, Patel S, Buist SM D, Bowles JA E, Evans R DG, Eccles D, Hopper J et al. ( 2019 ) . 66 Should we offer multi-gene testing to all patients with breast cancer: a cost-effectiveness analysis . Regional plenaryA36.2 - A37 .

Rebolj M, Brentnall AR, Mathews C, Denton K, Holbrook M, Levine T, Sargent A, Smith J et al. ( 2019 ) . 16/18 genotyping in triage of persistent human papillomavirus infections with negative cytology in the English cervical screening pilot . British Journal of Cancer vol. 121 , ( 6 ) 455 - 463 .

Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB et al. ( 2019 ) . The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy . The Journal of Pathology vol. 249 , ( 3 ) 332 - 342 .

Brentnall AR, van Veen EM, Harkness EF, Rafiq S, Byers H, Astley SM, Sampson S, Howell A et al. ( 2019 ) . A case–control evaluation of 143 single nucleotide polymorphisms for breast cancer risk stratification with classical factors and mammographic density . International Journal of Cancer vol. 146 , ( 8 ) 2122 - 2129 .

Brentnall AR, Cuzick J ( 2019 ) . Risk models for breast cancer and their validation . Statist. Sci. vol. 35 , ( 1 ) 14 - 30 .

Brentnall AR, Cohn WF, Knaus WA, Yaffe MJ, Cuzick J, Harvey JA ( 2019 ) . A Case-Control Study to Add Volumetric or Clinical Mammographic Density into the Tyrer-Cuzick Breast Cancer Risk Model . Journal of Breast Imaging vol. 1 , ( 2 ) 99 - 106 .

Evans DGR, Harkness EF, Brentnall AR, van Veen EM, Astley SM, Byers H, Sampson S, Southworth J et al. ( 2019 ) . Breast cancer pathology and stage are better predicted by risk stratification models that include mammographic density and common genetic variants . Breast Cancer Research and Treatment vol. 176 , ( 1 ) 141 - 148 .

Escala-Garcia M, Guo Q, Dörk T, Canisius S, Keeman R, Dennis J, Beesley J, Lecarpentier J et al. ( 2019 ) . Genome-wide association study of germline variants and breast cancer-specific mortality . British Journal of Cancer vol. 120 , ( 6 ) 647 - 657 .

Ionescu GV, Fergie M, Berks M, Harkness EF, Hulleman J, Brentnall AR, Cuzick J, Evans DG et al. ( 2019 ) . Prediction of reader estimates of mammographic density using convolutional neural networks . Journal of Medical Imaging vol. 6 , ( 03 ) 1 - 1 .

( 2019 ) . Commentary on Terry et al., 10-Year Performance of Four Models of Breast Cancer Risk: A Validation Study. Lancet Oncol. 2019;20(4):504-17 . Med One vol. 4 , ( 2 )

Brentnall AR, Buist DSM, Cuzick J ( 2019 ) . Competing Risks for a Diagnosis of Invasive Breast Cancer—Reply . JAMA Oncology vol. 5 , ( 1 ) 111 - 111 .

Evans DG, Thomas S, Caunt J, Burch A, Brentnall AR, Roberts L, Howell A, Wilson M et al. ( 2019 ) . Final Results of the Prospective FH02 Mammographic Surveillance Study of Women Aged 35–39 at Increased Familial Risk of Breast Cancer . EClinicalMedicine vol. 7 , 39 - 46 .

Mavaddat N, Michailidou K, Dennis J, Lush M, Fachal L, Lee A, Tyrer JP, Chen T-H et al. ( 2019 ) . Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes . The American Journal of Human Genetics vol. 104 , ( 1 ) 21 - 34 .

Cook DA, Krajden M, Brentnall AR, Gondara L, Chan T, Law JH, Smith LW, van Niekerk DJ et al. ( 2018 ) . Evaluation of a validated methylation triage signature for human papillomavirus positive women in the HPV FOCAL cervical cancer screening trial . International Journal of Cancer vol. 144 , ( 10 ) 2587 - 2595 .

Rebolj M, Brentnall A, Duffy SW ( 2018 ) . Reply to ‘Comment on ‘Addition of ultrasound to mammography in the case of dense breast tissue: systematic review and meta-analysis” . British Journal of Cancer vol. 119 , ( 11 ) 1444 - 1444 .

Zakharova NA, Brentnall AR, Belaya J, Bilan E ( 2018 ) . 10-year results of the breast cancer screening program in Khanty-Mansiysk state region Ugra . Annals of Oncology vol. 29 , viii573 - viii573 .

Brentnall AR, Cuzick J, Buist DSM, Bowles EJA ( 2018 ) . Long-term Accuracy of Breast Cancer Risk Assessment Combining Classic Risk Factors and Breast Density . JAMA Oncology vol. 4 , ( 9 ) e180174 - e180174 .

Buus R, Yeo B, Brentnall AR, Klintman M, Cheang MCU, Khabra K, Sestak I, Gao Q et al. ( 2018 ) . Novel 18-gene signature for predicting relapse in ER-positive, HER2-negative breast cancer . Breast Cancer Research vol. 20 , ( 1 ) Article 103 ,

Atakpa EC, Thorat MA, Cuzick J, Brentnall AR ( 2018 ) . Mammographic density, endocrine therapy and breast cancer risk: a prognostic and predictive biomarker review . Cochrane Database of Systematic Reviews

Fergie M, Berks M, Harkness EF, Astley S, Hulleman J, Brentnall AR, Cuzick J, Evans G et al. ( 2018 ) . Using a convolutional neural network to predict readers' estimates of mammographic density for breast cancer risk assessment . 14th International Workshop on Breast Imaging (IWBI 2018) . Conference: Fourteenth International Workshop on Breast Imaging from: 08/07/2018 to: 11/07/2018 , 70 - 70 .

Wang C, Brentnall AR, Cuzick J, Harkness EF, Evans DG, Astley S ( 2018 ) . Exploring the prediction performance for breast cancer risk based on volumetric mammographic density at different thresholds . Breast Cancer Research vol. 20 , ( 1 ) Article 49 ,

Rebolj M, Assi V, Brentnall A, Parmar D, Duffy SW ( 2018 ) . Addition of ultrasound to mammography in the case of dense breast tissue: systematic review and meta-analysis . British Journal of Cancer vol. 118 , ( 12 ) 1559 - 1570 .

van Veen EM, Brentnall AR, Byers H, Harkness EF, Astley SM, Sampson S, Howell A, Newman WG et al. ( 2018 ) . Use of Single-Nucleotide Polymorphisms and Mammographic Density Plus Classic Risk Factors for Breast Cancer Risk Prediction . JAMA Oncology vol. 4 , ( 4 ) 476 - 476 .

Astley SM, Harkness EF, Sergeant JC, Warwick J, Stavrinos P, Warren R, Wilson M, Beetles U et al. ( 2018 ) . A comparison of five methods of measuring mammographic density: a case-control study . Breast Cancer Research vol. 20 , ( 1 ) Article 10 ,

Evans DG, Brentnall AR, Harvie M, Astley S, Harkness EF, Stavrinos P, Donnelly LS, Sampson S et al. ( 2018 ) . Breast cancer risk in a screening cohort of Asian and white British/Irish women from Manchester UK . BMC Public Health vol. 18 , ( 1 ) Article 178 ,

Howell A, Ashcroft L, Fallowfield L, Eccles DM, Eeles RA, Ward A, Brentnall AR, Dowsett M et al. ( 2018 ) . RAZOR: A Phase II Open Randomized Trial of Screening Plus Goserelin and Raloxifene Versus Screening Alone in Premenopausal Women at Increased Risk of Breast Cancer . Cancer Epidemiology, Biomarkers &amp; Prevention vol. 27 , ( 1 ) 58 - 66 .

van Veen EM, Harkness EF, Brentnall AR, Astley SM, Sampson S, Howell A, Newman WG, Cuzick J et al. ( 2018 ) . Improving breast cancer risk prediction by combining 18 SNPs, mammographic density and the Tyrer-Cuzick model . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 26 , 681 - 681 .

Brentnall AR, Cuzick J ( 2018 ) . Use of the concordance index for predictors of censored survival data . STATISTICAL METHODS IN MEDICAL RESEARCH vol. 27 , ( 8 ) 2359 - 2373 .

Brentnall AR, Cheng RCH ( 2017 ) . Some effects of aircraft arrival sequence algorithms . Journal of the Operational Research Society vol. 60 , ( 7 ) 962 - 972 .

Brentnall A ( 2017 ) . Discrete-Event System Simulation (International Edition) . Journal of Simulation vol. 1 , ( 3 ) 223 - 223 .

Cuzick J, Brentnall A, Dowsett M ( 2017 ) . SNPs for breast cancer risk assessment . Oncotarget vol. 8 , ( 59 ) 99211 - 99212 .

Wang C, Brentnall AR, Cuzick J, Harkness EF, Evans DG, Astley S ( 2017 ) . A novel and fully automated mammographic texture analysis for risk prediction: results from two case-control studies . Breast Cancer Research vol. 19 , ( 1 ) Article 114 ,

Vasiljević N, Carter PD, Reuter C, Warman R, Brentnall AR, Carton JR, Cuzick J, Lorincz AT ( 2017 ) . Role of quantitative p16^INK4A mRNA assay and digital reading of p16^INK4A immunostained sections in diagnosis of cervical intraepithelial neoplasia . International Journal of Cancer vol. 141 , ( 4 ) 829 - 836 .

Brentnall AR, Sasieni P, Cuzick J ( 2017 ) . Estimating efficacy in trials with selective crossover . Statistics in Medicine vol. 36 , ( 15 ) 2333 - 2346 .

Cuzick J, Brentnall AR, Segal C, Byers H, Reuter C, Detre S, Lopez-Knowles E, Sestak I et al. ( 2017 ) . Impact of a Panel of 88 Single Nucleotide Polymorphisms on the Risk of Breast Cancer in High-Risk Women: Results From Two Randomized Tamoxifen Prevention Trials . Journal of Clinical Oncology vol. 35 , ( 7 ) 743 - 750 .

( 2017 ) . Breast-Cancer Tumor Size and Screening Effectiveness . vol. 376 , is. 1 , pp. 93 - 95 . Massachusetts Medical Society

Evans DG, Brentnall A, Byers H, Harkness E, Stavrinos P, Howell A, Newman WG, Cuzick J ( 2016 ) . The impact of a panel of 18 SNPs on breast cancer risk in women attending a UK familial screening clinic: a case–control study . Journal of Medical Genetics vol. 54 , ( 2 ) 111 - 113 .

Sasieni P, Brentnall AR ( 2016 ) . On Standardized Relative Survival . Biometrics vol. 73 , ( 2 ) 473 - 482 .

Evans DG, Astley S, Stavrinos P, Harkness E, Donnelly LS, Dawe S, Jacob I, Harvie M et al. ( 2016 ) . Improvement in risk prediction, early detection and prevention of breast cancer in the NHS Breast Screening Programme and family history clinics: a dual cohort study . Programme Grants for Applied Research vol. 4 , ( 11 ) 1 - 210 .

Brentnall AR, Cuzick J, Byers H, Segal C, Reuter C, Detre S, Sestak I, Howell A et al. ( 2016 ) . Relationship of ZNF423 and CTSO with breast cancer risk in two randomised tamoxifen prevention trials . Breast Cancer Research and Treatment vol. 158 , ( 3 ) 591 - 596 .

Astley S, Harkness E, Sergeant J, Stavrinos P, Warren R, Wilson M, Brentnall A, Cuzick J et al. ( 2016 ) . Proffered Paper: A comparison of four methods of mammographic density measurement in the UK Predicting Risk Of Cancer At Screening (PROCAS) study – on behalf of the PROCAS Study team . European Journal of Cancer vol. 61 , S6 - S6 .

Evans DGR, Donnelly LS, Harkness EF, Astley SM, Stavrinos P, Dawe S, Watterson D, Fox L et al. ( 2016 ) . Breast cancer risk feedback to women in the UK NHS breast screening population . British Journal of Cancer vol. 114 , ( 9 ) 1045 - 1052 .

Evans DG, Astley SM, Brentnall A, Howell A, Cuzick J ( 2016 ) . Abstract PD1-07: Mammographic density and SNPs add to Tyrer-Cuzick and Gail model breast cancer risk in a UK screening cohort . Cancer Research . vol. 76 ,

Lorincz AT, Brentnall AR, Scibior‐Bentkowska D, Reuter C, Banwait R, Cadman L, Austin J, Cuzick J et al. ( 2016 ) . Validation of a <scp>DNA</scp> methylation <scp>HPV</scp> triage classifier in a screening sample . International Journal of Cancer vol. 138 , ( 11 ) 2745 - 2751 .

Astley S, Harkness E, Sergeant J, Stavrinos P, Warren R, Wilson M, Brentnall A, Cuzick J et al. ( 2016 ) . A comparison of four methods of mammographic density measurement in the UK Predicting Risk Of Cancer At Screening (PROCAS) study - on behalf of the PROCAS Study team . EUROPEAN JOURNAL OF CANCER . vol. 61 , S6 - S6 .

Brentnall AR, Harkness EF, Astley SM, Donnelly LS, Stavrinos P, Sampson S, Fox L, Sergeant JC et al. ( 2015 ) . Mammographic density adds accuracy to both the Tyrer-Cuzick and Gail breast cancer risk models in a prospective UK screening cohort . Breast Cancer Research vol. 17 , ( 1 )

Brentnall AR, Vasiljevic N, Scibior-Bentkowska D, Cadman L, Austin J, Cuzick J, Lorincz AT ( 2015 ) . HPV33 DNA methylation measurement improves cervical pre-cancer risk estimation of an HPV16, HPV18, HPV31 and \\textit{EPB41L3} methylation classifier . Cancer Biomarkers vol. 15 , ( 5 ) 669 - 675 .

( 2015 ) . Atypical Hyperplasia of the Breast . New England Journal of Medicine vol. 372 , ( 13 ) 1269 - 1272 .

Brentnall AR, Cuzick J ( 2015 ) . Atypical hyperplasia of the breast . New England Journal of Medicine vol. 372 , ( 13 ) 1269 - 1272 .

Hartmann LC, Degnim AC, Dupont WD ( 2015 ) . The authors reply . New England Journal of Medicine vol. 372 , ( 13 ) 1271 - 1272 .

Assi V, Massat NJ, Thomas S, MacKay J, Warwick J, Kataoka M, Warsi I, Brentnall A et al. ( 2014 ) . A case‐control study to assess the impact of mammographic density on breast cancer risk in women aged 40–49 at intermediate familial risk . International Journal of Cancer vol. 136 , ( 10 ) 2378 - 2387 .

Brentnall AR, Cuzick J, Field J, Duffy SW ( 2014 ) . A concordance index for matched case-control studies with applications in cancer risk . Statistics in Medicine vol. 34 , ( 3 ) 396 - 405 .

Warwick J, Birke H, Stone J, Warren RML, Pinney E, Brentnall AR, Duffy SW, Howell A et al. ( 2014 ) . Mammographic breast density refines Tyrer-Cuzick estimates of breast cancer risk in high-risk women: findings from the placebo arm of the International Breast Cancer Intervention Study I . Breast Cancer Research vol. 16 , ( 5 ) Article 451 ,

Evans DG, Brentnall AR, Harvie M, Dawe S, Sergeant JC, Stavrinos P, Astley S, Wilson M et al. ( 2014 ) . Breast Cancer Risk in Young Women in the National Breast Screening Programme: Implications for Applying NICE Guidelines for Additional Screening and Chemoprevention . Cancer Prevention Research vol. 7 , ( 10 ) 993 - 1001 .

Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al. ( 2014 ) . Abstract B046: Therapeutic targeting of integrin αvβ6 in high-risk breast cancer . Molecular Cancer Research vol. 11 , ( 10_Supplement ) B046 - B046 .

Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al. ( 2014 ) . Therapeutic Targeting of Integrin αvβ6 in Breast Cancer . JNCI: Journal of the National Cancer Institute vol. 106 , ( 8 )

Cuzick JM, Brentnall A, Segal C, Sestak I, Kealy R, Howell A, Powles TJ, Orr N et al. ( 2014 ) . Use of a SNP panel to refine risk estimates in women at high risk of breast cancer: Results from two randomized tamoxifen prevention trials . Journal of Clinical Oncology . vol. 32 , 1519 - 1519 .

Brentnall AR, Vasiljević N, Scibior‐Bentkowska D, Cadman L, Austin J, Szarewski A, Cuzick J, Lorincz AT ( 2014 ) . A DNA methylation classifier of cervical precancer based on human papillomavirus and human genes . International Journal of Cancer vol. 135 , ( 6 ) 1425 - 1432 .

Evans G, Stavrinos P, Dawe S, Harvie M, Wilson M, Maxwell A, Brentnall A, Cuzick J et al. ( 2014 ) . 8LBA Assessing individual breast cancer risk within the UK National Health Service Breast Screening Programme: First prospective results from PROCAS . European Journal of Cancer . vol. 50 , S3 - S4 .

Vasiljević N, Scibior-Bentkowska D, Brentnall A, Cuzick J, Lorincz A ( 2014 ) . A comparison of methylation levels in HPV18, HPV31 and HPV33 genomes reveals similar associations with cervical precancers . Journal of Clinical Virology vol. 59 , ( 3 ) 161 - 166 .

Vasiljević N, Scibior-Bentkowska D, Brentnall AR, Cuzick J, Lorincz AT ( 2014 ) . Credentialing of DNA methylation assays for human genes as diagnostic biomarkers of cervical intraepithelial neoplasia in high-risk HPV positive women . Gynecologic Oncology vol. 132 , ( 3 ) 709 - 714 .

Brentnall AR, Evans DG, Cuzick J ( 2014 ) . Distribution of breast cancer risk from SNPs and classical risk factors in women of routine screening age in the UK . British Journal of Cancer vol. 110 , ( 3 ) 827 - 828 .

Sasieni PD, Brentnall AR ( 2014 ) . Survival Analysis . Handbook of Epidemiology , Springer New York

Evans DGR, Ingham S, Dawe S, Roberts L, Lalloo F, Brentnall AR, Stavrinos P, Howell A ( 2013 ) . Breast cancer risk assessment in 8,824 women attending a family history evaluation and screening programme . Familial Cancer vol. 13 , ( 2 ) 189 - 196 .

Ho‐Yen CM, Green AR, Rakha EA, Brentnall AR, Ellis IO, Kermorgant S, Jones JL ( 2013 ) . C‐Met in invasive breast cancer . Cancer vol. 120 , ( 2 ) 163 - 171 .

Lorincz AT, Brentnall AR, Vasiljević N, Scibior‐Bentkowska D, Castanon A, Fiander A, Powell N, Tristram A et al. ( 2013 ) . HPV16 L1 and L2 DNA methylation predicts high‐grade cervical intraepithelial neoplasia in women with mildly abnormal cervical cytology . International Journal of Cancer vol. 133 , ( 3 ) 637 - 644 .

Brentnall AR ( 2013 ) . Value of Phenotypic and Single-Nucleotide Polymorphism Panel Markers in Predicting the Risk of Breast Cancer . Journal of Genetic Syndromes &amp; Gene Therapy vol. 04 , ( 11 )

Yang Z, Brentnall AR, Cuzick J, Sasieni P ( 2012 ) . Estimating the Complier Average Causal Effect for Exponential Survival in the Presence of Mid-Trial Switching . International Journal of Statistics in Medical Research vol. 1 , ( 2 ) 84 - 90 .

Brentnall AR, Duffy SW, Crowder MJ, Gillan MGC, Astley SM, Wallis MG, James J, Boggis CRM et al. ( 2012 ) . A method for exploratory repeated-measures analysis applied to a breast-cancer screening study .

Brentnall AR, Duffy SW, Crowder MJ, Gillan MGC, Astley SM, Wallis MG, James J, Boggis CRM et al. ( 2012 ) . A method for exploratory repeated-measures analysis applied to a\n breast-cancer screening study . Annals of Applied Statistics vol. 5 , ( 4 ) 2448 - 2469 .

Brentnall AR, Duffy SW, Baio G, Raine R ( 2012 ) . Strategy for power calculation for interactions: Application to a trial of interventions to improve uptake of bowel cancer screening . Contemporary Clinical Trials vol. 33 , ( 1 ) 213 - 217 .

Allen MD, Vaziri R, Green M, Chelala C, Brentnall AR, Dreger S, Vallath S, Nitch-Smith H et al. ( 2011 ) . Clinical and functional significance of alpha 9 beta 1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion . J PATHOL vol. 223 , ( 5 ) 646 - 658 .

Brentnall AR, Crowder MJ, Hand DJ ( 2011 ) . Approximate repeated-measures shrinkage . Computational Statistics &amp; Data Analysis vol. 55 , ( 2 ) 1150 - 1159 .

Vasiljevic N, Wu KQ, Brentnall AR, Kim DC, Thorat MA, Kudahetti SC, Mao XY, Xue LY et al. ( 2011 ) . Absolute quantitation of DNA methylation of 28 candidate genes in prostate cancer using pyrosequencing . DIS MARKERS vol. 30 , ( 4 ) 151 - 161 .

( 2010 ) . Mammographic surveillance in women younger than 50 years who have a family history of breast cancer: tumour characteristics and projected effect on mortality in the prospective, single-arm, FH01 study . The Lancet Oncology vol. 11 , ( 12 ) 1127 - 1134 .

Brentnall AR, Crowder MJ, Hand DJ ( 2010 ) . Predictive-sequential forecasting system development for cash machine stocking . International Journal of Forecasting vol. 26 , ( 4 ) 764 - 776 .

James JJ, Gilbert FJ, Wallis MG, Gillan MGC, Astley SM, Boggis CRM, Agbaje OF, Brentnall AR et al. ( 2010 ) . Mammographic Features of Breast Cancers at Single Reading with Computer-aided Detection and at Double Reading in a Large Multicenter Prospective Trial of Computer-aided Detection: CADET II . Radiology vol. 256 , ( 2 ) 379 - 386 .

Brentnall AR, Crowder MJ, Hand DJ ( 2010 ) . Predicting the amount individuals withdraw at cash machines using a random effects multinomial model . Statistical Modelling vol. 10 , ( 2 ) 197 - 214 .

Brentnall AR, Crowder MJ, Hand DJ ( 2008 ) . A Statistical Model for the Temporal Pattern of Individual Automated Teller Machine Withdrawals . Journal of the Royal Statistical Society Series C: Applied Statistics vol. 57 , ( 1 ) 43 - 59 .

Brentnall AR, Cheng RC, Drew A ( 2004 ) . Statistical analysis of an air traffic control problem . International Journal of Simulation Systems Science and Technology vol. 5 , ( 1-2 ) 26 - 32 .

Evans DGR, van Veen EM, Harkness EF, Brentnall AR, Astley SM, Byers H, Woodward ER, Sampson S et al. . Breast Cancer Risk Stratification in Women of Screening Age: Incremental Effects of Adding Mammographic Density, Polygenic Risk and a Gene Panel .

Sia J, Lane E, Brentnall A, Manchanda R . Estimands for clinical effectiveness of risk-reducing early-salpingectomy from prospective studies . Jama Network Open