Publications: PROF Aine Mcknight
(
2025
)
.
Retraction notice to “Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-centre, double blind, placebo-controlled, randomised trial” [J. Clin. Virol. 155C (2022) 105248]
.
Journal of Clinical Virology
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178
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Article
105782
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105782
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(
2025
)
.
Temporary 2-week suspension of methotrexate treatment to enhance COVID-19 vaccine response in people with immune-mediated inflammatory diseases: the VROOM RCT
.
Efficacy and Mechanism Evaluation1
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42
.
(
2025
)
.
Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial
.
Efficacy and Mechanism Evaluation
vol.
12
,
(
05
)
47
-
48
.
(
2025
)
.
Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial
.
Efficacy and Mechanism Evaluation
vol.
12
,
(
05
)
45
-
46
.
(
2025
)
.
Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study)
.
Efficacy and Mechanism Evaluation
vol.
12
,
(
05
)
43
-
44
.
(
2025
)
.
HIV-1 Vpr alters cellular transcription by targeting the PAF1 complex
.
(
2024
)
.
Preservation of memory B cell homeostasis in an individual producing broadly neutralising antibodies against HIV-1
.
(
2024
)
.
Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial
.
The Lancet Rheumatology
vol.
6
,
(
2
)
e92
-
e104
.
(
2023
)
.
The innate immune factor RPRD2/REAF and its role in the Lv2 restriction of HIV
.
mBio
vol.
14
,
(
6
)
Article
e02572-21
,
Miyashita L, Foley G, Semple S, Gibbons JM, Pade C, McKnight Á, Grigg J
(
2023
)
.
Curbside particulate matter and susceptibility to SARS–CoV-2 infection
.
Journal of Allergy and Clinical Immunology: Global
vol.
2
,
(
4
)
Article
100141
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100141
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100141
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(
2023
)
.
Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity
.
Nature Communications
vol.
14
,
(
1
)
Article
5139
,
(
2022
)
.
Persistent symptoms after COVID-19 during the first wave are not associated with differential immunity to SARS-CoV-2
.
(
2022
)
.
Plasma proteomic signature predicts who will get persistent symptoms following SARS-CoV-2 infection
.
eBioMedicine
vol.
85
,
Article
104293
,
104293
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104293
.
(
2022
)
.
RETRACTED: Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-centre, double blind, placebo-controlled, randomised trial
.
Journal of Clinical Virology
vol.
155
,
Article
105248
,
105248
-
105248
.
(
2022
)
.
Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled Trial
.
Nutrients
vol.
14
,
(
18
)
3821
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3821
.
(
2022
)
.
Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial
.
The Lancet Respiratory Medicine
vol.
10
,
(
9
)
840
-
850
.
(
2022
)
.
Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response
.
Cell Reports Methods
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2
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(
9
)
Article
100279
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100279
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100279
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(
2022
)
.
Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study
.
The Journal of Infectious Diseases
vol.
226
,
(
11
)
1903
-
1908
.
(
2022
)
.
Influence of vitamin D supplementation on SARS-CoV-2 vaccine efficacy and immunogenicity
.
(
2022
)
.
Immune boosting by B.1.1.529\n <b>(</b>\n Omicron) depends on previous SARS-CoV-2 exposure
.
Science
vol.
377
,
(
6603
)
Article
eabq1841
,
(
2022
)
.
Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study)
.
BMJ Open
vol.
12
,
(
5
)
e062599
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e062599
.
(
2022
)
.
HLA‐DR polymorphism in SARS‐CoV‐2 infection and susceptibility to symptomatic COVID‐19
.
Immunology
vol.
166
,
(
1
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68
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77
.
(
2022
)
.
Rapid synchronous type 1 IFN and virus-specific T cell responses characterize first wave non-severe SARS-CoV-2 infections
.
Cell Reports Medicine
vol.
3
,
(
3
)
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100557
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100557
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(
2022
)
.
Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response
.
(
2022
)
.
Generation of novel SARS-CoV-2 variants on B.1.1.7 lineage in three patients with advanced HIV disease
.
(
2022
)
.
Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants
.
Science
vol.
375
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6577
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183
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192
.
(
2022
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The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19
.
Frontiers in Immunology
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12
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813300
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(
2021
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.
The β-NGF/TrkA signalling pathway is associated with the production of anti- nucleoprotein IgG in convalescent COVID-19
.
(
2021
)
.
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2
.
Nature
(
2021
)
.
Prospective Case-Control Study of Cardiovascular Abnormalities 6 Months Following Mild COVID-19 in Healthcare Workers
.
JACC: Cardiovascular Imaging
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14
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11
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2155
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2166
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(
2021
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Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study
.
The Lancet Microbe
vol.
2
,
(
10
)
e508
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e517
.
(
2021
)
.
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 infection
.
(
2021
)
.
Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose
.
Science
vol.
372
,
(
6549
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1418
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1423
.
(
2021
)
.
Longitudinal assessment of symptoms and risk of SARS-CoV-2 infection in healthcare workers across 5 hospitals to understand ethnic differences in infection risk
.
EClinicalMedicine
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34
,
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100835
.
(
2021
)
.
Non-severe SARS-CoV-2 infection is characterised by very early T cell proliferation independent of type 1 interferon responses and distinct from other acute respiratory viruses
.
(
2021
)
.
Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals
.
The Lancet
vol.
397
,
(
10279
)
1057
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1058
.
(
2021
)
.
Time series analysis and mechanistic modelling of heterogeneity and sero-reversion in antibody responses to mild SARS‑CoV-2 infection
.
EBioMedicine
vol.
65
,
Article
103259
,
103259
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103259
.
(
2021
)
.
Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection
.
(
2020
)
.
Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection
.
Science Immunology
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5
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(
54
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,
(
2020
)
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Characterising heterogeneity and sero-reversion in antibody responses to mild SARS⍰CoV-2 infection: a cohort study using time series analysis and mechanistic modelling
.
(
2020
)
.
Healthcare workers with mild / asymptomatic SARS-CoV-2 infection show T cell responses and neutralising antibodies after the first wave
.
(
2020
)
.
Healthcare Workers Bioresource: Study outline and baseline characteristics of a prospective healthcare worker cohort to study immune protection and pathogenesis in COVID-19
.
Wellcome Open Research
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5
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179
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179
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(
2020
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Healthcare Workers Bioresource: Study outline and baseline characteristics of a prospective healthcare worker cohort to study immune protection and pathogenesis in COVID-19
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Wellcome Open Research
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5
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179
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179
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COVID-19: PCR screening of asymptomatic health-care workers at London hospital
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HIV-1 Accessory Protein Vpr Interacts with REAF/RPRD2 To Mitigate Its Antiviral Activity
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(
4
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Healthcare Workers Bioresource: Study outline and baseline characteristics of a prospective healthcare worker cohort to study immune protection and pathogenesis in COVID-19
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(
2019
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HIV-1 Vpr accessory protein interacts with REAF and mitigates its associated anti-viral activity
.
Access Microbiology
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1
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1A
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(
2019
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HIV-1 infectivity of cells is enhanced at mitosis: a role for Vpr?
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1
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1A
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2018
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HIV-1 accessory protein Vpr interacts with REAF/RPRD2 to mitigate its antiviral activity
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(
2017
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Control of HIV infection by IFN-α: implications for latency and a cure
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5
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775
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783
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The evolution of structured illumination microscopy in studies of HIV
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Novel restriction factor RNA-associated early-stage anti-viral factor (REAF) inhibits human and simian immunodeficiency viruses
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The ins and outs of HIV restriction
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