Publications: Dr Gunnel Hallden
Phillips MM, Pavlyk I, Allen M, Ghazaly E, Cutts R, Carpentier J, Berry JS, Nattress C et al.
(
2023
)
.
Correction: A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma
.
Pharmacological Reports
vol.
75
,
(
3
)
753
-
753
.
Phillips MM, Pavlyk I, Allen M, Ghazaly E, Cutts R, Carpentier J, Berry JS, Nattress C et al.
(
2023
)
.
A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma
.
Pharmacological Reports
vol.
75
,
(
3
)
570
-
584
.
Gonzalez-Pastor R, Hernandez Y, Gimeno M, de Martino A, Man YKS, Hallden G, Quintanilla M, de la Fuente JM et al.
(
2021
)
.
Coating an adenovirus with functionalized gold nanoparticles favors uptake, intracellular trafficking and anti-cancer therapeutic efficacy
.
Acta Biomaterialia
vol.
134
,
593
-
604
.
Stella Man YK, Foster J, Carapuça E, Davies JA, Parker AL, Sosabowski J, Halldén G
(
2019
)
.
Systemic delivery and SPECT/CT in vivo imaging of 125I-labelled oncolytic adenoviral mutants in models of pancreatic cancer
.
Scientific Reports
vol.
9
,
(
1
)
Hallden G
(
2019
)
.
Improved replication and selectivity of oncolytic Ad Delta Delta and Ad-3 Delta-A20T promotes targeting to distant lesions in preclinical pancreatic cancer models
.
HUMAN GENE THERAPY
.
Conference:
IAM 2020 2021
vol.
30
,
A7
-
A8
.
Hallden G, Wang Y, Wong H-H, Lemoine NR
(
2019
)
.
ONCOLYTIC ADENOVIRUSES FOR CANCER GENE THERAPY
.
Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology
,
World Scientific Publishing
Nattress CB, Halldén G
(
2018
)
.
Advances in oncolytic adenovirus therapy for pancreatic cancer
.
Cancer Letters
vol.
434
,
56
-
69
.
Baker AT, Aguirre-Hernández C, Halldén G, Parker AL
(
2018
)
.
Designer Oncolytic Adenovirus: Coming of Age
.
Cancers
vol.
10
,
(
6
)
Man YKS, Davies JA, Coughlan L, Pantelidou C, Blázquez-Moreno A, Marshall JF, Parker AL, Halldén G
(
2018
)
.
The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells
.
Molecular Cancer Therapeutics
vol.
17
,
(
2
)
575
-
587
.
Aguirre-Hernández C, Maya-Pineda H, Millán JS, Man YKS, Lu Y-J, Halldén G
(
2018
)
.
Sensitisation to mitoxantrone-induced apoptosis by the oncolytic adenovirus Ad∆∆ through Bcl-2-dependent attenuation of autophagy
.
Oncogenesis
vol.
7
,
(
1
)
Aguirre-Hernandez C, Maya-Pineda H, Millan JS, Man YKS, Lu YJ, Hallden G
(
2017
)
.
Sensitisation to mitoxantrone-induced apoptosis by the oncolytic adenovirus Ad Delta Delta through Bcl-2-dependent attenuation of autophagy
.
HUMAN GENE THERAPY
.
Conference:
ESGCT workshop Croatia
vol.
28
,
A26
-
A26
.
Man YKS, Davies JA, Coughlan L, Pantelidou C, Marshall JF, Parker AL, Hallden G
(
2017
)
.
The novel oncolytic adenoviral mutant Ad5-3 Delta-A20T retargeted to alpha v beta 6-integrins efficiently eliminates pancreatic cancer cells
.
HUMAN GENE THERAPY
.
Conference:
IAM Mexico
vol.
28
,
A27
-
A27
.
Hallden G
(
2017
)
.
Targeting pancreatic and prostate cancer with E1B19K-deleted oncolytic adenoviruses
.
vol.
28
,
is.
8
,
pp.
A6
-
A6
.
Abstract:
java.sql.Clob
org.hibernate.engine.jdbc.WrappedClob
java.io.Serializable
,
Sweeney K, Halldén G
(
2016
)
.
Oncolytic adenovirus-mediated therapy for prostate cancer
.
Oncolytic Virotherapy
vol.
5
,
(
0
)
45
-
57
.
Hernandez CA, Hallden G
(
2016
)
.
The adenoviral AdDD mutant enhances mitoxantrone-induced cell death by promoting apoptosis and attenuating autophagy in prostate cancer cells
.
HUMAN GENE THERAPY
.
Conference:
ESGCT London
vol.
27
,
A5
-
A6
.
Pantelidou C, Cherubini G, Lemoine NR, Halldén G
(
2016
)
.
The E1B19K-deleted oncolytic adenovirus mutant AdΔ19K sensitizes pancreatic cancer cells to drug-induced DNA-damage by down-regulating Claspin and Mre11
.
Oncotarget
vol.
7
,
(
13
)
15703
-
15724
.
Pantelidou C, Man YKS, Coughlan L, Marshall J, Kocher H, Hallden G
(
2016
)
.
Oncolytic adenoviral mutants deleted in the anti-apoptotic E1B19K gene sensitize pancreatic cancer cells to drug-induced DNA damage
.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
vol.
38
,
S58
-
S58
.
Aguirre-Hernandez C, Millan JS, Hallden G
(
2016
)
.
The adenoviral AdΔΔ mutant enhances mitoxantrone-induced apoptosis and attenuates drug-induced autophagy in prostate cancer cells
.
Pantelidou C, Hallden G
(
2015
)
.
An oncolytic adenovirus (AdΔ19K) sensitizes pancreatic cancer cells to cytotoxic drugs by promoting DNA-damage and aberrant mitosis through inactivation of checkpoint mediators
.
HUMAN GENE THERAPY
.
vol.
26
,
A19
-
A20
.
Mercer EJ, Imrali A, Sharpe K, Hallden G, Lu Y-J
(
2014
)
.
Abstract 713: Utilizing a potent and selective nonreplicating adenoviral mutant (Ad5-TV-CU), with gene expression controlled by androgen receptor-dependent activation domains in the TMPRSS2 gene, as a novel prodrug-converting enzyme therapy for prostate cancer
.
Cancer Research
.
vol.
74
,
713
-
713
.
Hallden G, Wang Y, Wong H-H, Lemoine NR
(
2014
)
.
18: ONCOLYTIC ADENOVIRUSES FOR CANCER GENE THERAPY
.
Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology
,
vol.
1
,
World Scientific Publishing
Pantelidou C, Lemoine N, Hallden G
(
2014
)
.
Adenoviruses deleted in the anti-apoptotic E1B19K-gene synergise with DNA-damaging drugs through attenuation of DNA-damage repair responses and checkpoint activation in pancreatic cancer cells
.
HUMAN GENE THERAPY
.
vol.
25
,
A17
-
A17
.
Man YKS, Coughlan L, Pantelidou C, Hallden G
(
2014
)
.
Oncolysis is greatly enhanced by retargeting of replication-selective adenoviral mutants to avβ6-integrin expressing cancers and in combination with cytotoxic drugs
.
HUMAN GENE THERAPY
.
vol.
25
,
A18
-
A18
.
Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G et al.
(
2013
)
.
Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells
.
Endocr Relat Cancer
vol.
20
,
(
5
)
633
-
647
.
Halldén G, Portella G
(
2012
)
.
Oncolytic virotherapy with modified adenoviruses and novel therapeutic targets
.
Expert Opin Ther Targets
vol.
16
,
(
10
)
945
-
958
.
Adam V, Ekblad M, Sweeney K, Müller H, Busch KH, Johnsen CT, Kang NR, Lemoine NR et al.
(
2012
)
.
Synergistic and Selective Cancer Cell Killing Mediated by the Oncolytic Adenoviral Mutant AdΔΔ and Dietary Phytochemicals in Prostate Cancer Models
.
Hum Gene Ther
vol.
23
,
(
9
)
1003
-
1015
.
Botta G, Passaro C, Libertini S, Abagnale A, Barbato S, Maione AS, Hallden G, Beguinot F et al.
(
2012
)
.
Inhibition of autophagy enhances the effects of E1A-defective oncolytic adenovirus dl922-947 against glioma cells in vitro and in vivo
.
Hum Gene Ther
vol.
23
,
(
6
)
623
-
634
.
Sweeney KG, Cheong SC, Lemoine NR, Hallden G
(
2012
)
.
Abstract 2712: A non-replicating adenovirus expressing Hey1 is cytotoxic to prostate cancer cells
.
Cancer Research
vol.
72
,
(
8_Supplement
)
2712
-
2712
.
Maya-Pineda HR, Miranda-Rota E, Lemoine NR, Halldén G
(
2012
)
.
Abstract 2713: Adenovirus E1A binding to p300 is essential for synergistic cell killing in combination with chemotherapeutic drugs in prostate cancer cells
.
Cancer Research
vol.
72
,
(
8_Supplement
)
2713
-
2713
.
Halldén G
(
2012
)
.
Adenoviral gene expression and replication in human tumor explant models
.
Methods Mol Biol
vol.
797
,
65
-
78
.
Miranda E, Maya Pineda H, Öberg D, Cherubini G, Garate Z, Lemoine NR, Halldén G
(
2012
)
.
Adenovirus-mediated sensitization to the cytotoxic drugs docetaxel and mitoxantrone is dependent on regulatory domains in the E1ACR1 gene-region
.
PLoS One
vol.
7
,
(
10
)
Cherubini G, Kallin C, Mozetic A, Hammaren-Busch K, Müller H, Lemoine NR, Halldén G
(
2011
)
.
The oncolytic adenovirus AdΔΔ enhances selective cancer cell killing in combination with DNA-damaging drugs in pancreatic cancer models
.
Gene Ther
vol.
18
,
(
12
)
1157
-
1165
.
Bhattacharyya M, Francis J, Eddouadi A, Lemoine NR, Halldén G
(
2011
)
.
An oncolytic adenovirus defective in pRb-binding (dl922-947) can efficiently eliminate pancreatic cancer cells and tumors in vivo in combination with 5-FU or gemcitabine
.
Cancer Gene Ther
vol.
18
,
(
10
)
734
-
743
.
Sweeney K, Cheong SC, Lemoine N, Hallden G
(
2011
)
.
A non-replicating adenovirus expressing Hey1 is cytotoxic to prostate cancer cells
.
HUMAN GENE THERAPY
vol.
22
,
(
10
)
A122
-
A122
.
Maya-Pineda H, Miranda E, Lemoine N, Hallden G
(
2011
)
.
Adenovirus CIA binding to p300 is essential for synergistic cell killing in combination with chemotherapeutics in prostate cancer cells
.
HUMAN GENE THERAPY
vol.
22
,
(
10
)
A104
-
A104
.
Pantelidou C, Cherubini G, Lemoine NR, Hallden G
(
2011
)
.
Adenovirus sensitizes pancreatic cancer cells to DNA-damaging chemotherapeutics through mitotic catastrophe induction and this is further enhanced by the deletion of the anti-apoptotic E1B19K gene
.
HUMAN GENE THERAPY
vol.
22
,
(
10
)
A119
-
A120
.
Ingemarsdotter CK, Baird SK, Connell CM, Öberg D, Halldén G, McNeish IA
(
2010
)
.
Low-dose paclitaxel synergizes with oncolytic adenoviruses via mitotic slippage and apoptosis in ovarian cancer
.
Oncogene
vol.
29
,
(
45
)
6051
-
6063
.
Sweeney K, Cheong SC, Lemoine N, Hallden G
(
2010
)
.
A non-replicating adenovirus expressing Hey1 is cytotoxic to prostate cancer cells
.
HUMAN GENE THERAPY
.
vol.
21
,
1398
-
1398
.
Ekblad M, Oberg D, Lemoine N, Hallden G
(
2010
)
.
Development of an oncolytic adenovirus expressing the prodrug-converting enzyme CD/UPRT (Ad Delta Delta CU)
.
HUMAN GENE THERAPY
.
vol.
21
,
1473
-
1473
.
Radhakrishnan S, Miranda E, Ekblad M, Holford A, Pizarro MT, Lemoine NR, Halldén G
(
2010
)
.
Efficacy of oncolytic mutants targeting pRb and p53 pathways is synergistically enhanced when combined with cytotoxic drugs in prostate cancer cells and tumor xenografts
.
Hum Gene Ther
vol.
21
,
(
10
)
1311
-
1325
.
Cherubini G, Kalllin C, Mozetic A, Hammaren-Busch K, Muller H, Lemoine N, Hallden G
(
2010
)
.
Investigating a new potent and selective oncolytic adenovirus (Ad Delta Delta) in combination with chemotherapy
.
HUMAN GENE THERAPY
.
vol.
21
,
1473
-
1474
.
Ekblad M, Halldén G
(
2010
)
.
Adenovirus-based therapy for prostate cancer
.
Curr Opin Mol Ther
vol.
12
,
(
4
)
421
-
431
.
Oberg D, Yanover E, Adam V, Sweeney K, Costas C, Lemoine NR, Halldén G
(
2010
)
.
Improved potency and selectivity of an oncolytic E1ACR2 and E1B19K deleted adenoviral mutant in prostate and pancreatic cancers
.
Clin Cancer Res
vol.
16
,
(
2
)
541
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553
.
Lee M, Choi S, Halldén G, Yo SJ, Schichnes D, Aponte GW
(
2009
)
.
P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion
.
Am J Physiol Gastrointest Liver Physiol
vol.
297
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(
4
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G641
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G654
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Hallden G
(
2009
)
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Optimisation of replication-selective oncolytic adenoviral mutants in combination with chemotherapeutics
.
J BUON
vol.
14
,
S61
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S67
.
Flak MB, Connell CM, Hill RM, Hallden G, Chelala C, McNeish IA
(
2009
)
.
Critical Role for p21 and p27 in Efficacy of Oncolytic Adenovirus dl922-947 in Ovarian Cancer
.
MOLECULAR THERAPY
.
vol.
17
,
S100
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S100
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Adam V, Oberg D, Lemoine N, Hallden G
(
2009
)
.
Prostate Cancer Targeting by Replication-Selective Adenoviral Mutants: Combination Treatments with Phytochemical Drugs
.
MOLECULAR THERAPY
.
vol.
17
,
S320
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S320
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Leitner S, Sweeney K, Oberg D, Davies D, Miranda E, Lemoine NR, Halldén G
(
2009
)
.
Oncolytic adenoviral mutants with E1B19K gene deletions enhance gemcitabine-induced apoptosis in pancreatic carcinoma cells and anti-tumor efficacy in vivo
.
Clin Cancer Res
vol.
15
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(
5
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1730
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1740
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Libertini S, Iacuzzo I, Perruolo G, Scala S, Ierano C, Franco R, Hallden G, Portella G
(
2008
)
.
Bevacizumab Increases Viral Distribution in Human Anaplastic Thyroid Carcinoma Xenografts and Enhances the Effects of E1A-Defective Adenovirus d/922-947
.
CLIN CANCER RES
vol.
14
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(
20
)
6505
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6514
.
Flak MB, Connell CM, Hill RM, Hallden G, Chelala C, McNeish IA
(
2008
)
.
Host cell factors in ovarian cancer influencing efficacy of oncolytic adenovirus dl922-947
.
HUMAN GENE THERAPY
.
vol.
19
,
1083
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1083
.
Cheong SC, Oberg D, Nick L, Hallden G
(
2008
)
.
Inhibition of late-stage prostate cancer using adenoviral mutants: Expression of an androgen receptor co-repressor and AR-siRNA
.
HUMAN GENE THERAPY
.
vol.
19
,
1082
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1082
.
Adam V, Lemoine N, Hallden G
(
2008
)
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Prostate cancer targeting by replication-selective adenoviral mutants: combination treatments with phytochemical drugs
.
HUMAN GENE THERAPY
.
vol.
19
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1165
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1165
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Bazan-Peregrino M, Carlisle RC, Hernandez-Alcoceba R, Iggo R, Homicsko K, Fisher KD, Halldén G, Mautner V et al.
(
2008
)
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Comparison of molecular strategies for breast cancer virotherapy using oncolytic adenovirus
.
Hum Gene Ther
vol.
19
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(
9
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873
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886
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Seymour LW, Bazan-Peregrino M, Carlisle R, Hernandez-Alcoceba R, Iggo R, Homicsko K, Hallden G, Mautner V et al.
(
2008
)
.
Comparison of Molecular Strategies for Breast Cancer Virotherapy using Oncolytic Adenovirus
.
Hum Gene Ther
Adam VS, Lemoine N, Hallden G
(
2008
)
.
Prostate cancer targeting by replication-selective adenoviral mutants: Combination treatments with phytochemical drugs
.
HUMAN GENE THERAPY
.
vol.
19
,
419
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419
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Cheong SC, Wang Y, Meng J-H, Hill R, Sweeney K, Kirn D, Lemoine NR, Halldén G
(
2008
)
.
E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models
.
Cancer Gene Ther
vol.
15
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(
1
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40
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50
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Cheong SC, Lemoine N, Hallden G
(
2007
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Inhibition of androgen receptor signaling pathways in prostate cancer cells by adenoviral vectors expressing Hey1
.
HUMAN GENE THERAPY
.
vol.
18
,
1004
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1004
.
Gaballah K, Hills A, Curiel D, Hallden G, Harrison P, Partridge M
(
2007
)
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Lysis of dysplastic but not normal oral keratinocytes and tissue-engineered epithelia with conditionally replicating adenoviruses
.
CANCER RES
vol.
67
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15
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7284
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7294
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Radhakrishnan S, Hallden G, Chinegwundoh F, Lemoine N
(
2007
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Synergistic enhancement of prostate cancer cell death by combination therapy of adenovirus and chemotherapy
.
BJU INTERNATIONAL
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vol.
99
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28
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28
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Choi S, Lee M, Shiu AL, Yo SJ, Hallden G, Aponte GW
(
2007
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GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells
.
AM J PHYSIOL-GASTR L
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292
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5
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G1366
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Gaballah K, Partridge M, Hills A, Curiel D, Hallden G, Harrison P
(
2007
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Lysis of dysplastic but not normal organotypical oral epithelium with conditionally replicating adenoviruses
.
ORAL ONCOLOGY
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vol.
2
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181
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181
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Radhakrishnan S, Hallden GK, Chinegwundoh F, Lemoine N
(
2007
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Synergistic enhancement of cell death by combination therapy with adenovirus and chemotherapy
.
JOURNAL OF UROLOGY
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vol.
177
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182
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183
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Bapat U, Wang Y, Alusi G, Chisholm E, Francis J, Hallden G, Lemoine N
(
2006
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Oncolytic virotherapy for nasopharyngeal cancer
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Clinical Otolaryngology
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31
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6
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582
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583
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Bhattacharyya M, Hallden G, Francis J, Lemoine NR
(
2006
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Synergistic interactions between adenovirus and chemotherapy in pancreatic cancer cell lines: Effects of chemotherapy on expression of coxsackie-adenovirus receptor (CAR) and infectability by adenovirus
.
CANCER RESEARCH
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vol.
66
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Liu T-C, Wang Y, Hallden G, Brooks G, Francis J, Lemoine NR, Kirn D
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2005
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Functional interactions of antiapoptotic proteins and tumor necrosis factor in the context of a replication-competent adenovirus
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Gene Ther
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1333
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1346
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Wang Y, Xue S-A, Hallden G, Francis J, Yuan M, Griffin BE, Lemoine NR
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2005
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Virus-associated RNA I-deleted adenovirus, a potential oncolytic agent targeting EBV-associated tumors
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Cancer Res
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4
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1523
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1531
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Lee M, Hadi M, Halldén G, Aponte GW
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2005
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Peptide YY and neuropeptide Y induce villin expression, reduce adhesion, and enhance migration in small intestinal cells through the regulation of CD63, matrix metalloproteinase-3, and Cdc42 activity
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J Biol Chem
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Wang Y, Thorne S, Hannock J, Francis J, Au T, Reid T, Lemoine N, Kirn D et al.
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2005
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A novel assay to assess primary human cancer infectibility by replication-selective oncolytic adenoviruses
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Clin Cancer Res
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351
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360
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Hu JC, Hallden G, Shorrock C, Simpson G, Coffin R, Kamalati T, Coombes C
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2004
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Combination of a second generation genetically modified herpes simplex virus 1 (HSV1) with paclitaxel in the treatment of breast cancer in vitro
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JOURNAL OF CLINICAL ONCOLOGY
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Wang Y, Faux SP, Hallden G, Kirn DH, Houghton CE, Lemoine NR, Patrick G
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Interleukin-1beta and tumour necrosis factor-alpha promote the transformation of human immortalised mesothelial cells by erionite
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Int J Oncol
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173
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Liu T-C, Hallden G, Wang Y, Brooks G, Francis J, Lemoine N, Kirn D
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2004
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An E1B-19 kDa gene deletion mutant adenovirus demonstrates tumor necrosis factor-enhanced cancer selectivity and enhanced oncolytic potency
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Mol Ther
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9
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6
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786
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803
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Hu J, Hallden G, Shorrock C, Simpson G, Coffin R, Kamalati T, Coombes R
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2004
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Combination of a second generation genetically modified herpes simplex virus 1 (HSV 1) with paclitaxel in the treatment of breast cancer in vitro
.
MOLECULAR THERAPY
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vol.
9
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S105
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Hallden GK, Meng JH, Hill R, Wang YH, Francis J, Lemoine NN, Kirn DH
(
2004
)
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Combination therapy with adenovirus (Ad5) and cytotoxic drugs can act synergistically to induce cell death in carcinoma cell lines in culture
.
MOLECULAR THERAPY
.
vol.
9
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S113
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S113
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Liu TC, Wang YH, Hallden G, Francis J, Brooks G, Lemoine N, Kirn D
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2004
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Oncolytic adenovirus E1B-19kD deletion and E3B retention results in both enhanced potency and tumor necrosis factor-mediated selectivity
.
MOLECULAR THERAPY
.
vol.
9
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S109
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Hill RJ, Hallden GK, Wang YH, Francis J, Simpson C, Kirn DH, Lemoine NR
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2004
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The gene expression and function of adenoviral E3-genes in murine tumour cell lines
.
MOLECULAR THERAPY
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vol.
9
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S374
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S375
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Wang YH, Xue SA, Hallden G, Francis J, Griffin BE, Lemoine NR
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2004
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VAI deleted adenovirus as an oncolytic agent targeting human EBV-associated tumours
.
MOLECULAR THERAPY
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9
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Halldén G, Thorne SH, Yang J, Kirn DH
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2004
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Replication-selective oncolytic adenoviruses
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Methods Mol Med
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Wang Y, Hallden G, Hill R, Anand A, Liu T-C, Francis J, Brooks G, Lemoine N et al.
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2003
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