Publications: PROF Costantino Pitzalis

Rivellese F, Pontarini E, Pitzalis C ( 2025 ) . Reply . Arthritis & Rheumatology Article art.43307 ,

De Lima J, Boutet M-A, Bortolotti O, Chépeaux L-A, Glasson Y, Dumé A-S, Lau R, Humbert P et al. ( 2025 ) . Spatial mapping of rheumatoid arthritis synovial niches reveals a LYVE1+ macrophage network associated with response to therapy . Annals of the Rheumatic Diseases

Pontarini E, Lucchesi D, Sciacca E, Cavallaro G, Song Q, Galbraith D, Thomas E, Marino A et al. ( 2025 ) . Transcriptomic profiling of Sjögren’s disease salivary glands identifies signatures associated with both follicular and extrafollicular responses linked to rheumatoid factor and anti-La/SSB seropositivity . Annals of the Rheumatic Diseases

Rivellese F, Pontarini E, Fossati‐Jimack L, Moura RA, Romão VC, Fonseca JE, Nerviani A, Çubuk C et al. ( 2025 ) . Comparative Analysis of Circulating and Synovial Immune Cells in Early Untreated Rheumatoid Arthritis and Their Relationship With Molecular Pathology and Disease Outcomes . Arthritis & Rheumatology Article art.43194 ,

Lewis MJ, Çubuk C, Surace AEA, Sciacca E, Lau R, Goldmann K, Giorli G, Fossati-Jimack L et al. ( 2025 ) . Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis . Nature Communications vol. 16 , ( 1 ) Article 5374 ,

Banda N, Moreland LW, Deane KD, Simberg D, Scheinman RI, Frank RM, Clay MR, Seifert JA et al. ( 2025 ) . Analysis of human factor H-related gene and protein expression in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation . Immunobiology vol. 230 , ( 4 ) Article 153016 , 153016 - 153016 .

Gavan SP, Chang S, Rivellese F, Ide Z, Stadler M, Payne K, Plant D, Barton A et al. ( 2025 ) . Estimating pain visual analogue scale from health assessment questionnaire for rheumatoid arthritis with beta mixture models . Rheumatology International vol. 45 , ( 7 ) Article 154 ,

Gallagher-Syed A, Senior H, Alwazzan O, Pontarini E, Bombardieri M, Pitzalis C, Lewis MJ, Barnes MR et al. ( 2025 ) . BioX-CPath: Biologically-driven Explainable Diagnostics for Multistain IHC Computational Pathology . 2025 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR) . Conference: 2025 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR) from: 10/06/2025 to: 17/06/2025 , 10372 - 10383 .

Banda NK, Moreland LW, Deane KD, Simberg D, Scheinman RI, Frank RM, Seifert JA, Anolik J et al. ( 2025 ) . Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation . Scientific Reports vol. 15 , ( 1 ) Article 19633 ,

Chang S, Rivellese F, Ide Z, Barton A, Payne K, Pitzalis C, Gavan S ( 2025 ) . ABS0909 COST-EFFECTIVENESS ANALYSIS OF A SYNOVIAL TISSUE BIOPSY TO INFORM SECOND-LINE BIOLOGIC TREATMENT AFTER INADEQUATE RESPONSE TO A TUMOUR NECROSIS FACTOR-ALPHA INHIBITOR FOR RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases vol. 84 , 2037 - 2038 .

den Hond IC, Reinders MJT, Lewis M, Pitzalis C, Knevel R, van den Akker EB ( 2025 ) . OP0155 RA RISK GENES ARE DIFFERENTIALLY EXPRESSED BETWEEN (PEAC) PATHOTYPES IN SYNOVIUM WITH A CLEAR ENRICHMENT IN THE LYMPHOID-RICH PATHOTYPE . Annals of the Rheumatic Diseases vol. 84 , 133 - 134 .

Martínez-Paz P, Nerviani A, Cubuk C, Lau R, Fossati-Jimack L, Rivellese F, Somma D, Alivernini S et al. ( 2025 ) . POS0070 SPECIFIC SYNOVIAL TISSUE MACROPHAGE CLUSTER SUBTYPES ARE ASSOCIATED WITH MULTI-BIOLOGIC REFRACTORINESS IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases vol. 84 , 376 - 376 .

Dellinger M, Tosevska A, Kartnig F, Preglej T, Brinkmann M, Luckerbauer B, Emilius L, Iaquinta FS et al. ( 2025 ) . POS0241 THE SYNOVIAL CYTOKINE MILIEU SHAPES FIBROBLAST-LIKE SYNOVIOCYTE-IMMUNE CELL INTERACTION DRIVING IMMUNE CELL ACTIVATION AND SYNOVIAL PATHOTYPE DEVELOPMENT IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases vol. 84 , 511 - 512 .

Anderle K, Popescu C, Sieghart D, Bonnay F, Aletaha D, Knevel R, Pitzalis C, Kristianslund E et al. ( 2025 ) . POS0561 Pan-European study on prescription patterns of methotrexate in patients with rheumatoid arthritis . Annals of the Rheumatic Diseases vol. 84 , 763 - 764 .

Hughes STO, Costa D, Soria AD, Hill D, Figueras AC, Scott R, Dimonte S, Monaco F et al. ( 2025 ) . P112 Cytokine driven disease and epigenetic heterogeneity in rheumatoid arthritis . Rheumatology vol. 64 , ( Supplement_3 ) Article keaf142.152 ,

Gallagher-Syed A, Senior H, Alwazzan O, Pontarini E, Bombardieri M, Pitzalis C, Lewis MJ, Barnes MR et al. ( 2025 ) . BioX-CPath: Biologically-driven Explainable Diagnostics for Multistain IHC Computational Pathology .

Inamo J, Keegan J, Griffith A, Ghosh T, Horisberger A, Howard K, Pulford JF, Murzin E et al. ( 2025 ) . Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis . Journal of Clinical Investigation vol. 135 , ( 6 ) Article e185217 ,

Bhamidipati K, McIntyre ABR, Kazerounian S, Ce G, Tran M, Prell SA, Lau R, Khedgikar V et al. ( 2025 ) . Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis .

Spiliopoulou A, Iakovliev A, Plant D, Sutcliffe M, Sharma S, Cubuk C, Lewis M, Pitzalis C et al. ( 2025 ) . Genome‐Wide Aggregated <i>Trans</i> Effects Analysis Identifies Genes Encoding Immune Checkpoints as Core Genes for Rheumatoid Arthritis . Arthritis &amp; Rheumatology vol. 77 , ( 7 ) 817 - 826 .

Donado CA, Theisen E, Zhang F, Nathan A, Fairfield ML, Rupani KV, Jones D, Johannes KP et al. ( 2025 ) . Granzyme K activates the entire complement cascade . Nature vol. 641 , ( 8061 ) 211 - 221 .

Baker KF, Spierings J, Brom M, Radstake T, Smith E, Weiss R, Burmester GR, Bijlsma JWJ et al. ( 2025 ) . Cure as a treatment target in rheumatoid arthritis and systemic sclerosis—achievable aim or mission impossible? FOREUM stimulates new industry-academia collaboration . vol. 84 , is. 2 , pp. 153 - 157 . Elsevier BV

Chang S, Rivellese F, Payne K, Ide Z, Barton A, Pitzalis C, Gavan SP ( 2025 ) . Ultrasound-guided synovial tissue biopsy for people with rheumatoid arthritis: a micro-costing study . Rheumatology Advances in Practice vol. 9 , ( 1 ) Article rkaf011 ,

Faust HJ, Cheng T-Y, Korsunsky I, Watts GFM, Gal-Oz ST, Trim WV, Kongthong S, Jonsson AH et al. ( 2024 ) . Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis . Nature Communications vol. 15 , ( 1 ) Article 9859 ,

Ruscitti P, Currado D, Rivellese F, Vomero M, Navarini L, Cipriani P, Pitzalis C, Giacomelli R ( 2024 ) . Diminished expression of the ubiquitin-proteasome system in early treatment-naïve patients with rheumatoid arthritis and concomitant type 2 diabetes may be linked to IL-1 pathway hyper-activity; results from PEAC cohort . Arthritis Research &amp; Therapy vol. 26 , ( 1 ) Article 171 ,

Hanlon MM, Smith CM, Canavan M, Neto NGB, Song Q, Lewis MJ, O’Rourke AM, Tynan O et al. ( 2024 ) . Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset . Science Advances vol. 10 , ( 39 ) Article eadj1252 ,

Derrac Soria A, Lewis M, Liu X, Twohig JP, Monaco F, Dimonte S, Cardus Figueras A, Morrin A et al. ( 2024 ) . IL-6 and IL-27 negatively regulate CRTAM-expressing CD4⁺T-cells associated with lymphoid-driven synovitis .

Bell RD, Brendel M, Konnaris MA, Xiang J, Otero M, Fontana MA, Bai Z, Albrecht J et al. ( 2024 ) . Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue . Nature Communications vol. 15 , ( 1 ) Article 7503 ,

Thomas BL, Montero‐Melendez T, Oggero S, Kaneva MK, Chambers D, Pinto AL, Nerviani A, Lucchesi D et al. ( 2024 ) . Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis . Arthritis &amp; Rheumatology vol. 76 , ( 12 ) 1705 - 1718 .

Zack SR, Alzoubi O, Satoeya N, Singh KP, Deen S, Nijim W, Lewis MJ, Pitzalis C et al. ( 2024 ) . Another Notch in the Belt of Rheumatoid Arthritis . Arthritis &amp; Rheumatology Article art.42937 ,

Law C, Wacleche VS, Cao Y, Pillai A, Sowerby J, Hancock B, Horisberger A, Bracero S et al. ( 2024 ) . Publisher Correction: Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus . Nature vol. 632 , ( 8025 ) E6 - E6 .

Law C, Wacleche VS, Cao Y, Pillai A, Sowerby J, Hancock B, Horisberger A, Bracero S et al. ( 2024 ) . Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus . Nature vol. 631 , ( 8022 ) 857 - 866 .

Ruscitti P, Allanore Y, Baldini C, Barilaro G, Bartoloni Bocci E, Bearzi P, Bellis E, Berardicurti O et al. ( 2024 ) . Tailoring the treatment of inflammatory rheumatic diseases by a better stratification and characterization of the clinical patient heterogeneity. Findings from a systematic literature review and experts' consensus . Autoimmunity Reviews vol. 23 , ( 7-8 ) Article 103581 , 103581 - 103581 .

Rolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L et al. ( 2024 ) . Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues . EMBO Reports vol. 25 , ( 9 ) 3842 - 3869 .

Çubuk C, Lau R, Cutillas P, Rajeeve V, John CR, Surace AEA, Hands R, Fossati-Jimack L et al. ( 2024 ) . Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes . Arthritis Research &amp; Therapy vol. 26 , ( 1 ) Article 120 ,

Dunlap G, Wagner A, Meednu N, Wang R, Zhang F, Ekabe JC, Jonsson AH, Wei K et al. ( 2024 ) . Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium . Nature Communications vol. 15 , ( 1 ) Article 4991 ,

Stadler M, Rivellese F, Plant D, Hyrich K, Isaacs J, Morgan A, Wilson AG, Verstappen S et al. ( 2024 ) . AB0757 TREATMENT RESPONSE CRITERIA FOR THE TWO-COMPONENT DISEASE ACTIVITY SCORE . Annals of the Rheumatic Diseases . vol. 83 , 1670 - 1670 .

Caliste M, Prediletto E, Corsiero E, Jagemann L, Pitzalis C, Bombardieri M ( 2024 ) . AB0784 STROMAL B-CELL CROSSTALK PROMOTES THE ESTABLISHMENT OF SYNOVIAL EBV+B-CELL NICHES THROUGH TYPE I INTERFERON SIGNALLING ACTIVATION . Annals of the Rheumatic Diseases vol. 83 , 1684 - 1684 .

Pontarini E, Sciacca E, Cavallaro G, Galbraith D, Pulvirenti A, Hao LY, Sivils K, Lewis M et al. ( 2024 ) . AB0809 USER-FRIENDLY TOOL FOR EXPLORING RNA-SEQUENCE AND BIOMARKER DISCOVERY IN SJOGREN’S DISEASE: ANALYSE THE TWO BIGGEST DATASETS OF BLOOD AND SALIVARY GLAND RNA-SEQUENCING DATA USING R SHINY APPS . Annals of the Rheumatic Diseases . vol. 83 , 1699 - 1699 .

Maurits MP, Cameron A, Jelinsky S, Blüml S, Abasolo L, Askling J, Barton A, Böhringer S et al. ( 2024 ) . OP0033 FIBROBLAST GENE, FKBP7 INDUCED BY Ca2+ DEPENDENT ER STRESS ASSOCIATED WITH CLINICAL OUTCOME IN RHEUMATOID ARTHRITIS AND CROHN’S DISEASE; MULTI-CENTRE GWAS AND FUNCTIONAL STUDIES . Annals of the Rheumatic Diseases . vol. 83 , 28 - 29 .

Lau R, Cubuk C, Rajeeve V, Cutillas P, Hands R, Fossati-Jimack L, Surace A, Lewis M et al. ( 2024 ) . OP0218 SYNOVIAL PHOSPHOPROTEOME ANALYSIS OF LATE-STAGE RHEUMATOID ARTHRITIS PATIENTS (R4RA TRIAL) IDENTIFIES SIGNALLING PATHWAYS ASSOCIATED WITH PATHOTYPE AND RESPONSE TO RITUXIMAB AND TOCILIZUMAB . Annals of the Rheumatic Diseases . vol. 83 , 12 - 12 .

Wang S, Nair N, Cubuk C, Yap CF, Lau R, Giorli G, Fossati-Jimack L, Plant D et al. ( 2024 ) . OP0224 INTEGRATION OF DNA METHYLATION INTO MULTI-OMIC ANALYSIS OF SYNOVIAL BIOPSIES FROM THE STRAP RANDOMIZED CLINICAL TRIAL IDENTIFIES PREDICTORS OF RESPONSE TO ANTI-TNF THERAPY IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 83 , 13 - 13 .

Surace A, Overend L, Sciacca E, Fossati-Jimack L, Jaworska E, Pontarini E, Bashford-Rogers RJM, Pitzalis C et al. ( 2024 ) . OP0242 SYNOVIAL TISSUE AND BLOOD DEEP B/T CELL PHENOTYPING EXPLAINS RESPONSE MECHANISMS TO RITUXIMAB IN RHEUMATOID ARTHRITIS IN R4RA . Annals of the Rheumatic Diseases . vol. 83 , 13 - 14 .

Pontarini E, Rizzo MT, Liefers SC, Cavallaro G, Van der Vegt B, Colafrancesco S, Zabotti A, Quartuccio L et al. ( 2024 ) . POS0265 ESTABLISHING CONSISTENCY IN THE DIGITAL IMAGING ANALYSIS OF HISTOLOGICAL PARAMETERS IN SJOGREN’S DISEASE . Annals of the Rheumatic Diseases . vol. 83 , 282 - 283 .

Iaquinta FS, Sciacca E, Abatecola F, Fossati-Jimack L, Pitzalis C, Rivellese F ( 2024 ) . POS0351 A POST-HOC ANALYSIS OF THE BIOPSY-DRIVEN, MULTICENTRE, RANDOMISED R4RA CLINICAL TRIAL REVEALS AN INNATE IMMUNE SIGNATURE IN MULTI-DRUG RESISTANT RHEUMATOID ARTHRITIS PATIENTS WITH A LYMPHO-MYELOID PATHOTYPE . Annals of the Rheumatic Diseases . vol. 83 , 302 - 303 .

Colafrancesco S, Simoncelli E, Pontarini E, Cavallaro G, Lucchesi D, Marino A, Buoncuore G, Barbati C et al. ( 2024 ) . POS0997 INFLAMMATION IN SJÖGREN DISEASE INDUCES SALIVARY GLAND EPITHELIAL CELLS (SGECS) METABOLIC REPROGRAMMING: FOCUS ON GLYCOLYSIS AND ITS REGULATION OF EPITHELIAL CELL ACTIVATION . Annals of the Rheumatic Diseases . vol. 83 , 862 - 863 .

Dellinger M, Tosevska A, Kartnig F, Preglej T, Heinz L, Brinkmann M, Luckerbauer B, Steiner G et al. ( 2024 ) . POS1217 FIBROBLAST-LIKE SYNOVIOCYTE – IMMUNE CELL INTERACTIONS: DRIVERS OF SYNOVIAL INFLAMMATION IN RHEUMATOID ARTHRITIS? . Annals of the Rheumatic Diseases . vol. 83 , 743 - 744 .

Weinand K, Sakaue S, Nathan A, Jonsson AH, Zhang F, Watts GFM, Al Suqri M, Zhu Z et al. ( 2024 ) . The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis . Nature Communications vol. 15 , ( 1 ) Article 4650 ,

Corsiero E, Caliste M, Jagemann L, Fossati-Jimack L, Goldmann K, Cubuk C, Ghirardi GM, Prediletto E et al. ( 2024 ) . Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response . Journal of Clinical Investigation vol. 134 , ( 12 ) Article e169754 ,

Perera J, Delrosso CA, Nerviani A, Pitzalis C ( 2024 ) . Clinical Phenotypes, Serological Biomarkers, and Synovial Features Defining Seropositive and Seronegative Rheumatoid Arthritis: A Literature Review . Cells vol. 13 , ( 9 ) 743 - 743 .

Bai Z, Bartelo N, Aslam M, Murphy EA, Hale CR, Blachere NE, Parveen S, Spolaore E et al. ( 2024 ) . Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis . Science Translational Medicine vol. 16 , ( 742 ) Article eadk3506 ,

Sakaue S, Weinand K, Isaac S, Dey KK, Jagadeesh K, Kanai M, Watts GFM, Zhu Z et al. ( 2024 ) . Tissue-specific enhancer–gene maps from multimodal single-cell data identify causal disease alleles . Nature Genetics vol. 56 , ( 4 ) 615 - 626 .

Carlucci PM, Preisinger K, Deonaraine KK, Zaminski D, Dall'Era M, Gold HT, Kalunian K, Fava A et al. ( 2024 ) . Extrarenal symptoms associate with worse quality of life in patients enrolled in the AMP RA/SLE Lupus Nephritis Network . Rheumatology Article keae189 ,

Nerviani A, Boutet M-A, Ghirardi GM, Goldmann K, Sciacca E, Rivellese F, Pontarini E, Prediletto E et al. ( 2024 ) . Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis . Nature Communications vol. 15 , ( 1 ) Article 2398 ,

Goldmann K, Spiliopoulou A, Iakovliev A, Plant D, Nair N, Cubuk C, McKeigue P, Barnes MR et al. ( 2024 ) . Expression quantitative trait loci analysis in rheumatoid arthritis identifies tissue specific variants associated with severity and outcome . Annals of the Rheumatic Diseases vol. 83 , ( 3 ) 288 - 299 .

Pontarini E, Sciacca E, Chowdhury F, Grigoriadou S, Rivellese F, Murray‐Brown WJ, Lucchesi D, Fossati‐Jimack L et al. ( 2024 ) . Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) to B Cell–Targeted Therapy in the Trial of Anti–B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS) . Arthritis &amp; Rheumatology vol. 76 , ( 5 ) 763 - 776 .

Pitzalis C ( 2024 ) . Advances in Targeted Therapies (ATT) What's cooking in the academic's kitchen? 3TR (IMI) . Seminars in Arthritis and Rheumatism vol. 64 , Article 152317 , 152317 - 152317 .

Boutet M-A, Nerviani A, Fossati-Jimack L, Hands-Greenwood R, Ahmed M, Rivellese F, Pitzalis C ( 2024 ) . Comparative analysis of late-stage rheumatoid arthritis and osteoarthritis reveals shared histopathological features . Osteoarthritis and Cartilage vol. 32 , ( 2 ) 166 - 176 .

Weisenfeld D, Zhang F, Donlin L, Jonsson AH, Apruzzese W, Campbell D, Rao DA, Wei K et al. ( 2024 ) . Associations Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Types and States . Arthritis &amp; Rheumatology vol. 76 , ( 3 ) 356 - 362 .

Meyer A, Zack SR, Nijim W, Burgos A, Patel V, Zanotti B, Volin MV, Amin MA et al. ( 2023 ) . Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis . Cellular &amp; Molecular Immunology vol. 21 , ( 1 ) 33 - 46 .

Iaquinta FS, Rivellese F, Pitzalis C ( 2023 ) . Synovial biopsies for molecular definition of rheumatoid arthritis and treatment response phenotyping: where can we improve? . Expert Review of Molecular Diagnostics vol. 23 , ( 12 ) 1071 - 1076 .

Zhang F, Jonsson AH, Nathan A, Millard N, Curtis M, Xiao Q, Gutierrez-Arcelus M, Apruzzese W et al. ( 2023 ) . Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes . Nature vol. 623 , ( 7987 ) 616 - 624 .

Rivellese F, Nerviani A, Giorli G, Warren L, Jaworska E, Bombardieri M, Lewis MJ, Humby F et al. ( 2023 ) . Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials . The Lancet Rheumatology vol. 5 , ( 11 ) e648 - e659 .

MacBrayne A, Curzon P, Soyel H, Marsh W, Fenton N, Pitzalis C, Humby F ( 2023 ) . Attitudes towards technology supported rheumatoid arthritis care: investigating patient- and clinician-perceived opportunities and barriers . Rheumatology Advances in Practice vol. 7 , ( 3 ) Article rkad089 ,

De Lima J, Boutet M-A, Bortolotti O, Chépeaux L-A, Glasson Y, Dumé A-S, Le Pluart A, Nerviani A et al. ( 2023 ) . Spatial mapping of rheumatoid arthritis synovial niches reveals specific macrophage networks associated with response to therapy .

Zack SR, Meyer A, Zanotti B, Volin MV, Deen S, Satoeya N, Sweiss N, Lewis MJ et al. ( 2023 ) . Notch ligands are biomarkers of anti-TNF response in RA patients . Angiogenesis vol. 27 , ( 2 ) 273 - 283 .

Gallagher-Syed A, Rossi L, Rivellese F, Pitzalis C, Lewis M, Barnes M, Slabaugh G ( 2023 ) . MUSTANG: Multi-Stain Self-Attention Graph Multiple Instance Learning Pipeline for Histopathology Whole Slide Images .

Gallagher-Syed A, Khan A, Rivellese F, Pitzalis C, Lewis MJ, Slabaugh G, Barnes MR ( 2023 ) . Automated segmentation of rheumatoid arthritis immunohistochemistry stained synovial tissue .

Kugler M, Dellinger M, Kartnig F, Müller L, Preglej T, Heinz LX, Simader E, Göschl L et al. ( 2023 ) . Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid arthritis . Annals of the Rheumatic Diseases vol. 82 , ( 9 ) 1142 - 1152 .

Bai Z, Bartelo N, Aslam M, Hale C, Blachere NE, Parveen S, Spolaore E, DiCarlo E et al. ( 2023 ) . Machine Learning Reveals Synovial Fibroblast Genes Associated with Pain Affect Sensory Nerve Growth in Rheumatoid Arthritis .

Wang SS, Lewis MJ, Pitzalis C ( 2023 ) . DNA Methylation Signatures of Response to Conventional Synthetic and Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis . Biomedicines vol. 11 , ( 7 ) 1987 - 1987 .

Inamo J, Keegan J, Griffith A, Ghosh T, Horisberger A, Howard K, Pulford J, Murzin E et al. ( 2023 ) . Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis .

Vigorito E, Barton A, Pitzalis C, Lewis MJ, Wallace C ( 2023 ) . BBmix: a Bayesian beta-binomial mixture model for accurate genotyping from RNA-sequencing . Bioinformatics vol. 39 , ( 7 ) Article btad393 ,

Khmelevskaya A, Houtman M, Buerki K, Pauli C, Rivellese F, Prediletto E, Pitzalis C, Distler O et al. ( 2023 ) . AB0062 ABUNDANCE AND ACTIVATION OF MEMORY B-CELLS CHARACTERIZE SYNOVITIS IN RHEUMATOID ARTHRITIS PATIENTS WITH EARLY TREATMENT RESPONSE . Annals of the Rheumatic Diseases vol. 82 , 1210 - 1210 .

Ghirardi GM, Nerviani A, Fossati-Jimack L, Pontarini E, Italiani P, Pratesi F, Abdelmoaty S, Högerkorp C et al. ( 2023 ) . AB0067 MODE OF ACTION AND TARGET INVESTIGATION OF THE NEW ANTI-RHEUMATIC DRUG RABEXIMOD . Annals of the Rheumatic Diseases vol. 82 , 1212 - 1213 .

Rivellese F, Currado D, Giorli G, Prediletto E, Nerviani A, Khmelevskaya A, Micheroli R, Ospelt C et al. ( 2023 ) . AB0340 MULTI-DRUG RESISTANT RA IS ASSOCIATED WITH HIGHER BASELINE DISEASE ACTIVITY, MULTI-MORBIDITY, AND LOWER QUALITY OF LIFE: ANALYSES FROM THE R4RA BIOPSY-DRIVEN CLINICAL TRIAL . Annals of the Rheumatic Diseases vol. 82 , 1353 - 1354 .

Pontarini E, Lucchesi D, Goldmann K, Lewis M, Song Q, Thomas E, Hao LY, Sivils K et al. ( 2023 ) . POS0292 TRANSCRIPTOMIC PROFILING OF SJOGREN'S SALIVARY GLANDS IDENTIFIES FOLLICULAR AND EXTRA-FOLLICULAR GENE SIGNATURES ASSOCIATED WITH RHEUMATOID FACTOR SEROPOSITIVITY . Annals of the Rheumatic Diseases vol. 82 , 388 - 388 .

Ruscitti P, Currado D, Rivellese F, Vomero M, Navarini L, Cipriani P, Pitzalis C, Giacomelli R ( 2023 ) . POS1020 A DIMINISHED EXPRESSION OF THE UBIQUITIN-PROTEASOME SYSTEM IN PATIENTS WITH RHEUMATOID ARTHRITIS AND DIABETES IS LINKED TO IL-1 PATHWAY HYPER-ACTIVITY . Annals of the Rheumatic Diseases vol. 82 , 826 - 827 .

MacBrayne A, Soyel H, Marsh W, Fenton N, Pitzalis C, Curzon P, Humby F ( 2023 ) . E073 Attitudes to technology-supported rheumatoid arthritis care, questionnaire study: opportunities for technology to improve RA care . Rheumatology . vol. 62 ,

MacBrayne A, Soyel H, Marsh W, Fenton N, Pitzalis C, Curzon P, Humby F ( 2023 ) . P113 Attitudes to Technology supported Rheumatoid Arthritis care Questionnaire study: Barriers to People with RA &amp; their clinicians using Technology in the care pathway . Rheumatology . vol. 62 ,

MacBrayne A, Curzon P, Soyel H, Marsh W, Fenton N, Pitzalis C, Humby F ( 2023 ) . P133 Attitudes to Technology supported Rheumatoid Arthritis care: Opportunities &amp; Barriers for technology in RA - Key themes from Qualitative arm of Mixed-Methods Study . Rheumatology . vol. 62 ,

Lewis MJ, Spiliopoulou A, Goldmann K, Pitzalis C, McKeigue P, Barnes MR ( 2023 ) . nestedcv: an R package for fast implementation of nested cross-validation with embedded feature selection designed for transcriptomics and high-dimensional data . Bioinformatics Advances vol. 3 , ( 1 ) Article vbad048 ,

Sciacca EC, Alaimo S, Silluzio G, Ferro A, Latora V, Pitzalis C, Pulvirenti A, Lewis MJ ( 2023 ) . DEGGs: an R package with shiny app for the identification of differentially expressed gene-gene interactions in high-throughput sequencing data . Bioinform. vol. 39 , Article 4 ,

Meyer A, Sienes RE, Nijim W, Zanotti B, Umar S, Volin MV, Van Raemdonck K, Lewis M et al. ( 2023 ) . Syntenin-1-mediated arthritogenicity is advanced by reprogramming RA metabolic macrophages and Th1 cells . Annals of the Rheumatic Diseases vol. 82 , ( 4 ) 483 - 495 .

Mauro D, Manou-Stathopoulou S, Rivellese F, Sciacca E, Goldmann K, Tsang V, Lucey-Clayton I, Pagani S et al. ( 2023 ) . UBE2L3 regulates TLR7-induced B cell autoreactivity in Systemic Lupus Erythematosus . Journal of Autoimmunity vol. 136 , Article 103023 , 103023 - 103023 .

Dunlap G, Wagner A, Meednu N, Zhang F, Jonsson AH, Wei K, Sakaue S, Nathan A et al. ( 2023 ) . Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium .

Aly NAR, Rizk S, Aboul Enein A, El Desoukey N, Zawam H, Ahmed M, El Shikh ME, Pitzalis C ( 2022 ) . The role of lymphoid tissue SPARC in the pathogenesis and response to treatment of multiple myeloma . Frontiers in Oncology vol. 12 , Article 1009993 ,

Lewis MJ, Pitzalis C ( 2022 ) . Progress continues in prediction of the response to treatment of RA . Nature Reviews Rheumatology vol. 19 , ( 2 ) 68 - 69 .

Caxaria S, Kouvatsos N, Eldridge SE, Alvarez‐Fallas M, Thorup A, Cici D, Barawi A, Arshed A et al. ( 2022 ) . Disease modification and symptom relief in osteoarthritis using a mutated\n <scp>GCP</scp>\n ‐2/\n <scp>CXCL6</scp>\n chemokine . EMBO Molecular Medicine vol. 15 , ( 1 ) Article e16218 ,

Vigorito E, Barton A, Pitzalis C, Lewis MJ, Wallace C ( 2022 ) . BBmix: a Bayesian Beta-Binomial mixture model for accurate genotyping from RNA-sequencing .

Najm A, Costantino F, Alivernini S, Alunno A, Bianchi E, Bignall J, Boyce B, Cañete JD et al. ( 2022 ) . EULAR points to consider for minimal reporting requirements in synovial tissue research in rheumatology . Annals of the Rheumatic Diseases vol. 81 , ( 12 ) 1640 - 1646 .

El Shikh MEM, El Sayed R, Aly NAR, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis MJ et al. ( 2022 ) . Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis . Frontiers in Medicine vol. 9 , Article 1013660 ,

Flak MB, Colas RA, Muñoz-Atienza E, Curtis MA, Dalli J, Pitzalis C ( 2022 ) . Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis . JCI Insight vol. 7 , ( 20 ) Article e165600 ,

Wang J, Conlon D, Rivellese F, Nerviani A, Lewis MJ, Housley W, Levesque MC, Cao X et al. ( 2022 ) . Synovial Inflammatory Pathways Characterize <scp>Anti‐TNF</scp>–Responsive Rheumatoid Arthritis Patients . Arthritis &amp; Rheumatology vol. 74 , ( 12 ) 1916 - 1927 .

Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CMA, Millar B, Maney NJ, Anderson AE et al. ( 2022 ) . Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming . Annals of the Rheumatic Diseases vol. 81 , ( 9 ) 1214 - 1223 .

Humby F, Durez P, Buch MH, Lewis MJ, Bombardieri M, John C, Rizvi H, Warren L et al. ( 2022 ) . Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients: the R4-RA RCT . Efficacy and Mechanism Evaluation vol. 9 , ( 7 ) 1 - 58 .

Carlotti E, Murray-Brown W, Blighe K, Caliste M, Astorri E, Sutcliffe N, Tappuni AR, Pitzalis C et al. ( 2022 ) . High-throughput sequencing of IgH gene in minor salivary glands from Sjögren's syndrome patients reveals dynamic B cell recirculation between ectopic lymphoid structures . Clinical and Experimental Rheumatology

Sciacca E, Surace AEA, Alaimo S, Pulvirenti A, Rivellese F, Goldmann K, Ferro A, Latora V et al. ( 2022 ) . Network analysis of synovial RNA sequencing identifies gene-gene interactions predictive of response in rheumatoid arthritis . Arthritis Research &amp; Therapy vol. 24 , ( 1 ) Article 166 ,

Papandrikopoulou A, Burmester GR, Fang F, Kivitz A, Njenga M, Pano A, Pitzalis C, Samant M et al. ( 2022 ) . AB0379 DOSE-DEPENDENT SUPPRESSION OF T CELL-DEPENDENT ANTIBODY RESPONSE IN HEALTHY VOLUNTEERS BY KPL-404, AN ANTI-CD40 MONOCLONAL ANTIBODY, SUPPORTS CHRONIC DOSING STUDY IN PATIENTS WITH RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 81 , 1316 - 1317 .

Banda NK, Deane KD, Bemis EA, Strickland C, Seifert J, Jordan K, Goldman K, Morgan BP et al. ( 2022 ) . Analysis of Complement Gene Expression, Clinical Associations, and Biodistribution of Complement Proteins in the Synovium of Early Rheumatoid Arthritis Patients Reveals Unique Pathophysiologic Features . The Journal of Immunology vol. 208 , ( 11 ) 2482 - 2496 .

Dejaco C, Machado PM, Carubbi F, Bosch P, Terslev L, Tamborrini G, Sconfienza LM, Scirè CA et al. ( 2022 ) . EULAR points to consider for the use of imaging to guide interventional procedures in patients with rheumatic and musculoskeletal diseases (RMDs) . Annals of the Rheumatic Diseases vol. 81 , ( 6 ) 760 - 767 .

Surace A, Sciacca E, Goldmann K, Rivellese F, Cubuk C, Giorli G, Fossati-Jimack L, Ahmed M et al. ( 2022 ) . OP0077 SYNOVIAL RNA-SEQ ANALYSIS OF THE R4RA TRIAL IDENTIFIES SIGNATURES OF TREATMENT RESISTANCE AND REFRACTORY STATE IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases vol. 81 , 52 - 53 .

Rivellese F, Cubuk C, Surace A, Goldmann K, Sciacca E, Giorli G, Nerviani A, Fossati-Jimack L et al. ( 2022 ) . OP0085 CELL LINEAGE-SPECIFIC TRANSCRIPT DECONVOLUTION OF SYNOVIAL BIOPSIES FROM THE R4RA TRIAL IDENTIFIES CELL POPULATIONS ASSOCIATED WITH RESPONSE TO RITUXIMAB AND TOCILIZUMAB . Annals of the Rheumatic Diseases vol. 81 , 56 - 57 .

Goldmann K, Vigorito E, Wallace C, Barnes M, Barton A, Pitzalis C, Lewis M ( 2022 ) . OP0109 EXPRESSION QUANTITATIVE TRAIT LOCI IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 81 , 71 - 72 .

Prediletto E, Cubuk C, Pontarini E, Rivellese F, Nerviani A, Lucchesi D, Caliste M, Corsiero E et al. ( 2022 ) . POS0138 RHEUMATOID SYNOVIAL FIBROBLASTS DISPLAY IMPRINTED MEMORY OF THEIR SYNOVIAL ENDOTYPE WHICH CAN BE PLASTICALLY MODULATED BY B-CELLS CROSSTALK . Annals of the Rheumatic Diseases vol. 81 , 296 - 296 .

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Murray-Brown W, Rivellese F, Lucchesi D, Goldmann K et al. ( 2022 ) . POS0145 CLINICAL RESPONSE TO RITUXIMAB IS ASSOCIATED WITH PREVENTION OF B-CELL DRIVEN SALIVARY GLAND INFLAMMATION AND EPITHELIAL RESTORATION AS REVEALED BY MOLECULAR PATHOLOGY: RESULTS FROM THE TRACTISS TRIAL IN PRIMARY SJOGREN'S SYNDROME . Annals of the Rheumatic Diseases . vol. 81 , 299 - 300 .

Corsiero E, Caliste M, Jagemann L, Prediletto E, Pitzalis C, Bombardieri M ( 2022 ) . POS0399 CHARACTERIZATION OF HSP60, A STROMAL-DERIVED AUTOANTIGEN, RECOGNIZED BY RA SYNOVIAL RECOMBINANT MONOCLONAL ANTIBODIES . Annals of the Rheumatic Diseases vol. 81 , 456 - 456 .

Elshikh M, El Sayed R, Aly N, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis M et al. ( 2022 ) . POS0431 PDGF-BB, TNF-α, AND LT-β REGULATE FOLLICULAR DENDRITIC CELL DEVELOPMENT IN THE RHEUMATOID SYNOVIUM . Annals of the Rheumatic Diseases vol. 81 , 470 - 470 .

Caliste M, Prediletto E, Corsiero E, Jagemann L, Pitzalis C, Bombardieri M ( 2022 ) . POS0439 STROMAL B-CELL CROSSTALK PROMOTES THE ESTABLISHMENT OF SYNOVIAL B CELL NICHES THROUGH THE SELECTION, ACTIVATION OF NATURALLY OCCURRING EBV+ B CELLS . Annals of the Rheumatic Diseases vol. 81 , 474 - 475 .

Nerviani A, Boutet MA, Ghirardi GM, Goldmann K, Sciacca E, Rivellese F, Pontarini E, Caliste M et al. ( 2022 ) . POS0441 IN-DEPTH ANALYSIS OF Axl AND MerTK EXPRESSION PATTERNS AND REGULATION BY BIOLOGIC TREATMENTS IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 81 , 475 - 476 .

Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A et al. ( 2022 ) . Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial . Nature Medicine vol. 28 , ( 6 ) 1256 - 1268 .

Isaacs JD, Brockbank S, Pedersen AW, Hilkens C, Anderson A, Stocks P, Lendrem D, Tarn J et al. ( 2022 ) . RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients . Scientific Data vol. 9 , ( 1 ) Article 196 ,

Banda NK, Deane KD, Seifert J, Strickland C, Bemis E, Jordan K, Goldmann K, Morgan BP et al. ( 2022 ) . A Snap Shot of Complement Gene Expression and Presence of Complement Proteins in Synovial Biopsies from Early Rheumatoid Arthritis Patients . The Journal of Immunology vol. 208 , ( Supplement_1 ) 108.03 - 108.03 .

Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S et al. ( 2022 ) . Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression . Cell Reports vol. 39 , ( 5 ) Article 110766 , 110766 - 110766 .

Pistorius K, Ly L, Souza PR, Gomez EA, Koenis DS, Rodriguez AR, Foster J, Sosabowski J et al. ( 2022 ) . MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis . eBioMedicine vol. 79 , Article 103974 , 103974 - 103974 .

Thorup A-S, Wilson J, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G et al. ( 2022 ) . BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS, IN PART BY MODULATING YAP SIGNALLING . Osteoarthritis and Cartilage vol. 30 , S159 - S159 .

Zhang F, Jonsson AH, Nathan A, Wei K, Millard N, Xiao Q, Gutierrez-Arcelus M, Apruzzese W et al. ( 2022 ) . Cellular deconstruction of inflamed synovium defines diverse inflammatory phenotypes in rheumatoid arthritis .

Carlucci PM, Li J, Fava A, Deonaraine KK, Wofsy D, James JA, Putterman C, Diamond B et al. ( 2022 ) . High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership . Rheumatology vol. 61 , ( 11 ) 4335 - 4343 .

Micheroli R, Elhai M, Edalat S, Frank-Bertoncelj M, Bürki K, Ciurea A, MacDonald L, Kurowska-Stolarska M et al. ( 2022 ) . Role of synovial fibroblast subsets across synovial pathotypes in rheumatoid arthritis: a deconvolution analysis . RMD Open vol. 8 , ( 1 ) e001949 - e001949 .

Iakovliev A, Ling SF, Colombo M, Plant D, Lewis M, Pitzalis C, Barton A, McKeigue P et al. ( 2022 ) . Association of Genetic Loci for Human Plasma Proteins with Response to Treatment in People with Rheumatoid Arthritis . GENETIC EPIDEMIOLOGY . vol. 46 , 501 - 502 .

Banda N, Deane K, Seifert J, Strickland C, Bemis E, Jordan K, Goldman K, Morgan BP et al. ( 2022 ) . Complement gene expression and biodistribution of complement proteins in the synovium from early rheumatoid arthritis patients . MOLECULAR IMMUNOLOGY . vol. 141 , 156 - 156 .

Pupim L, Burmester G, Fang F, Kivitz A, Njenga M, Pitzalis C, Chatfield J, Papandrikopoulou A et al. ( 2022 ) . Dose-dependent Suppression of T Cell-Dependent Antibody Response in Healthy Volunteers by KPL-404, an Anti-CD40 Monoclonal Antibody, Supports Phase 2 Study in Patients with Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 609 - 610 .

Pistorius K, Souza PR, Gomez EA, Koenis DS, Rodriguez AR, Foster J, Sosabowski J, Hopkinson M et al. ( 2022 ) . MCTR3 reprogramming arthritic monocytes to exert pro-resolving and tissue-protective functions in inflammatory arthritis . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 103 , A5 - A6 .

Rivellese F, Pontarini E, Cubuk C, Nerviani A, Fossati-Jimack L, Surace A, Sciacca E, Goldmann K et al. ( 2022 ) . Module Signatures of Synovial Single-cell States Identify Disease Phenotypes in Early Treatment-naive Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 3345 - 3347 .

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Emery P, Ng WF, Sutcliffe N, Rivellese F et al. ( 2022 ) . RITUXIMAB PREVENTS WORSENING OF B-CELL DRIVEN SALIVARY GLAND INFLAMMATION AND EXCRETORY FUNCTION IN PRIMARY SJOGREN'S SYNDROME: RESULTS FROM THE TRACTISS TRIAL . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 40 , 91 - 92 .

Prediletto E, Cubuk C, Pontarini E, Rivellese F, Nerviani A, Lucchesi D, Caliste M, Corsiero E et al. ( 2022 ) . Rheumatoid Synovial Fibroblasts Display Imprinted Memory of Their Synovial Endotype Which Can Be Plastically Modulated by B-cells Crosstalk . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 1242 - 1244 .

Dunlap G, Wagner A, Meednu N, Jonsson A, Zhang F, Wei K, Utz P, Robinson W et al. ( 2022 ) . Single-Cell Characterization of the TCR Repertoire Across Tissue and Blood in Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 3442 - 3444 .

Wagner A, Meednu N, Dunlap G, Zhang F, Jonsson A, Wei K, Ben-Artzi A, Forbess L et al. ( 2022 ) . Single-cell Profiling of B Cell Repertoire and Gene Expression in the RA Synovium Reveals Tissue Specific Clonal Expansion . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 3239 - 3240 .

Pitzalis C, Hands R, Venuturupalli S, Ben-Artzi A, Ruderman E, Perlman H, Mandelin A, Leach M et al. ( 2022 ) . Tc99m Tilmanocept Imaging Can Differentiate the Fibroid Pathotype of Rheumatoid Arthritis from Non-Fibroid Pathotypes in Patients . ARTHRITIS & RHEUMATOLOGY . vol. 74 , 3906 - 3907 .

Coleby R, Lucchesi D, Pontarini E, Pitzalis C, Bombardieri M ( 2021 ) . Stepwise changes in the murine salivary gland immune response during virally-induced ectopic lymphoid structure formation . Clinical and Experimental Rheumatology vol. 39 , ( 6 ) 39 - 48 .

Sciacca E, Surace AEA, Alaimo S, Pulvirenti A, Rivellese F, Goldmann K, Ferro A, Latora V et al. ( 2021 ) . Harnessing gene-gene interactions via an RNA-Sequencing network analysis framework improves precision medicine prediction in rheumatoid arthritis .

Rivellese F, Pitzalis C ( 2021 ) . Cellular and molecular diversity in Rheumatoid Arthritis . Seminars in Immunology vol. 58 , Article 101519 , 101519 - 101519 .

Rivellese F, Pitzalis C ( 2021 ) . Introduction to the special issue: Cellular and molecular diversity in rheumatic autoimmune diseases . Seminars in Immunology vol. 58 , Article 101667 , 101667 - 101667 .

Iqbal AJ, Krautter F, Blacksell IA, Wright RD, Austin‐Williams SN, Voisin M, Hussain MT, Law HL et al. ( 2021 ) . Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent manner . The FASEB Journal vol. 36 , ( 1 )

Barnes M, Brockbank S, Bruce IN, Ciurtin C, Cop AP, Ehrenstein MR, Emery P, Fisher BA et al. ( 2021 ) . Characterization of disease course and remission in early seropositive rheumatoid arthritis: results from the TACERA longitudinal cohort study . Therapeutic Advances in Musculoskeletal Disease vol. 13 , Article 1759720X211043977 ,

Romão VC, Fonseca JE, Pitzalis C ( 2021 ) . Elderly-onset rheumatoid arthritis is a unique disease subset associated with poor overall outcomes: Response to the letter by Haroon and Ayamer . Seminars in Arthritis and Rheumatism vol. 51 , ( 5 ) e11 - e12 .

Pontarini E, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Fossati-Jimack L, Coleby R, Chowdhury F et al. ( 2021 ) . NKp30 Receptor Upregulation in Salivary Glands of Sjögren’s Syndrome Characterizes Ectopic Lymphoid Structures and Is Restricted by Rituximab Treatment . Frontiers in Immunology vol. 12 , Article 706737 ,

Deonaraine KK, Carlucci PM, Fava A, Li J, Wofsy D, James JA, Putterman C, Diamond B et al. ( 2021 ) . Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network . Lupus Science &amp; Medicine vol. 8 , ( 1 ) e000522 - e000522 .

Serrano-Blesa E, Porter A, Lendrem DW, Pitzalis C, Barton A, Treumann A, Isaacs JD ( 2021 ) . Robust optimization of SWATH-MS workflow for human blood serum proteome analysis using a quality by design approach . Clinical Proteomics vol. 18 , ( 1 ) Article 20 ,

Silva-Gomes R, Mapelli SN, Boutet M-A, Mattiola I, Sironi M, Grizzi F, Colombo F, Supino D et al. ( 2021 ) . Differential expression and regulation of MS4A family members in myeloid cells in physiological and pathological conditions . Journal of Leukocyte Biology vol. 111 , ( 4 ) 817 - 836 .

Boutet M-A, Nerviani A, Lliso-Ribera G, Leone R, Sironi M, Hands R, Rivellese F, Del Prete A et al. ( 2021 ) . Circulating and Synovial Pentraxin-3 (PTX3) Expression Levels Correlate With Rheumatoid Arthritis Severity and Tissue Infiltration Independently of Conventional Treatments Response . Frontiers in Immunology vol. 12 , Article 686795 ,

Colombo F, Corsiero E, Lewis MJ, Pitzalis C ( 2021 ) . Generation of restriction endonucleases barcode map to trace SARS-CoV-2 origin and evolution . Scientific Reports vol. 11 , ( 1 ) Article 11773 ,

Eldridge S, Barawi A, Wang H, Roelofs A, Kaneva M, Guan Z, Lydon H, Thomas B et al. ( 2021 ) . AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO . Annals of the Rheumatic Diseases vol. 80 , 1052 - 1052 .

Rivellese F, Pontarini E, Fossati-Jimack L, Moura RA, Romão VC, Fonseca JE, Nerviani A, Cubuk C et al. ( 2021 ) . OP0011 INTEGRATION OF FLOW AND DIGITAL CYTOMETRY IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS IDENTIFIES DISTINCT IMMUNOPHENOTYPES IN PERIPHERAL BLOOD AND DISEASE TISSUE . Annals of the Rheumatic Diseases vol. 80 , 7 - 7 .

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Goldmann K, Fossati-Jimack L et al. ( 2021 ) . OP0136 RITUXIMAB PREVENTS THE PROGRESSION OF B-CELL DRIVEN INFLAMMATORY INFILTRATE IN THE MINOR SALIVARY GLANDS OF PRIMARY SJOGREN'S SYNDROME BY DOWNREGULATING IMMUNOLOGICAL PATHWAYS KEY IN ECTOPIC GERMINAL CENTRE ORGANIZATION: RESULTS FROM THE TRACTISS TRIAL . Annals of the Rheumatic Diseases vol. 80 , 79 - 80 .

Thorup AS, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J et al. ( 2021 ) . OP0200 BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS . Annals of the Rheumatic Diseases vol. 80 , 120 - 121 .

Pagani S, Colombo F, Pitzalis C ( 2021 ) . POS0206 DESIGN AND CHARACTERISATION OF A THERAPEUTIC BISPECIFIC TANDEM scFv-Fc FUSION PROTEIN WITH ANTI-TNF AND SYNOVIUM-TARGETING SPECIFICITY FOR THE TREATMENT OF RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 80 , 319 - 320 .

Thomas BL, Eldridge SE, Nosrati B, Alvarez M, Thorup A, Nalesso G, Caxaria S, Barawi A et al. ( 2021 ) . WNT3A‐loaded exosomes enable cartilage repair . Journal of Extracellular Vesicles vol. 10 , ( 7 ) Article e12088 ,

Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S et al. ( 2021 ) . Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression .

Nerviani A, Boutet M-A, Tan WSG, Goldmann K, Purkayastha N, Lajtos TA, Hands R, Lewis M et al. ( 2021 ) . IL-23 skin and joint profiling in psoriatic arthritis: novel perspectives in understanding clinical responses to IL-23 inhibitors . Annals of the Rheumatic Diseases vol. 80 , ( 5 ) 591 - 597 .

Fanelli G, Romano M, Nova-Lamperti E, Werner Sunderland M, Nerviani A, Scottà C, Bombardieri M, Quezada SA et al. ( 2021 ) . PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype . PLOS Biology vol. 19 , ( 4 ) e3001199 - e3001199 .

Serrano-Blesa E, Porter A, Lendrem DW, Pitzalis C, Barton A, Treumann A, Isaacs JD ( 2021 ) . Robust Optimization of SWATH-MS workflow for human blood serum proteome analysis using a Quality by Design approach .

Rivellese F, Manou-Stathopoulou S, Mauro D, Goldmann K, Pyne D, Rajakariar R, Gordon P, Schafer P et al. ( 2021 ) . Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus . Lupus Science &amp; Medicine vol. 8 , ( 1 ) e000445 - e000445 .

Nalesso G, Thorup A-S, Eldridge SE, De Palma A, Kaur A, Peddireddi K, Blighe K, Rana S et al. ( 2021 ) . Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis . Scientific Reports vol. 11 , ( 1 ) Article 5682 ,

Boutet M-A, Courties G, Nerviani A, Le Goff B, Apparailly F, Pitzalis C, Blanchard F ( 2021 ) . Novel insights into macrophage diversity in rheumatoid arthritis synovium . Autoimmunity Reviews vol. 20 , ( 3 ) Article 102758 , 102758 - 102758 .

Ferrari M, Onuoha SC, Fossati-Jimack L, Nerviani A, Alves PL, Pagani S, Deantonio C, Colombo F et al. ( 2021 ) . Novel Bispecific Antibody for Synovial-Specific Target Delivery of Anti-TNF Therapy in Rheumatoid Arthritis . Frontiers in Immunology vol. 12 , Article 640070 ,

Bellan M, Quaglia M, Nerviani A, Mauro D, Lewis M, Goegan F, Gibbin A, Pagani S et al. ( 2021 ) . Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis . Clinical and Experimental Rheumatology vol. 39 , ( 1 ) 132 - 138 .

Giacomelli R, Afeltra A, Bartoloni E, Berardicurti O, Bombardieri M, Bortoluzzi A, Carubbi F, Caso F et al. ( 2021 ) . The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus . Autoimmunity Reviews vol. 20 , ( 2 ) Article 102738 , 102738 - 102738 .

Pitzalis C, Humby F, Rivellese F, Nerviani A, Lewis M ( 2021 ) . Rituximab versus Tocilizumab in anti-TNF inadequate responder patients with Rheumatoid Arthritis (R4RA): a stratified, biopsy-driven, multi-centre, randomised, open label, controlled clinical trial – 16 week outcomes\nArticle (Randomised Controlled Trial) . The Lancet

Silva-Gomes R, Mapelli SN, Boutet M-A, Mattiola I, Sironi M, Grizzi F, Colombo F, Supino D et al. ( 2021 ) . Expression and regulation of MS4A molecules in myeloid cells . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 51 , 166 - 167 .

Boutet MA, Nerviani A, Ribera GL, Leone R, Sironi M, Hands R, Rivellese F, Del Prete A et al. ( 2021 ) . Pentraxin-3 (PTX3) circulating and synovial expression levels correlate with rheumatoid arthritis severity and tissue infiltration independently of the response to conventional treatments . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 51 , 66 - 66 .

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou SA, Rivellese F, Lucchesi D, Goldmann K, Fossati-Jimack L et al. ( 2021 ) . Rituximab Prevents the Progression of B-cell Driven Inflammatory Infiltrate in the Minor Salivary Glands of Primary Sjogren's Syndrome by Downregulating Immunological Pathways Key in Ectopic Germinal Centre Organization: Results from the TRACTISS Trial . ARTHRITIS & RHEUMATOLOGY . vol. 73 , 2065 - 2066 .

Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G et al. ( 2021 ) . Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial . The Lancet vol. 397 , ( 10271 ) 305 - 317 .

Meednu N, Wagner A, Dunlap G, Zhang F, Jonsson AH, Wei K, Utz P, Robinson W et al. ( 2021 ) . Single-cell Profiling of B and T Cell Repertoire and Gene Expression in the RA Synovium Reveals Tissue Specific Clonal Expansion . ARTHRITIS & RHEUMATOLOGY . vol. 73 , 951 - 952 .

Pontarini E, Murray-Brown WJ, Croia C, Lucchesi D, Conway J, Rivellese F, Fossati-Jimack L, Astorri E et al. ( 2020 ) . Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren's syndrome with ectopic germinal centres and MALT lymphoma . Annals of the Rheumatic Diseases vol. 79 , ( 12 ) 1588 - 1599 .

Colombo F, Corsiero E, Lewis MJ, Pitzalis C ( 2020 ) . Generation of restriction endonucleases barcode map to trace SARS-CoV-2 origin and evolution .

( 2020 ) . Abstract Supplement ACR Convergence 2020 . Arthritis &amp; Rheumatology . vol. 72 , 1 - 4259 .

Fahmi A, MacBrayne A, Kyrimi E, McLachlan S, Humby F, Marsh W, Pitzalis C ( 2020 ) . Causal Bayesian Networks for Medical Diagnosis: A Case Study in Rheumatoid Arthritis . 2020 IEEE International Conference on Healthcare Informatics (ICHI) . Conference: 2020 IEEE International Conference on Healthcare Informatics (ICHI) from: 30/11/2020 to: 03/12/2020 , 1 - 7 .

Cherlin S, Lewis MJ, Plant D, Nair N, Goldmann K, Tzanis E, Barnes MR, McKeigue P et al. ( 2020 ) . Investigation of genetically regulated gene expression and response to treatment in rheumatoid arthritis highlights an association between IL18RAP expression and treatment response . Annals of the Rheumatic Diseases vol. 79 , ( 11 ) 1446 - 1452 .

Humby F, Lewis M, Townsend MJ, Pitzalis C ( 2020 ) . Response to: ‘Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients’ by Buch et al . Annals of the Rheumatic Diseases vol. 79 , ( 11 ) e141 - e141 .

Gomez EA, Colas RA, Souza PR, Hands R, Lewis MJ, Bessant C, Pitzalis C, Dalli J ( 2020 ) . Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis . Nature Communications vol. 11 , ( 1 ) Article 5420 ,

Romão VC, Polido‐Pereira J, Barros R, Luís R, Vidal B, Vieira‐Sousa E, Vitorino E, Humby F et al. ( 2020 ) . Efficacy, Safety, and Sample Quality of Ultrasound‐Guided Synovial Needle Biopsy in Clinical Practice and Research: A Prospective Observational Study . Arthritis Care &amp; Research vol. 72 , ( 10 ) 1497 - 1505 .

Thorup A-S, Strachan D, Caxaria S, Poulet B, Thomas BL, Eldridge SE, Nalesso G, Whiteford JR et al. ( 2020 ) . ROR2 blockade as a therapy for osteoarthritis . Science Translational Medicine vol. 12 , ( 561 ) Article eaax3063 ,

Pitzalis C, Choy EHS, Buch MH ( 2020 ) . Transforming clinical trials in rheumatology: towards patient-centric precision medicine . Nature Reviews Rheumatology vol. 16 , ( 10 ) 590 - 599 .

Eldridge SE, Barawi A, Wang H, Roelofs AJ, Kaneva M, Guan Z, Lydon H, Thomas BL et al. ( 2020 ) . Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis . Science Translational Medicine vol. 12 , ( 559 ) Article eaax9086 ,

Romão VC, Humby F, Kelly S, Di Cicco M, Mahto A, Lazarou I, Hands R, Rocher-Ros V et al. ( 2020 ) . Treatment-resistant synovitis and radiographic progression are increased in elderly-onset rheumatoid arthritis patients: findings from a prospective observational longitudinal early arthritis cohort study . Seminars in Arthritis and Rheumatism vol. 50 , ( 4 ) 735 - 743 .

Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill DG, Derrac Soria A, Jones SA et al. ( 2020 ) . Impaired Interleukin‐27–Mediated Control of <scp>CD</scp>4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjögren's Syndrome . Arthritis &amp; Rheumatology vol. 72 , ( 9 ) 1559 - 1570 .

Rivellese F, Rossi FW, Giorli G, Napolitano F, de Paulis A, Pitzalis C ( 2020 ) . Persistence of Mast Cell-Positive Synovitis in Early Rheumatoid Arthritis Following Treatment With Conventional Synthetic Disease Modifying Anti-Rheumatic Drugs . Frontiers in Pharmacology vol. 11 , Article 1051 ,

Alivernini S, MacDonald L, Elmesmari A, Finlay S, Tolusso B, Gigante MR, Petricca L, Di Mario C et al. ( 2020 ) . Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis . Nature Medicine vol. 26 , ( 8 ) 1295 - 1306 .

Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F et al. ( 2020 ) . Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal . Science Advances vol. 6 , ( 26 ) Article eaba4353 ,

Rivellese F, Pontarini E, Pitzalis C ( 2020 ) . Tertiary Lymphoid Organs in Rheumatoid Arthritis . 119 - 141 .

Rivellese F, Humby F, Lliso Ribera G, Nerviani A, Sciacca E, Giorli G, Hands R, Fossati-Jimack L et al. ( 2020 ) . OP0217 INVOLVEMENT OF LARGE JOINTS AT DISEASE PRESENTATION IS ASSOCIATED WITH DIVERSE HISTOPATHOLOGICAL FEATURES AND CLINICAL OUTCOMES IN EARLY RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 79 , 134 - 135 .

Nerviani A, Boutet MA, Ghirardi GM, Lliso Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2020 ) . THU0082 MERTK SYNOVIAL EXPRESSION CORRELATES WITH TREATMENT RESPONSE IN RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 79 , 253 - 253 .

Nerviani A, Di Cicco M, Mahto A, Lliso-Ribera G, Rivellese F, Thorborn G, Hands R, Bellan M et al. ( 2020 ) . A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients . Frontiers in Immunology vol. 11 , Article 845 ,

Huizinga TWJ, Holers VM, Anolik J, Brenner MB, Buckley CD, Bykerk V, Connolly SE, Deane KD et al. ( 2020 ) . Disruptive innovation in rheumatology: new networks of global public–private partnerships are needed to take advantage of scientific progress . Annals of the Rheumatic Diseases vol. 79 , ( 5 ) 553 - 555 .

Corsiero E, Carlotti E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M ( 2020 ) . H and L Chain Affinity Maturation and/or Fab <i>N</i>-Glycosylation Influence Immunoreactivity toward Neutrophil Extracellular Trap Antigens in Rheumatoid Arthritis Synovial B Cell Clones . The Journal of Immunology vol. 204 , ( 9 ) 2374 - 2379 .

Wei K, Korsunsky I, Marshall JL, Gao A, Watts GFM, Major T, Croft AP, Watts J et al. ( 2020 ) . Notch signalling drives synovial fibroblast identity and arthritis pathology . Nature vol. 582 , ( 7811 ) 259 - 264 .

Humby FC, Lewis M, Durez P, Buch MH, Bombardieri M, Rizvi H, Rivellese F, Fossati L et al. ( 2020 ) . O07 Randomised, open labelled clinical trial to investigate synovial mechanisms determining response: resistance to rituximab versus tocilizumab in RA patients failing TNF inhibitor therapy . Rheumatology . vol. 59 ,

Nerviani A, Lliso-Ribera G, Boutet M-A, Goldmann K, Rivellese F, Kelly S, Bombardieri M, Lewis M et al. ( 2020 ) . O20 Histological and molecular features of the diseased synovium in early untreated PsA in comparison with RA . Rheumatology . vol. 59 ,

Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill D, Soria AD, Jones S et al. ( 2020 ) . O31 IL-27 regulates the magnitude of ectopic germinal centres in experimental sialadenitis but fails to modulate IL-17 and IFNg production in CD4 T cells from patients with Sjögren's syndrome . Rheumatology . vol. 59 ,

MacBrayne ACB, Pott J, Petrovic V, Pitzalis C, Humby F ( 2020 ) . P214 Preliminary results: driving improvements in disease outcomes for rheumatoid arthritis patients using remote disease activity monitoring via smartphone app . Rheumatology vol. 59 , ( Supplement_2 ) Article keaa111.209 ,

Sciacca E, Alaimo S, Pulvirenti A, Latora V, Humby F, Ferro A, Lewis MJ, Pitzalis C ( 2020 ) . P22 Micro-RNA enriched pathway impact analysis applied to synovial RNA-seq in early rheumatoid arthritis identifies response prediction pathways . Rheumatology . vol. 59 ,

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . P233 B cell-rich synovitis in early and established rheumatoid arthritis . Rheumatology vol. 59 , ( Supplement_2 )

Pernicova I, Kelly S, Ajodha S, Sahdev A, Bestwick JP, Gabrovska P, Akanle O, Ajjan R et al. ( 2020 ) . Metformin to reduce metabolic complications and inflammation in patients on systemic glucocorticoid therapy: a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial . The Lancet Diabetes &amp; Endocrinology vol. 8 , ( 4 ) 278 - 291 .

Rivellese F, Humby F, Bugatti S, Fossati‐Jimack L, Rizvi H, Lucchesi D, Lliso‐Ribera G, Nerviani A et al. ( 2020 ) . B Cell Synovitis and Clinical Phenotypes in Rheumatoid Arthritis: Relationship to Disease Stages and Drug Exposure . Arthritis &amp; Rheumatology vol. 72 , ( 5 ) 714 - 725 .

John CR, Watson D, Russ D, Goldmann K, Ehrenstein M, Pitzalis C, Lewis M, Barnes M ( 2020 ) . M3C: Monte Carlo reference-based consensus clustering . Scientific Reports vol. 10 , ( 1 ) Article 1816 ,

Pagani S, Bellan M, Mauro D, Castello LM, Avanzi GC, Lewis MJ, Sainaghi PP, Pitzalis C et al. ( 2020 ) . New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis . Disease Markers vol. 2020 , 1 - 9 .

Muñoz-Atienza E, Flak MB, Sirr J, Paramonov NA, Aduse-Opoku J, Pitzalis C, Curtis MA ( 2020 ) . The <i>P. gingivalis</i> Autocitrullinome Is Not a Target for ACPA in Early Rheumatoid Arthritis . Journal of Dental Research vol. 99 , ( 4 ) 456 - 462 .

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A et al. ( 2020 ) . B CELL-RICH SYNOVITIS IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 59 ,

Nerviani A, Lliso-Ribera G, Boutet M-A, Goldmann K, Rivellese F, Kelly S, Bombardieri M, Lewis M et al. ( 2020 ) . HISTOLOGICAL AND MOLECULAR FEATURES OF THE DISEASED SYNOVIUM IN EARLY UNTREATED PSA IN COMPARISON WITH RA . RHEUMATOLOGY . vol. 59 ,

Rivellese F, Humby F, Giorli G, Nerviani A, Hands R, Fossati-Jimack L, Thorborn G, Lewis M et al. ( 2020 ) . Histo-pathological Cellular Markers of Treatment Response to Rituximab and Tocilizumab in Matched Pre- and Post-treatment Synovial Biopsies from the R4RA Randomised Clinical Trial in Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,

Lucchesi D, Coleby R, Pontarini E, Prediletto E, Rivellese F, Hill D, Soria AD, Jones S et al. ( 2020 ) . IL-27 REGULATES THE MAGNITUDE OF ECTOPIC GERMINAL CENTRES IN EXPERIMENTAL SIALADENITIS BUT FAILS TO MODULATE IL-17 AND IFNG PRODUCTION IN CD4 T CELLS FROM PATIENTS WITH SJOGREN'S SYNDROME . RHEUMATOLOGY . vol. 59 ,

Nerviani A, Boutet M-A, Ghirardi GM, Lliso-Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2020 ) . MerTK Synovial Expression Correlates with Disease Activity and Treatment Response in Rheumatoid Arthritis Patients . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,

MacBrayne ACB, Pott J, Petrovic V, Pitzalis C, Humby F ( 2020 ) . PRELIMINARY RESULTS: DRIVING IMPROVEMENTS IN DISEASE OUTCOMES FOR RHEUMATOID ARTHRITIS PATIENTS USING REMOTE DISEASE ACTIVITY MONITORING VIA SMARTPHONE APP . RHEUMATOLOGY . vol. 59 ,

Humby FC, Lewis M, Durez P, Buch MH, Bombardieri M, Rizvi H, Rivellese F, Fossati L et al. ( 2020 ) . RANDOMISED, OPEN LABELLED CLINICAL TRIAL TO INVESTIGATE SYNOVIAL MECHANISMS DETERMINING RESPONSE: RESISTANCE TO RITUXIMAB VERSUS TOCILIZUMAB IN RA PATIENTS FAILING TNF INHIBITOR THERAPY . RHEUMATOLOGY . vol. 59 , 3 - + .

Meednu N, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, Bombardieri M, DiCarlo E, Orange D et al. ( 2020 ) . Role of NR4A Nuclear Receptor Family in RA Synovial Ectopic Lymphoid Neogenesis Revealed by Single Cell Profiling . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,

El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R, Fossati-Jimack L, Lewis MJ et al. ( 2019 ) . Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis . Journal of Autoimmunity vol. 105 , Article 102297 , 102297 - 102297 .

Pucino V, Certo M, Bulusu V, Cucchi D, Goldmann K, Pontarini E, Haas R, Smith J et al. ( 2019 ) . Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring . Cell Metabolism vol. 30 , ( 6 ) 1055 - 1074.e8 .

Lliso-Ribera G, Humby F, Lewis M, Nerviani A, Mauro D, Rivellese F, Kelly S, Hands R et al. ( 2019 ) . Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases vol. 78 , ( 12 ) 1642 - 1652 .

Rodríguez-Ubreva J, de la Calle-Fabregat C, Li T, Ciudad L, Ballestar ML, Català-Moll F, Morante-Palacios O, Garcia-Gomez A et al. ( 2019 ) . Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis . Annals of the Rheumatic Diseases vol. 78 , ( 11 ) 1505 - 1516 .

Tarn JR, Howard-Tripp N, Lendrem DW, Mariette X, Saraux A, Devauchelle-Pensec V, Seror R, Skelton AJ et al. ( 2019 ) . Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials . The Lancet Rheumatology vol. 1 , ( 2 ) e85 - e94 .

John CR, Watson D, Barnes MR, Pitzalis C, Lewis MJ ( 2019 ) . Spectrum: fast density-aware spectral clustering for single and multi-omic data . Bioinformatics vol. 36 , ( 4 ) 1159 - 1166 .

Boutet M-A, Nerviani A, Lliso-Ribera G, Lucchesi D, Prediletto E, Ghirardi GM, Goldmann K, Lewis M et al. ( 2019 ) . Interleukin-36 family dysregulation drives joint inflammation and therapy response in psoriatic arthritis . Rheumatology vol. 59 , ( 4 ) 828 - 838 .

Colombo F, Durigutto P, De Maso L, Biffi S, Belmonte B, Tripodo C, Oliva R, Bardini P et al. ( 2019 ) . Targeting CD34+ cells of the inflamed synovial endothelium by guided nanoparticles for the treatment of rheumatoid arthritis . Journal of Autoimmunity vol. 103 , Article 102288 , 102288 - 102288 .

Spiliopoulou A, Colombo M, Plant D, Nair N, Cui J, Coenen MJH, Ikari K, Yamanaka H et al. ( 2019 ) . Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39 . Annals of the Rheumatic Diseases vol. 78 , ( 8 ) 1055 - 1061 .

Lewis MJ, Barnes MR, Blighe K, Goldmann K, Rana S, Hackney JA, Ramamoorthi N, John CR et al. ( 2019 ) . Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes . Cell Reports vol. 28 , ( 9 ) 2455 - 2470.e5 .

Flak MB, Colas RA, Muñoz-Atienza E, Curtis MA, Dalli J, Pitzalis C ( 2019 ) . Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis . JCI Insight vol. 4 , ( 13 ) Article e125191 ,

Mattiola I, Tomay F, De Pizzol M, Silva-Gomes R, Savino B, Gulic T, Doni A, Lonardi S et al. ( 2019 ) . The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis . Nature Immunology vol. 20 , ( 8 ) 1012 - 1022 .

Davies K, Mirza K, Tarn J, Howard-Tripp N, Bowman SJ, Lendrem D, Ng W-F ( 2019 ) . Fatigue in primary Sjögren’s syndrome (pSS) is associated with lower levels of proinflammatory cytokines: a validation study . Rheumatology International vol. 39 , ( 11 ) 1867 - 1873 .

Manou-Stathopoulou S, Rivellese F, Mauro D, Goldmann K, Pyne D, Schafer P, Bombardieri M, Pitzalis C et al. ( 2019 ) . AB0179 THE TRANSCRIPTION FACTORS IKZF1 AND IKZF3 CONTROL B CELL ACTIVATION AND DIFFERENTIATION IN SYSTEMIC LUPUS ERYTHEMATOSUS . Annals of the Rheumatic Diseases . vol. 78 , 1548 - 1548 .

Nerviani A, Ribera GL, Boutet MA, Goldmann K, Kelly S, Bombardieri M, Lewis M, Humby F et al. ( 2019 ) . OP0113 HISTOLOGICAL AND MOLECULAR PORTRAIT OF THE SYNOVIAL TISSUE IN EARLY TREATMENT-NAÏVE PSORIATIC ARTHRITIS IN COMPARISON WITH RHEUMATOID ARTHRITIS . Annals of the Rheumatic Diseases . vol. 78 , 130 - 131 .

Ribera GL, Humby F, Nerviani A, Lewis M, Kelly S, Bombardieri M, Goldmann K, Hands R et al. ( 2019 ) . OP0120 BASELINE CELLULAR AND MOLECULAR CHARACTERISTICS OF SYNOVIAL TISSUE AND RELATION WITH TNFI RESPONSE. RESULTS FROM THE PATHOBIOLOGY OF THE EARLY ARTHRITIS COHORT (PEAC) . Annals of the Rheumatic Diseases . vol. 78 , 134 - 134 .

Lucchesi D, Coleby R, Pontarini E, Prediletto E, Hill D, Soria AD, Rivellese F, Pitzalis C et al. ( 2019 ) . OP0276 DENDRITIC CELL-DERIVED IL-27 REGULATES THE MAGNITUDE OF INDUCIBLE ECTOPIC GERMINAL CENTRES BUT FAILS TO DOWNMODULATE IL-17 PRODUCTION IN CD4 T CELLS FROM PATIENTS WITH SJÖGREN'S SYNDROME . Annals of the Rheumatic Diseases . vol. 78 , 220 - 220 .

Pontarini E, Brown WM, Croia C, Lucchesi D, Rivellese F, Fossati-Jimack L, Ruscitti P, Prediletto E et al. ( 2019 ) . OP0279 A UNIQUE IL-21 SIGNATURE CHARACTERIZES LESIONAL AND CIRCULATING T-FOLLICULAR HELPER CELLS IN SJÖGREN'S SYNDROME PATIENTS WITH ECTOPIC GERMINAL CENTRES AND MALT LYMPHOMA . Annals of the Rheumatic Diseases . vol. 78 , 221 - 221 .

Purkayastha N, Ismail S, Taylor PC, Pitzalis C, Kelly S ( 2019 ) . OP0350 ULTRASOUND POWER DOPPLER SEMI-QUANTITATIVE SCORING, IS IT TIME WE MOVED TO A RED PIXEL DENSITY ALGORITHMIC PROGRAM TO DETERMINE TRUE TREATMENT RESPONSE? . Annals of the Rheumatic Diseases . vol. 78 , 258 - 259 .

Mauro D, Rivellese F, Manou-Stathopoulou S, Goldmann K, Pyne D, Ciccia F, Pitzalis C, Lewis M ( 2019 ) . SAT0025 THE EFFECT OF DIMETHYL FUMARATE ON PLASMABLAST DIFFERENTIATION TRANSCRIPTIONAL PROGRAMMES IN SYSTEMIC LUPUS ERYTHEMATOSUS . Annals of the Rheumatic Diseases . vol. 78 , 1077 - 1077 .

Humby F, Lewis M, Ramamoorthi N, Hackney JA, Barnes MR, Bombardieri M, Setiadi AF, Kelly S et al. ( 2019 ) . Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients . Annals of the Rheumatic Diseases vol. 78 , ( 6 ) 761 - 772 .

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Ribera GL, Nerviani A et al. ( 2019 ) . THU0058 B CELL SYNOVITIS AND CLINICAL PHENOTYPES IN RHEUMATOID ARTHRITIS AT DIFFERENT DISEASE STAGES . Annals of the Rheumatic Diseases . vol. 78 , 296 - 297 .

Nerviani A, Humby F, Ribera GL, Rivellese F, Kelly S, Hands R, Pitzalis C ( 2019 ) . THU0092 DEFINING A LEARNING CURVE FOR CLINICIANS PERFORMING ULTRASOUND-GUIDED DEFINING A LEARNING CURVE FOR CLINICIANS PERFORMING ULTRASOUND-GUIDED NEEDLE SYNOVIAL BIOPSIES: A RETROSPECTIVE ANALYSIS OF THE EXPERIENCE AT THE EXPERIMENTAL MEDICINE AND RHEUMATOLOGY, QUEEN MARY UNIVERSITY OF LONDON . Annals of the Rheumatic Diseases . vol. 78 , 317 - 317 .

Rivellese F, Manou-Stathopoulou S, Mauro D, Pontarini E, Lucchesi D, Congia M, Schafer P, Sutcliffe N et al. ( 2019 ) . THU0234 THE TRANSCRIPTION FACTORS IKAROS (IKZF1) AND AIOLOS (IKZF3) ARE EXPRESSED IN THE SALIVARY GLANDS OF SJÖGREN'S SYNDROME PATIENTS WITH LYMPHOID AGGREGATES AND MODULATE B CELL ACTIVATION IN VITRO . Annals of the Rheumatic Diseases . vol. 78 , 394 - 395 .

John CR, Watson D, Barnes M, Pitzalis C, Lewis MJ ( 2019 ) . Spectrum: Fast density-aware spectral clustering for single and multi-omic data .

Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D et al. ( 2019 ) . Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry . Nature Immunology vol. 20 , ( 7 ) 928 - 942 .

Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V et al. ( 2019 ) . PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes . Annals of the Rheumatic Diseases vol. 78 , ( 5 ) 600 - 609 .

Rivellese F, Rossi FW, Galdiero MR, Pitzalis C, de Paulis A ( 2019 ) . Mast Cells in Early Rheumatoid Arthritis . International Journal of Molecular Sciences vol. 20 , ( 8 ) 2040 - 2040 .

Hackett KL, Davies K, Tarn J, Bragg R, Hargreaves B, Miyamoto S, McMeekin P, Mitchell S et al. ( 2019 ) . Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome . RMD Open vol. 5 , ( 1 ) e000885 - e000885 .

Manou-Stathopoulou S, Rivellese F, Mauro D, Goldmann K, Pyne D, Schafer P, Bombardieri M, Pitzalis C et al. ( 2019 ) . 235 IKZF1 and IKZF3 inhibition impairs B cell differentiation and modulates gene expression in systemic lupus erythematosus . Abstracts . Conference: 13th International Congress on Systemic Lupus Erythematosus (LUPUS 2019), San Francisco, California, USA, April 5–8, 2019, Abstract PresentationsA174.2 - A175 .

Corsiero E, Delvecchio FR, Bombardieri M, Pitzalis C ( 2019 ) . B cells in the formation of tertiary lymphoid organs in autoimmunity, transplantation and tumorigenesis . Current Opinion in Immunology vol. 57 , 46 - 52 .

Fisher BA, Emery P, Pitzalis C, Bombardieri M, Bowman SJ ( 2019 ) . Response to: Can ultrasound of the major salivary glands assess histopathological changes induced by treatment with rituximab in primary Sjögren's syndrome? . Annals of the Rheumatic Diseases vol. 78 , ( 4 ) e28 - e28 .

Twohig JP, Cardus Figueras A, Andrews R, Wiede F, Cossins BC, Derrac Soria A, Lewis MJ, Townsend MJ et al. ( 2019 ) . Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells . Nature Immunology vol. 20 , ( 4 ) 458 - 470 .

Boutet M-A, Nerviani A, Pitzalis C ( 2019 ) . IL-36, IL-37, and IL-38 Cytokines in Skin and Joint Inflammation: A Comprehensive Review of Their Therapeutic Potential . International Journal of Molecular Sciences vol. 20 , ( 6 ) 1257 - 1257 .

Boutet M-A, Nerviani A, Lliso-Ribera G, Goldmann K, Lewis M, Pitzalis C ( 2019 ) . P125 IL-36 axis is an emerging therapeutic target in psoriatic arthritis synovial tissue . Annals of the Rheumatic Diseases . vol. 78 , A56 - A56 .

Hensor EMA, McKeigue P, Ling SF, Colombo M, Barrett JH, Nam JL, Freeston J, Buch MH et al. ( 2019 ) . Validity of a two-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis . Rheumatology vol. 58 , ( 8 ) 1400 - 1409 .

Purkayastha N, Humby F, Rocher-Ros V, Pitzalis C, Kelly S ( 2019 ) . Wrist ultrasound - the model method for grey-scale and power Doppler scoring . Annals of the Rheumatic Diseases vol. 78 , ( 3 ) 441 - 442 .

Dorris ER, Tazzyman SJ, Moylett J, Ramamoorthi N, Hackney J, Townsend M, Muthana M, Lewis MJ et al. ( 2019 ) . The Autoimmune Susceptibility Gene <i>C5orf30</i> Regulates Macrophage-Mediated Resolution of Inflammation . The Journal of Immunology vol. 202 , ( 4 ) 1069 - 1078 .

Humby F, Buch MH, Durez P, Lewis M, Bombardieri M, Rizvi H, Kelly S, Fosatti L et al. ( 2019 ) . A Randomised, Open Labelled Clinical Trial to Investigate Synovial Mechanisms Determining Response - Resistance to Rituximab versus Tocilizumab in Rheumatoid Arthritis Patients Failing TNF Inhibitor Therapy . ARTHRITIS & RHEUMATOLOGY . vol. 71 ,

Corsiero E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M ( 2019 ) . Characterization of calreticulin, a stromal-derived autoantigens, recognized by RA synovial recombinant monoclonal antibodies . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 773 - 774 .

Pucino V, Certo M, Bulusu V, Goldmann K, Cucchi D, Haas R, Smith J, Blighe K et al. ( 2019 ) . Lactate influx into human CD4+T-cells, via SLC5A12, causes STAT3-and fatty acid synthesis-mediated IL17 expression and tissue retention . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 1276 - 1277 .

Rivellese F, Lliso-Ribera G, Nerviani A, Humby F, Pitzalis C ( 2019 ) . Persistence of B Cell-rich Synovitis Following Conventional Synthetic Disease Modifying Anti-Rheumatic Drug Treatment in Early Rheumatoid Arthritis Is Associated with Radiographic Progression Independently of Clinical Response . ARTHRITIS & RHEUMATOLOGY . vol. 71 ,

Prediletto E, Pontarini E, Lucchesi D, Corsiero E, Pratesi F, Migliorini P, Pitzalis C, Bombardieri M ( 2019 ) . Synovial fluid fibroblast-like synoviocytes enhance long-term survival of EBV infected memory B cells in rheumatoid arthritis . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 791 - 791 .

Mauro D, Macaluso F, Nerviani A, Boutet M-A, Rizzo A, Alessandro R, Guggino G, Pitzalis C et al. ( 2019 ) . The Deubiquitinase TRABID Is a Potential Therapeutic Target in Spondyloarthritis . ARTHRITIS & RHEUMATOLOGY . vol. 71 ,

Mattiola I, Tomay F, De Pizzol M, Silva-Gomes R, Savino B, Gulic T, Doni A, Lonardi S et al. ( 2019 ) . The macrophage tetraspan MS4A4A enhances Dectin-1-dependent NK cell-mediated resistance to metastasis . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 1517 - 1518 .

Rivellese F, Mauro D, Nerviani A, Pagani S, Fossati-Jimack L, Messemaker T, Kurreeman FAS, Toes REM et al. ( 2018 ) . Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production . Annals of the Rheumatic Diseases vol. 77 , ( 12 ) 1773 - 1781 .

Just SA, Humby F, Lindegaard H, Meric de Bellefon L, Durez P, Vieira-Sousa E, Teixeira R, Stoenoiu M et al. ( 2018 ) . Patient-reported outcomes and safety in patients undergoing synovial biopsy: comparison of ultrasound-guided needle biopsy, ultrasound-guided portal and forceps and arthroscopic-guided synovial biopsy techniques in five centres across Europe . RMD Open vol. 4 , ( 2 ) e000799 - e000799 .

( 2018 ) . Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data . RMD Open vol. 4 , ( 2 ) e000721 - e000721 .

Cherlin S, Plant D, Taylor JC, Colombo M, Spiliopoulou A, Tzanis E, Morgan AW, Barnes MR et al. ( 2018 ) . Prediction of treatment response in rheumatoid arthritis patients using genome‐wide SNP data . Genetic Epidemiology vol. 42 , ( 8 ) 754 - 771 .

Cecchinato V, D'Agostino G, Raeli L, Nerviani A, Schiraldi M, Danelon G, Manzo A, Thelen M et al. ( 2018 ) . Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis . Frontiers in Immunology vol. 9 , Article 2118 ,

Corsiero E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M ( 2018 ) . Characterization of a Synovial B Cell–Derived Recombinant Monoclonal Antibody Targeting Stromal Calreticulin in the Rheumatoid Joints . The Journal of Immunology vol. 201 , ( 5 ) 1373 - 1381 .

Massey J, Plant D, Hyrich K, Morgan AW, Wilson AG, Spiliopoulou A, Colombo M, McKeigue P et al. ( 2018 ) . Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis . The Pharmacogenomics Journal vol. 18 , ( 5 ) 657 - 664 .

Corsiero E, Jagemann L, Bombardieri M, Pitzalis C ( 2018 ) . Generation of Recombinant Monoclonal Antibodies from Single B Cells Isolated from Synovial Tissue of Rheumatoid Arthritis Patients . 159 - 187 .

John CR, Watson D, Russ D, Goldmann K, Ehrenstein M, Pitzalis C, Lewis M, Barnes M ( 2018 ) . M3C: Monte Carlo reference-based consensus clustering .

Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F et al. ( 2018 ) . Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue . Arthritis Research &amp; Therapy vol. 20 , ( 1 ) Article 139 ,

Nerviani A, Pitzalis C ( 2018 ) . Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer . Journal of Leukocyte Biology vol. 104 , ( 2 ) 333 - 341 .

Mauro D, Tsang V, Lucey-Clayton I, Rivellese F, Pagani S, Alam F, Pontarini E, Nerviani A et al. ( 2018 ) . FRI0271 Dimethyl fumarate inhibits ube2l3 mediated tlr7 signalling and autoreactive b cell development in sle . Annals of the Rheumatic Diseases . vol. 77 , 674 - 674 .

Lliso-Ribera G, Humby F, Nerviani A, Boutet MA, Kelly S, Bombardieri M, Lewis M, Hands R et al. ( 2018 ) . OP0040 Synovial cell infiltration in acpa-ve patients displays similar signatures to other seronegative inflammatory arthritis. results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases . vol. 77 , 71 - 72 .

Just SA, Humby F, Lindegaard H, Meric de Bellefon L, Durez P, Vieira-Sousa E, Teixeira R, Stoenoiu M et al. ( 2018 ) . OP0278-HPR Patient reported outcomes and safety in patients undergoing synovial biopsy: comparison of arthroscopic, ultrasound-guided portal-forceps and ultrasound-guided needle biopsy techniques, in five centres across europe . Annals of the Rheumatic Diseases . vol. 77 , 187 - 187 .

Boutet M-A, Nerviani A, Lliso-Ribera G, Goldmann K, Lewis M, Pitzalis C ( 2018 ) . SAT0024 Il-36 axis is an emerging therapeutic target in psoriatic arthritis synovial tissue . Annals of the Rheumatic Diseases . vol. 77 , 885 - 885 .

Ruiz-Romero C, Picchi F, González-Rodríguez L, Fernández-Puente P, Hands R, Calamia V, Camacho-Encina M, Bessant C et al. ( 2018 ) . SAT0074 Identification of a protein panel useful for the prediction of response to methotrexate in rheumatoid arthritis patients . Annals of the Rheumatic Diseases . vol. 77 , 899 - 900 .

Rivellese F, Nerviani A, Mauro D, Pagani S, Humby F, Pitzalis C ( 2018 ) . SAT0076 Synovial mast cells and responses to synthetic and biologic dmards in early and established rheumatoid arthritis . Annals of the Rheumatic Diseases . vol. 77 , 900 - 901 .

Ruiz-Romero C, Picchi F, Fernández-Puente P, González-Rodríguez L, Hands R, Calamia V, Camacho-Encina M, Bessant C et al. ( 2018 ) . THU0052 A circulating protein signature correlates with synovial pathotypes in rheumatoid arthritis patients . Annals of the Rheumatic Diseases . vol. 77 , 251 - 251 .

Nerviani A, Mauro D, Pagani S, Lliso-Ribera G, Rivellese F, Lewis M, Bombardieri M, Humby F et al. ( 2018 ) . THU0061 Restricted axl synovial expression and increased cleavage of axl ectodomain correlate with highly inflamed synovitis and more severe rheumatoid arthritis . Annals of the Rheumatic Diseases . vol. 77 , 255 - 255 .

Rivellese F, Congia M, Mauro D, Bombardieri M, Lewis M, Pitzalis C ( 2018 ) . THU0070 The transcription factors ikaros and aiolos are expressed in the synovial membrane of early rheumatoid arthritis patients in association with synovial lymphoid aggregates . Annals of the Rheumatic Diseases . vol. 77 , 259 - 259 .

Purkayastha N, Tan WS, Mahto A, Lewis M, Lliso G, Nerviani A, Rocher V, Humby F et al. ( 2018 ) . THU0122 Imaging characterisation of remission in rheumatoid arthritis . Annals of the Rheumatic Diseases . vol. 77 , 282 - 283 .

Taylor JC, Bongartz T, Massey J, Mifsud B, Spiliopoulou A, Scott IC, Wang J, Morgan M et al. ( 2018 ) . Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients . The Pharmacogenomics Journal vol. 18 , ( 4 ) 528 - 538 .

Mandelin AM, Homan PJ, Shaffer AM, Cuda CM, Dominguez ST, Bacalao E, Carns M, Hinchcliff M et al. ( 2018 ) . Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound‐Guided Synovial Biopsies in Rheumatoid Arthritis . Arthritis &amp; Rheumatology vol. 70 , ( 6 ) 841 - 854 .

Cole S, Walsh A, Yin X, Wechalekar MD, Smith MD, Proudman SM, Veale DJ, Fearon U et al. ( 2018 ) . Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus . Arthritis Research &amp; Therapy vol. 20 , ( 1 ) Article 85 ,

Cole S, Walsh A, Yin X, Wechalekar M, Smith M, Proudman SM, Veale DJ, Fearon U et al. ( 2018 ) . Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich rheumatoid arthritis, pre-rheumatoid arthritis and systemic lupus erythematosus . The Journal of Immunology vol. 200 , ( Supplement_1 ) 175.18 - 175.18 .

Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . 244 The clinical phenotype of inflammatory arthritis correlates with synovial immune cell infiltration: results from the pathobiology of early arthritis cohort . Rheumatology vol. 57 , ( suppl_3 )

Massey J, Plant D, Hyrich K, Morgan AW, Wilson AG, Spiliopoulou A, Colombo M, McKeigue P et al. ( 2018 ) . 248 Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis . Rheumatology vol. 57 , ( suppl_3 )

Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . O09 A lymphoid pathotype at baseline, in early inflammatory arthritis, significantly associates with requirement for biologic therapy at 12 months follow up: results from the pathobiology of early arthritis cohort . Rheumatology vol. 57 , ( suppl_3 )

Hensor EMA, McKeigue P, Buch MH, Barrett JH, Nam JL, Freeston J, Colombo M, Spiliopoulou A et al. ( 2018 ) . O12 Validity of a2-component imaging-derived disease activity score (2C-DAS28) for improved assessment of synovitis in early rheumatoid arthritis . Rheumatology vol. 57 , ( suppl_3 )

Humby F, Romão VC, Manzo A, Filer A, Bugatti S, Vieira‐Sousa E, Kelly S, Wechalekar M et al. ( 2018 ) . A Multicenter Retrospective Analysis Evaluating Performance of Synovial Biopsy Techniques in Patients With Inflammatory Arthritis . Arthritis &amp; Rheumatology vol. 70 , ( 5 ) 702 - 710 .

Thomas BL, Jones HR, Norling LV, Headland SE, Pitzalis C, Dell'Accio F, Perretti M ( 2018 ) . Neutrophil extracellular vesicles have a cartilage protective effect during inflammatory arthritis . Osteoarthritis and Cartilage . vol. 26 , S125 - S126 .

Fallas MA, Caxaria S, Sherwood J, Luyten F, Pitzalis C, Dell'Accio F ( 2018 ) . The role of GCP-2 in cartilage differentiation and repair . Osteoarthritis and Cartilage . vol. 26 , S138 - S138 .

James K, Chipeta C, Parker A, Harding S, Cockell SJ, Gillespie CS, Hallinan J, Barone F et al. ( 2018 ) . B-cell activity markers are associated with different disease activity domains in primary Sjögren’s syndrome . Rheumatology vol. 57 , ( 7 ) 1222 - 1227 .

Fisher BA, Everett CC, Rout J, O'Dwyer JL, Emery P, Pitzalis C, Ng W-F, Carr A et al. ( 2018 ) . Effect of rituximab on a salivary gland ultrasound score in primary Sjögren's syndrome: results of the TRACTISS randomised double-blind multicentre substudy . Annals of the Rheumatic Diseases vol. 77 , ( 3 ) 412 - 416 .

Rhys HI, Dell'Accio F, Pitzalis C, Moore A, Norling LV, Perretti M ( 2018 ) . Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages . EBioMedicine vol. 29 , 60 - 69 .

El Shikh MEM, El Sayed R, Fossati-Jimack L, Pitzalis C ( 2018 ) . O001 Lymphoid tissue macrophages express peptidylarginine deiminase 2 and 4: new implications in citrullination and anti-citrulline antibodies production in autoimmune arthritis . Annals of the Rheumatic Diseases . vol. 77 , A1 - A1 .

Lucchesi D, Pontarini E, Coleby R, Jones GW, Hill DG, Pitzalis C, Bombardieri M ( 2018 ) . P079 Interleukin-27 regulates the magnitude of the ectopic germinal centre response in a viral-inducible model of sialadenitis . Annals of the Rheumatic Diseases . vol. 77 , A46 - A47 .

Guo Y, Walsh AM, Canavan M, Wechalekar MD, Cole S, Yin X, Scott B, Loza M et al. ( 2018 ) . Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression . PLOS ONE vol. 13 , ( 2 ) e0192704 - e0192704 .

Boutet M-A, Nerviani A, Gallo Afflitto G, Pitzalis C ( 2018 ) . Role of the IL-23/IL-17 Axis in Psoriasis and Psoriatic Arthritis: The Clinical Importance of Its Divergence in Skin and Joints . International Journal of Molecular Sciences vol. 19 , ( 2 ) 530 - 530 .

Dumusc A, Ng W-F, James K, Griffiths B, Price E, Pease CT, Emery P, Lanyon P et al. ( 2018 ) . Comparison of ESSDAI and ClinESSDAI in potential optimisation of trial outcomes in primary Sjögren’s syndrome: examination of data from the UK Primary Sjögren’s Syndrome Registry . Swiss Medical Weekly vol. 148 , ( 0506 ) w14588 - w14588 .

Ribera GL, Humby F, Kelly S, Lewis M, Bombardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . A LYMPHOID PATHOTYPE AT BASELINE, IN EARLY INFLAMMATORY ARTHRITIS, SIGNIFICANTLY ASSOCIATES WITH REQUIREMENT FOR BIOLOGIC THERAPY AT 12 MONTHS FOLLOW UP: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT . RHEUMATOLOGY . vol. 57 ,

Notarstefano C, Croia C, Pontarini E, Lucchesi D, Sutcliffe N, Tappuni A, Donati V, Pitzalis C et al. ( 2018 ) . A clinical and histopathological analysis of the anti-centromere antibody positive subset of primary Sjogren's syndrome . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 36 , ( 3 ) S145 - S149 .

Notarstefano C, Croia C, Pontarini E, Lucchesi D, Sutcliffe N, Tappuni A, Donati V, Pitzalis C et al. ( 2018 ) . A clinical and histopathological analysis of the anti-centromere antibody positive subset of primary Sjögren's syndrome . Clinical and Experimental Rheumatology vol. 36 , S145 - S149 .

Nerviani A, Humby F, Ribera GL, Tan WS, Boutet MA, Goldmann K, Bene F, Hands R et al. ( 2018 ) . Comparative Histologic and Molecular Analysis of Synovial Tissue in Early Treatment-Naive Psoriatic and Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,

Rivellese F, Mauro D, Congia M, Pontarini E, Schafer P, Bombardieri M, Pitzalis C, Lewis MJ ( 2018 ) . Expression and Functions of the Transcription Factors Ikaros and Aiolos in Sjogren's Syndrome and Systemic Lupus Erythematosus . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,

Massey J, Plant D, Hyrich K, Morgan AW, Wilson AG, Spiliopoulou A, Colombo M, McKeigue P et al. ( 2018 ) . GENOME-WIDE ASSOCIATION STUDY OF RESPONSE TO TUMOUR NECROSIS FACTOR INHIBITOR THERAPY IN RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 57 ,

Ruiz-Romero C, Picchi F, Fernandez P, Gonzalez L, Hands R, Calamia V, Camacho M, Bessant C et al. ( 2018 ) . Identification of a Panel of Circulating Proteins Associated to Synovial Pathotypes in Early Rheumatoid Arthritis Patients . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,

Ruiz-Romero C, Picchi F, Gonzalez L, Hands R, Calamia V, Fernandez P, Camacho M, Paz R et al. ( 2018 ) . Identification of a Protein Profile Useful to Predict Response to Methotrexate in Early Rheumatoid Arthritis Patients . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,

Cole S, Walsh A, Yin X, Wechalekar M, Smith M, Proudman SM, Veale DJ, Fearon U et al. ( 2018 ) . Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich rheumatoid arthritis, pre-rheumatoid arthritis and systemic lupus erythematosus . JOURNAL OF IMMUNOLOGY . vol. 200 ,

Lucchesi D, Pontarini E, Coleby R, Jones GW, Hill DG, Pitzalis C, Bombardieri M ( 2018 ) . Interleukin-27 regulates the magnitude of the ectopic germinal centre response in a virus-induced murine model of sialadenitis . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 36 , S244 - S244 .

Bottini A, Wu DJ, Ai R, LeRoux M, Bartok B, Bombardieri M, Zhang V, Doody KM et al. ( 2018 ) . Non-Receptor Protein Tyrosine Phosphatase 14 (PTPN14) Promotes YAP-Dependent Tgfbeta Signaling in RA FLS . ARTHRITIS & RHEUMATOLOGY . vol. 70 ,

Corsiero E, Jagemann L, Pontarini E, Fossati-Jimack L, Pitzalis C, Bombardieri M ( 2018 ) . Single-cell VH and VL Ig gene analysis reveal clonal relationship between IgM plus neoplastic B cells and plasmablasts in SS patients with parotid MALT lymphoma . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 36 , S249 - S249 .

Pontarini E, Murray-Brown W, Croia C, Corsiero E, Fossati-Jimack L, Astorri E, Lucchesi D, Lepse N et al. ( 2018 ) . T follicular-helper cells (TFH) enrichment and follicular T regulatory cells (TFR) exclusion from ectopic germinal centers in salivary glands of Sjogren's Syndrome patients . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 36 , S291 - S291 .

Ribera GL, Humby F, Kelly S, Lewis M, Bornbardieri M, Nerviani A, Hands R, Bene F et al. ( 2018 ) . THE CLINICAL PHENOTYPE OF INFLAMMATORY ARTHRITIS CORRELATES WITH SYNOVIAL IMMUNE CELL INFILTRATION: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT . RHEUMATOLOGY . vol. 57 ,

Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA et al. ( 2017 ) . The RA-MAP Consortium: a working model for academia–industry collaboration . Nature Reviews Rheumatology vol. 14 , ( 1 ) 53 - 60 .

Bezzina OM, Gallagher P, Mitchell S, Bowman SJ, Griffiths B, Hindmarsh V, Hargreaves B, Price EJ et al. ( 2017 ) . Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy . Arthritis Care &amp; Research vol. 69 , ( 11 ) 1714 - 1723 .

Lownik JC, Luker AJ, Damle SR, Cooley LF, El Sayed R, Hutloff A, Pitzalis C, Martin RK et al. ( 2017 ) . ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses . The Journal of Immunology vol. 199 , ( 7 ) 2305 - 2315 .

Orr C, Vieira-Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS et al. ( 2017 ) . Erratum: Synovial tissue research: a state-of-the-art review . Nature Reviews Rheumatology vol. 13 , ( 10 ) 630 - 630 .

Balasubramaniam G, Parker T, Turner D, Parker M, Scales J, Harnett P, Harrison M, Ahmed K et al. ( 2017 ) . Feasibility randomised multicentre, double-blind, double-dummy controlled trial of anakinra, an interleukin-1 receptor antagonist versus intramuscular methylprednisolone for acute gout attacks in patients with chronic kidney disease (ASGARD): protocol study . BMJ Open vol. 7 , ( 9 ) e017121 - e017121 .

Oni C, Mitchell S, James K, Ng W-F, Griffiths B, Hindmarsh V, Price E, Pease CT et al. ( 2017 ) . Eligibility for clinical trials in primary Sjögren’s syndrome: lessons from the UK Primary Sjögren’s Syndrome Registry . Rheumatology vol. 56 , ( 12 ) 2255 - 2255 .

Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Lin N-Y, Dietel K et al. ( 2017 ) . Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells . Nature Medicine vol. 23 , ( 8 ) 938 - 944 .

Humby F, Mahto A, Ahmed M, Barr A, Kelly S, Buch M, Pitzalis C, Conaghan PG ( 2017 ) . The Relationship Between Synovial Pathobiology and Magnetic Resonance Imaging Abnormalities in Rheumatoid Arthritis: A Systematic Review . The Journal of Rheumatology vol. 44 , ( 9 ) 1311 - 1324 .

Ursini F, Leporini C, Bene F, D’Angelo S, Mauro D, Russo E, De Sarro G, Olivieri I et al. ( 2017 ) . Anti-TNF-alpha agents and endothelial function in rheumatoid arthritis: a systematic review and meta-analysis . Scientific Reports vol. 7 , ( 1 ) Article 5346 ,

Orr C, Vieira-Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS et al. ( 2017 ) . Synovial tissue research: a state-of-the-art review . Nature Reviews Rheumatology vol. 13 , ( 8 ) 463 - 475 .

Muñoz-Atienza E, Aduse-Opoku J, Flak MB, Paramonov NA, Pitzalis C, Curtis MA ( 2017 ) . Generation and characterisation of <i>Porphyromonas gingivalis</i> mutant lacking peptidylarginine deiminase activity . Journal of Oral Microbiology vol. 9 , ( sup1 ) 1325258 - 1325258 .

El Shikh MEM, El Sayed R, Pitzalis C ( 2017 ) . Isolation and Characterization of Mouse and Human Follicular Dendritic Cells . 113 - 123 .

Bowman SJ, Everett CC, O'Dwyer JL, Emery P, Pitzalis C, Ng W, Pease CT, Price EJ et al. ( 2017 ) . Randomized Controlled Trial of Rituximab and Cost‐Effectiveness Analysis in Treating Fatigue and Oral Dryness in Primary Sjögren's Syndrome . Arthritis &amp; Rheumatology vol. 69 , ( 7 ) 1440 - 1450 .

Mandelin AM, Homan P, Cuda CM, Dominguez ST, Bridges SL, Bathon JM, Atkinson J, Fox D et al. ( 2017 ) . AB0220 The promise of ultrasound guided minimally invasive synovial biopsies in the united states . Annals of the Rheumatic Diseases . vol. 76 , 1125 - 1125 .

Fisher BA, Everett CC, Rout J, O'Dywer JL, Emery P, Pitzalis C, Ng W-F, Carr A et al. ( 2017 ) . AB0444 Effect of rituximab on a salivary gland ultrasound score in primary sjÖgren's syndrome: results of the tractiss multicentre randomised trial sub-study . Annals of the Rheumatic Diseases . vol. 76 , 1205 - 1206 .

Guo Y, Walsh AM, Fearon U, Smith MD, Wechalekar MD, Yin X, Cole S, Orr C et al. ( 2017 ) . CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression . The Journal of Immunology vol. 198 , ( 11 ) 4490 - 4501 .

Rivellese F, Humby F, Nerviani A, Pagani S, Mauro D, Paulis AD, Marone G, Pitzalis C ( 2017 ) . FRI0030 Synovial mast cells identify patients with a severe phenotype in a cohort of dmard naÏve patients with early rheumatoid arthritis . Annals of the Rheumatic Diseases . vol. 76 , 490 - 491 .

Pucino V, Smith J, Cucchi D, Blighe K, Bombardieri M, Pitzalis C, Mauro C ( 2017 ) . FRI0076 LACTATE/SLC5A12-induced metabolic signalling network: a new target in rheumatoid arthritis . Annals of the Rheumatic Diseases . vol. 76 , 506 - 506 .

Lliso-Ribera G, Humby F, Kelly S, Bombardieri M, Lewis M, Hands R, Rocher V, Bene F et al. ( 2017 ) . FRI0088 Synovial pathobiology correlates with diagnostic subgroups in early inflammatory arthritis: results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases . vol. 76 , 511 - 511 .

Rivellese F, Nerviani A, Rossi FW, Marone G, Matucci-Cerinic M, de Paulis A, Pitzalis C ( 2017 ) . Mast cells in rheumatoid arthritis: friends or foes? . Autoimmunity Reviews vol. 16 , ( 6 ) 557 - 563 .

Corsiero E, Jagemann L, Prediletto E, Pitzalis C, Bombardieri M ( 2017 ) . OP0175 Characterization of novel stromal-derived autoantigens recognized by ra synovial monoclonal antibodies . Annals of the Rheumatic Diseases . vol. 76 , 125 - 125 .

Pontarini E, Murray-Brown W, Croia C, Astorri E, Lucchesi D, Lepse N, Sutcliffe N, Tappuni A et al. ( 2017 ) . OP0300 Enrichment of T follicular-helper cells (TFH) and exclusion of t follicular-regulatory cells (TFR) from ectoPIC germinal centers in salivary glands of sjogren's syndrome patients . Annals of the Rheumatic Diseases . vol. 76 , 180 - 180 .

Walsh AM, Canavan M, Guo Y, McGarry T, Yin X, Wechalekar MD, Smith MD, Proudman SM et al. ( 2017 ) . THU0011 Immune signal 2 checkpoint molecule expression in rheumatoid arthritis disease progression . Annals of the Rheumatic Diseases . vol. 76 , 203 - 204 .

Lliso-Ribera G, Humby F, Kelly S, Bombardieri M, Lewis M, Hands R, Rocher V, Bene F et al. ( 2017 ) . THU0100 In early inflammatory arthritis a lymphoid pathotype signficantly associates with requirement for biologic therapy at 12 months follow up: results from the pathobiology of early arthritis cohort (PEAC) . Annals of the Rheumatic Diseases . vol. 76 , 238 - 238 .

Humby F, Bugatti S, Filer A, Kelly S, Manzo A, Souza E, Romao V, Rocher V et al. ( 2017 ) . THU0667 A qualitative and quantitative comparison of synovial biopsy techniques during clinical trials of inflammatory arthritis . Annals of the Rheumatic Diseases . vol. 76 , 458 - 458 .

Humby FC, Al Balushi F, Lliso G, Cauli A, Pitzalis C ( 2017 ) . Can Synovial Pathobiology Integrate with Current Clinical and Imaging Prediction Models to Achieve Personalized Health Care in Rheumatoid Arthritis? . Frontiers in Medicine vol. 4 , Article 41 ,

Thorup A-S, Eldridge SE, Caxaria S, Nalesso G, Thomas BL, Pitzalis C, Luyten F, Dell'Accio F ( 2017 ) . A Potency Assay for Assessing the Chondrogenic Efficiency of Bioactive Molecules in Human Cartilage in vivo . Osteoarthritis and Cartilage . vol. 25 , S273 - S273 .

Eldridge SE, Thomas BL, Shanmuganathan K, Strachan D, Ali A, Thorup A-S, Caxaria S, Nalesso G et al. ( 2017 ) . Agrin inhibits canonical WNT signalling through LRP4 . Osteoarthritis and Cartilage . vol. 25 , S165 - S165 .

Kaneva MK, Greco KV, Headland SE, Montero-Melendez T, Mori P, Greenslade K, Pitzalis C, Moore A et al. ( 2017 ) . Identification of Novel Chondroprotective Mediators in Resolving Inflammatory Exudates . The Journal of Immunology vol. 198 , ( 7 ) 2876 - 2885 .

Caxaria S, Sherwood J, Roeder E, Luyten F, Pitzalis C, Dell'Accio F ( 2017 ) . The Role of CXCl6 in Cartilage Development and Homeostasis . Osteoarthritis and Cartilage . vol. 25 , S301 - S301 .

Thomas BL, Nalesso G, Eldridge SE, Pitzalis C, Dell'accio F ( 2017 ) . WNT16 is up-regulated in the joint following inflammation . Osteoarthritis and Cartilage . vol. 25 , S156 - S156 .

Lucchesi D, Pontarini E, Pitzalis C, Mavilio D, Bombardieri M ( 2017 ) . 01.09 Myeloid cells drive early inflammation and orchestrate salivary glands tertiary lymphoid structures formation in a model of inducible sialadenitis . Annals of the Rheumatic Diseases . vol. 76 , A4 - A4 .

Corsiero E, Jagemann L, Prediletto E, Pitzalis C, Bombardieri M ( 2017 ) . 08.34 Ra synovial recombinant monoclonal antibodies from single b cells target citrullinated calreticulin . Annals of the Rheumatic Diseases . vol. 76 , A89 - A90 .

Bombardieri M, Lewis M, Pitzalis C ( 2017 ) . Ectopic lymphoid neogenesis in rheumatic autoimmune diseases . Nature Reviews Rheumatology vol. 13 , ( 3 ) 141 - 154 .

Zhang F, Slowikowski K, Fonseka C, Wei K, Gutierrez-Arcelus M, Lederer J, Hacohen N, Bykerk VP et al. ( 2017 ) . A Novel Statistical Method to Resolve Cellular Heterogeneity in Disease Tissues: Integrating Transcriptomic Data in Accelerating Medicines Partnership (AMP) - RA Network Phase 1 Data . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Eldridge S, Thomas B, Roelofs A, Nosrati B, Shanmuganathan K, Strachen D, Caxaria S, Ali A et al. ( 2017 ) . Agrin is a potent WNT inhibitor which supports the healing of osteochondral defects . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 98 , A6 - A6 .

Corsiero E, Jagemann L, Pitzalis C, Bombardieri M ( 2017 ) . Characterization of Novel Stromal-Derived Autoantigens Recognized By RA Synovial Monoclonal Antibodies . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Fisher B, Everett C, Rout J, O'Dwyer J, Emery P, Pitzalis C, Ng W-F, Carr A et al. ( 2017 ) . Effect of Rituximab on a Salivary Gland Ultrasound Score in Primary Sjgren's Syndrome: Results of Multicentre Double-Blind Randomised Controlled Trial Sub-Study . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Hill D, Liu X, Uceda J, Cossins B, Morgan J, Williams N, Andrews R, Williams A et al. ( 2017 ) . Global transcriptomic analysis identifies cytokineregulated pathways that determine discrete synovial pathotypes in inflammatory arthritis . CYTOKINE . vol. 100 , 107 - 108 .

Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Bozec A, Herrmann M et al. ( 2017 ) . IL-9-Producing Innate Lymphoid Cells - Keyplayers That Orchestrate Resolution of Chronic Inflammation in Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Davies K, Mirza K, Tarn J, Regan M, Vadivelu S, Clunie G, Andrews J, Price E et al. ( 2017 ) . Longitudinal Analysis of Different Therapeutic Strategies in Patients with Primary Sjogren's Syndrome . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Rao D, Donlin LT, Wei K, Meednu N, Turner J, McGeachy MJ, Mizoguchi F, Keegan J et al. ( 2017 ) . Methods for Generating Multiple High-Dimensional Analyses of Cryopreserved Synovial Tissue Developed By the Accelerating Medicines Partnership RA/SLE Network . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Rivellese F, Humby F, Pagani S, Nerviani A, Pitzalis C ( 2017 ) . Persistence of Mast Cell-Rich Synovitis Is Associated with Lack of Response to Synthetic Disease Modifying Anti-Rheumatic Drugs in Patients with Early Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Mauro D, Tsang V, Clayton-Lucey IA, Pagani S, Alam F, Pontarini E, Nerviani A, Pakozdi A et al. ( 2017 ) . Regulation of TLR7 Signalling By UBE2L3 Dependent Linear Ubiquitination Explains Dimethyl Fumarate Suppression of Autoreactive B Cell Development in SLE . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Secchi C, Doody KM, Svensson MND, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K et al. ( 2017 ) . Synergistic Reversal of Arthritis By Synoviocyte-Targeted Therapy and TNF Immunomodulation . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Pontarini E, Brown WM, Croia C, Corsiero E, Lucchesi D, Astorri E, Sutcliffe N, Tappuni A et al. ( 2017 ) . T Follicular- Helper CELLS (TFH) Enrichment and T Follicular-Regulatory CELLS (TFR) Exclusion from Ectopic Germinal Centers in Salivary Glands of Sjogren's Syndrome Patients . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Homan PJ, Mandelin AMII, Dominguez S, Bacalao E, Bridges SLJ, Bathon JM, Atkinson J, Fox D et al. ( 2017 ) . Transcriptional Profiling of Synovial Macrophages from RA Patients to Capture Disease Heterogeneity . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Nerviani A, Pagani S, Mauro D, Humby F, Kelly S, Rivellese F, Ribera GL, Lewis MJ et al. ( 2017 ) . Tyrosine Kinase Receptor Axl Is Down Regulated in Highly Inflamed Rheumatoid Synovium and Negatively Correlates with Markers of Disease Activity . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Wei K, Rao D, Zhang F, Fonseka C, Slowikowski K, Keegan J, Donlin LT, Turner J et al. ( 2017 ) . Using Flow and Mass Cytometry to Demonstrate Robust Tissue Processing to Query Molecular Heterogeneity in Phase 1 of the Accelerating Medicines Partnership (AMP) - RA Network . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,

Nalesso G, Thomas BL, Sherwood JC, Yu J, Addimanda O, Eldridge SE, Thorup A-S, Dale L et al. ( 2017 ) . WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis . Annals of the Rheumatic Diseases vol. 76 , ( 1 ) 218 - 226 .

Ng W-F, Miller A, Bowman SJ, Price EJ, Kitas GD, Pease C, Emery P, Lanyon P et al. ( 2016 ) . Physical activity but not sedentary activity is reduced in primary Sjögren’s syndrome . Rheumatology International vol. 37 , ( 4 ) 623 - 631 .

Barton A, Pitzalis C ( 2016 ) . Stratified medicine in rheumatoid arthritis—the MATURA programme . Rheumatology vol. 56 , ( 8 ) 1247 - 1250 .

Pucino V, Bombardieri M, Pitzalis C, Mauro C ( 2016 ) . Lactate at the crossroads of metabolism, inflammation, and autoimmunity . European Journal of Immunology vol. 47 , ( 1 ) 14 - 21 .

Corsiero E, Nerviani A, Bombardieri M, Pitzalis C ( 2016 ) . Ectopic Lymphoid Structures: Powerhouse of Autoimmunity . Frontiers in Immunology vol. 7 ,

Tan WSG, Kelly S, Pitzalis C ( 2016 ) . Targeted therapies: what they teach us about the pathogenesis of psoriasis and psoriatic arthritis . Expert Review of Clinical Immunology vol. 13 , ( 3 ) 207 - 222 .

Corsiero E, Bombardieri M, Carlotti E, Pratesi F, Robinson W, Migliorini P, Pitzalis C ( 2016 ) . Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs . Annals of the Rheumatic Diseases vol. 75 , ( 10 ) 1866 - 1875 .

Howard Tripp N, Tarn J, Natasari A, Gillespie C, Mitchell S, Hackett KL, Bowman SJ, Price E et al. ( 2016 ) . Fatigue in primary Sjögren's syndrome is associated with lower levels of proinflammatory cytokines . RMD Open vol. 2 , ( 2 ) e000282 - e000282 .

Porter D, van Melckebeke J, Dale J, Messow CM, McConnachie A, Walker A, Munro R, McLaren J et al. ( 2016 ) . Tumour necrosis factor inhibition versus rituximab for patients with rheumatoid arthritis who require biological treatment (ORBIT): an open-label, randomised controlled, non-inferiority, trial . The Lancet vol. 388 , ( 10041 ) 239 - 247 .

Eldridge S, Nalesso G, Ismail H, Vicente-Greco K, Kabouridis P, Ramachandran M, Niemeier A, Herz J et al. ( 2016 ) . Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo . Annals of the Rheumatic Diseases vol. 75 , ( 6 ) 1228 - 1235 .

Rivellese F, Humby F, Kelly S, Nerviani A, Mauro D, Rocher-Ros V, El Shikh ME, de Paulis A et al. ( 2016 ) . FRI0043 Synovial Mast Cells Correlate with Local and Systemic Inflammation and Are Functionally Associated with Ectopic Lymphoid Structures in Patients with Early Rheumatoid Arthritis .

Nerviani A, DiCicco M, Humby F, Kelly S, Zou L, Lewis M, Hands R, Rocher V et al. ( 2016 ) . FRI0157 A Baseline Prediction Model for Response To Certolizumab-Pegol: Role of Synovial Histopathology . Annals of the Rheumatic Diseases . vol. 75 , 485 - 486 .

Nerviani A, Tan WS, Mahto A, Di Cicco M, Lazarou I, Ng N, Purkayastha N, Bellan M et al. ( 2016 ) . FRI0442 Histopathology of Treatment-Naïve Psoriatic Synovitis: A Comparison with Early Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 75 , 595 - 596 .

Mauro D, Lewis MJ, Pullabhatla V, Vyse S, Simpson M, Cunninghame-Graham D, Syvanen AC, Pitzalis C et al. ( 2016 ) . OP0232 C1qtnf4 Mutation Identified by Exome Sequencing Is Associated with Systemic Lupus Erythematosus and Dysregulation of Tnf-Induced Apoptosis . Annals of the Rheumatic Diseases vol. 75 , 145 - 146 .

Humby F, Dicicco M, Kelly S, Bombardieri M, Hands R, Rocher V, Zou L, Myles L et al. ( 2016 ) . OP0240 Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease Progression at 12 Months: Results from The Pathobiology of Early Arthritis Cohort . Annals of the Rheumatic Diseases vol. 75 , 149 - 149 .

Blidberg K ( 2016 ) . OP0252-PARE Increasing The Interest in Research in Rheumatology . Annals of the Rheumatic Diseases . vol. 75 , 153 - 154 .

Mahto A, Humby F, Gregoriadou S, Ng N, Blighe K, Zou L, Lewis M, Bombardieri M et al. ( 2016 ) . OP0263 Synovial B-Cell Gene Signature Predicts Response To Rituximab Therapy . Annals of the Rheumatic Diseases . vol. 75 , 158 - 158 .

Genovese M, Fleischmann R, Furst D, Janssen N, Carter J, Dasgupta B, Pitzalis C, Vasyutin I et al. ( 2016 ) . SAT0148 Improvements in Patient-Reported Outcomes with Olokizumab Treatment in Patients with Active, Moderate To Severe Rheumatoid Arthritis Who Had Failed Previous Anti-TNF Therapy: Results from The Ra0056 Double-Blind, Randomized Controlled Study, and RA0057, Its Open-Label Extension . Annals of the Rheumatic Diseases . vol. 75 , 718 - 719 .

( 2016 ) . 069 T Follicular Helper–Like Cells in the Rheumatoid Arthritis Synovium are Selectively Associated with Interleukin-21 Production and Ectopic Lymphoid Structures . Rheumatology

( 2016 ) . 071 Synovial Mast Cells Correlate with Inflammation and Cellular Infiltration and are Associated with Ectopic Lymphoid Structures in Patients with Early Rheumatoid Arthritis . Rheumatology

( 2016 ) . 205 Correlation of Soluble Vascular Cell Adhesion Molecule 1 with B Cell Activation and Plasma Cells in Systemic Lupus Erythematosus . Rheumatology

( 2016 ) . I27 Stratified Medicine Approaches in Rheumatoid Arthritis . Rheumatology

( 2016 ) . O49 Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease Progression at 12 Months: Results from the Pathobiology of Early Arthritis Cohort . Rheumatology

. O53 Fibroid Synovial Pathotype and Tyrosine Kinase AXL Correlate with Poor Clinical Response to Certolizumab Pegol in Rheumatoid Arthritis Patients . Rheumatology .

Eldridge SE, Petrycki E, Pitzalis C, Whiteford J, Dell'Accio F ( 2016 ) . MMP3 cleaves agrin in cartilage and reduces its chondrogenic potency . Osteoarthritis and Cartilage . vol. 24 , S379 - S379 .

Nalesso G, Wagner K, Bertrand J, Sherwood JC, Thomas BL, Eldridge SE, Pitzalis C, Dell'Accio F ( 2016 ) . Pharmacological blockade of CAMKII is detrimental for osteoarthritis progression . Osteoarthritis and Cartilage . vol. 24 , S149 - S149 .

Rivellese F, de Paulis A, Marone G, Pitzalis C, Toes REM ( 2016 ) . Reply . Arthritis &amp; Rheumatology vol. 68 , ( 3 ) 769 - 770 .

Corsiero E, Carlotti E, Prediletto E, Jagemann L, Pitzalis C, Bombardieri M ( 2016 ) . A2.04 The role of somatic hypermutation and n-glycosylation in the anti-nets immunoreactivity of ra synovial monoclonal antibodies . Annals of the Rheumatic Diseases . vol. 75 , A16 - A16 .

Lepse N, Nerviani A, Pitzalis C, Bombardieri M ( 2016 ) . A2.30 TFH-like cells in the ra synovium are selectively associated with IL-21 production and ectopic lymphoid structures . Annals of the Rheumatic Diseases . vol. 75 , A27 - A27 .

De Groof A, Ducreux J, Humby F, Nzeusseu Toukap A, Badot V, Pitzalis C, Houssiau FA, Durez P et al. ( 2016 ) . Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy . Arthritis Research &amp; Therapy vol. 18 , ( 1 ) Article 19 ,

Lewis MJ, Vyse S, Shields AM, Zou L, Khamashta M, Gordon PA, Pitzalis C, Vyse TJ et al. ( 2016 ) . Improved monitoring of clinical response in Systemic Lupus Erythematosus by longitudinal trend in soluble vascular cell adhesion molecule-1 . Arthritis Research &amp; Therapy vol. 18 , ( 1 ) Article 5 ,

Lewis MJ, Vyse S, Shields AM, Zou L, Khamashta M, Gordon PA, Pitzalis C, Vyse TJ et al. ( 2016 ) . CORRELATION OF SOLUBLE VASCULAR CELL ADHESION MOLECULE 1 WITH B CELL ACTIVATION AND PLASMA CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS . RHEUMATOLOGY . vol. 55 , 145 - 146 .

Astorri E, Lucchesi D, Pitzalis C, Bombardieri M ( 2016 ) . Chapter 7 Spontaneous and Inducible Animal Models of Sjögren’s Syndrome . Sjogren's Syndrome , Elsevier

Oni C, Mitchell S, James K, Ng W-F, Griffiths B, Hindmarsh V, Prices E, Pease CT et al. ( 2016 ) . Eligibility for clinical trials in primary Sjogren's syndrome: lessons from the UK Primary Sjogren's Syndrome Registry . RHEUMATOLOGY vol. 55 , ( 3 ) 544 - 552 .

Guo Y, Walsh A, Fearon U, Smith MD, Wechalekar MD, Yin X, Cole S, Orr C et al. ( 2016 ) . Gene Enrichment Analysis Identifies Active CD40-CD40L Signaling in Early and Established Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 68 ,

Taylor JC, Verstappen S, Wang J, Bongartz T, Scott I, Emery P, Pitzalis C, Barton A et al. ( 2016 ) . Genome-Wide Meta-Analysis of Response to Methotrexate in Rheumatoid Arthritis Patients on behalf of the MATURA Consortium . GENETIC EPIDEMIOLOGY . vol. 40 , 666 - 667 .

Ferrari M, Onuoha SC, Pitzalis C ( 2016 ) . Going with the flow: harnessing the power of the vasculature for targeted therapy in rheumatoid arthritis . Drug Discovery Today vol. 21 , ( 1 ) 172 - 179 .

Jones GW, Bombardieri M, Greenhill CJ, McLeod L, Nerviani A, Rocher-Ros V, Cardus A, Williams AS et al. ( 2016 ) . Interleukin-27 inhibits synovial lymphoid neogenesis in inflammatory arthritis . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 46 , 1024 - 1024 .

Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Mehr R et al. ( 2016 ) . Next-generation sequencing demonstrates dynamic recirculation of B cell clones in ectopic lymphoid structures of Sjogren's syndrome . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 46 , 939 - 940 .

Pitzalis C ( 2016 ) . STRATIFIED MEDICINE APPROACHES IN RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 55 , 5 - 5 .

DiCicco M, Humby F, Kelly S, Bombardieri M, Rebecca H, Rocher V, Zou L, Myles L et al. ( 2016 ) . SYNOVIAL LYMPHOCYTIC AGGREGATES ASSOCIATE WITH HIGHLY ACTIVE RA AND PREDICT EROSIVE DISEASE PROGRESSION AT 12 MONTHS: RESULTS FROM THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT . RHEUMATOLOGY . vol. 55 , 59 - 59 .

Rivellese F, Humby F, Kelly S, Rocher V, Pitzalis C ( 2016 ) . SYNOVIAL MAST CELLS CORRELATE WITH INFLAMMATION AND CELLULAR INFILTRATION AND ARE ASSOCIATED WITH ECTOPIC LYMPHOID STRUCTURES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 55 , 89 - 90 .

Astorri E, Lucchesi D, Pitzalis C, Bombardieri M ( 2016 ) . Spontaneous and Inducible Animal Models of Sjögren’s Syndrome . Sjogren's Syndrome , Elsevier

Rivellese F, Humby F, Kelly S, de Paulis A, Marone G, Pitzalis C ( 2016 ) . Synovial Mast Cells Associate with High Disease Activity and Predict Radiographic Progression at 12 Months in Patients with Early Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 68 ,

Lepse N, Nerviani A, Pitzalis C, Bombardieri M ( 2016 ) . T FOLLICULAR HELPER-LIKE CELLS IN THE RHEUMATOID ARTHRITIS SYNOVIUM ARE SELECTIVELY ASSOCIATED WITH INTERLEUKIN-21 PRODUCTION AND ECTOPIC LYMPHOID STRUCTURES . RHEUMATOLOGY . vol. 55 , 89 - 89 .

Corsiero E, Carlotti E, Prediletto E, Jagemann L, Pitzalis C, Bombardieri M ( 2016 ) . The role of somatic hypermutation and N-glycosylation in the anti-NET immunoreactivity of RA synovial monoclonal antibodies . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 46 , 116 - 117 .

Lazarou I, Kelly S, Humby F, Di Cicco M, Zou L, Rocher-Ros V, Hands RE, Ng N et al. ( 2016 ) . Ultrasound-guided synovial biopsy of the wrist does not alter subsequent clinical or ultrasound disease activity assessments: a prospective study for incorporation of imaging in clinical trials . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 34 , ( 5 ) 802 - 807 .

Hensor EMA, McKeigue P, Conaghan PG, Buch MH, Barrett JH, Nam JL, Colombo M, Spiliopoulou A et al. ( 2016 ) . Validity of a 2-Component Disease Activity Score for Accurate Assessment of Synovitis in Rheumatoid Arthritis . ARTHRITIS & RHEUMATOLOGY . vol. 68 ,

James K, Al-Ali S, Tarn J, Cockell SJ, Gillespie CS, Hindmarsh V, Locke J, Mitchell S et al. ( 2015 ) . A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren’s Syndrome . PLOS ONE vol. 10 , ( 12 ) e0143970 - e0143970 .

Astorri E, Sutcliffe N, Richards PS, Suchak K, Pitzalis C, Bombardieri M, Tappuni AR ( 2015 ) . Ultrasound of the salivary glands is a strong predictor of labial gland biopsy histopathology in patients with sicca symptoms . Journal of Oral Pathology &amp; Medicine vol. 45 , ( 6 ) 450 - 454 .

Sherwood J, Bertrand J, Nalesso G, Poulet B, Pitsillides A, Brandolini L, Karystinou A, De Bari C et al. ( 2015 ) . A homeostatic function of CXCR2 signalling in articular cartilage . Annals of the Rheumatic Diseases vol. 74 , ( 12 ) 2207 - 2215 .

Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A et al. ( 2015 ) . Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis . Science Translational Medicine vol. 7 , ( 315 )

Oni C, Mitchell S, James K, Ng W-F, Griffiths B, Hindmarsh V, Price E, Pease CT et al. ( 2015 ) . Eligibility for clinical trials in primary Sjögren’s syndrome: lessons from the UK Primary Sjögren’s Syndrome Registry . Rheumatologykev373 - kev373 .

Jones GW, Bombardieri M, Greenhill CJ, McLeod L, Nerviani A, Rocher-Ros V, Cardus A, Williams AS et al. ( 2015 ) . Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis . Journal of Experimental Medicine vol. 212 , ( 11 ) 1793 - 1802 .

Onuoha SC, Ferrari M, Sblattero D, Pitzalis C ( 2015 ) . Rational Design of Antirheumatic Prodrugs Specific for Sites of Inflammation . Arthritis &amp; Rheumatology vol. 67 , ( 10 ) 2661 - 2672 .

Humby F, Kelly S, Hands R, Rocher V, DiCicco M, Ng N, Zou L, Bugatti S et al. ( 2015 ) . Use of Ultrasound‐Guided Small Joint Biopsy to Evaluate the Histopathologic Response to Rheumatoid Arthritis Therapy: Recommendations for Application to Clinical Trials . Arthritis &amp; Rheumatology vol. 67 , ( 10 ) 2601 - 2610 .

Rivellese F, Suurmond J, Habets K, Dorjée AL, Ramamoorthi N, Townsend MJ, de Paulis A, Marone G et al. ( 2015 ) . Ability of Interleukin‐33– and Immune Complex–Triggered Activation of Human Mast Cells to Down‐Regulate Monocyte‐Mediated Immune Responses . Arthritis &amp; Rheumatology vol. 67 , ( 9 ) 2343 - 2353 .

Barone F, Nayar S, Campos J, Cloake T, Withers DR, Toellner K-M, Zhang Y, Fouser L et al. ( 2015 ) . IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs . Proceedings of the National Academy of Sciences vol. 112 , ( 35 ) 11024 - 11029 .

Haas R, Smith J, Rocher-Ros V, Nadkarni S, Montero-Melendez T, D’Acquisto F, Bland EJ, Bombardieri M et al. ( 2015 ) . Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions . PLOS Biology vol. 13 , ( 7 ) e1002202 - e1002202 .

Humby F, Kelly S, Bugatti S, Manzo A, Filer A, Mahto A, Fonseca JE, Lauwerys B et al. ( 2015 ) . Evaluation of Minimally Invasive, Ultrasound-guided Synovial Biopsy Techniques by the OMERACT Filter — Determining Validation Requirements . The Journal of Rheumatology vol. 43 , ( 1 ) 208 - 213 .

Corsiero E, Carlotti E, Pitzalis C, Bombardieri M ( 2015 ) . FRI0007 The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETS)-Citrullinated Autoantigens of Ra Synovial Monoclonal Antibodies . Annals of the Rheumatic Diseases . vol. 74 , 422 - 422 .

Carlotti E, Floyd J, Murray-Brown W, Barnes M, Mehr R, Bombardieri M, Pitzalis C ( 2015 ) . FRI0008 Longitudinal Analysis of the IGH-VH Gene by High-Throughput Sequencing in Early Rheumatoid Arthritis Paired Biopsies and its Association with Response to Dmards . Annals of the Rheumatic Diseases . vol. 74 , 422 - 422 .

Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Mehr R et al. ( 2015 ) . FRI0020 Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjögren's Syndrome . Annals of the Rheumatic Diseases . vol. 74 , 425 - 426 .

Ferrari M, Onuoha SC, Sblattero D, Pitzalis C ( 2015 ) . FRI0103 Synovial Specific Prodrug for the Next Generation of Anti-TNF Therapy in Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 74 , 456 - 457 .

Komarowska I, Coe D, Wang G, Haas R, Mauro C, Kishore M, Cooper D, Nadkarni S et al. ( 2015 ) . Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release . Immunity vol. 42 , ( 6 ) 1087 - 1099 .

Decourcey J, Nerviani A, Melgar S, Bulfone-Paus S, Loscher CE, Bombardieri M, Pitzalis C ( 2015 ) . OP0117 Snare Regulation of TH17 Cells and Ectopic Lymphoid Structure (ELS) Formation in Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 74 , 112 - 113 .

De Groof A, Humby F, Ducreux J, Kelly S, Nzeusseu Toukap A, Pitzalis C, Durez P, Lauwerys B ( 2015 ) . OP0129 Higher Expression of TNF Alpha-Induced Genes in the Synovium of Early RA Patients Correlates with Disease Activity, and Predicts Absence of Response to First Line Therapy . Annals of the Rheumatic Diseases . vol. 74 , 117 - 117 .

Tan WS, Bellan M, Nerviani A, Di Cicco M, Mahto A, Lazarou I, Hands R, Humby F et al. ( 2015 ) . OP0208 Synovial Immunopathology Defines Clinical Responsiveness to Dmard Therapy in Early Psoriatic Arthritis: A Pre- and Post-Treatment Mechanistic Study Using a Minimally Invasive Ultrasound-Guided Synovial Biopsy Procedure . Annals of the Rheumatic Diseases . vol. 74 , 149 - 150 .

Nayar S, Campos J, Cloake T, Bowman S, Bombardieri M, Pitzalis C, Luther S, Buckley C et al. ( 2015 ) . SAT0005 IL22 Regulates Autoantibody Production by Inducing Lymphoid Chemokine Expression in Tertiary Lymphoid Organs . Annals of the Rheumatic Diseases . vol. 74 , 651 - 651 .

Rivellese F, Suurmond J, Habets K, Dorjée AL, de Paulis A, Marone G, Pitzalis C, Huizinga TW et al. ( 2015 ) . THU0024 Human Mast Cells Stimulated with IL-33 and Immune Complexes Down-Regulate Monocyte Activation in Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 74 , 201 - 201 .

Nerviani A, Humby F, Kelly S, Bombardieri M, Pitzalis C ( 2015 ) . THU0033 A Functional Inhibitory Role for the GAS6/MERTK Axis in Modulating Synovial Inflammation in Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 74 , 204 - 204 .

Romao VC, DiCicco M, Lazarou I, Mahto A, Fonseca JE, Kelly S, Humby F, Pitzalis C ( 2015 ) . THU0116 Higher Ultrasound Synovitis in Elderly-Onset Rheumatoid Arthritis as Compared to Younger-Onset: THE Barts Early Arthritis Cohort . Annals of the Rheumatic Diseases . vol. 74 , 236 - 236 .

Astorri E, Nerviani A, Bombardieri M, Pitzalis C ( 2015 ) . Towards a Stratified Targeted Approach with Biologic Treatments in Rheumatoid Arthritis: Role of Synovial Pathobiology . Current Pharmaceutical Design vol. 21 , ( 17 ) 2216 - 2224 .

( 2015 ) . &lt;inline-formula&gt;&lt;inline-graphic href=\kev046.pdf\ type=\simple\ /&gt;&lt;/inline-formula&gt;Young Investigator Awadr&lt;break /&gt;I32. Synovial Pathotype Predicts Response to TNF-Alpha Inhibitors In Patients With Rheumatoid Arthritis . Rheumatology

( 2015 ) . 109. An Essential Part of the Rheumatologist's Toolkit? An Audit of a Rheumatology Led Ultrasound Guided Synovial Biopsy Service . Rheumatology

( 2015 ) . 229. A Comparison of Clinical and Synovial Immunohistochemical Characteristics between Psoriatic Arthritis and Rheumatoid Arthritis in an Early Arthritis Cohort . Rheumatology

( 2015 ) . O37. The Autoimmune Risk Gene UBE2L3 is Highly Expressed During B Cell Proliferation and is Correlated with Plasmablast and Plasma Cell Expansion in SLE . Rheumatology

Kelly S, Bombardieri M, Humby F, Ng N, Marrelli A, Riahi S, DiCicco M, Mahto A et al. ( 2015 ) . Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early rheumatoid arthritis: An observational study . Arthritis Research and Therapy vol. 17 , ( 1 )

Kelly S, Bombardieri M, Humby F, Ng N, Marrelli A, Riahi S, DiCicco M, Mahto A et al. ( 2015 ) . Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early rheumatoid arthritis: an observational study . Arthritis Research &amp; Therapy vol. 17 , ( 1 ) Article 58 ,

Ferrari M, Onuoha SC, Pitzalis C ( 2015 ) . Trojan horses and guided missiles: targeted therapies in the war on arthritis . Nature Reviews Rheumatology vol. 11 , ( 6 ) 328 - 337 .

Romão VC, DiCicco M, Mahto A, Lazarou I, Fonseca JE, Kelly S, Humby F, Pitzalis C ( 2015 ) . A7.6 Clinical and pathological differences of elderly- and younger-onset rheumatoid arthritis in an early arthritis cohort . Annals of the Rheumatic Diseases . vol. 74 , A76 - A77 .

Ferrari M, Onuoha SC, Sblattero D, Pitzalis C ( 2015 ) . A8.18 Tissue specific pro-drug for the next generation of anti-TNF therapy in rheumatoid arthritis . Annals of the Rheumatic Diseases . vol. 74 , A88 - A89 .

Kelly S, Humby F, Filer A, Ng N, Di Cicco M, Hands RE, Rocher V, Bombardieri M et al. ( 2015 ) . Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients . Annals of the Rheumatic Diseases vol. 74 , ( 3 ) 611 - 617 .

Sin W, Tan G, Di Cicco M, Mahto A, Lazarou I, Hands R, Kelly S, Pitzalis C ( 2015 ) . A COMPARISON OF CLINICAL AND SYNOVIAL IMMUNOHISTOCHEMICAL CHARACTERISTICS BETWEEN PSORIATIC ARTHRITIS AND RHEUMATOID ARTHRITIS IN AN EARLY ARTHRITIS COHORT . RHEUMATOLOGY . vol. 54 , 138 - 138 .

Mahto A, Lazarou I, Ng N, DiCicco M, Tan G, Humby F, Pitzalis C, Kelly S ( 2015 ) . AN ESSENTIAL PART OF THE RHEUMATOLOGIST'S TOOLKIT? AN AUDIT OF A RHEUMATOLOGY LED ULTRASOUND GUIDED SYNOVIAL BIOPSY SERVICE . RHEUMATOLOGY . vol. 54 , 93 - 94 .

Nayar S, Campos J, Cloake T, Bowman S, Bombardieri M, Pitzalis C, Luther S, Buckley C et al. ( 2015 ) . IL22 Regulates Autoantibody Production by Inducing Lymphoid Chemokine Expression in Tertiary Lymphoid Organs . SCANDINAVIAN JOURNAL OF IMMUNOLOGY . vol. 81 , 425 - 425 .

Murray-Brown W, Carlotti E, Tappuni A, Sutcliffe N, Pitzalis C, Bombardieri M ( 2015 ) . Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjogren's Syndrome . ARTHRITIS & RHEUMATOLOGY vol. 67 ,

Bowman S, Everett C, Bombardieri M, Busch R, Emery P, Hall F, Pease CT, Pitzalis C et al. ( 2015 ) . Preliminary Results of a Double-Blind Randomised Trial of Rituximab Anti-B-Cell Therapy in Patients with Primary Sjogrens Syndrome . ARTHRITIS & RHEUMATOLOGY vol. 67 ,

Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Lazarou I, Hands RE, Rocher V et al. ( 2015 ) . SYNOVIAL PATHOTYPE PREDICTS RESPONSE TO TNF-ALPHA INHIBITORS IN PATIENTS WITH RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 54 , 6 - 6 .

DiCicco M, Humby F, Kelly S, Hands R, Ng N, Mahto A, Lazarou I, Rocher V et al. ( 2015 ) . Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease at 12 Months: Results from the Pathobiology of Early Arthritis Cohort . ARTHRITIS & RHEUMATOLOGY vol. 67 ,

Romao VC, Pitzalis C ( 2015 ) . Synovial heterogeneity in rheumatoid arthritis: the key for rational patient stratification? . ACTA REUMATOLOGICA PORTUGUESA vol. 40 , ( 1 ) 6 - 8 .

Shields AM, Vyse S, Walczak H, Lehner PH, Pitzalis C, Spector TD, Vyse TJ, Lewis MJ ( 2015 ) . THE AUTOIMMUNE RISK GENE UBE2L3 IS HIGHLY EXPRESSED DURING B CELL PROLIFERATION AND IS CORRELATED WITH PLASMABLAST AND PLASMA CELL EXPANSION IN SLE . RHEUMATOLOGY . vol. 54 , 41 - 41 .

Corsiero E, Carlotti E, Pitzalis C, Bombardieri M ( 2015 ) . The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETs)-Citrullinated Autoantigens of RA Synovial Monoclonal Antibodies . ARTHRITIS & RHEUMATOLOGY vol. 67 ,

Corsiero E, Sutcliffe N, Pitzalis C, Bombardieri M ( 2014 ) . Accumulation of Self-Reactive Naïve and Memory B Cell Reveals Sequential Defects in B Cell Tolerance Checkpoints in Sjögren’s Syndrome . PLoS ONE vol. 9 , ( 12 ) e114575 - e114575 .

El Shikh ME, Kmieciak M, Manjili MH, Szakal AK, Pitzalis C, Tew JG ( 2014 ) . Multi-therapeutic potential of autoantibodies induced by immune complexes trapped on follicular dendritic cells . Human Vaccines &amp; Immunotherapeutics vol. 9 , ( 11 ) 2434 - 2444 .

Lendrem D, Mitchell S, McMeekin P, Gompels L, Hackett K, Bowman S, Price E, Pease CT et al. ( 2014 ) . Do the EULAR Sjogren's syndrome outcome measures correlate with health status in primary Sjogren's syndrome? . Rheumatology vol. 54 , ( 4 ) 655 - 659 .

Genovese MC, Fleischmann R, Furst D, Janssen N, Carter J, Dasgupta B, Bryson J, Duncan B et al. ( 2014 ) . Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study . Annals of the Rheumatic Diseases vol. 73 , ( 9 ) 1607 - 1615 .

Croia C, Astorri E, Murray‐Brown W, Willis A, Brokstad KA, Sutcliffe N, Piper K, Jonsson R et al. ( 2014 ) . Implication of Epstein‐Barr Virus Infection in Disease‐Specific Autoreactive B Cell Activation in Ectopic Lymphoid Structures of Sjögren's Syndrome . Arthritis &amp; Rheumatology vol. 66 , ( 9 ) 2545 - 2557 .

Pitzalis C ( 2014 ) . Pathogenesis of rheumatoid arthritis: from systemic autoimmunity to localised joint disease . Drug Discovery Today vol. 19 , ( 8 ) 1152 - 1154 .

Corsiero E, Pitzalis C, Bombardieri M ( 2014 ) . Peripheral and synovial mechanisms of humoral autoimmunity in rheumatoid arthritis . Drug Discovery Today vol. 19 , ( 8 ) 1161 - 1165 .

Ahmed TJ, Kaneva MK, Pitzalis C, Cooper D, Perretti M ( 2014 ) . Resolution of inflammation: examples of peptidergic players and pathways . Drug Discovery Today vol. 19 , ( 8 ) 1166 - 1171 .

Lendrem D, Mitchell S, McMeekin P, Bowman S, Price E, T Pease C, Emery P, Andrews J et al. ( 2014 ) . Health-related utility values of patients with primary Sjögren's syndrome and its predictors . Annals of the Rheumatic Diseases vol. 73 , ( 7 ) 1362 - 1368 .

Pitzalis C, Jones GW, Bombardieri M, Jones SA ( 2014 ) . Ectopic lymphoid-like structures in infection, cancer and autoimmunity . Nature Reviews Immunology vol. 14 , ( 7 ) 447 - 462 .

Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Hands R, Rocher V, Bombardieri M et al. ( 2014 ) . AB0132 Presence of Synovial Lymphocyte Aggregates Correlates with A More Severe Clinical Phenotype in Patients with Early Inflammatory Arthritis . Annals of the Rheumatic Diseases . vol. 73 , 847 - 847 .

Di Cicco M, Humby FC, Kelly S, Ng N, Mahto A, Hands R, Rocher V, Zou L et al. ( 2014 ) . FRI0020 Presence of Synovial Lymphocyte Aggregates Predicts Clinical Response to DMARD Therapy in Patients with Early Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 73 , 388 - 388 .

Lazarou I, Zou L, Mahto A, Di Cicco M, Ng N, Humby F, Pitzalis C, Kelly S ( 2014 ) . FRI0243 Ultrasound-Guided Synovial Biopsy Does not Alter Subsequent Ultrasound Assessments . Annals of the Rheumatic Diseases . vol. 73 , 471 - 471 .

Mahto A, Humby F, Ng N, DiCicco M, Rocher V, Lazarou I, Hands R, Gregoriadou S et al. ( 2014 ) . OP0032 Baseline Synovial B-Cell Status Predicts Response to Rituximab Therapy in RA . Annals of the Rheumatic Diseases . vol. 73 , 72 - 72 .

Ng N, Kelly S, Humby F, DiCicco M, Rocher V, Hands R, Bombardieri M, Pitzalis C ( 2014 ) . OP0054 Ultrasound Synovitis Reflects Synovial Inflammation at A Histopathological Level . Annals of the Rheumatic Diseases . vol. 73 , 81 - 81 .

Corsiero E, Carlotti E, Pratesi F, Wardemann H, Robinson W, Migliorini P, Pitzalis C, Bombardieri M ( 2014 ) . OP0266 Monoclonal Antibodies Derived from Single CD19+ Synovial B Cells of RA Patients with Tertiary Lymphoid Structures Display Preferential Immunoreactivity towards Citrullinated Proteins of Nets . Annals of the Rheumatic Diseases . vol. 73 , 162 - 162 .

Di Cicco M, Kelly S, Humby F, Ng N, Nerviani A, Rocher V, Hands R, Bombardieri M et al. ( 2014 ) . SAT0048 Synovial Lymphocytic Aggregates Predict Clinical Response to Certolizumab Pegol in Rheumatoid Arthritis (Clinical and Pathological Response to Certolizumab-Pegol (Clip-Cert) Study) . Annals of the Rheumatic Diseases . vol. 73 , 606 - 607 .

Astorri E, Tappuni A, Sutcliffe N, Richards P, Pitzalis C, Bombardieri M ( 2014 ) . THU0008 A Negative High-Resolution Salivary Gland Ultrasound is Highly Predictive of Negative Labial Gland Biopsy in Patients with SICCA Symptoms . Annals of the Rheumatic Diseases . vol. 73 , 179 - 179 .

Bugatti S, Manzo A, Vitolo B, Benaglio F, Binda E, Scarabelli M, Humby F, Caporali R et al. ( 2014 ) . High expression levels of the B cell chemoattractant CXCL13 in rheumatoid synovium are a marker of severe disease . Rheumatology vol. 53 , ( 10 ) 1886 - 1895 .

Juarez M, Toms TE, de Pablo P, Mitchell S, Bowman S, Nightingale P, Price EJ, Griffiths B et al. ( 2014 ) . Cardiovascular Risk Factors in Women With Primary Sjögren's Syndrome: United Kingdom Primary Sjögren's Syndrome Registry Results . Arthritis Care &amp; Research vol. 66 , ( 5 ) 757 - 764 .

Helliwell PS, Kavanaugh A ( 2014 ) . Comparison of Composite Measures of Disease Activity in Psoriatic Arthritis Using Data From an Interventional Study With Golimumab . Arthritis Care &amp; Research vol. 66 , ( 5 ) 749 - 756 .

James K, Lendrem D, Mitchell S, Hindmarsh V, Bowman S, Price EJ, Pease CT, Emery P et al. ( 2014 ) . 205. The UK Primary Sjögren’s Syndrome Registry (UKPSSR): A Valuable Resource for Future Sjögren’s Syndrom Research . Rheumatology vol. 53 , ( suppl_1 ) i136 - i136 .

Di Cicco M, Kelly S, Humby F, Ng N, Hands RE, Rocher V, Nerviani A, Zou L et al. ( 2014 ) . 101. Synovial Ectopic Lymphoneogenesis Predicts Primary Clinical Response to Certolizumab Pegol in Patients with Rheumatoid Arthritis . Rheumatology vol. 53 , ( suppl_1 ) i95 - i95 .

Mahto A, Ng N, DiCicco M, Rocher V, Hands R, Kelly S, Humby F, Pitzalis C ( 2014 ) . 107. Synovial B-Cells Predict Response/Resistance to Rituximab Therapy in Rheumatoid Arthritis: Preliminary Results from a Pilot Study . Rheumatology vol. 53 , ( suppl_1 ) i98 - i98 .

Ng N, Humby F, Di Cicco M, Deidda S, Mahto A, Pyne D, Kidd B, Bombardieri M et al. ( 2014 ) . 124. Ultrasound-Guided Diagnostic Synovial Biopsies: An Audit of a Rheumatology-Led Service . Rheumatology vol. 53 , ( suppl_1 ) i105 - i106 .

Al-Mousawi AZ, El Shikh MEM, Pitzalis C ( 2014 ) . 76. Immune Complex Retention by Synovial Fibroblasts in Rheumatoid Arthritis . Rheumatology vol. 53 , ( suppl_1 ) i84 - i84 .

Ahmed TJ, Perretti M, Pitzalis C ( 2014 ) . 81. Translational Medicine in Rheumatoid Arthritis: Exploiting Melanocortin Receptors . Rheumatology vol. 53 , ( suppl_1 ) i85 - i86 .

Pitzalis C ( 2014 ) . I104. From the Disease Tissue to the Whole Patient: The Role of Pathobiology in Patient Stratification . Rheumatology vol. 53 , ( suppl_1 ) i22 - i23 .

Ng N, Kelly S, Humby F, Di Cicco M, Rocher V, Hands RE, Bombardieri M, Pitzalis C ( 2014 ) . O37. Ultrasound Measures of Synovitis Reflects Histological Synovial Inflammation in Early Arthritis Patients . Rheumatology vol. 53 , ( suppl_1 ) i45 - i45 .

Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Hands RE, Rocher V, Buckley C et al. ( 2014 ) . O44. Presence of Synovial Lymphocyte Aggregates Correlates with a More Severe Clinical Phenotype in Patients with Early Inflammatory Arthritis . Rheumatology vol. 53 , ( suppl_1 ) i48 - i48 .

Headland S, Norling L, Patel H, Dalli J, Kelly S, Pitzalis C, Dell'Accio F, Perretti M ( 2014 ) . A novel mechanism for protecting the arthritic joint: microparticles deliver Annexin A1 into cartilage (146.8) . The FASEB Journal . vol. 28 ,

Nalesso G, Thomas BL, Sherwood J, Schett G, Dale L, Addimanda O, Eltawil N, Pitzalis C et al. ( 2014 ) . Wnt16 is induced by oxidative stress following cartilage injury and contributes to cartilage homeostasis in osteoarthritis . Osteoarthritis and Cartilage . vol. 22 , S8 - S9 .

Thomas BL, Nalesso G, Sherwood J, Bertrand J, Achan P, Pitzalis C, Dell’Accio F ( 2014 ) . Wnt16 supports the phenotype of the superficial zone cells in cartilage . Osteoarthritis and Cartilage . vol. 22 , S160 - S160 .

Kam NW, Brentano F, Kyburz D, Gay S, Filer A, Buckley C, Pitzalis C, Bombardieri M ( 2014 ) . A1.12 Endogenous SLPI released by rheumatoid synovial fibroblasts control BAFF-dependent-B cell activation in vitro and in the CIA and RA/SCID-arthritis models . Annals of the Rheumatic Diseases vol. 73 , A5 - A5 .

Corsiero E, Carlotti E, Wardemann H, Robinson W, Migliorini P, Pratesi F, Pitzalis C, Bombardieri M ( 2014 ) . A1.31 Monoclonal antibodies from CD19+ synovial B cells of RA patients with tertiary lymphoid structures display a strong immunoreactivity towards citrullinated histones from neutrophils NETs . Annals of the Rheumatic Diseases . vol. 73 , A13 - A13 .

Ferrari M, Onuoha S, Sblattero D, Pitzalis C ( 2014 ) . A1.54 Development of a novel bispecific therapeutic for rheumatoid arthritis . Annals of the Rheumatic Diseases . vol. 73 , A23 - A23 .

Lucchesi D, Pitzalis C, Bombardieri M ( 2014 ) . EBV and other viruses as triggers of tertiary lymphoid structures in primary Sjögren’s syndrome . Expert Review of Clinical Immunology vol. 10 , ( 4 ) 445 - 455 .

Brown S, Navarro Coy N, Pitzalis C, Emery P, Pavitt S, Gray J, Hulme C, Hall F et al. ( 2014 ) . The TRACTISS Protocol: a randomised double blind placebo controlled clinical TRial of Anti-B-Cell Therapy In patients with primary Sjögren’s Syndrome . BMC Musculoskeletal Disorders vol. 15 , ( 1 ) Article 21 ,

Eldridge S, Vicente-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P, Dell'Accio F ( 2014 ) . Agrin expression is downregulated in OA and is required for chondrocyte differentiation . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 95 , A8 - A9 .

Corsiero E, Bombardieri M, Carlotti E, Pratesi F, Robinson W, Migliorini P, Pitzalis C ( 2014 ) . Citrullinated histones from neutrophil extracellular traps (NETs) fuel ectopic germinal centre responses and ACPA production in rheumatoid joints . IMMUNOLOGY vol. 143 , 43 - 43 .

Pitzalis C ( 2014 ) . FROM THE DISEASE TISSUE TO THE WHOLE PATIENT: THE ROLE OF PATHOBIOLOGY IN PATIENT STRATIFICATION . RHEUMATOLOGY . vol. 53 , 22 - 23 .

Haas R, Smith J, Rocher-Ros V, Montero-Melendez T, D'Acquisto F, Bland EJ, Bombardieri M, Pitzalis C et al. ( 2014 ) . How the microenvironment contributes to the establishment of chronic inflammatory diseases: lactate regulates metabolic and pro-inflammatory circuits in control of T cell migration and functions . IMMUNOLOGY vol. 143 , 151 - 151 .

Al-Mousawi AZ, El Shikh MEM, Pitzalis C ( 2014 ) . IMMUNE COMPLEX RETENTION BY SYNOVIAL FIBROBLASTS IN RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 53 , 84 - 84 .

Lucchesi D, Pontarini E, Pitzalis C, Bombardieri M ( 2014 ) . Innate immune system early activation precedes the formation of functional tertiary lymphoid structures in a novel model of salivary gland ectopic lymphoid neogenesis . IMMUNOLOGY vol. 143 , 95 - 95 .

Di Cicco M, Humby F, Kelly S, Ng N, Mahto A, Hands RE, Rocher V, Buckley C et al. ( 2014 ) . PRESENCE OF SYNOVIAL LYMPHOCYTE AGGREGATES CORRELATES WITH A MORE SEVERE CLINICAL PHENOTYPE IN PATIENTS WITH EARLY INFLAMMATORY ARTHRITIS . RHEUMATOLOGY . vol. 53 , 48 - 48 .

Mahto A, Ng N, DiCicco M, Rocher V, Hands R, Kelly S, Humby F, Pitzalis C ( 2014 ) . SYNOVIAL B-CELLS PREDICT RESPONSE/RESISTANCE TO RITUXIMAB THERAPY IN RHEUMATOID ARTHRITIS: PRELIMINARY RESULTS FROM A PILOT STUDY . RHEUMATOLOGY . vol. 53 , 98 - 98 .

Di Cicco M, Kelly S, Humby F, Ng N, Hands RE, Rocher V, Nerviani A, Zou L et al. ( 2014 ) . SYNOVIAL ECTOPIC LYMPHONEOGENESIS PREDICTS PRIMARY CLINICAL RESPONSE TO CERTOLIZUMAB PEGOL IN PATIENTS WITH RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 53 , 95 - 95 .

James K, Lendrem D, Mitchell S, Hindmarsh V, Bowman S, Price EJ, Pease CT, Emery P et al. ( 2014 ) . THE UK PRIMARY SJOGREN'S SYNDROME REGISTRY (UKPSSR): A VALUABLE RESOURCE FOR FUTURE SJOGREN'S SYNDROM RESEARCH . RHEUMATOLOGY . vol. 53 , 136 - 136 .

Ahmed TJ, Perretti M, Pitzalis C ( 2014 ) . TRANSLATIONAL MEDICINE IN RHEUMATOID ARTHRITIS: EXPLOITING MELANOCORTIN RECEPTORS . RHEUMATOLOGY . vol. 53 , 85 - 86 .

Nalesso G, Thomas B, Wagner K, Bertrand J, Sherwood J, Eldridge S, Pap T, Achan P et al. ( 2014 ) . The WNT/CaMKII pathway is activated in human and experimental osteoarthritis and promotes chondrocyte de-differentiation . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 95 , A25 - A26 .

Ng N, Kelly S, Humby F, Di Cicco M, Rocher V, Hands RE, Bombardieri M, Pitzalis C ( 2014 ) . ULTRASOUND MEASURES OF SYNOVITIS REFLECTS HISTOLOGICAL SYNOVIAL INFLAMMATION IN EARLY ARTHRITIS PATIENTS . RHEUMATOLOGY . vol. 53 , 45 - 45 .

Ng N, Humby F, Di Cicco M, Deidda S, Mahto A, Pyne D, Kidd B, Bombardieri M et al. ( 2014 ) . ULTRASOUND-GUIDED DIAGNOSTIC SYNOVIAL BIOPSIES: AN AUDIT OF A RHEUMATOLOGY-LED SERVICE . RHEUMATOLOGY . vol. 53 , 105 - 106 .

Ng N, Kelly S, Humby F, DiCicco M, Rocher V, Hands R, Bombardieri M, Pitzalis C ( 2014 ) . Ultrasound Synovitis Reflects Synovial Inflammation at a Histopathological Level . ARTHRITIS & RHEUMATOLOGY vol. 66 , S400 - S400 .

Nordmark G, Wang C, Vasaitis L, Eriksson P, Theander E, Kvarnström M, Forsblad‐d'Elia H, Jazebi H et al. ( 2013 ) . Association of Genes in the <scp>NF</scp>‐κB Pathway with Antibody‐Positive Primary Sjögren's Syndrome . Scandinavian Journal of Immunology vol. 78 , ( 5 ) 447 - 454 .

Jones GW, Bombardieri M, Greenhill CJ, McLeod L, Rocher V, Williams AS, Pitzalis C, Jenkins BJ et al. ( 2013 ) . 134 . Cytokine . vol. 63 , 274 - 274 .

Croia C, Serafini B, Bombardieri M, Kelly S, Humby F, Severa M, Rizzo F, Coccia EM et al. ( 2013 ) . Epstein–Barr virus persistence and infection of autoreactive plasma cells in synovial lymphoid structures in rheumatoid arthritis . Annals of the Rheumatic Diseases vol. 72 , ( 9 ) 1559 - 1568 .

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . AB0022 Accumulation of circulating autoreactive naïve b cells reveal defects of early b cell tolerance checkpoints in patients with sjögren's syndrome . Annals of the Rheumatic Diseases vol. 72 , A792 - A792 .

Ng N, Humby F, Kelly S, Di Cicco M, Dadoun S, Bombardieri M, Hands R, Rocher V et al. ( 2013 ) . AB0247 Rheumatoid arthritis patient characteristics at different therapeutic timepoints . Annals of the Rheumatic Diseases vol. 72 , A862 - A862 .

Ng N, Di Cicco M, Humby F, Deidda S, Pyne D, Kidd B, Sutcliffe N, Jawad A et al. ( 2013 ) . AB0742 Minimally invasive ultrasound guided synovial biopsy as a clinical diagnostic tool . Annals of the Rheumatic Diseases vol. 72 , A1015 - A1016 .

Croia C, Serafini B, Tappuni A, Aloisi F, Sutcliffe N, Pitzalis C, Bombardieri M ( 2013 ) . FRI0259 Ectopic lymphoid structures support epstein-barr virus persistence and autoreactive plasma cell infection in sjogren's syndrome salivary glands . Annals of the Rheumatic Diseases vol. 72 , A462 - A462 .

Ng W-F, Miller A, Bowman S, Price E, Kitas G, Pease C, Emery P, Lanyon P et al. ( 2013 ) . FRI0323 Level of physical activity in primary sjögren's syndrome and its predictors . Annals of the Rheumatic Diseases vol. 72 , A483 - A484 .

Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Pitzalis C, Bombardieri M ( 2013 ) . OP0080 Lesional IL-21 Expression Correlates with Functional Germinal Center Formation and T Follicular Helper Cell Infiltration in the Salivary Glands of Sjögren's Syndrome . Annals of the Rheumatic Diseases vol. 72 , A77 - A77 .

Nayar S, Cloake T, Lane P, Pitzalis C, Coles M, Luther S, Buckley C, Barone F ( 2013 ) . OP0258 IL-22 Regulates Lymphoid Stromal Cell Expansion, Development of Germinal Centers and Humoral Response in Mucosal Ectopic Lymphoneogenesis . Annals of the Rheumatic Diseases vol. 72 , A140 - A140 .

Bombardieri M, Rocher V, Mittereder N, Carlesso G, Herbst R, Sleeman M, Pitzalis C ( 2013 ) . OP0303 Mavrilimumab Reduces Pro-Inflammatory Cytokines and CD68 Positive Macrophages in Synovial Explants from Rheumatoid Arthritis Subjects Engrafted Into SCID/Beige Mice . Annals of the Rheumatic Diseases vol. 72 , A156 - A157 .

Deidda S, Humby F, Kelly S, Di Cicco M, Ng N, Hands R, Bombardieri M, Pitzalis C ( 2013 ) . SAT0014 Synovial Sublining Macrophages: A Sensitive Biomarker for Response to Treatment in Early RA Patients . Annals of the Rheumatic Diseases vol. 72 , A583 - A584 .

Di Cicco M, Dadoun S, Humby F, Kelly S, Ng N, Hands RE, Buckley C, McInnes I et al. ( 2013 ) . THU0087 Synovial Ectopic Lymphoid-like Structures are Associated with Diagnosis of Rheumatoid Arthritis, Disease Activity and Antibody Status in Early Arthritis Patients . Annals of the Rheumatic Diseases vol. 72 , A192 - A192 .

Pitzalis C, Kelly S, Humby F ( 2013 ) . New learnings on the pathophysiology of RA from synovial biopsies . Current Opinion in Rheumatology vol. 25 , ( 3 ) 334 - 344 .

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . ACCUMULATION OF CIRCULATING AUTOREACTIVE NAIVE B CELLS REVEALS DEFECTS OF EARLY B-CELL TOLERANCE CHECKPOINTS IN PATIENTS WITH SJOGREN'S SYNDROME . RHEUMATOLOGY . vol. 52 , 159 - 159 .

Patel HB, Bombardieri M, Pitzalis C, Perretti M ( 2013 ) . Activation of Melanocortin Receptor 3 as a new strategy to control experimental and rheumatoid arthritis . The FASEB Journal . vol. 27 ,

Eldridge S, Vicent-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P, Dell'Accio F ( 2013 ) . Agrin expression is downregulated in OA and is required for chondrocyte differentiation . Osteoarthritis and Cartilage vol. 21 , S112 - S113 .

Ng N, Humby F, Bombardieri M, Kelly S, Di Cicco M, Dadoun S, Hands R, Rocher V et al. ( 2013 ) . CLINICAL, IMAGING AND HISTOLOGICAL CHARACTERISTICS OF PATIENTS WITH RHEUMATOID ARTHRITIS AT DIFFERENT STAGES OF DISEASE PROGRESSION . RHEUMATOLOGY . vol. 52 , 71 - 71 .

Kam NW, Filter A, Buckley C, Pitzalis C, Bombardieri M ( 2013 ) . MEMBRANE-BOUND AND SOLUBLE BAFF EXPRESSION BY HUMAN RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTES IN RESPONSE TO TLR STIMULATION . RHEUMATOLOGY . vol. 52 , 80 - 80 .

Di Cicco M, Humby F, Kelly S, Ng N, Hands R, Dadoun S, Buckley C, McInnes IB et al. ( 2013 ) . SYNOVIAL LYMPHOCYTE AGGREGATES IN EARLY INFLAMMATORY ARTHRITIS: CORRELATION WITH DIAGNOSIS, DISEASE ACTIVITY AND ANTIBODY STATUS . RHEUMATOLOGY . vol. 52 , 29 - 29 .

Sherwood J, Bertrand J, Nalesso G, Achan P, Pitzalis C, Pap T, Dell'Accio F ( 2013 ) . The role of CXCR2 signaling in articular cartilage homeostasis . Osteoarthritis and Cartilage . vol. 21 , S19 - S20 .

Nalesso G, Thomas BL, Eldridge SE, Wagner K, Sherwood J, Bertrand J, Pap T, Pitzalis C et al. ( 2013 ) . Wnt5a/CaMKII pathway is activated in osteoarthritis and promotes loss of chondrocyte phenotype . Osteoarthritis and Cartilage . vol. 21 , S226 - S226 .

Kam NW, Filer A, Buckley C, Bombardieri M, Pitzalis C ( 2013 ) . A5.22 Membrane-Bound and Soluble Baff Expression by Human Rheumatoid Fibroblast-Like Synoviocytes in Response to TLR Stimulation . Annals of the Rheumatic Diseases . vol. 72 , A38 - A38 .

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . A5.2 Accumulation of Circulating Autoreactive Naïve B Cells Reveal Defects of Early B Cell Tolerance Checkpoints in Patients with Sjögren's Syndrome . Annals of the Rheumatic Diseases . vol. 72 , A30 - A31 .

Lucchesi D, Bombardieri M, Barone F, Nayar S, Proctor G, Buckley CD, Pitzalis C ( 2013 ) . A6.2 Inducible Tertiary Lymphoid Structures and Autoimmunity in a Novel model of Sialoadenitis in Wild-Type Mice . Annals of the Rheumatic Diseases . vol. 72 , A42 - A42 .

Croia C, Serafini B, Bombardieri M, Kelly S, Humby F, Severa M, Rizzo F, Coccia EM et al. ( 2013 ) . A6.5 Synovial Lymphoid Structures Support Epstein-Barr Virus Persistence and Autoreactive Plasma Cell Infection in Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 72 , A43 - A44 .

Sherwood J, Bertrand J, Nalesso G, Achan P, Pitzalis C, Pap T, Dell'Accio F ( 2013 ) . A8.17 The Role of CXCR2 Signalling in Articular Cartilage Homeostasis . Annals of the Rheumatic Diseases . vol. 72 , A63 - A64 .

Tarn JR, Natasari A, Mitchell S, Bowman S, Price E, Pease C, Emery P, Andrews J et al. ( 2013 ) . Soluble molecule profiling and network analysis of primary Sjögren's Syndrome patient serum . BMC Musculoskeletal Disorders vol. 14 , ( S1 ) Article A2 ,

Sherwood J, Nalesso G, Bertrand J, Brandolini L, Achan P, Pitzalis C, Pap T, Dell'Accio F ( 2013 ) . A homoeostatic role for ELR plus CXC chemokine signalling in articular and epiphyseal cartilage . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 94 , A7 - A8 .

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . ACCUMULATION OF CIRCULATING AUTOREACTIVE NAIVE B CELLS REVEAL DEFECTS OF EARLY B CELL TOLERANCE CHECKPOINTS IN PATIENTS WITH SJOGREN'S SYNDROME . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 792 - 792 .

Ahmed TJ, Montero-Melendez T, Perretti M, Pitzalis C ( 2013 ) . Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides . International Journal of Inflammation vol. 2013 , 1 - 10 .

Ferrari M, Onuoha S, Kamalati T, Sblattero D, Pitzalis C ( 2013 ) . Development Of a Novel Bispecific Therapeutic For Arthritic Diseases . ARTHRITIS AND RHEUMATISM . vol. 65 , S218 - S218 .

Croia C, Serafini B, Tappuni A, Aloisi F, Sutcliffe N, Pitzalis C, Bombardieri M ( 2013 ) . ECTOPIC LYMPHOID STRUCTURES SUPPORT EPSTEIN-BARR VIRUS PERSISTENCE AND AUTOREACTIVE PLASMA CELL INFECTION IN SJOGREN'S SYNDROME SALIVARY GLANDS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 462 - 462 .

Nayar S, Cloake T, Lane P, Pitzalis C, Coles M, Luther S, Buckley C, Barone F ( 2013 ) . IL-22 REGULATES LYMPHOID STROMAL CELL EXPANSION, DEVELOPMENT OF GERMINAL CENTERS AND HUMORAL RESPONSE IN MUCOSAL ECTOPIC LYMPHONEOGENESIS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 140 - 140 .

Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Pitzalis C, Bombardieri M ( 2013 ) . LESIONAL IL-21 EXPRESSION CORRELATES WITH FUNCTIONAL GERMINAL CENTER FORMATION AND T FOLLICULAR HELPER CELL INFILTRATION IN THE SALIVARY GLANDS OF SJOGREN'S SYNDROME . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 77 - 77 .

Ng W-F, Miller A, Bowman S, Price E, Kitas G, Pease C, Emery P, Lanyon P et al. ( 2013 ) . LEVEL OF PHYSICAL ACTIVITY IN PRIMARY SJOGREN'S SYNDROME AND ITS PREDICTORS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 483 - 484 .

Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Pitzalis C, Bombardieri M ( 2013 ) . Lesional Intereukin-21 Expression Correlates With Functional Germinal Center Formation and T Follicular Helper Cell Infiltration In The Salivary Glands Of Sjogren's Syndrome . ARTHRITIS AND RHEUMATISM . vol. 65 , S634 - S634 .

Bombardieri M, Rocher V, Mittereder N, Carlesso G, Herbst R, Sleeman M, Pitzalis C ( 2013 ) . MAVRILIMUMAB REDUCES PRO-INFLAMMATORY CYTOKINES AND CD68 POSITIVE MACROPHAGES IN SYNOVIAL EXPLANTS FROM RHEUMATOID ARTHRITIS SUBJECTS ENGRAFTED INTO SCID/BEIGE MICE . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 156 - 157 .

Ng N, Di Cicco M, Humby F, Deidda S, Pyne D, Kidd B, Sutcliffe N, Jawad A et al. ( 2013 ) . MINIMALLY INVASIVE ULTRASOUND GUIDED SYNOVIAL BIOPSY AS A CLINICAL DIAGNOSTIC TOOL . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 1015 - 1016 .

Ng N, Humby F, Kelly S, Di Cicco M, Dadoun S, Bombardieri M, Hands R, Rocher V et al. ( 2013 ) . RHEUMATOID ARTHRITIS PATIENT CHARACTERISTICS AT DIFFERENT THERAPEUTIC TIMEPOINTS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 862 - 862 .

Corsiero E, Bombardieri M, Carlotti E, Wardemann H, Robinson WH, Pitzalis C ( 2013 ) . Recombinant Monoclonal Antibodies Derived From Single CD19+Synovial B Cells Of RA Patients With Tertiary Lymphoid Structures Display a Strong Immunoreactivity Towards Citrullinated Histones . ARTHRITIS AND RHEUMATISM . vol. 65 , S1127 - S1128 .

Di Cicco M, Dadoun S, Humby F, Kelly S, Ng N, Hands RE, Buckley C, McInnes I et al. ( 2013 ) . SYNOVIAL ECTOPIC LYMPHOID-LIKE STRUCTURES ARE ASSOCIATED WITH DIAGNOSIS OF RHEUMATOID ARTHRITIS, DISEASE ACTIVITY AND ANTIBODY STATUS IN EARLY ARTHRITIS PATIENTS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 192 - 192 .

Deidda S, Humby F, Kelly S, Di Cicco M, Ng N, Hands R, Bombardieri M, Pitzalis C ( 2013 ) . SYNOVIAL SUBLINING MACROPHAGES: A SENSITIVE BIOMARKER FOR RESPONSE TO TREATMENT IN EARLY RA PATIENTS . ANNALS OF THE RHEUMATIC DISEASES vol. 72 , 583 - 584 .

Kam YNW, Filer A, Buckley CD, Pitzalis C, Bombardieri M ( 2013 ) . Secretory Leukocyte Protease Inhibitor Released By Rheumatoid Synovial Fibroblasts Exerts a Negative Control Of BAFF-Dependent B Cell Activation In Vitro and In Vivo In The Collagen-Induced and Chimeric RA/SCID Arthritis Models . ARTHRITIS AND RHEUMATISM . vol. 65 , S1029 - S1029 .

Di Cicco M, Kelly S, Humby F, Ng N, Dadoun S, Hands R, Rocher V, Nerviani A et al. ( 2013 ) . Synovial Ectopic Lymphoneogenesis Predicts Clinical Response To Certolizumab Pegol In Patients With Rheumatoid Arthritis . ARTHRITIS AND RHEUMATISM . vol. 65 , S556 - S556 .

Wythe SE, DiCara D, Taher TEI, Finucane CM, Jones R, Bombardieri M, Man YKS, Nissim A et al. ( 2013 ) . Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide . Annals of the Rheumatic Diseases vol. 72 , ( 1 ) 129 - 135 .

Newton JL, Frith J, Powell D, Hackett K, Wilton K, Bowman S, Price E, Pease C et al. ( 2012 ) . Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjögren's syndrome . Annals of the Rheumatic Diseases vol. 71 , ( 12 ) 1973 - 1979 .

Patel HB, Kornerup KN, Sampaio ALF, D'Acquisto F, Seed MP, Girol AP, Gray M, Pitzalis C et al. ( 2012 ) . The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis . Annals of the Rheumatic Diseases vol. 71 , ( 11 ) 1872 - 1880 .

Pitzalis C, Veale D, Dayer J-M ( 2012 ) . Introduction to “Synovitis – an inflammation of joints destroying the bone” . Swiss Medical Weekly vol. 142 , ( 4142 ) w13712 - w13712 .

SCHEINBERG M, FILIPPI RZ, HANDS R, PITZALIS C ( 2012 ) . Failure to Control Progression of Rheumatoid Arthritis After a Decade of Biologic Therapy . The Journal of Rheumatology vol. 39 , ( 10 ) 2049 - 2050 .

Bombardieri M, Barone F, Lucchesi D, Nayar S, van den Berg WB, Proctor G, Buckley CD, Pitzalis C ( 2012 ) . Inducible Tertiary Lymphoid Structures, Autoimmunity, and Exocrine Dysfunction in a Novel Model of Salivary Gland Inflammation in C57BL/6 Mice . The Journal of Immunology vol. 189 , ( 7 ) 3767 - 3776 .

Seymour MW, Kelly S, Beals CR, Malice M-P, Bolognese JA, Dardzinski BJ, Cheng AS, Cummings CE et al. ( 2012 ) . Ultrasound of metacarpophalangeal joints is a sensitive and reliable endpoint for drug therapies in rheumatoid arthritis: results of a randomized, two-center placebo-controlled study . Arthritis Research &amp; Therapy vol. 14 , ( 5 ) Article R198 ,

Macor P, Durigutto P, De Maso L, Garrovo C, Biffi S, Cortini A, Fischetti F, Sblattero D et al. ( 2012 ) . Treatment of experimental arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5 . Arthritis &amp; Rheumatism vol. 64 , ( 8 ) 2559 - 2567 .

Bombardieri M, Pitzalis C ( 2012 ) . Ectopic Lymphoid Neogenesis and Lymphoid Chemokines in Sjogren’s Syndrome: At the Interplay between Chronic Inflammation, Autoimmunity and Lymphomagenesis . Current Pharmaceutical Biotechnology vol. 13 , ( 10 ) 1989 - 1996 .

Corsiero E, Bombardieri M, Manzo A, Bugatti S, Uguccioni M, Pitzalis C ( 2012 ) . Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases . Immunology Letters vol. 145 , ( 1-2 ) 62 - 67 .

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2012 ) . AB0044 Analysis of recombinant monoclonal antibodies from single B cells reveals early defects of B cell tolerance checkpoints in patients with sjÖgren's syndrome . Annals of the Rheumatic Diseases vol. 71 , 640 - 640 .

Kam NW, Bombardieri M, Filter A, Buckley C, Pitzalis C ( 2012 ) . AB0099 Aberrant basal and TLR-stimulated expression of TSLP in rheumatoid synovial fibroblasts . Annals of the Rheumatic Diseases vol. 71 , 643 - 643 .

Croia C, Bombardieri M, Serafini B, Humby F, Migliorini P, Aloisi F, Pitzalis C ( 2012 ) . AB0155 Anti-VCA and EBNA1 antibodies are produced in the rheumatoid synovium in the presence of ectopic lymphoid structures and correlate with ACPA production . Annals of the Rheumatic Diseases vol. 71 , 646 - 646 .

Murray-Brown W, Picarelli G, Vartoukian S, Sutcliffe N, Fortune F, Valesini G, Pitzalis C, Tappuni A et al. ( 2012 ) . AB0222 Monocyte-derived IL-32 expression correlates with the level of inflammation in salivary glands of sjÖgren's syndrome . Annals of the Rheumatic Diseases vol. 71 , 650 - 650 .

Ng W-F, Lendrem D, Mitchell S, Bowman S, Price E, Pease C, Emery P, Andrews J et al. ( 2012 ) . FRI0448 Evaluating health status of 620 patients with primary sjÖgren's syndrome using EQ-5D . Annals of the Rheumatic Diseases vol. 71 , 466 - 466 .

El Shikh ME, Biggioggero M, El Sayed R, Kmieciak M, Manjili M, Szakal A, Meroni PL, Pitzalis C et al. ( 2012 ) . OP0218 Regulation of auto-antibody production by auto-immune complexes on follicular dendritic cells . Annals of the Rheumatic Diseases vol. 71 , 129 - 129 .

Tarn J, Mitchell S, Bowman S, Price E, Pease C, Sutcliffe N, Emery P, Andrews J et al. ( 2012 ) . SAT0166 Serum cytokine and chemokine profiling in primary sjögren's syndrome . Annals of the Rheumatic Diseases vol. 71 , 527 - 528 .

Ng W-F, Mitchell S, Lendrem D, Bowman S, Price E, Pease C, Emery P, Andrews J et al. ( 2012 ) . SAT0242 How good are the eular sjögren's syndrome disease activity index (ESSDAI), and EULAR sjögren's syndrome patients reported index (ESSPRI) in predicting health status in primary sjögren's syndrome? . Annals of the Rheumatic Diseases vol. 71 , 553 - 554 .

Pitzalis C ( 2012 ) . SP0162 “human scid chimeras: Models to dissect autoimmunity and inflammation” . Annals of the Rheumatic Diseases vol. 71 , 40 - 40 .

Sherwood J, Nalesso G, Bertrand J, Achan P, Brandolini L, Pap T, Pitzalis C, Dell'Accio F ( 2012 ) . THU0023 A novel role for ELR+ CXC chemokine signaling in cartilage homeostasis . Annals of the Rheumatic Diseases vol. 71 , 161 - 161 .

Whitehead MA, Bombardieri M, Pitzalis C, Vanhaesebroeck B ( 2012 ) . Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible <i>PIK3CD</i> promoter . Biochemical Journal vol. 443 , ( 3 ) 857 - 867 .

Sherwood J, Nalesso G, Bertrand J, Achan P, Brandolini L, Pap T, Pitzalis C, Dell'Accio F ( 2012 ) . ELR+ CXC chemokine signalling in cartilage homeostasis . Osteoarthritis and Cartilage . vol. 20 , S116 - S116 .

Nayar S, Cloake T, Bombardieri M, Pitzalis C, Lane PJ, Coles M, Buckley CD, Barone F ( 2012 ) . Cooperation of innate and acquired immune system derived signals induces stromal cell activation in chronic inflammation and ectopic lymphoneogenesis . Annals of the Rheumatic Diseases vol. 71 , A45 - A46 .

Sherwood J, Nalesso G, Bertrand J, Pap T, Achan P, Pitzalis C, Dell'Accio F ( 2012 ) . ELR+ CXC chemokine signalling in articular chondrocyte phenotypic stability . Annals of the Rheumatic Diseases . vol. 71 , A63 - A64 .

El Shikh MEM, Biggioggero M, El Sayed RM, Kmieciak M, Manjili MH, Szakal AK, Meroni PL, Pitzalis C et al. ( 2012 ) . Regulation of auto-antibody production by persisting auto-immune complexes on follicular dendritic cells . Annals of the Rheumatic Diseases . vol. 71 , A38 - A38 .

De Bari C, Pitzalis C, Dell'Accio F ( 2012 ) . Joint Tissue Engineering . Stem Cell Repair and Regeneration , PUBLISHED BY IMPERIAL COLLEGE PRESS AND DISTRIBUTED BY WORLD SCIENTIFIC PUBLISHING CO.

Pitzalis C ( 2012 ) . ADVANCES IN PATHOGENESIS: THE RHEUMATOLOGY VIEW: WHAT BIOLOGICAL PROCESSES DRIVE DIFFERENT DISEASE EXPRESSIONS IN PSA? . RHEUMATOLOGY . vol. 51 , 15 - 15 .

Croia C, Bombardieri M, Francesca A, Serafini B, Humby F, Kelly S, Migliorini P, Pitzalis C ( 2012 ) . ANTI-VCA AND EBNA1 ANTIBODIES ARE PRODUCED IN THE RHEUMATOID SYNOVIUM IN THE PRESENCE OF ECTOPIC LYMPHOID STRUCTURES AND CORRELATE WITH ACPA PRODUCTION . RHEUMATOLOGY . vol. 51 , 43 - 43 .

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2012 ) . Accumulation of circulating autoreactive naive B cells reveal defects of early B cell tolerance checkpoints in patients with Sjogren's syndrome . IMMUNOLOGY . vol. 137 , 327 - 327 .

Coates LC, Aslam T, Burden AD, Burden-Teh E, Caperon AR, Cerio R, Chattopadhyay C, Chinoy H et al. ( 2012 ) . Comparison of Three Screening Tools in Psoriatic Arthritis: The Contest Study . ARTHRITIS AND RHEUMATISM . vol. 64 , S580 - S580 .

Ferrari M, Kamalati T, Pitzalis C ( 2012 ) . DEVELOPMENT OF A NOVEL RECOMBINANT BIOTHERAPEUTIC WITH APPLICATIONS IN TARGETED THERAPY OF HUMAN ARTHRITIS . RHEUMATOLOGY . vol. 51 , 123 - 123 .

Nayar S, Cloake T, Bombardieri M, Pitzalis C, Buckley C, Barone F ( 2012 ) . ECTOPIC LYMPHONEOGENESIS IN A NOVEL MURINE MODEL OF SALIVARY GLANDS SIALOADENITIS IS CHARACTERIZED BY ASYNCHRONY IN THE LYMPHANGIOGENETIC AND ANGIOGENETIC PROGRAM . RHEUMATOLOGY . vol. 51 , 143 - 144 .

Sherwood J, Nalesso G, Bertrand J, Pap T, Achan P, Pitzalis C, Dell'Accio F ( 2012 ) . ELR plus CXC chemokine signaling is required for phenotypic stability of human articular chondrocytes . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 93 , A6 - A7 .

Lendrem D, Mitchell S, Bowman S, Price E, Pease CT, Emery P, Andrews J, Bombardieri M et al. ( 2012 ) . EVALUATING HEALTH STATUS OF 620 PATIENTS WITH PRIMARY SJOGREN'S SYNDROME USING EQ-5D . RHEUMATOLOGY . vol. 51 , 171 - 171 .

El Shikh MEM, Pitzalis C ( 2012 ) . Follicular dendritic cells in health and disease . Frontiers in Immunology vol. 3 ,

Lendrem D, Mitchell S, Bowman S, Price E, Pease CT, Emery P, Andrews J, Bombardieri M et al. ( 2012 ) . HOW GOOD ARE THE EULAR SJOGREN'S SYNDROME DISEASE ACTIVITY INDEX, AND EULAR SJOGREN'S SYNDROME PATIENTS REPORTED INDEX IN PREDICTING HEALTH STATUS IN PRIMARY SJOGREN'S SYNDROME? . RHEUMATOLOGY . vol. 51 , 176 - 176 .

Jones GW, Greenhill CJ, Williams AS, Nowell MA, Bombardieri M, Pitzalis C, Jenkins BJ, Jones SA ( 2012 ) . IL-27 control of ectopic lymphoid structures in inflammatory arthritis . IMMUNOLOGY . vol. 137 , 44 - 44 .

Lucchesi D, Bombardieri M, Barone F, Nayar S, Proctor G, Buckley CD, Pitzalis C ( 2012 ) . Inducible tertiary lymphoid structures formation in a novel model of sialoadenitis in wild-type mice is preceded by ectopic expression of lymphoid chemokines . IMMUNOLOGY . vol. 137 , 189 - 189 .

Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Pitzalis C, Bombardieri M ( 2012 ) . Lesional IL-21 expression correlates with functional germinal center formation and T follicular helper cell infiltration in the salivary glands of Sjogren's syndrome . IMMUNOLOGY . vol. 137 , 491 - 491 .

Nayar S, Chung MM, Rankin P, Cloake T, Pitzalis C, Lane P, Buckley C, Barone F ( 2012 ) . Lymphotoxin beta regulates lymphatic vessel expansion in mucosal ectopic lymphoneogenesis . IMMUNOLOGY . vol. 137 , 430 - 430 .

Murray-Brown W, Priori R, Tappuni T, Vartoukian S, Seoudi N, Picarelli G, Fortune F, Valesini G et al. ( 2012 ) . MONOCYTE-DERIVED IL-32 EXPRESSION CORRELATES WITH THE LEVEL OF INFLAMMATION IN SALIVARY GLANDS OF SJOGREN'S SYNDROME . RHEUMATOLOGY . vol. 51 , 176 - 176 .

Kam NW, Filer A, Buckley C, Bombardieri M, Pitzalis C ( 2012 ) . Membrane-bound and soluble BAFF expression by human rheumatoid fibroblast-like synoviocytes in response to TLR stimulation . IMMUNOLOGY . vol. 137 , 583 - 584 .

Vila J, Mitchell S, Bowman S, Price E, Pease CT, Emery P, Andrews J, Bombardieri M et al. ( 2012 ) . THE CLINICAL RELEVANCE OF ANTI-RO52 AND ANTI-RO60 IN PATIENTS IN THE UNITED KINGDOM PRIMARY SJOGREN'S SYNDROME REGISTRY (UKPSSR) . RHEUMATOLOGY . vol. 51 , 35 - 35 .

DiCicco M, Humby F, Kelly S, Hands R, Buckley C, McInnes I, Taylor P, Bombardieri M et al. ( 2012 ) . THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT: A PRELIMINARY ANALYSIS CORRELATING HISTOMORPHOLOGY AND DISEASE ACTIVITY . RHEUMATOLOGY . vol. 51 , 149 - 149 .

Patel HB, Kornerup KN, Sampaio ALF, Acquisto FD, Seed MP, Girol AP, Gray M, Pitzalis C et al. ( 2012 ) . The impact of endogenous annexin A1 on glucocorticoid control of in ammatory arthritis . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , ( 11 ) 1872 - 1880 .

Kelly S, Bombardieri M, Humby F, Ng N, Di Cicco M, Hands R, Epis O, Filer A et al. ( 2012 ) . ULTRASOUND GUIDED SYNOVIAL BIOPSIES: SAFETY, TOLERABILITY, AND TISSUE QUALITY . RHEUMATOLOGY . vol. 51 , 68 - 68 .

Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, Pitzalis C, Dell'Accio F ( 2012 ) . WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 93 , A8 - A8 .

Kamperidis P, Kamalati T, Ferrari M, Jones M, Garrood T, Smith MD, Diez-Posada S, Hughes C et al. ( 2011 ) . Development of a novel recombinant biotherapeutic with applications in targeted therapy of human arthritis . Arthritis &amp; Rheumatism vol. 63 , ( 12 ) 3758 - 3767 .

Bombardieri M, Kam NW, Brentano F, Choi K, Filer A, Kyburz D, McInnes IB, Gay S et al. ( 2011 ) . A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells . ANN RHEUM DIS vol. 70 , ( 10 ) 1857 - 1865 .

Miossec P, Verweij CL, Klareskog L, Pitzalis C, Barton A, Lekkerkerker F, Reiter S, Laslop A et al. ( 2011 ) . Biomarkers and personalised medicine in rheumatoid arthritis: a proposal for interactions between academia, industry and regulatory bodies . Annals of the Rheumatic Diseases vol. 70 , ( 10 ) 1713 - 1718 .

Ingegnoli F, Blades M, Manzo A, Wahid S, Perretti M, Panay G, Pitzalis C ( 2011 ) . Role of cell migration in the pathogenesis of rheumatoid arthritis: in vivo studies in SCID mice transplanted with human synovial membrane . Reumatismo vol. 54 , ( 2 )

Ingegnoli F, Manzo A, Fantini F, Caporali R, Montecucco C, Pipitone N, Pitzalis C ( 2011 ) . Role of chemokines in the pathogenesis of rheumatoid synovitis . Reumatismo vol. 54 , ( 1 )

de HAIR MJH, HARTY LC, GERLAG DM, PITZALIS C, VEALE DJ, TAK PP ( 2011 ) . Synovial Tissue Analysis for the Discovery of Diagnostic and Prognostic Biomarkers in Patients with Early Arthritis: Table 1 . The Journal of Rheumatology vol. 38 , ( 9 ) 2068 - 2072 .

Bugatti S, Manzo A, Bombardieri M, Vitolo B, Humby F, Kelly S, Montecucco C, Pitzalis C ( 2011 ) . Synovial Tissue Heterogeneity and Peripheral Blood Biomarkers . Current Rheumatology Reports vol. 13 , ( 5 ) 440 - 448 .

Macor P, Durigutto P, De Maso L, Fischetti F, Cortini A, Edomi P, Pitzalis C, Tedesco F ( 2011 ) . Treatment of antigen-induced and collagen-induced arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5 . Molecular Immunology . vol. 48 , 1676 - 1676 .

Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, Pitzalis C, Dell'Accio F ( 2011 ) . WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways . J CELL BIOL vol. 193 , ( 3 ) 551 - 564 .

Priori R, Barone F, Alessandri C, Colafrancesco S, McInnes IB, Pitzalis C, Valesini G, Bombardieri M ( 2011 ) . Markedly increased IL-18 liver expression in adult-onset Still's disease-related hepatitis . RHEUMATOLOGY vol. 50 , ( 4 ) 776 - 780 .

Nalesso G, Sherwood J, Ramachandran M, De Bari C, Pitzalis C, Dell'Accio F ( 2011 ) . Biology of bone, cartilage and connectve tissue disease: 92. WNT3A Modulates Chondrocyte Phenotype through Activation of both Canonical and Non-Canonical Pathways . Rheumatology vol. 50 , ( Supplement 3 ) iii77 - iii77 .

Ciurtin C, Majeed Y, Naylor J, Sukumar P, English A, Emery P, Beech D, Malik N et al. ( 2011 ) . Cell receptor-ligand interaction, signalling, activation and apoptosis: 21. Pregnenolone Sulphate is Similar to Dexamethasone in Supressing the Unfettered Secretion of Hyaluronan: In Vitro Study on Cultured Synovial Fibroblasts from Patients with Longstanding Rheumatoid Arthritis . Rheumatology vol. 50 , ( Supplement 3 ) iii50 - iii52 .

Nesbitt A, Fossati G, Whittall CE, Askari A, Middleton J, Astorri E, Bombardi M, Peakman M et al. ( 2011 ) . Cytokines and inflammatory mediators: 25. Certolizumab Pegol has a Different Profile from the other Anti-TNFS, Including Golimumab, in a Variety of in Vitro Assays . Rheumatology vol. 50 , ( Supplement 3 ) iii52 - iii55 .

Rajak R, Amos N, Camilleri J, Charles PJ, Plant D, Chowdhury M, Worthington J, Venables P et al. ( 2011 ) . Rheumatoid arthritis - aetiopathogenesis and animal models: 87. Do We Need to Redefine Seropositivity in RA? . Rheumatology vol. 50 , ( Supplement 3 ) iii74 - iii76 .

Mahoney DJ, Swales C, Athanasou NA, Bombardieri M, Pitzalis C, Kliskey K, Sharif M, Day AJ et al. ( 2011 ) . TSG‐6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin . Arthritis &amp; Rheumatism vol. 63 , ( 4 ) 1034 - 1043 .

Bugatti S, Manzo A, Vitolo B, Fusetti C, Humby F, Caporali R, Pitzalis C, Montecucco C ( 2011 ) . B cell distribution and activation-induced cytidine deaminase expression in rheumatoid synovitis: clinical and bio-molecular correlates . Annals of the Rheumatic Diseases . vol. 70 , A55 - A55 .

El Shikh ME, El Sayed RM, Kmieciak M, Manjili M, Szakal A, Pitzalis C, Tew J ( 2011 ) . Breakage of B cell tolerance by antigens on follicular dendritic cells . Annals of the Rheumatic Diseases . vol. 70 , A57 - A57 .

van de Sande MGH, Gerlag DM, Lodde BM, van Baarsen LGM, Alivernini S, Codullo V, Felea I, Vieira-Sousa E et al. ( 2011 ) . Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials . Annals of the Rheumatic Diseases vol. 70 , ( 3 ) 423 - 427 .

Astorri E, Bombardieri M, Gabba S, Peakman M, Pozzilli P, Pitzalis C ( 2011 ) . Evolution of ectopic lymphoid neogenesis and in situ autoantibodies production in autoimmune diabetic NOD mice: cellular and molecular characterisation of tertiary lymphoid structures in pancreatic islets . Annals of the Rheumatic Diseases . vol. 70 , A54 - A54 .

Astorri E ( 2011 ) . Interplay between inflammation, autoimmunity and regeneration in the NOD mouse model of type 1 diabetes and Sjogren’s syndrome .

Humby F ( 2011 ) . The clinical and immunological significance of ectopic lymphoneogenesis within the rheumatoid synovial membrane .

Bombardieri M, Kam YNW, Filer A, Buckley CD, Pitzalis C ( 2011 ) . Aberrant Basal and TLR-Stimulated Expression of TSLP in Rheumatoid Synovial Fibroblasts . ARTHRITIS AND RHEUMATISM . vol. 63 , S140 - S140 .

Kam NW, Bombardieri M, Filer A, Buckley C, Pitzalis C ( 2011 ) . Aberrant basal and TLR-stimulated expression of TSLP in rheumatoid synovial fibroblasts . IMMUNOLOGY . vol. 135 , 125 - 125 .

Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2011 ) . Analysis of recombinant monoclonal antibodies from single B cells reveals early defects of B cell tolerance checkpoints in patients with Sjogren's syndrome . IMMUNOLOGY . vol. 135 , 72 - 72 .

El Shikh ME, El Sayed R, Kmieciak M, Manjili M, Szakal A, Pitzalis C, Tew J ( 2011 ) . BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS . RHEUMATOLOGY . vol. 50 , 51 - 51 .

Pitzalis C ( 2011 ) . CAN PATHOBIOLOGY INFORM DISEASE OUTCOME AND RESPONSE TO THERAPY? . RHEUMATOLOGY . vol. 50 , 22 - 22 .

Marrelli A, Bombardieri M, Kelly S, Cipriani P, Giacomelli R, Pitzalis C ( 2011 ) . DIGITAL IMAGE ANALYSIS FOR THE EVALUATION OF BLOOD VESSEL DENSITY IN RHEUMATOID SYNOVIUM: CORRELATION WITH QUANTITATIVE REAL-TIME PCR EXPRESSION OF ENDOTHELIAL ANTIGEN AND ANGIOGENIC GROWTH FACTORS . RHEUMATOLOGY . vol. 50 , 75 - 75 .

Kamperidis P, Kamalati T, Ferrari M, Lee L, Jones R, Garrood T, Smith MD, Diez-Posada S et al. ( 2011 ) . Development of a Novel Recombinant Biotherapeutic with Applications in Targeted Therapy of Human Arthritis . ARTHRITIS AND RHEUMATISM . vol. 63 , S499 - S499 .

Croia C, Serafini B, Bombardieri M, Kelly S, Coccia EM, Severa M, Francesca A, Pitzalis C ( 2011 ) . EBV INFECTION IN THE RHEUMATOID ARTHRITIS SYNOVIUM: RELATIONSHIP TO ECTOPIC LYMPHOID STRUCTURES AND CD8 T CELL ACTIVATION . RHEUMATOLOGY . vol. 50 , 75 - 75 .

Croia C, Bombardieri M, Serafini B, Coccia EM, Severa M, Kelly S, Aloisi F, Pitzalis C ( 2011 ) . EBV Infection In the Rheumatoid Synovium: Relationship with Ectopic Lymphoid Structures, In Situ Autoantobody Production and CD8 T Cell Activation . ARTHRITIS AND RHEUMATISM . vol. 63 , S140 - S140 .

Astorri E, Bombardi M, Peakman M, Pozzilli P, Pitzalis C ( 2011 ) . EVOLUTION OF ECTOPIC LYMPHOID NEOGENESIS AND IN SITU AUTOANTIBODY PRODUCTION IN AUTOIMMUNE DIABETIC NOD MICE: CELLULAR AND MOLECULAR CHARACTERIZATION OF TERTIARY LYMPHOID STRUCTURES IN PANCREATIC ISLETS . RHEUMATOLOGY . vol. 50 , 52 - 53 .

Nayar S, Barone F, Choy P, Chang M-M, Bombardieri M, Lucchesi D, Pitzalis C, Buckley C ( 2011 ) . Ectopic lymphoneogenesis in a novel murine model of salivary glands sialoadenitis is characterized by asynchrony in the lymphangiogenetic and angiogenetic program . IMMUNOLOGY . vol. 135 , 49 - 49 .

Bombardieri M, Lucchesi D, Barone F, Nayar S, Proctor G, Buckley CD, Pitzalis C ( 2011 ) . Inducible functional tertiary lymphoid structures, autoimmunity and exocrine dysfunction in wild-type mouse salivary glands via local adenoviral delivery . IMMUNOLOGY . vol. 135 , 167 - 167 .

Pitzalis C ( 2011 ) . THE ROLE OF SYNOVIAL BIOPSY IN THE DIAGNOSIS OF INFLAMMATORY ARTHRITIS . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 29 , ( 1 ) 154 - 154 .

Kurunadalingam H, Parwaiz I, Kumar K, Howlett K, Hands B, Raza K, Pitzalis C, Buckley C et al. ( 2011 ) . THE SAFETY AND ACCEPTABILITY OF ULTRASOUND-GUIDED BIOPSY IN EARLY ARTHRITIS PATIENTS . RHEUMATOLOGY . vol. 50 , 101 - 101 .

Patel HB, Bombardieri M, Sampaio ALF, D'Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C et al. ( 2010 ) . Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis . FASEB J vol. 24 , ( 12 ) 4835 - 4843 .

Astorri E, Guglielmi C, Bombardieri M, Alessandri C, Buzzetti R, Maggi D, Valesini G, Pitzalis C et al. ( 2010 ) . Circulating Reg1 alpha Proteins and Autoantibodies to Reg1 alpha Proteins as Biomarkers of beta-Cell Regeneration and Damage in Type 1 Diabetes . HORM METAB RES vol. 42 , ( 13 ) 955 - 960 .

Ciccia F, Bombardieri M, Rizzo A, Principato A, Giardina AR, Raiata F, Peralta S, Ferrante A et al. ( 2010 ) . Over-expression of paneth cell-derived anti-microbial peptides in the gut of patients with ankylosing spondylitis and subclinical intestinal inflammation . RHEUMATOLOGY vol. 49 , ( 11 ) 2076 - 2083 .

Sherwood J, Key S, Achan P, Nalesso G, Pitzalis C, Dell'Accio F ( 2010 ) . 203 CXCR1 AND CXCR2 SIGNALLING IS REQUIRED BUT IS NOT SUFFICIENT TO MAINTAIN THE PHENOTYPIC STABILITY OF HUMAN ARTICULAR CHONDROCYTES . Osteoarthritis and Cartilage . vol. 18 , S96 - S96 .

Nalesso G, Achan P, Pitzalis C, Dell'Accio F ( 2010 ) . 225 WNT3A MODULATES CHONDROCYTE PHENOTYPE THROUGH ACTIVATION OF BOTH CANONICAL AND NON-CANONICAL PATHWAYS . Osteoarthritis and Cartilage . vol. 18 , S104 - S105 .

Astorri E, Bombardieri M, Gabba S, Peakman M, Pozzilli P, Pitzalis C ( 2010 ) . Evolution of Ectopic Lymphoid Neogenesis and In Situ Autoantibody Production in Autoimmune Nonobese Diabetic Mice: Cellular and Molecular Characterization of Tertiary Lymphoid Structures in Pancreatic Islets . J IMMUNOL vol. 185 , ( 6 ) 3359 - 3368 .

Patel HB, Bombardieri M, Sampaio ALF, D’Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C et al. ( 2010 ) . Anti‐inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis . The FASEB Journal vol. 24 , ( 12 ) 4835 - 4843 .

Ng W-F, Bowman SJ, Griffiths B ( 2010 ) . United Kingdom Primary Sjogren's Syndrome Registry--a united effort to tackle an orphan rheumatic disease . Rheumatology vol. 50 , ( 1 ) 32 - 39 .

Connolly M, Marrelli A, Blades M, McCormick J, Maderna P, Godson C, Mullan R, FitzGerald O et al. ( 2010 ) . Acute Serum Amyloid A Induces Migration, Angiogenesis, and Inflammation in Synovial Cells In Vitro and in a Human Rheumatoid Arthritis/SCID Mouse Chimera Model . The Journal of Immunology vol. 184 , ( 11 ) 6427 - 6437 .

Mahoney DJ, Swales C, Athanasou N, Bombardieri M, Pitzalis C, Kliskey K, Sharif M, Day A et al. ( 2010 ) . TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with OPG . Bone vol. 47 , S141 - S141 .

Astorri E, Bombardieri M, Corsiero E, Gabba S, Barone F, Proctor G, Pitzalis C, Bowman SJ et al. ( 2010 ) . Concurrent Oral 10 - Connective Tissue Disease [OP65-OP72]: OP65. Molecular and Cellular Evolution of Functional Tertiary Lymphoid Structures in Salivary Glands of NOD Mice . Rheumatology . vol. 49 , i28 - i31 .

Gillespie J, Savic S, Wong C, Emery P, Grigg R, McDermott MF, Goodall JC, Wu C et al. ( 2010 ) . Concurrent Oral 4 - Basic Science [OP24-OP31]: OP24. Hdac Activity: A Therapeutic Target in Rheumatoid Arthritis? . Rheumatology vol. 49 , ( Supplement 1 ) i11 - i13 .

Bombardieri M, Astorri E, Corsiero E, Gabba S, Barone F, Proctor G, Pitzalis C ( 2010 ) . Molecular and cellular evolution of functional tertiary lymphoid structures in salivary glands of NOD mice . Annals of the Rheumatic Diseases . vol. 69 , A12 - A13 .

RITCHLIN CT, QURESHI AA, de VLAM KURT, PITZALIS C, HELLIWELL PS, MEASE PJ, GLADMAN DD, KRUEGER GG et al. ( 2010 ) . Biomarkers in Psoriasis and Psoriatic Arthritis: GRAPPA 2008 . The Journal of Rheumatology vol. 37 , ( 2 ) 462 - 467 .

Sherwood JC, Achan P, Ramachandran M, Pitzalis C, Dell'Accio F ( 2010 ) . CXCR1/2 SIGNALLING IS REQUIRED FOR THE PHENOTYPIC STABILITY OF HUMAN ARTICULAR CHONDROCYTES . RHEUMATOLOGY . vol. 49 , I13 - I13 .

Sherwood JC, Pitzalis C, Dell'Accio F ( 2010 ) . CXCR1/2 signalling in the phenotypic stability of <i>in vitro</i> expanded adult human articular chondrocytes . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 91 , A40 - A40 .

Shirlaw P, Hullah E, Barone F, Panayi G, Kirkham B, Larkin G, Pitzalis C, Cook R et al. ( 2010 ) . Changes in parameters of Sjogrens syndrome (SS) assessed after 10 years on a combined SS clinic . ORAL DISEASES vol. 16 , ( 6 ) 539 - 539 .

Corsiero E, Bombardieri M, Humby F, Manzo A, Kelly S, Pitzalis C ( 2010 ) . Characterization of inter follicular large B cells, a new subpopulation of B lymphocytes, in tertiary lymphoid organs in rheumatic autoimmune diseases . IMMUNOLOGY . vol. 131 , 33 - 33 .

Croia C, Serafini B, Bombardieri M, Kelly S, Coccia EM, Severa M, Aloisi F, Pitzalis C ( 2010 ) . EBV infection in the rheumatoid arthritis synovium: relationship to tertiary lymphoid structures and CD8 T cell activation . IMMUNOLOGY . vol. 131 , 124 - 124 .

Nalesso G, Eltawil NM, Pitzalis C, Dell'Accio F ( 2010 ) . Effects of the modulation of Wnt-canonical pathway on the phenotypic stability of human articular chondrocytes . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 91 , A40 - A41 .

Astorri E, Bombardieri M, Gabba S, Peakman M, Pozzilli P, Pitzalis C ( 2010 ) . Evolution of ectopic lymphoid neogenesis and <i>in</i>-<i>situ</i> autoantibodies production in autoimmune diabetic NOD mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islet . IMMUNOLOGY . vol. 131 , 63 - 63 .

Burmester GR, Lipsky PE, Dörner T, the Kitasato Meeting Faculty F ( 2010 ) . Kitasato symposium 2010: new prospects for cytokines . Arthritis Research &amp; Therapy vol. 12 , ( 6 ) 301 - 301 .

Lucchesi D, Astorri E, Bombardieri M, Corsiero E, Barone F, Proctor G, Pitzalis C ( 2010 ) . Molecular and cellular evolution of functional tertiary lymphoid structures in salivary glands of NOD mice . IMMUNOLOGY . vol. 131 , 59 - 59 .

Eltawil N, Pitzalis C, Dell'Accio F ( 2010 ) . Molecular response of articular cartilage to injury: Wnt signaling in an <i>in vivo</i> model of joint surface injury . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 91 , A29 - A29 .

Bombardieri M, Kam YNW, Brentano F, Choi K, Kyburz D, Gay S, McInnes IB, Pitzalis C ( 2010 ) . RHEUMATOID SYNOVIAL FIBROBLASTS SUPPORT AID EXPRESSION AND IG CLASS-SWITCHING IN B CELLS VIA A BAFF-DEPENDENT TLR3-STIMULATED PATHWAY . RHEUMATOLOGY . vol. 49 , I26 - I27 .

Kam NW, Bombardieri M, Brentano F, Choi K, Kyburz D, Gay S, Mclnnes IB, Pitzalis C ( 2010 ) . Rheumatoid synovial fibroblasts support AID expression and Ig class-switching in B cells via a Baff-dependent TLR3-stimulated pathway . IMMUNOLOGY . vol. 131 , 71 - 71 .

Swales C, Mahoney DJ, Athanasou NA, Bombardieri M, Pitzalis C, Sharif O, Day AJ, Milner CM et al. ( 2010 ) . TSG-6: AN AUTOCRINE REGULATOR OF INFLAMMATORY JOINT DISEASE? . RHEUMATOLOGY . vol. 49 , I27 - I27 .

Manzo A, Bombardieri M, Humby F, Pitzalis C ( 2009 ) . Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling . Immunological Reviews vol. 233 , ( 1 ) 267 - 285 .

Duchene J, Cayla C, Vessillier S, Scotland R, Yamashiro K, Lecomte F, Syed I, Vo P et al. ( 2009 ) . Laminar Shear Stress Regulates Endothelial Kinin B1 Receptor Expression and Function Potential Implication in Atherogenesis . ARTERIOSCL THROM VAS vol. 29 , ( 11 ) 1757 - 1763 .

Scheiermann C, Colom B, Meda P, Patel NSA, Voisin MB, Marrelli A, Woodfin A, Pitzalis C et al. ( 2009 ) . Junctional Adhesion Molecule-C Mediates Leukocyte Infiltration in Response to Ischemia Reperfusion Injury . ARTERIOSCL THROM VAS vol. 29 , ( 10 ) 1509 - U254 .

Macor P, Durigutto P, De Maso L, Cortini A, Garrovo C, Edomi P, Pitzalis C, Tedesco F ( 2009 ) . Prevention of antigen-induced arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5 . Molecular Immunology . vol. 46 , 2837 - 2837 .

Garrood T, Blades M, Haskard DO, Mather S, Pitzalis C ( 2009 ) . A novel model for the pre-clinical imaging of inflamed human synovial vasculature . RHEUMATOLOGY vol. 48 , ( 8 ) 926 - 931 .

Robinson H, Kelly S, Pitzalis C ( 2009 ) . Basic Synovial Biology and Immunopathology in Psoriatic Arthritis . JOURNAL OF RHEUMATOLOGY . vol. 36 , 14 - 16 .

Eltawil NM, De Bari C, Achan P, Pitzalis C, Dell'Accio F ( 2009 ) . A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury . OSTEOARTHR CARTILAGE vol. 17 , ( 6 ) 695 - 704 .

Evans HG, Gullick NJ, Kelly S, Pitzalis C, Lord GM, Kirkham BW, Taams LS ( 2009 ) . In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses . P NATL ACAD SCI USA vol. 106 , ( 15 ) 6232 - 6237 .

Colom B, Scheiermann C, Woodfin A, Meda P, Patel N, Marrelli A, Pitzalis C, Thiemermann C et al. ( 2009 ) . Effect of soluble JAM‐C on leukocyte transmigration in models of ischemia/reperfusion injury . The FASEB Journal vol. 23 , ( S1 )

Ciccia F, Bombardieri M, Principato A, Giardina A, Tripodo C, Porcasi R, Peralta S, Franco V et al. ( 2009 ) . Overexpression of interleukin‐23, but not interleukin‐17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis . Arthritis &amp; Rheumatism vol. 60 , ( 4 ) 955 - 965 .

Conigliaro P, Priori R, Bombardieri M, Alessandri C, Barone F, Pitzalis C, McInnes IB, Valesini G ( 2009 ) . Lymph node IL-18 expression in adult-onset Still’s disease . Annals of the Rheumatic Diseases vol. 68 , ( 3 ) 442 - 443 .

Kamperidis P ( 2009 ) . Identification of Single-Chain Antibody Fragments Specific for Human Synovial Microvasclar Endothelium by In-Vivo Phage Display .

Keeble J, Blades M, Pitzalis C, Castro da Rocha FA, Brain SD ( 2009 ) . The role of substance P in microvascular responses in murine joint inflammation . British Journal of Pharmacology vol. 144 , ( 8 ) 1059 - 1066 .

Patel HB, Bombardieri M, Pitzalis C, Perretti M ( 2009 ) . Activation of melanocortin receptor type 3 as a new strategy to control experimental and rheumatoid arthritis . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION vol. 39 , 29 - 29 .

Humby F, Bombardieri M, Manzo A, Kelly S, Blades MC, Kirkham B, Spencer J, Pitzalis C ( 2009 ) . Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium . PLOS MED vol. 6 , ( 1 ) Article e1 , 59 - 75 .

Bombardieri M, Ciccia F, Principato A, Tripodo C, Peralta S, Triolo G, Pitzalis C ( 2009 ) . IL-23 OVEREXPRESSION AS IMMUNOLOGICAL SIGNATURE OF SUBCLINICAL INTESTINAL INFLAMMATION IN ANKYLOSING SPONDYLITIS . RHEUMATOLOGY . vol. 48 , I6 - I6 .

Garrood T, Lee L, Blades M, Kamperidis P, Pitzalis C ( 2009 ) . TNF-ALPHA MODULATES TISSUE-SPECIFIC VASCULAR DETERMINANTS RECOGNIZED IN VIVO BY A PHAGE CLONE DISPLAYING A SYNOVIAL-HOMING PEPTIDE IN THE HUMAN/SCID MOUSE TRANSPLANTATION MODEL . RHEUMATOLOGY . vol. 48 , I39 - I39 .

Dell'Accio F, Eltawil NM, De Bari C, Pitzalis C ( 2009 ) . WNT16 in joint surface injury and osteoarthritis . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 90 , A84 - A84 .

Manzo A, Vitolo B, Humby F, Caporali R, Jarrossay D, Dell'Accio F, Ciardelli L, Uguccioni M et al. ( 2008 ) . Mature antigen‐experienced T helper cells synthesize and secrete the B cell chemoattractant CXCL13 in the inflammatory environment of the rheumatoid joint . Arthritis &amp; Rheumatism vol. 58 , ( 11 ) 3377 - 3387 .

Eltawil NM, De Bari C, Achan P, Pitzalis C, Dell’Accio F ( 2008 ) . 54 A NOVEL AGE- AND STRAIN-DEPENDENT IN VIVO MODEL OF ARTICULAR CARTILAGE HEALING IN MICE . Osteoarthritis and Cartilage vol. 16 , S38 - S38 .

Astorri E, Bombardieri M, Guglielmi C, Pitzalis C, Pozzilli P ( 2008 ) . Beta cell regeneration in type 1 diabetes: the role of Reg genes in NOD mice . DIABETOLOGIA vol. 51 , S186 - S186 .

Kelly S, Taylor P, Pitzalis C ( 2008 ) . Ultrasound imaging in spondyloathropathies: from imaging to diagnostic intervention . CURR OPIN RHEUMATOL vol. 20 , ( 4 ) 408 - 415 .

COSTANTINIDES Y, KINGSLEY G, PITZALIS C, PANAYI GS ( 2008 ) . Inhibition of lymphocyte proliferation by a monoclonal antibody (RFT2) against CD7 . Clinical and Experimental Immunology vol. 85 , ( 1 ) 164 - 167 .

RODRIGUEZ RM, PITZALIS C, KINGSLEY GH, HENDERSON E, HUMPHRIES MJ, PANAYI GS ( 2008 ) . T lymphocyte adhesion to fibronectin (FN): a possible mechanism for T cell accumulation in the rheumatoid joint . Clinical and Experimental Immunology vol. 89 , ( 3 ) 439 - 445 .

Quartuccio L, Fabris M, Moretti M, Barone F, Bombardieri M, Rupolo M, Lombardi S, Pitzalis C et al. ( 2008 ) . Resistance to Rituximab Therapy and Local BAFF Overexpression in Sjogren's Syndrome-Related Myoepithelial Sialadenitis and Low-Grade Parotid B-Cell Lymphoma . The Open Rheumatology Journal vol. 2 , ( 1 ) 38 - 43 .

Choy EHS, Smith CM, Farewell V, Walker D, Hassell A, Chau L, Scott DL ( 2008 ) . Factorial randomised controlled trial of glucocorticoids and combination disease modifying drugs in early rheumatoid arthritis . Annals of the Rheumatic Diseases vol. 67 , ( 5 ) 656 - 663 .

Dell'Accio F, De Bari C, Eltawil NA, Vanhummelen P, Pitzalis C ( 2008 ) . Identification of the molecular response of articular cartilage to injury, by microarray screening . ARTHRITIS RHEUM vol. 58 , ( 5 ) 1410 - 1421 .

Humby F, Gullick N, Kelly S, Pitzalis C, Oakley SP ( 2008 ) . A synovial pathergy reaction leading to a pseudo-septic arthritis and a diagnosis of Behcet's disease . Rheumatology vol. 47 , ( 8 ) 1255 - 1256 .

Barone F, Bombardieri M, Rosado MM, Morgan PR, Challacombe SJ, De Vita S, Carsetti R, Spencer J et al. ( 2008 ) . CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: Association with reactive and malignant areas of lymphoid organization . J IMMUNOL vol. 180 , ( 7 ) 5130 - 5140 .

Bombardieri M, Barone F, Pitzalis C ( 2008 ) . Response to Comment on “Activation-Induced Cytidine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis and MALT Lymphoma in Sjögren’s Syndrome” . The Journal of Immunology vol. 180 , ( 4 ) 2008 - 2009 .

El Tawil NM, De Bari C, Pitzalis C, Dell'Accio F ( 2008 ) . A mouse model of joint surface injury and repair in mice. Age and strain-dependent outcome . ARTHRITIS AND RHEUMATISM . vol. 58 , S647 - S647 .

Connolly M, McCormick J, Marelli A, Blades M, FitzGerald O, Bresnihan B, Pitzalis C, Veale D et al. ( 2008 ) . A-SAA induces rho GTPase-dependent cytoskeletal rearrangement and <i>in vivo</i> migration of fluorochrome labelled monocytic (u937) cells in a human RA/SCID mice chimera model . ARTHRITIS AND RHEUMATISM . vol. 58 , S627 - S627 .

Bombardieri M, Barone F, Humby F, Morgan P, Challacombe S, Spencer J, Pitzalis C ( 2008 ) . Activation-induced cytidine deaminase expression supports functionality of ectopic lymphoid neogenesis in patients with and animal models of Sjogren's syndrome . RHEUMATOLOGY . vol. 47 , II85 - II85 .

Humby F, Bombardieri M, Manzo A, Blades M, Kirkham B, Spencer J, Pitzalis C ( 2008 ) . Activation-induced cytidine deaminase supports self sustained autoantibody production within RA synovium . RHEUMATOLOGY . vol. 47 , II59 - II59 .

Gerli R, Lunardi C, Bocci EB, Bobbio-Pallavicini F, Schillaci G, Caporali R, Bistoni O, Pirro M et al. ( 2008 ) . Anti-tumor necrosis factor-α response in rheumatoid arthritis is associated with an increase in serum soluble CD30 . JOURNAL OF RHEUMATOLOGY vol. 35 , ( 1 ) 14 - 19 .

Humby F, Bombardieri M, Antonio M, Blades M, Bruce K, Spencer J, Pitzalis C ( 2008 ) . Ectopic lymphoid structures expressing AID drive self sustained in situ prodction of autoantibodies in rheumatoid synovium . ARTHRITIS AND RHEUMATISM . vol. 58 , S633 - S634 .

Garrood T, Blades M, Mather S, Haskard D, Pitzalis C ( 2008 ) . Imaging E-selectin expression in human synovium in a scid mouse transplantation model . RHEUMATOLOGY . vol. 47 , II55 - II55 .

Bugatti S, Manzo A, Caporali R, Scire CA, Vitolo B, Codullo V, Epis OM, Fusetti C et al. ( 2008 ) . Lymphocyte organisation and lymphatic angiogenesis in rheumatoid synovitis:: Clinical and radiographic correlates . ARTHRITIS AND RHEUMATISM . vol. 58 , S767 - S768 .

Evans H, Gullick N, Kelly S, Pitzalis C, Lord G, Kirkham B, Taams L ( 2008 ) . OR.45. Potent Induction of Interleukin-17 Producing CD4+ T Cells (Th17 Cells) by Synovial Monocytes from Active RA Patients . Clinical Immunology . vol. 127 , S20 - S20 .

Evans HG, Gullick NJ, Kelly S, Pitzalis C, Kirkham B, Taams LS ( 2008 ) . Potent induction of Th17 cells by synovial monocytes from active rheumatoid arthritis patients . ARTHRITIS AND RHEUMATISM . vol. 58 , S634 - S634 .

Evans HG, Gullick NJ, Kelly S, Pitzalis C, Lord GM, Kirkham BW, Taams LS ( 2008 ) . Potent induction of interleukin-17 producing CD4+ T cells (TH17 cells) by synovial monocytes from active RA patients . RHEUMATOLOGY . vol. 47 , II59 - II59 .

Evans HG, Gullick NJ, Kelly S, Pitzalis C, Lord GM, Kirkham BW, Taams LS ( 2008 ) . Potent induction of th17 cells by synovial monocytes from active rheumatoid arthritis patients . ARTHRITIS AND RHEUMATISM . vol. 58 , S165 - S166 .

Manzo A ( 2008 ) . Re-programming of the CXCL13-CCL21 Lymphoid Chemokine System in Ectopic Lymphoid Neogenesis during Chronic Arthritis .

Dell'Accio F, Eltawil NM, De Bari C, Pitzalis C ( 2008 ) . Wnt16 in joint surface injury and osteoarthritis . RHEUMATOLOGY . vol. 47 , II177 - II178 .

De Bari C, Dell'Accio F, Karystinou A, Guillot PV, Fisk NM, Jones EA, McGonagle D, Khan IM et al. ( 2007 ) . A biomarker‐based mathematical model to predict bone‐forming potency of human synovial and periosteal mesenchymal stem cells . Arthritis &amp; Rheumatism vol. 58 , ( 1 ) 240 - 250 .

Manzo A, Bugatti S, Caporali R, Prevo R, Jackson DG, Uguccioni M, Buckley CD, Montecucco C et al. ( 2007 ) . CCL21 Expression Pattern of Human Secondary Lymphoid Organ Stroma Is Conserved in Inflammatory Lesions with Lymphoid Neogenesis . The American Journal of Pathology vol. 171 , ( 5 ) 1549 - 1562 .

Manzo A, Pitzalis C ( 2007 ) . Lymphoid tissue reactions in rheumatoid arthritis . Autoimmunity Reviews vol. 7 , ( 1 ) 30 - 34 .

Bombardieri M, Barone F, Humby F, Kelly S, McGurk M, Morgan P, Challacombe S, De Vita S et al. ( 2007 ) . Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjogren's syndrome . J IMMUNOL vol. 179 , ( 7 ) 4929 - 4938 .

Scirè CA, Epis O, Codullo V, Humby F, Morbini P, Manzo A, Caporali R, Pitzalis C et al. ( 2007 ) . Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure . Arthritis Research &amp; Therapy vol. 9 , ( 5 ) Article R101 ,

de Bari C, Guillot PV, Fisk NM, Jones EA, McGonagle D, Khan IM, Archer CW, Mitsiadis TA et al. ( 2007 ) . Mathematical modeling to predict bone forming potency of human mesenchymal stem cells . European Cells and Materials . vol. 14 ,

Kamperidis PS, Lee L, Blades M, Garrood T, Nissim A, George A, Pitzalis C ( 2007 ) . Identification of single-chain antibody fragments specific for human synovial microvascular endothelium by in vivo phage display . ANNALS OF THE RHEUMATIC DISEASES . vol. 66 , A12 - A13 .

Brunton F, Lee L, Nissim A, Grigoriadis A, Pitzalis C ( 2007 ) . Modulating osteoclast function by targeting the alphavbeta3 integrin . ANNALS OF THE RHEUMATIC DISEASES . vol. 66 , A19 - A19 .

Humby F, Manzo A, Kirkham B, Pitzalis C ( 2007 ) . The synovial membrane as a prognostic tool in rheumatoid arthritis . Autoimmunity Reviews vol. 6 , ( 4 ) 248 - 252 .

Tyndall A, Walker UA, Cope A, Dazzi F, De Bari C, Fibbe W, Guiducci S, Jones S et al. ( 2007 ) . . Arthritis Research &amp; Therapy vol. 9 , ( 1 ) 301 - 301 .

Barone F, Bombardieri M, Spencer J, Isaacson P, Humby F, Morgan P, Challacombe S, Valesini G et al. ( 2007 ) . CXCL13, CCL21 and CXCL12 are upregulated in mucosal-associated lymphoid tissue lymphomas in patients with Sjorgen's syndrome and cooperate in the maintenance of the immune response and malignant cell survival . Arthritis Research &amp; Therapy vol. 9 , ( Suppl 3 ) P15 - P15 .

Lee L, Garrood T, Pitzalis C ( 2007 ) . In Vivo Phage Display Selection in the Human/SCID Mouse Chimera Model for Defining Synovial Specific Determinants . 369 - 394 .

Brunton F, Lee L, Nissim A, Grigoriadis AE, Pitzalis C ( 2007 ) . Targeting osteoclasts in rheumatoid arthritis via the alpha(v)beta(3) integrin . JOURNAL OF BONE AND MINERAL RESEARCH . vol. 22 , 1113 - 1113 .

Bombardieri M, McInnes IB, Pitzalis C ( 2006 ) . Interleukin-18 as a potential therapeutic target in chronic autoimmune/inflammatory conditions . Expert Opinion on Biological Therapy vol. 7 , ( 1 ) 31 - 40 .

De Bari C, Pringle S, Pitzalis C, Dell'Accio F ( 2006 ) . The stem cell niche: a new target in medicine . Current Opinion in Orthopaedics vol. 17 , ( 5 ) 398 - 404 .

Dell'Accio F, De Bari C, El Tawil NMF, Barone F, Mitsiadis TA, O'Dowd J, Pitzalis C ( 2006 ) . Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury . Arthritis Research &amp; Therapy vol. 8 , ( 5 ) Article R139 ,

FILER A, PITZALIS C, BUCKLEY C ( 2006 ) . Targeting the stromal microenvironment in chronic inflammation . Current Opinion in Pharmacology vol. 6 , ( 4 ) 393 - 400 .

Pitzalis C, Garrood T ( 2006 ) . From ubiquitous antigens to joint-specific inflammation: could local vascular permeability be the missing link? . Trends in Immunology vol. 27 , ( 7 ) 299 - 302 .

KINGSLEY G, PITZALIS C, KYRIAZIS N, PANAYI GS ( 2006 ) . Abnormal Helper‐Inducer/Suppressor–Inducer T‐Cell Subset Distribution and T‐Cell Activation Status are Common to All Types of Chronic Synovitis . Scandinavian Journal of Immunology vol. 28 , ( 2 ) 225 - 232 .

Lozanoska-Ochser B, Barone F, Pitzalis C, Peakman M ( 2006 ) . Atorvastatin Fails to Prevent the Development of Autoimmune Diabetes Despite Inhibition of Pathogenic β-Cell–Specific CD8 T-Cells . Diabetes vol. 55 , ( 4 ) 1004 - 1010 .

Garrood T, Pitzalis C ( 2006 ) . Targeting the inflamed synovium: The quest for specificity . Arthritis &amp; Rheumatism vol. 54 , ( 4 ) 1055 - 1060 .

PITZALIS C, PIPITONE N, PERRETTI M ( 2002 ) . Regulation of Leukocyte‐Endothelial Interactions by Glucocorticoids . Annals of the New York Academy of Sciences . vol. 966 , 108 - 118 .

De Bari C, Dell'Accio F, Vanlauwe J, Eyckmans J, Khan IM, Archer CW, Jones EA, McGonagle D et al. ( 2006 ) . Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis . Arthritis &amp; Rheumatism vol. 54 , ( 4 ) 1209 - 1221 .

De Bari C, Pitzalis C, Dell’Accio F ( 2005 ) . Reparative Medicine: From Tissue Engineering to Joint Surface Regeneration . Regenerative Medicine vol. 1 , ( 1 ) 59 - 69 .

Pitzalis C, Kingsley GH, Haskard DO, Panayi GS ( 2005 ) . Comment on the article by Lasky et a1 . Arthritis &amp; Rheumatism vol. 32 , ( 1 ) 116 - 117 .

Pitzalis C, Cauli A, Pipitone N, Smith C, Barker J, Marchesoni A, Yanni G, Panayi GS ( 2005 ) . Cutaneous lymphocyte antigen‐positive T lymphocytes preferentially migrate to the skin but not to the joint in psoriatic arthritis . Arthritis &amp; Rheumatism vol. 39 , ( 1 ) 137 - 145 .

Choy EHS, Pitzalis C, Cauli A, Bijl JA, Schantz A, Woody J, Kingsley GH, Panayi GS ( 2005 ) . Percentage of anti‐CD4 monoclonal antibody‐coated lymphocytes in the rheumatoid joint is associated with clinical improvement. Implications for the development of immunotherapeutic dosing regimens . Arthritis &amp; Rheumatism vol. 39 , ( 1 ) 52 - 56 .

Sieper J, Kingsley G, Palacios‐Boix A, Pitzalis C, Panayi GS, Treharne J, Hughes R, Keat A ( 2005 ) . Synovial T lymphocyte–specific immune response to <i>Chlamydia trachomatis</i> in Reiter's disease . Arthritis &amp; Rheumatism vol. 34 , ( 5 ) 588 - 598 .

Garrood T, Lee L, Pitzalis C ( 2005 ) . Molecular mechanisms of cell recruitment to inflammatory sites: general and tissue-specific pathways . Rheumatology vol. 45 , ( 3 ) 250 - 260 .

Pitzalis C, Kingsley G, Haskard D, Panayi G ( 2005 ) . The preferential accumulation of helper‐inducer T lymphocytes in inflammatory lesions: evidence for regulation by selective endothelial and homotypic adhesion . European Journal of Immunology vol. 18 , ( 9 ) 1397 - 1404 .

Pitzalis C, Kingsley GH, Covelli M, Meliconi R, Markey A, Panayi GS ( 2005 ) . Selective migration of the human helper‐inducer memory T cell subset: confirmation by <i>in vivo</i> cellular kinetic studies . European Journal of Immunology vol. 21 , ( 2 ) 369 - 376 .

Bugatti S, Caporali R, Manzo A, Vitolo B, Pitzalis C, Montecucco C ( 2005 ) . Involvement of subchondral bone marrow in rheumatoid arthritis: Lymphoid neogenesis and in situ relationship to subchondral bone marrow osteoclast recruitment . Arthritis &amp; Rheumatism vol. 52 , ( 11 ) 3448 - 3459 .

Barone F, Bombardieri M, Manzo A, Blades MC, Morgan PR, Challacombe SJ, Valesini G, Pitzalis C ( 2005 ) . Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid‐like structures in Sjögren's syndrome . Arthritis &amp; Rheumatism vol. 52 , ( 6 ) 1773 - 1784 .

Pipitone N, Pitzalis C ( 2005 ) . Recent advances in the treatment of psoriatic arthritis . Expert Opinion on Therapeutic Patents vol. 14 , ( 4 ) 509 - 525 .

Manzo A, Paoletti S, Carulli M, Blades MC, Barone F, Yanni G, FitzGerald O, Bresnihan B et al. ( 2005 ) . Systematic microanatomical analysis of CXCL13 and CCL21 <i>in situ</i> production and progressive lymphoid organization in rheumatoid synovitis . European Journal of Immunology vol. 35 , ( 5 ) 1347 - 1359 .

De Bari C, Dell'Accio F, Vanlauwe J, Pitzalis C, Luyten FP ( 2005 ) . . Arthritis Research &amp; Therapy vol. 7 , ( Suppl 1 ) P107 - P107 .

Manzo A, Bugatti S, Buckley C, Jackson D, Caporali R, Montecucco C, Pitzalis C ( 2005 ) . . Arthritis Research &amp; Therapy vol. 7 , ( Suppl 1 ) P139 - P139 .

Bombardieri M, Barone F, Proctor G, van de Loo FA, van den Berg WB, Valesini G, McInnes IB, Pitzalis C ( 2005 ) . . Arthritis Research &amp; Therapy vol. 7 , ( Suppl 1 ) P94 - P94 .

Dell'Accio F, De Bari C, Pitzalis C ( 2005 ) . . Arthritis Research &amp; Therapy vol. 7 , ( Suppl 1 ) P131 - P131 .

Pipitone N, Pitzalis C ( 2004 ) . Arthritides in the elderly . Recenti Progressi in Medicina vol. 95 , ( 9 ) 432 - 456 .

Bombardieri M, Barone F, Pittoni V, Alessandri C, Conigliaro P, Blades MC, Priori R, McInnes IB et al. ( 2004 ) . Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate . Arthritis Res Ther vol. 6 , ( 5 ) Article R447 ,

Barone F, Bombardieri M, Blades MC, Manzo A, Morgan P, Challacombe S, Valesini G, Pitzalis C ( 2004 ) . . Arthritis Research &amp; Therapy vol. 6 , ( Suppl 3 ) 94 - 94 .

Pipitone N ( 2003 ) . Current concepts and new developments in the treatment of psoriatic arthritis . Rheumatology vol. 42 , ( 10 ) 1138 - 1148 .

George AJT, Lee L, Pitzalis C ( 2003 ) . Isolating ligands specific for human vasculature using in vivo phage selection . Trends in Biotechnology vol. 21 , ( 5 ) 199 - 203 .

Pitzalis C, Manzo A, Paoletti S, Barone F, Caporali R, Montecucco CM, Uguccioni M ( 2003 ) . . Arthritis Research &amp; Therapy vol. 5 , ( Suppl 3 ) 116 - 116 .

Lee L, Buckley C, Blades M, Panayi G, George AJ, Pitzalis C ( 2003 ) . . Arthritis Research &amp; Therapy vol. 5 , ( Suppl 1 ) 103 - 103 .

Barone F, Blades M, Manzo A, Morgan P, Montecucco M, Valesini G, Pitzalis C ( 2003 ) . . Arthritis Research &amp; Therapy vol. 5 , ( Suppl 1 ) 92 - 92 .

Manzo A, Carulli M, Paoletti S, Blades M, Barone F, Yanni G, Caporali R, Montecucco C et al. ( 2003 ) . . Arthritis Research &amp; Therapy vol. 5 , ( Suppl 1 ) 105 - 105 .

De Benedetti F, Pignatti P, Biffi M, Bono E, Wahid S, Ingegnoli F, Chang SYP, Alexander H et al. ( 2003 ) . Increased expression of α(1,3)-fucosyltransferase-VII and P-selectin binding of synovial fluid T cells in juvenile idiopathic arthritis . JOURNAL OF RHEUMATOLOGY vol. 30 , ( 7 ) 1611 - 1615 .

Manzo A, Caporali R, Montecucco C, Pitzalis C ( 2003 ) . Role of chemokines and chemokine receptors in regulating specific leukocyte trafficking in the immune/inflammatory response . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 21 , ( 4 ) 501 - 508 .

Gerli R ( 2002 ) . Unmasking the anti-inflammatory cytokine response in rheumatoid synovitis . Rheumatology vol. 41 , ( 12 ) 1341 - 1345 .

Perretti M, Ingegnoli F, Wheller SK, Blades MC, Solito E, Pitzalis C ( 2002 ) . Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model . J IMMUNOL vol. 169 , ( 4 ) 2085 - 2092 .

Lee L, Buckley C, Blades MC, Panayi G, George AJT, Pitzalis C ( 2002 ) . Identification of synovium‐specific homing peptides by in vivo phage display selection . Arthritis &amp; Rheumatism vol. 46 , ( 8 ) 2109 - 2120 .

Blades MC, Manzo A, Ingegnoli F, Taylor PR, Panayi GS, Irjala H, Jalkanen S, Haskard DO et al. ( 2002 ) . Stromal Cell-Derived Factor 1 (CXCL12) Induces Human Cell Migration into Human Lymph Nodes Transplanted into SCID Mice . The Journal of Immunology vol. 168 , ( 9 ) 4308 - 4317 .

Blades MC, Ingegnoli F, Wheller SK, Manzo A, Wahid S, Panayi GS, Perretti M, Pitzalis C ( 2002 ) . Stromal cell–derived factor 1 (CXCL12) induces monocyte migration into human synovium transplanted onto SCID Mice . Arthritis &amp; Rheumatism vol. 46 , ( 3 ) 824 - 836 .

Matsuno H, Yudoh K, Katayama R, Nakazawa F, Uzuki M, Sawai T, Yonezawa T, Saeki Y et al. ( 2002 ) . The role of TNF‐α in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): a study using a human RA/SCID mouse chimera . Rheumatology vol. 41 , ( 3 ) 329 - 337 .

Blades MC, Manzo A, Ingegnoli F, Taylor P, Irjala H, Jalkanen S, Haskard DO, Perretti M et al. ( 2002 ) . . Arthritis Research . vol. 4 , 32 - 32 .

Lee L, Buckley C, Blades MC, Panayi G, George AJT, Pitzalis C ( 2002 ) . . Arthritis Research vol. 4 , ( Suppl 1 ) 33 - 33 .

Perretti M, Blades MC, Wheller SK, Wahid S, Solito E, Pitzalis C ( 2002 ) . Monocytic cells over-expressing annexin 1 have reduced transmigration in vitro and elicitation in vivo . FASEB JOURNAL . vol. 16 , A598 - A598 .

Gerli R, Pitzalis C, Lunardi C ( 2002 ) . The role of T cell cytokines in modulating joint inflammation in rheumatoid arthritis . ISRAEL MEDICAL ASSOCIATION JOURNAL vol. 4 , ( 11 ) 949 - 952 .

Goulding NJ, Ogbourn S, Pipitone N, Biagini P, Gerli R, Pitzalis C ( 2001 ) . The inhibitory effect of dexamethasone on lymphocyte adhesion molecule expression and intercellular aggregation is not mediated by lipocortin 1 . Clinical and Experimental Immunology vol. 118 , ( 3 ) 376 - 383 .

Wahid S, Blades MC, De Lord D, Brown I, Blake G, Yanni G, Haskard DO, Panayi GS et al. ( 2001 ) . Tumour necrosis factor-alpha (TNF-<i>α</i>) enhances lymphocyte migration into rheumatoid synovial tissue transplanted into severe combined immunodeficient (SCID) mice . Clinical and Experimental Immunology vol. 122 , ( 1 ) 133 - 142 .

Pipitone N, Sinha M, Theodoridis E, Goulding N, Hall M, Lanchbury J, Corrigall V, Panayi G et al. ( 2001 ) . The glucocorticoid inhibition of LFA-1 and CD2 expression by human mononuclear cells is reversed by IL-2, IL-7 and IL-15 . European Journal of Immunology vol. 31 , ( 7 ) 2135 - 2142 .

Panayi GS, Corrigall VM, Pitzalis C ( 2001 ) . PATHOGENESIS OF RHEUMATOID ARTHRITIS . Rheumatic Disease Clinics of North America vol. 27 , ( 2 ) 317 - 334 .

Pitzalis C, Pipitone N, Pipitone V, Fioravanti A, Marcolongo R ( 2001 ) . Rheumatoid arthritis. Recent advances and new pathogenetic hypothesis . Recenti Progressi in Medicina vol. 92 , ( 3 ) 217 - 222 .

Gerli R, Lunardi C, Vinante F, Bistoni O, Pizzolo G, Pitzalis C ( 2001 ) . Role of CD30+ T cells in rheumatoid arthritis: a counter-regulatory paradigm for Th1-driven diseases . Trends in Immunology vol. 22 , ( 2 ) 72 - 77 .

Pitzalis C ( 2001 ) . . Arthritis Research vol. 3 , ( Suppl 1 ) P6 - P6 .

Pipitone N, Fioravanti A, Marcolongo R, Pitzalis C ( 2001 ) . Articular involvement in the course of primary hypogammaglobulinemia . Recenti Progressi in Medicina vol. 92 , ( 1 ) 63 - 67 .

Pitzalis C, Pipitone N, Perretti M ( 2001 ) . Glucocorticoids and leukocyte adhesion . Glucocorticoids , Birkhäuser Basel

Pipitone N, Pipitone V, Pitzalis C ( 2001 ) . Glucocorticoids at the threshold of the new millennium: recent findings on the anti-inflammatory and immunomodulator mechanisms of action and future perspectives . Annali Italiani Di Medicina Interna Organo Ufficiale Della Societa Italiana Di Medicina Interna vol. 16 , ( 3 ) 141 - 154 .

Huizinga TWJ, Keijsers V, Yanni G, Hall M, Ramage W, Lanchbury J, Pitzalis C, Drossaers‐Bakker WK et al. ( 2000 ) . Are differences in interleukin 10 production associated with joint damage? . Rheumatology vol. 39 , ( 11 ) 1180 - 1188 .

Pipitone N, Jolliffe VA, Cauli A, Scott DGI, Pitzalis C ( 2000 ) . Do B cells influence disease progression in chronic synovitis? Lessons from primary hypogammaglobulinaemia . Rheumatology vol. 39 , ( 11 ) 1280 - 1285 .

Pitzalis C, Koch A ( 2000 ) . THE VASCULAR ENDOTHELIAL SYSTEM IN THE PATHOGENESIS OF INFLAMMATION AND SYSTEMIC RHEUMATIC DISEASES: RELATION TO THE NEUROENDOCRINE SYSTEM . Rheumatic Disease Clinics of North America vol. 26 , ( 4 ) 765 - 773 .

Pitzalis C, Pipitone N ( 2000 ) . Psoriatic arthritis . Journal of the Royal Society of Medicine vol. 93 , ( 8 ) 412 - 415 .

Cauli A, Pitzalis C, Yanni G, Awad M, Panayi GS ( 2000 ) . CD1 expression in psoriatic and rheumatoid arthritis . Rheumatology vol. 39 , ( 6 ) 666 - 673 .

Gerli R, Pitzalis C, Bistoni O, Falini B, Costantini V, Russano A, Lunardi C ( 2000 ) . CD30+ T Cells in Rheumatoid Synovitis: Mechanisms of Recruitment and Functional Role . The Journal of Immunology vol. 164 , ( 8 ) 4399 - 4407 .

Pipitone N, Pitzalis C ( 2000 ) . The role of chemokines in inflammation and rheumatoid arthritis . Current Opinion in Anti Inflammatory and Immunomodulatory Investigational Drugs vol. 2 , ( 1 ) 9 - 15 .

Gerli R, Bistoni O, Lunardi C, Giacomelli R, Tomassini C, Biagini P, Pitzalis C ( 1999 ) . Soluble CD30 in early rheumatoid arthritis as a predictor of good response to second-line therapy . Rheumatology vol. 38 , ( 12 ) 1282 - 1284 .

Masi AT, Bijlsma JWJ, Chikanza IC, Pitzalis C, Cutolo M ( 1999 ) . Neuroendocrine, immunologic, and microvascular systems interactions in rheumatoid arthritis: physiopathogenetic and therapeutic perspectives . Seminars in Arthritis and Rheumatism vol. 29 , ( 2 ) 65 - 81 .

Perretti M, Wheller SK, Flower RJ, Wahid S, Pitzalis C ( 1999 ) . Modulation of cellular annexin I in human leukocytes infiltrating DTH skin reactions . J LEUKOCYTE BIOL vol. 65 , ( 5 ) 583 - 589 .

Howie D, Spencer J, DeLord D, Pitzalis C, Wathen NC, Dogan A, Akbar A, MacDonald TT ( 1998 ) . Extrathymic T Cell Differentiation in the Human Intestine Early in Life . The Journal of Immunology vol. 161 , ( 11 ) 5862 - 5872 .

Choy EH, Schantz A, Pitzalis C, Kingsley GH, Panayi GS ( 1998 ) . The pharmacokinetics and human anti-mouse antibody response in rheumatoid arthritis patients treated with a chimeric anti-CD4 monoclonal antibody . Rheumatology vol. 37 , ( 7 ) 801 - 802 .

Pitzalis C ( 1998 ) . Skin and joint disease in psoriatic arthritis: what is the link? . Rheumatology vol. 37 , ( 5 ) 480 - 483 .

Pitzalis C, Choy E ( 1998 ) . Fourth International Symposium on the Immunotherapy of the Rheumatic Diseases. 21-25 May 1997, Cyprus . Annals of the Rheumatic Diseases . vol. 57 ,

Pitzalis C, Choy E ( 1998 ) . Fourth International Symposium on the Immunotherapy of the Rheumatic Diseases . Annals of the Rheumatic Diseases . vol. 57 , 177 - 179 .

Pitzalis C, Pipitone N, Bajocchi G, Hall M, Goulding N, Lee A, Kingsley G, Lanchbury J et al. ( 1997 ) . Corticosteroids inhibit lymphocyte binding to endothelium and intercellular adhesion: an additional mechanism for their anti-inflammatory and immunosuppressive effect . The Journal of Immunology vol. 158 , ( 10 ) 5007 - 5016 .

Pitzalis C, Sharrack B, Gray IA, Lee A, Hughes RAC ( 1997 ) . Comparison of the effects of oral versus intravenous methylprednisolone regimens on peripheral blood T lymphocyte adhesion molecule expression, T cell subsets distribution and TNF alpha concentrations in multiple sclerosis . Journal of Neuroimmunology vol. 74 , ( 1-2 ) 62 - 68 .

Pitzalis C, Pipitone N, Marcolongo R, Galeazzi M ( 1997 ) . Monoclonal antibody therapy . Recenti Progressi in Medicina vol. 88 , ( 3 ) 128 - 133 .

Pitzalis C ( 1996 ) . The Michael Mason Prize Essay 1996. Role of adhesion mechanisms in the pathogenesis of chronic synovitis . Rheumatology vol. 35 , ( 12 ) 1198 - 1215 .

Yanni G, Ramage W, Pitzalis C, Hall M, Lanchbury J, Panayi G ( 1996 ) . Th1 and Th2 cytokines in rheumatoid arthritis . FASEB JOURNAL vol. 10 , ( 6 ) 320 - 320 .

Cauli A, Yanni G, Pitzalis C, Challacombe S, Panayi GS ( 1995 ) . Cytokine and adhesion molecule expression in the minor salivary glands of patients with Sjögren's syndrome and chronic sialoadenitis . Annals of the Rheumatic Diseases vol. 54 , ( 3 ) 209 - 215 .

Pipitone N, Bajocchi G, Pitzalis C ( 1995 ) . Leucocyte adhesion and migration mechanism during inflammation: Role in pathogenesis and prospects for therapy . Reumatismo vol. 47 , ( 2 ) 116 - 125 .

MELICONI R, UGUCCIONI M, CHIECOBIANCHI F, PITZALIS C, BOWMAN S, FACCHINI A, GASBARRINI G, PANAYI GS et al. ( 1995 ) . THE ROLE OF INTERLEUKIN-8 AND OTHER CYTOKINES IN THE PATHOGENESIS OF FELTYS-SYNDROME . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 13 , ( 3 ) 285 - 291 .

Pitzalis C, Kingsley G, Panayi G ( 1994 ) . Adhesion molecules in rheumatoid arthritis: role in the pathogenesis and prospects for therapy . Annals of the Rheumatic Diseases vol. 53 , ( 5 ) 287 - 288 .

ARNOLD MH, PITZALIS C, CORRIGALL VM, PANAYI GS ( 1994 ) . CD8 LYMPHOCYTES IN POLYMYALGIA-RHEUMATICA AND GIANT-CELL ARTERITIS - A REPLY . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 12 , ( 2 ) 228 - 228 .

PITZALIS C, CHOY E, KINGSLEY G ( 1994 ) . MONOCLONAL-ANTIBODY THERAPY IN RHEUMATIC DISEASE . PRESSE MEDICALE vol. 23 , ( 11 ) 532 - 539 .

Lanchbury JS, Pitzalis C ( 1993 ) . Cellular immune mechanisms in rheumatoid arthritis and other inflammatory arthritides . Current Opinion in Immunology vol. 5 , ( 6 ) 918 - 924 .

( 1993 ) . BSR Poster Session a . Rheumatology vol. 32 , ( suppl 1 ) 3 - 88 .

PITZALIS C ( 1993 ) . ADHESION AND MIGRATION OF INFLAMMATORY CELLS . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 11 , S71 - S76 .

ARNOLD MH, CORRIGALL VM, PITZALIS C, PANAYI GS ( 1993 ) . THE SENSITIVITY AND SPECIFICITY OF REDUCED CD8 LYMPHOCYTE LEVELS IN THE DIAGNOSIS OF POLYMYALGIA-RHEUMATICA GIANT-CELL ARTERITIS . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY vol. 11 , ( 6 ) 629 - 634 .

Panayi GS, Kingsley GH, Pitzalis C ( 1992 ) . Adhesion of peripheral blood lymphocytes to high endothelial venules of gut mucosa . Annals of the Rheumatic Diseases vol. 51 , ( 7 ) 926 - 926 .

Groves RW, Simpson KJ, Koblar S, Pitzalis C, Hay RJ ( 1992 ) . Tryptophan Induced Eosinophilia-Myalgia Syndrome: Clinical and Microscopic Findings . Journal of the Royal Society of Medicine vol. 85 , ( 2 ) 111 - 112 .

MELICONI R, KINGSLEY GH, PITZALIS C, SAKKAS L, PANAYI GS ( 1992 ) . ANALYSIS OF LYMPHOCYTE PHENOTYPE AND T-CELL RECEPTOR GENOTYPE IN FELTYS SYNDROME . JOURNAL OF RHEUMATOLOGY vol. 19 , ( 7 ) 1058 - 1064 .

KIRKHAM BW, THIEN F, PELTON BK, PITZALIS C, AMLOT P, DENMAN AM, PANAYI GS ( 1992 ) . CHIMERIC CD7 MONOCLONAL-ANTIBODY THERAPY IN RHEUMATOID-ARTHRITIS . JOURNAL OF RHEUMATOLOGY vol. 19 , ( 9 ) 1348 - 1352 .

Meliconi R, Pitzalis C, Kingsley GH, Panayi GS ( 1991 ) . T cells and their subpopulations in blood and synovial fluid from rheumatoid arthritis and spondyloarthritis . Clinical Immunology and Immunopathology vol. 59 , ( 1 ) 165 - 172 .

KIRKHAM BW, PITZALIS C, KINGSLEY GH, CHIKANZA IC, SABHARWAL S, BARBATIS C, GRAHAME R, GIBSON T et al. ( 1991 ) . MONOCLONAL ANTIBODY TREATMENT IN RHEUMATOID ARTHRITIS: THE CLINICAL AND IMMUNOLOGICAL EFFECTS OF A CD7 MONOCLONAL ANTIBODY . Rheumatology vol. 30 , ( 6 ) 459 - 463 .

Wellicome SM, Thornhill MH, Pitzalis C, Thomas DS, Lanchbury JSS, Panayi GS, Haskard DO ( 1990 ) . A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumor necrosis factor, IL-1, or lipopolysaccharide . The Journal of Immunology vol. 144 , ( 7 ) 2558 - 2565 .

MARKEY AC, ALLEN MH, PITZALIS C, MACDONALD DM ( 1990 ) . T-cell inducer populations in cutaneous inflammation: a predominance of T helper-inducer lymphocytes (THi) in the infiltrate of inflammatory dermatoses . British Journal of Dermatology vol. 122 , ( 3 ) 325 - 332 .

KINGSLEY G, PITZALIS C, PANAYI GS ( 1990 ) . IMMUNOGENETIC AND CELLULAR IMMUNE MECHANISMS IN RHEUMATOID ARTHRITIS: RELEVANCE TO NEW THERAPEUTIC STRATEGIES . Rheumatology vol. 29 , ( 1 ) 58 - 64 .

RIDLEY MG, KINGSLEY G, PITZALIS C, PANAYI GS ( 1990 ) . MONOCYTE ACTIVATION IN RHEUMATOID ARTHRITIS: EVIDENCE FOR <i>IN SITU</i> ACTIVATION AND DIFFERENTIATION IN JOINTS . Rheumatology vol. 29 , ( 2 ) 84 - 88 .

Pitzalis C, Sieper J, Kingsley G, Keat A, Panayi G ( 1990 ) . The immunopathology of sexually acquired reactive arthritis: The role of Chlamydia trachomatis . Reumatismo . vol. 42 , 191 - 197 .

Dasgupta B, Pitzalis C, Panayi GS ( 1989 ) . Inflammation of the uveal tract as a presenting feature of temporal arteritis . Annals of the Rheumatic Diseases vol. 48 , ( 11 ) 964 - 965 .

Dasgupta B, Duke O, Timms AM, Pitzalis C, Panayi GS ( 1989 ) . Selective depletion and activation of CD8+ lymphocytes from peripheral blood of patients with polymyalgia rheumatica and giant cell arteritis . Annals of the Rheumatic Diseases vol. 48 , ( 4 ) 307 - 311 .

HASKARD DO, STROBEL S, THORNHILL M, PITZALIS C, LEVINSKY RJ ( 1989 ) . MECHANISMS OF LYMPHOCYTE ADHESION TO ENDOTHELIAL-CELLS - STUDIES USING A LFA-1-DEFICIENT CELL-LINE . IMMUNOLOGY vol. 66 , ( 1 ) 111 - 116 .

KIRKHAM BW, PITZALIS C, KINGSLEY GH, TIMMS AM, KYRIAZIS N, PANAYI GS ( 1989 ) . RHEUMATOID LYMPHOCYTE-T MHC CLASS-II EXPRESSION - INVITRO STIMULATION PRODUCES NORMAL MHC CLASS-II EXPRESSION, INDEPENDENT OF PROLIFERATION . JOURNAL OF RHEUMATOLOGY vol. 16 , ( 3 ) 270 - 275 .

Kirkham B, Chikanza I, Pitzalis C, Kingsley GH, Grahame R, Gibson T, Panayi GS ( 1988 ) . RESPONSE TO MONOCLONAL CD7 ANTIBODY IN RHEUMATOID ARTHRITIS . The Lancet vol. 331 , ( 8585 ) 589 - 589 .

KINGSLEY G, PITZALIS C, WAUGH AP, PANAYI GS ( 1988 ) . CORRELATION OF IMMUNOREGULATORY FUNCTION WITH CELL PHENOTYPE IN CORD BLOOD-LYMPHOCYTES . CLINICAL AND EXPERIMENTAL IMMUNOLOGY vol. 73 , ( 1 ) 40 - 45 .

Pitzalis C, Kingsley G, Murphy J, Panayi G ( 1987 ) . Abnormal distribution of the helper-inducer and suppressor-inducer T-lymphocyte subsets in the rheumatoid joint . Clinical Immunology and Immunopathology vol. 45 , ( 2 ) 252 - 258 .

KINGSLEY GH, PITZALIS C, PANAYI GS ( 1987 ) . ABNORMAL LYMPHOCYTE-REACTIVITY TO SELF-MAJOR HISTOCOMPATIBILITY ANTIGENS IN RHEUMATOID-ARTHRITIS . JOURNAL OF RHEUMATOLOGY vol. 14 , ( 4 ) 667 - 673 .

PITZALIS C, KINGSLEY G, LANCHBURY JSS, MURPHY J, PANAYI GS ( 1987 ) . EXPRESSION OF HLA-DR, DQ AND DP ANTIGENS AND INTERLEUKIN-2 RECEPTOR ON SYNOVIAL-FLUID LYMPHOCYTE-T SUBSETS IN RHEUMATOID-ARTHRITIS - EVIDENCE FOR FRUSTRATED ACTIVATION . JOURNAL OF RHEUMATOLOGY vol. 14 , ( 4 ) 662 - 666 .

Nicholas NS, Panayi GS, Murphy J, Pitzalis C ( 1986 ) . Human retroplacental sera inhibit the expression of class II major histocompatibility antigens . Journal of Reproductive Immunology vol. 9 , ( 2 ) 95 - 102 .

Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S et al. . Dynamic Spectrum of Ectopic Lymphoid B Cell Activation in the RA Synovium Characterized by NR4A Nuclear Receptor Expression .

Bombardieri M, Nissim A, Mather S, Chernajovsky Y, Wythe S, DiCara D, Taher T, Finucane C et al. . Targeted delivery of anti-inflammatory therapy to rheumatoid tissue by fusion proteins containing an IL-4-linked synovial targeting peptide .