Publications: P Caroline Brennan

Hillman C, Fontana BD, Amstislavskaya TG, Gorbunova MA, Altenhofen S, Barthelson K, Bastos LM, Borba JV et al. ( 2025 ) . Housing and husbandry factors affecting zebrafish novel tank test responses: a global multi-laboratory study . Lab Animal vol. 54 , ( 6 ) 156 - 164 .

Wang X, Haworth O, Barry S, Leggieri A, Hall C, Martin J, Korbonits M, Brennan C ( 2025 ) . AIP deficiency in zebrafish causes loss of intestinal epithelial differentiation via disrupted wnt signaling . Endocrine Abstracts

Bilardo R, Leggieri A, Tomatis F, Traldi F, Vdovchenko A, Rizzi E, Lino M, Mysiorek C et al. ( 2025 ) . N-isopropylacrylamide based nanogels crossing the blood-brain barrier: evidence of high in vitro internalization in human endothelial cells and in vivo permeation in zebrafish .

Bilardo R, leggieri A, tomatis F, Traldi F, Vdovchenko A, Rizzi E, Lino M, Mysiorek C et al. ( 2025 ) . N-isopropylacrylamide based nanogels crossing the blood-brain barrier: evidence of high in vitro internalization in human endothelial cells and in vivo permeation in zebrafish .

Parker M, Hillman C, Fontana B, Amstislavskaya T, Gorbunova M, Altenhofen S, Barthelson K, Bastos L et al. ( 2024 ) . Housing and Husbandry Factors Affecting Zebrafish (Danio rerio) Novel Tank Test Responses: A Global Multi-Laboratory Study .

Leggieri A, García-González J, Hosseinian S, Ashdown P, Anagianni S, Wang X, Havelange W, Fernàndez-Castillo N et al. ( 2024 ) . <i>rbfox1</i> LoF mutants show disrupted <i>bdnf/trkb2</i> and <i>crhb/nr3c2</i> expression and increased cortisol levels during development coupled with signs of allostatic overload in adulthood .

Luu P, Nadtochiy A, Zanon M, Moreno N, Messina A, Petrazzini MEM, Torres Perez JV, Keomanee-Dizon K et al. ( 2024 ) . Neural Basis of Number Sense in Larval Zebrafish .

Korbonits M, Wang X, Barry S, Lim CT, Suleyman O, Tito SD, Uddin N, Vignola ML et al. ( 2024 ) . Biallelic Loss of Molecular Chaperone Molecule AIP Results in a Novel Severe Multisystem Disease Defined by Defective Proteostasis .

Antón-Galindo E, Adel MR, García-González J, Leggieri A, López-Blanch L, Irimia M, Norton WHJ, Brennan CH et al. ( 2024 ) . Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models . Translational Psychiatry vol. 14 , ( 1 ) Article 99 ,

Wang X, Haworth O, Abdi-Aziz N, Leggieri A, Jhosadara E-FA, Korbonits M, Brennan CH ( 2023 ) . Aryl hydrocarbon receptor-interacting protein (aip) loss causes failure-to-thrive and cardiac defects in zebrafish . Endocrine Abstracts

Wang X, Leggieri A, Anagianni S, Brennan CH, Korbonits M ( 2023 ) . THU079 Danio Rerio (Zebrafish): A New Model Of AIP Loss Of Function . Journal of the Endocrine Society vol. 7 , ( Supplement_1 ) Article bvad114.1159 ,

Brennan C, Sheardown E, Pérez JVT, Petrazzini MEM, Messina A, Potrich D, Anagianni S, Perrino M et al. ( 2023 ) . EXPLORING THE GENETICS OF NUMEROSITY, FROM FISH TO MAN . IBRO Neuroscience Reports vol. 15 , S156 - S156 .

Pérez JVT, Anagianni S, Sheardown E, Petrazzini MEM, Fraser S, Butterworth B, Vallortigara G, Brennan C ( 2023 ) . LOSS-OF-FUNCTION ZEBRAFISH (DANIO RERIO) FOR GENES ASSOCIATED WITH WILLIAMS SYNDROME SHOW ALTERED QUANTITY DISCRIMINATION . IBRO Neuroscience Reports vol. 15 , S904 - S904 .

Bilardo R, Traldi F, Brennan CH, Resmini M ( 2023 ) . The Role of Crosslinker Content of Positively Charged NIPAM Nanogels on the In Vivo Toxicity in Zebrafish . Pharmaceutics vol. 15 , ( 7 ) 1900 - 1900 .

Antón-Galindo E, Adel M, García-Gonzalez J, Leggieri A, López-Blanch L, Irimia M, Norton WHJ, Brennan CH et al. ( 2023 ) . Pleiotropic contribution of<i>rbfox1</i>to psychiatric and neurodevelopmental phenotypes in a zebrafish model .

Torres-Pérez JV, Anagianni S, Mech AM, Havelange W, García-González J, Fraser SE, Vallortigara G, Brennan CH ( 2023 ) . baz1b loss-of-function in zebrafish produces phenotypic alterations consistent with the domestication syndrome . iScience vol. 26 , ( 1 ) Article 105704 , 105704 - 105704 .

Wang X, Leggieri A, Anagianni S, Brennan CH, Korbonits M ( 2022 ) . A zebrafish model of <i>AIP</i> loss of function . Endocrine Abstracts

Messina A, Potrich D, Perrino M, Sheardown E, Miletto Petrazzini ME, Luu P, Nadtochiy A, Truong TV et al. ( 2022 ) . Quantity as a Fish Views It: Behavior and Neurobiology . Frontiers in Neuroanatomy vol. 16 , Article 943504 ,

Sheardown E, Mech AM, Petrazzini MEM, Leggieri A, Gidziela A, Hosseinian S, Sealy IM, Torres-Perez JV et al. ( 2022 ) . Translational relevance of forward genetic screens in animal models for the study of psychiatric disease . Neuroscience &amp; Biobehavioral Reviews vol. 135 , Article 104559 , 104559 - 104559 .

Sheardown E, Torres-Perez JV, Anagianni S, Fraser SE, Vallortigara G, Butterworth B, Miletto-Petrazzini ME, Brennan CH ( 2022 ) . Characterizing ontogeny of quantity discrimination in zebrafish . Proceedings of the Royal Society B: Biological Sciences vol. 289 , ( 1968 ) Article 20212544 ,

Leggieri A, García-González J, Torres-Perez JV, Havelange W, Hosseinian S, Mech AM, Keatinge M, Busch-Nentwich EM et al. ( 2022 ) . Ankk1 Loss of Function Disrupts Dopaminergic Pathways in Zebrafish . Frontiers in Neuroscience vol. 16 , Article 794653 ,

Torres-Perez JV, Anagianni S, Mech AM, Havelange W, Garcia-Gonzalez J, Fraser SE, Vallortigara G, Brennan CH ( 2022 ) . Behavioural analysis of loss of function zebrafish supports baz1b as master regulator of domestication .

( 2022 ) . A systematic review of the mental health risks and resilience among pollution-exposed adolescents . Journal of Psychiatric Research vol. 146 , 55 - 66 .

Mech AM, Merteroglu M, Sealy IM, Teh M-T, White RJ, Havelange W, Brennan CH, Busch-Nentwich EM ( 2022 ) . Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish . Frontiers in Psychiatry vol. 12 , Article 795175 ,

Ponzoni L, Melzi G, Marabini L, Martini A, Petrillo G, Teh M-T, Torres-Perez JV, Morara S et al. ( 2021 ) . Conservation of mechanisms regulating emotional-like responses on spontaneous nicotine withdrawal in zebrafish and mammals . Progress in Neuro-Psychopharmacology and Biological Psychiatry vol. 111 , Article 110334 , 110334 - 110334 .

( 2021 ) . Developmental Exposure to Low Concentrations of Methylmercury Causes Increase in Anxiety-Related Behaviour and Locomotor Impairments in Zebrafish . International Journal of Molecular Sciences vol. 22 , ( 20 ) 10961 - 10961 .

Messina A, Potrich D, Schiona I, Sovrano VA, Fraser SE, Brennan CH, Vallortigara G ( 2021 ) . Neurons in the Dorso-Central Division of Zebrafish Pallium Respond to Change in Visual Numerosity . Cerebral Cortex vol. 32 , ( 2 ) 418 - 428 .

( 2021 ) . Effects of pollution on adolescent mental health: a systematic review protocol . Systematic Reviews vol. 10 , ( 1 ) Article 85 ,

Sheardown E, Torres-Perez JV, Anagianni S, Fraser SE, Vallortigara G, Butterworth B, Miletto-Petrazzini ME, Brennan CH ( 2021 ) . Characterising ontogeny of quantity discrimination in zebrafish .

García-González J, de Quadros B, Havelange W, Brock AJ, Brennan CH ( 2021 ) . Behavioral Effects of Developmental Exposure to JWH-018 in Wild-Type and Disrupted in Schizophrenia 1 (disc1) Mutant Zebrafish . Biomolecules vol. 11 , ( 2 ) 319 - 319 .

Evans JR, Torres-Pérez JV, Miletto Petrazzini ME, Riley R, Brennan CH ( 2021 ) . Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio) . Scientific Reports vol. 11 , ( 1 ) Article 339 ,

Torres-Perez JV, Brennan CH ( 2021 ) . Restoring Wnt/β-catenin pathway as potential therapeutics for Williams syndrome-associated anxiety disorders . BRITISH JOURNAL OF PHARMACOLOGY . vol. 178 , 447 - 448 .

Miletto Petrazzini ME, Gambaretto L, Dadda M, Brennan C, Agrillo C ( 2020 ) . Are cerebral and behavioural lateralization related to anxiety-like traits in the animal model zebrafish (<i>Danio rerio</i>)? . Laterality vol. 26 , ( 1-2 ) 144 - 162 .

Ponzoni L, Teh M-T, Torres-Perez JV, Brennan CH, Braida D, Sala M ( 2020 ) . Increased Response to 3,4-Methylenedioxymethamphetamine (MDMA) Reward and Altered Gene Expression in Zebrafish During Short- and Long-Term Nicotine Withdrawal . Molecular Neurobiology vol. 58 , ( 4 ) 1650 - 1663 .

Messina A, Potrich D, Schiona I, Sovrano VA, Fraser SE, Brennan CH, Vallortigara G ( 2020 ) . Neurons in the dorso-central division of zebrafish pallium respond to change in visual numerosity .

Miletto Petrazzini ME, Brennan CH ( 2020 ) . Application of an abstract concept across magnitude dimensions by fish . Scientific Reports vol. 10 , ( 1 ) Article 16935 ,

( 2020 ) . The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank . Translational Psychiatry vol. 10 , ( 1 ) Article 330 ,

García-González J, de Quadros B, Brock AJ, Brennan CH ( 2020 ) . Behavioral effects of developmental exposure to JWH-018 in wild type and disrupted in schizophrenia 1 (<i>disc1</i>) mutant zebrafish .

Fontana BD, Gibbon AJ, Cleal M, Sudwarts A, Pritchett D, Miletto Petrazzini ME, Brennan CH, Parker MO ( 2020 ) . Moderate early life stress improves adult zebrafish (<i>Danio rerio</i>) working memory but does not affect social and anxiety‐like responses . Developmental Psychobiology vol. 63 , ( 1 ) 54 - 64 .

( 2020 ) . Effects of Pollution on Child and Adolescent Mental Health: A Protocol for a Systematic Review .

Evans JR, Torres-Pérez JV, Miletto Petrazzini ME, Riley R, Brennan CH ( 2020 ) . Stress reactivity elicits a tissue-specific reduction in telomere length in ageing zebrafish (<i>Danio rerio</i>) .

Messina A, Potrich D, Schiona I, Sovrano VA, Fraser SE, Brennan CH, Vallortigara G ( 2020 ) . Response to change in the number of visual stimuli in zebrafish:A behavioural and molecular study . Scientific Reports vol. 10 , ( 1 ) Article 5769 ,

( 2020 ) . Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour . eLife vol. 9 , Article e51295 ,

Fontana BD, Gibbon AJ, Cleal M, Sudwarts A, Pritchett D, Miletto Petrazzini ME, Brennan CH, Parker MO ( 2020 ) . Moderate early-life stress improves adult zebrafish (<i>Danio rerio</i>) spatial short-term memory but does not affect social and anxiety-like responses .

Pritchett D, Brennan CH ( 2020 ) . Classical and operant conditioning in larval zebrafish . Behavioral and Neural Genetics of Zebrafish , Elsevier

( 2019 ) . The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank .

Daggett JM, Brown VJ, Brennan CH ( 2019 ) . Food or friends? What motivates zebrafish (Danio rerio) performing a visual discrimination . Behavioural Brain Research vol. 359 , 190 - 196 .

García-González J, De Quadros B, Akkari M, Brennan C ( 2019 ) . SU12BEHAVIOURAL EFFECTS OF DEVELOPMENTAL EXPOSURE TO THE SYNTHETIC CANNABINOID JWH-018 IN WILD TYPE AND DISRUPTED IN SCHIZOPHRENIA 1 (DISC1) MUTANT ZEBRAFISH . European Neuropsychopharmacology . vol. 29 , S1274 - S1274 .

( 2018 ) . Identification of<i>Slit3</i>as a locus affecting nicotine preference in zebrafish and human smoking behaviour .

Brock AJ, Goody SMG, Mead AN, Sudwarts A, Parker MO, Brennan CH ( 2017 ) . Assessing the Value of the Zebrafish Conditioned Place Preference Model for Predicting Human Abuse Potential . The Journal of Pharmacology and Experimental Therapeutics vol. 363 , ( 1 ) 66 - 79 .

Brock AJ, Sudwarts A, Daggett J, Parker MO, Brennan CH ( 2017 ) . A fully automated computer-based ‘Skinner Box’ for testing learning and memory in zebrafish .

Brock AJ, Sudwarts A, Parker MO, Brennan CH ( 2017 ) . Zebrafish Behavioral Models of Ageing . The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish , Springer International Publishing

Parker M, Brennan C ( 2016 ) . Translational Pharmacology of a Putative Measure of Motor Impulsivity in Larval Zebrafish . Current Psychopharmacology vol. 5 , ( 2 ) 73 - 84 .

Barrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A et al. ( 2016 ) . Correction: Corrigendum: Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes . Nature Communications vol. 7 , ( 1 ) Article 12392 ,

Barrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A et al. ( 2016 ) . Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes . Nature Communications vol. 7 , ( 1 ) Article 11942 ,

( 2016 ) . A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion . Scientific Reports vol. 6 , ( 1 ) Article 26142 ,

Baiamonte M, Parker MO, Vinson GP, Brennan CH ( 2016 ) . Sustained Effects of Developmental Exposure to Ethanol on Zebrafish Anxiety-Like Behaviour . PLOS ONE vol. 11 , ( 2 ) e0148425 - e0148425 .

Parker MO, Brock AJ, Sudwarts A, Teh M-T, Combe FJ, Brennan CH ( 2015 ) . Developmental role of acetylcholinesterase in impulse control in zebrafish . Frontiers in Behavioral Neuroscience vol. 9 ,

( 2015 ) . Suppression of TGF_βand Angiogenesis by Type VII Collagen in Cutaneous SCC . Journal of the National Cancer Institute vol. 108 , ( 1 ) djv293 - djv293 .

Baiamonte M, Brennan CH, Vinson GP ( 2015 ) . Correction: Sustained Action of Developmental Ethanol Exposure on the Cortisol Response to Stress in Zebrafish Larvae and Adults . PLOS ONE vol. 10 , ( 5 ) e0128050 - e0128050 .

Wang M-Y, Brennan CH, Lachlan RF, Chittka L ( 2015 ) . Speed–accuracy trade-offs and individually consistent decision making by individuals and dyads of zebrafish in a colour discrimination task . Animal Behaviour vol. 103 , 277 - 283 .

Baiamonte M, Brennan CH, Vinson GP ( 2015 ) . Sustained Action of Developmental Ethanol Exposure on the Cortisol Response to Stress in Zebrafish Larvae and Adults . PLOS ONE vol. 10 , ( 4 ) e0124488 - e0124488 .

Parker MO, Annan LV, Kanellopoulos AH, Brock AJ, Combe FJ, Baiamonte M, Teh MT, Brennan CH ( 2014 ) . The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain development . Progress in Neuro Psychopharmacology and Biological Psychiatry vol. 55 , 94 - 100 .

Parker MO, Annan LV, Kanellopoulos AH, Brock AJ, Combe FJ, Baiamonte M, Teh M-T, Brennan CH ( 2014 ) . The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain development . Progress in Neuro-Psychopharmacology and Biological Psychiatry vol. 55 , 94 - 100 .

Proulx MJ, Parker MO, Tahir Y, Brennan CH ( 2014 ) . Parallel Mechanisms for Visual Search in Zebrafish . PLoS ONE vol. 9 , ( 10 ) e111540 - e111540 .

Stewart AM, Ullmann JFP, Norton WHJ, Parker MO, Brennan CH, Gerlai R, Kalueff AV ( 2014 ) . Molecular psychiatry of zebrafish . Molecular Psychiatry vol. 20 , ( 1 ) 2 - 17 .

Parker MO, Evans AM, Brock AJ, Combe FJ, Teh M, Brennan CH ( 2014 ) . Moderate alcohol exposure during early brain development increases stimulus‐response habits in adulthood . Addiction Biology vol. 21 , ( 1 ) 49 - 60 .

Parker MO, Brock AJ, Sudwarts A, Brennan CH ( 2014 ) . Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish . Psychopharmacology vol. 231 , ( 13 ) 2671 - 2679 .

Parker MO, Brock AJ, Millington ME, Brennan CH ( 2013 ) . Behavioral Phenotyping of<i>Casper</i>Mutant and 1-Pheny-2-Thiourea Treated Adult Zebrafish . Zebrafish vol. 10 , ( 4 ) 466 - 471 .

Cichoń MA, Szentpetery Z, Caley MP, Papadakis ES, Mackenzie IC, Brennan CH, O'Toole EA ( 2013 ) . The receptor tyrosine kinase Axl regulates cell–cell adhesion and stemness in cutaneous squamous cell carcinoma . Oncogene vol. 33 , ( 32 ) 4185 - 4192 .

Vinson GP, Brennan CH ( 2013 ) . Addiction and the adrenal cortex . Endocrine Connections vol. 2 , ( 3 ) R1 - R14 .

Parker MO, Ife D, Ma J, Pancholi M, Smeraldi F, Straw C, Brennan CH ( 2013 ) . Development and automation of a test of impulse control in zebrafish . Frontiers in Systems Neuroscience vol. 7 ,

Parker MO, Brock AJ, Walton RT, Brennan CH ( 2013 ) . The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function . Frontiers in Neural Circuits vol. 7 ,

PARKER M, BRENNAN CH ( 2012 ) . Low and Moderate alcohol consumption during pregnancy: effects on social behaviour and propensity to develop substance abuse in later life . BJOG: an International Journal of Obstetrics and Gynaecology ( 13 ) 1671 - 1672 .

Parker MO, Brennan CH ( 2012 ) . Low and moderate alcohol consumption during pregnancy: effects on social behaviour and propensity to develop substance abuse in later life . BJOG: An International Journal of Obstetrics &amp; Gynaecology vol. 119 , ( 13 ) 1671 - 1672 .

Cogger K, Guasti L, Ashworth R, Brennan C, Beales P, Marion V, King P ( 2012 ) . The role of primary cilia in mouse adrenal and zebrafish interrenal development . Cilia vol. 1 , ( S1 ) Article P64 ,

Barry S, Chelala C, Lines K, Sunamura M, Wang A, Marelli-Berg FM, Brennan C, Lemoine NR et al. ( 2012 ) . S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells . Clinical &amp; Experimental Metastasis vol. 30 , ( 3 ) 251 - 264 .

Parker MO, Gaviria J, Haigh A, Millington ME, Brown VJ, Combe FJ, Brennan CH ( 2012 ) . Discrimination reversal and attentional sets in zebrafish (Danio rerio) . Behavioural Brain Research vol. 232 , ( 1 ) 264 - 268 .

Parker MO, Millington ME, Combe FJ, Brennan CH ( 2012 ) . Housing Conditions Differentially Affect Physiological and Behavioural Stress Responses of Zebrafish, as well as the Response to Anxiolytics . PLoS ONE vol. 7 , ( 4 ) e34992 - e34992 .

Parker MO, Millington ME, Combe FJ, Brennan CH ( 2012 ) . Development and implementation of a three-choice serial reaction time task for zebrafish (Danio rerio) . Behavioural Brain Research vol. 227 , ( 1 ) 73 - 80 .

Brennan CH, Parker MO ( 2012 ) . Zebrafish (Danio rerio) models of substance abuse: Harnessing the capabilities . Behaviour vol. 149 , ( 10-12 ) 1037 - 1062 .

Wu HHT, Brennan C, Ashworth R ( 2011 ) . Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development . BMC Research Notes vol. 4 , ( 1 ) Article 541 ,

Dumartin L, Whiteman HJ, Weeks ME, Hariharan D, Dmitrovic B, Iacobuzio-Donahue CA, Brentnall TA, Bronner MP et al. ( 2011 ) . AGR2 Is a Novel Surface Antigen That Promotes the Dissemination of Pancreatic Cancer Cells through Regulation of Cathepsins B and D . Cancer Research vol. 71 , ( 22 ) 7091 - 7102 .

( 2011 ) . Erratum . Personalized Medicine vol. 8 , ( 6 ) 692 - 692 .

Brock AJ, Takeda A, Brennan C, Walton RT ( 2011 ) . Treatment for Tobacco Dependence: A Potential Application for Stratified Medicine? . Personalized Medicine vol. 8 , ( 5 ) 571 - 579 .

Jobe K, Brennan CH, Motevalli M, Goldup SM, Watkinson M ( 2011 ) . ChemInform Abstract: Modular “Click” Sensors for Zinc and Their Application in vivo . ChemInform vol. 42 , ( 40 ) Article chin.201140167 ,

Brennan CH ( 2011 ) . Zebrafish behavioural assays of translational relevance for the study of psychiatric disease . revneuro vol. 22 , ( 1 ) 37 - 48 .

Jobe K, Brennan CH, Motevalli M, Goldup SM, Watkinson M ( 2011 ) . Modular 'click' sensors for zinc and their application in vivo . CHEM COMMUN vol. 47 , ( 21 ) 6036 - 6038 .

Brennan CH, Parker MO, Millington ME ( 2011 ) . USING ZEBRAFISH TO EXAMINE THE GENETICS OF DRUG SEEKING AND IMPULSIVITY . JOURNAL OF PSYCHOPHARMACOLOGY . vol. 25 , A6 - A6 .

Parmar A, Parmar M, Brennan CH ( 2010 ) . Zebrafish Conditioned Place Preference Models of Drug Reinforcement and Relapse to Drug Seeking . 75 - 84 .

Brennan CH, Parmar A, Kily LKM, Ananthathevan A, Doshi A, Patel S ( 2010 ) . Conditioned Place Preference Models of Drug Dependence and Relapse to Drug Seeking: Studies with Nicotine and Ethanol . 163 - 179 .

Brennan C, Dosch R, Haramis A-P, Luckenbach T, Martinez-Morales J-R, Moro E, Polok B, Ramesh TM et al. ( 2010 ) . Report of the European Zebrafish Principal Investigator Meeting in Padua, Italy, March 18–22, 2010 . Zebrafish vol. 7 , ( 3 ) 305 - 310 .

Dumartin L, Whiteman HJ, Weeks ME, Timms JF, Brentnall TA, Bronner MP, Brennan C, Lemoine NR et al. ( 2010 ) . AGR2 Regulates the Invasion of Pancreatic Cancer Cells Through Cathepsins B and D . PANCREAS vol. 39 , ( 8 ) 1318 - 1319 .

Littleton JM, Harper JC, Brennan CH, Guppy LJ ( 2009 ) . Adaptation in Membrane Ca²⁺ Channels as a Basis for Alcohol‐Related Pathology . Australian Drug and Alcohol Review vol. 7 , ( 1 ) 35 - 38 .

Wu HH-T, Brennan C, Ashworth R ( 2009 ) . A Novel Role for Ryanodine Receptors during Embryonic Development: Studies in Zebrafish . JOURNAL OF GENERAL PHYSIOLOGY . vol. 134 , 17A - 17A .

Brennan CH, Chittka A, Barker S, Vinson GP ( 2008 ) . Eph receptors and zonation in the rat adrenal cortex . J ENDOCRINOL vol. 198 , ( 1 ) 185 - 191 .

Kily LJM, Cowe YCM, Hussain O, Patel S, McElwaine S, Cotter FE, Brennan CH ( 2008 ) . Gene expression changes in a zebrafish model of drug dependency suggest conservation of neuro-adaptation pathways . J EXP BIOL vol. 211 , ( 10 ) 1623 - 1634 .

Fabes J, Anderson P, Brennan C, Bolsover S ( 2007 ) . Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord . EUR J NEUROSCI vol. 26 , ( 9 ) 2496 - 2505 .

BRENNAN CH, GUPPY LJ, LITTLETON JM ( 2006 ) . Chronic Exposure to Ethanol Increases Dihydropyridine‐Sensitive Calcium Channels in Excitable Cells . Annals of the New York Academy of Sciences vol. 560 , ( 1 ) 467 - 469 .

HUDSPITH MJ, BRENNAN CH, CHARLES S, LITTLETON JM ( 2006 ) . Dihydropyridine‐Sensitive Ca²⁺ Channels and Inositol Phospholipid Metabolism in Ethanol Physical Dependence^a . Annals of the New York Academy of Sciences vol. 492 , ( 1 ) 156 - 170 .

LITTLETON JM, BRENNAN C, BOUCHENAFA O ( 2006 ) . The Role of Calcium Flux in the Central Nervous System Actions of Ethanol . Annals of the New York Academy of Sciences vol. 625 , ( 1 ) 388 - 394 .

Holder N, Brennan C, Cooke J, Durbin L, Xu Q ( 2006 ) . 34 The role of signalling through eph receptors in patterning the zebrafish neural plate . International Journal of Developmental Neuroscience vol. 14 , ( S1 ) 59 - 59 .

Fabes J, Anderson P, Yáñez‐Muñoz RJ, Thrasher A, Brennan C, Bolsover S ( 2006 ) . Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion . European Journal of Neuroscience vol. 23 , ( 7 ) 1721 - 1730 .

Brennan C, Mangoli M, Dyer CEF, Ashworth R ( 2005 ) . Acetylcholine and calcium signalling regulates muscle fibre formation in the zebrafish embryo . J CELL SCI vol. 118 , ( 22 ) 5181 - 5190 .

Auer RL, Costagli A, Newland AC, Fegan CD, Brennan C, Cotter FE ( 2005 ) . Definition and zebrafish modelling of the 11 q23 critical region of deletion in CLL . BRITISH JOURNAL OF HAEMATOLOGY . vol. 129 , 25 - 26 .

Ashworth R ( 2005 ) . Use of transgenic zebrafish reporter lines to study calcium signalling in development . Briefings in Functional Genomics and Proteomics vol. 4 , ( 2 ) 186 - 193 .

Auer R, Costagli A, Newland A, Fegan C, Brennan C, Cotter F ( 2005 ) . Zebrafish in vivo modelling of the 11Q23 region of deletion in chronic lymphatic leukaemia . ANNALS OF ONCOLOGY . vol. 16 , 87 - 87 .

Rodger J, Vitale PN, Tee LBG, King CE, Bartlett CA, Fall A, Brennan C, O'Shea JE et al. ( 2004 ) . EphA/ephrin-A interactions during optic nerve regeneration: restoration of topography and regulation of ephrin-A2 expression . Molecular and Cellular Neuroscience vol. 25 , ( 1 ) 56 - 68 .

Barrios A, Poole RJ, Durbin L, Brennan C, Holder N, Wilson SW ( 2003 ) . Eph/Ephrin Signaling Regulates the Mesenchymal-to-Epithelial Transition of the Paraxial Mesoderm during Somite Morphogenesis . Current Biology vol. 13 , ( 18 ) 1571 - 1582 .

Brennan C, Fabes J ( 2003 ) . Alkaline Phosphatase Fusion Proteins as Affinity Probes for Protein Localization Studies . Science's STKE vol. 2003 , ( 168 )

Brennan C, Amacher SL, Currie PD ( 2002 ) . Somitogenesis . 271 - 297 .

Holder N, Cooke J, Brennan C ( 2001 ) . MINI‐REVIEW The Eph receptor tyrosine kinases and the ephrins – roles in nervous system development . European Journal of Neuroscience vol. 10 , ( 2 ) 405 - 408 .

Chan J, Mably JD, Serluca FC, Chen J-N, Goldstein NB, Thomas MC, Cleary JA, Brennan C et al. ( 2001 ) . Morphogenesis of Prechordal Plate and Notochord Requires Intact Eph/Ephrin B Signaling . Developmental Biology vol. 234 , ( 2 ) 470 - 482 .

Cooke JE, Moens CB, Roth LWA, Durbin L, Shiomi K, Brennan C, Kimmel CB, Wilson SW et al. ( 2001 ) . Eph signalling functions downstream of Val to regulate cell sorting and boundary formation in the caudal hindbrain . DEVELOPMENT vol. 128 , ( 4 ) 571 - 580 .

BRENNAN CH ( 2001 ) . Eph Receptor Signalling and Formation of the Somites in Zebrafish . The origin and fate of somites , IOS Press. ( Amsterdam ; Oxford ),

Durbin L, Sordino P, Barrios A, Gering M, Thisse C, Thisse B, Brennan C, Green A et al. ( 2000 ) . Anteroposterior patterning is required within segments for somite boundary formation in developing zebrafish . Development vol. 127 , ( 8 ) 1703 - 1713 .

Nakagawa S, Brennan C, Johnson KG, Shewan D, Harris WA, Holt CE ( 2000 ) . Ephrin-B Regulates the Ipsilateral Routing of Retinal Axons at the Optic Chiasm . Neuron vol. 25 , ( 3 ) 599 - 610 .

Picker A, Brennan C, Reifers F, Clarke JDW, Holder N, Brand M ( 1999 ) . Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projection* . Development vol. 126 , ( 13 ) 2967 - 2978 .

Heisenberg C-P, Brennan C, Wilson SW ( 1999 ) . Zebrafish <i>aussicht</i> mutant embryos exhibit widespread overexpression of <i>ace</i> (<i>fgf8</i>) and coincident defects in CNS development . Development vol. 126 , ( 10 ) 2129 - 2140 .

Oates AC, Lackmann M, Power M-A, Brennan C, Down LM, Do C, Evans B, Holder N et al. ( 1999 ) . An early developmental role for Eph-ephrin interaction during vertebrate gastrulation . Mechanisms of Development vol. 83 , ( 1-2 ) 77 - 94 .

Durbin L, Brennan C, Shiomi K, Cooke J, Barrios A, Shanmugalingam S, Guthrie B, Lindberg R et al. ( 1998 ) . Eph signaling is required for segmentation and differentiation of the somites . Genes &amp; Development vol. 12 , ( 19 ) 3096 - 3109 .

Wilson SW, Brennan C, Macdonald R, Brand M, Holder N ( 1997 ) . Analysis of axon tract formation in the zebrafish brain: the role of territories of gene expression and their boundaries . Cell and Tissue Research vol. 290 , ( 2 ) 189 - 196 .

Macdonald R, Scholes J, Strähle U, Brennan C, Holder N, Brand M, Wilson SW ( 1997 ) . The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain . Development vol. 124 , ( 12 ) 2397 - 2408 .

Brennan C, Monschau B, Lindberg R, Guthrie B, Drescher U, Bonhoeffer F, Holder N ( 1997 ) . Two Eph receptor tyrosine kinase ligands control axon growth and may be involved in the creation of the retinotectal map in the zebrafish . Development vol. 124 , ( 3 ) 655 - 664 .

Bell JD, Barnard ML, Parkes HG, Thomas EL, Brennan CH, Cunnane SC, Dagnelie PC ( 1996 ) . Effects of n-3 fatty acids on the NMR profile of plasma lipoproteins . Journal of Lipid Research vol. 37 , ( 8 ) 1664 - 1674 .

Verhoeven AJM, Woods A, Brennan CH, Hawley SA, Hardie DG, Scott J, Beri RK, Carling D ( 1995 ) . The AMP-activated Protein Kinase Gene is Highly Expressed in Rat Skeletal Muscle. Alternative Splicing and Tissue Distribution of the mRNA . European Journal of Biochemistry vol. 228 , ( 2 ) 236 - 243 .

Carling D, Aguan K, Woods A, Verhoeven AJ, Beri RK, Brennan CH, Sidebottom C, Davison MD et al. ( 1994 ) . Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism . Journal of Biological Chemistry vol. 269 , ( 15 ) 11442 - 11448 .

Littleton J, Brennan C ( 1993 ) . Adaptive changes in numbers of calcium channels in drug dependence . Biochemical Society Symposium vol. 59 , 193 - 203 .

BRENNAN C, LITTLETON J ( 1991 ) . Chronic exposure to anxiolytic drugs, working by different mechanisms causes up-regulation of dihydropyridine binding sites on cultured bovine adrenal chromaffin cells . Neuropharmacology vol. 30 , ( 2 ) 199 - 205 .

Brennan CH, Littleton JM ( 1990 ) . Second messengers involved in genetic regulation of the number of calcium channels in bovine adrenal chromaffin cells in culture . Neuropharmacology vol. 29 , ( 7 ) 689 - 693 .

Brennan CH, Crabbe J, Littleton JM ( 1990 ) . Genetic regulation of dihydropyridine-sensitive calcium channels in brain may determine susceptibility to physical dependence on alcohol . Neuropharmacology vol. 29 , ( 5 ) 429 - 432 .

HARPER J, BRENNAN C, LITTLETON J ( 1989 ) . Genetic up-regulation of calcium channels in a cellular model of ethanol dependence . Neuropharmacology vol. 28 , ( 12 ) 1299 - 1302 .

BRENNAN C, LEWIS A, LITTLETON J ( 1989 ) . Membrane receptors, involved in up-regulation of calcium channels in bovine adrenal chromaffin cells, chronically exposed to ethanol . Neuropharmacology vol. 28 , ( 12 ) 1303 - 1307 .

Torres-Perez JV, Leggieri A, Mech AM, Anagianni S, Havelange W, Brennan CH . Disrupting fzd9b in zebrafish recapitulates stress- and anxiety-like behaviours associated with Williams syndrome .