Publications: PROF Mauro Perretti

Gonzalez Nuñez M, da Costa Vasconcellos LR, Garrido Mesa J, Cardoso Maciel Costa Silva R, Hachani A, Bosquet Agudo A, Simeoli R, Medrano Gonzalez L et al. ( 2025 ) . PI3Kδ Bridges Microbial Surveillance with Antigen Presentation to Reinforce Intestinal Immunity .

Margraf A, Chen J, Christoforou M, Claria-Ribas P, Henriques Schneider A, Cecconello C, Bu W, Imbert PRC et al. ( 2025 ) . Formyl-peptide receptor type 2 activation mitigates heart and lung damage in inflammatory arthritis . EMBO Molecular Medicine vol. 17 , ( 5 ) 1153 - 1183 .

Lara ES, Carvalho AFS, Cardoso C, Zaidan I, Grossi LC, Carneiro FS, Lima EBS, Monteiro AHA et al. ( 2025 ) . Annexin A1/FPR2 pathway modulates leukocyte function during <scp><i>Escherichia coli</i></scp>‐induced pneumonia to promote resolution of inflammation and restores lung function . British Journal of Pharmacology vol. 182 , ( 15 ) 3539 - 3558 .

Oggero S, Voisin M-B, Picco F, Huerta MÁ, Cecconello C, Burgoyne T, Perretti M, Malcangio M ( 2025 ) . Activation of proresolving macrophages in dorsal root ganglia attenuates persistent arthritis pain . Proceedings of the National Academy of Sciences vol. 122 , ( 11 ) Article e2416343122 ,

Margraf A, Chen J, Christoforou M, Claria-Ribas P, Schneider AH, Cecconello C, Bu W, Imbert PRC et al. ( 2025 ) . Formyl-peptide receptor type 2 activation mitigates secondary organ damage in inflammatory arthritis .

Pessolano E, Belvedere R, Bizzarro V, Franco P, De Marco I, Porta A, Tosco A, Parente L et al. ( 2024 ) . Correction: Pessolano et al. Annexin A1 May Induce Pancreatic Cancer Progression as a Key Player of Extracellular Vesicles Effects as Evidenced in the In Vitro MIA PaCa-2 Model System. Int. J. Mol. Sci. 2018, 19, 3878 . International Journal of Molecular Sciences vol. 25 , ( 17 ) 9349 - 9349 .

Almeida PRJ, Periard AM, Tana FL, Avila RE, Milhorato LB, Alcantara KMM, Resende CB, Serufo AV et al. ( 2024 ) . Effects of a pro‐resolving drug in COVID‐19: preclinical studies to a randomized, placebo‐controlled, phase Ib/IIa trial in hospitalized patients . British Journal of Pharmacology vol. 181 , ( 23 ) 4750 - 4765 .

Thomas BL, Montero‐Melendez T, Oggero S, Kaneva MK, Chambers D, Pinto AL, Nerviani A, Lucchesi D et al. ( 2024 ) . Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis . Arthritis &amp; Rheumatology vol. 76 , ( 12 ) 1705 - 1718 .

Corsiero E, Caliste M, Pontarini E, Dal Ferro M, Figini M, Luison E, Currado D, Perretti M et al. ( 2024 ) . POS0250 GENERATION AND VALIDATION OF A HUMAN IMMUNE scFv LIBRARY FROM SJÖGREN’S SYNDROME SALIVARY GLAND B-CELLS . Annals of the Rheumatic Diseases . vol. 83 , 281 - 281 .

Andriani A, Marchetti L, Rossi F, Raja S, Perretti MA, Recine U ( 2024 ) . Doct . Mediterranean Journal of Hematology and Infectious Diseases vol. 16 , ( 1 ) e2024030 - e2024030 .

Walker ME, De Matteis R, Perretti M, Dalli J ( 2024 ) . Resolvin T4 enhances macrophage cholesterol efflux to reduce vascular disease . Nature Communications vol. 15 , ( 1 ) Article 975 ,

Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR et al. ( 2024 ) . Addendum: Resolvins suppress tumor growth and enhance cancer therapy . Journal of Experimental Medicine vol. 221 , ( 3 ) Article e2017068101232024a ,

Vestweber D, Claesson-Welsh L, McDonald DM, Williams T, Schwartz MA, Scallan J, Gavins FNE, van Buul J et al. ( 2023 ) . Report from the 2023 workshop on endothelial permeability, edema and inflammation . Nature Cardiovascular Research vol. 2 , ( 12 ) 1120 - 1124 .

Chen J, Oggero S, Cecconello C, Dalli J, Hayat H, Hjiej Andaloussi A, Sanni S, Jonassen TEN et al. ( 2023 ) . The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activation . Pharmacological Research vol. 198 , Article 107005 , 107005 - 107005 .

Granell R, Curtin JA, Haider S, Kitaba NT, Mathie SA, Gregory LG, Yates LL, Tutino M et al. ( 2023 ) . A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing . eLife vol. 12 , Article e84315 ,

Chen J, Austin-Williams S, O'Riordan CE, Claria-Ribas P, Sugimoto MA, Norling LV, Thiemermann C, Perretti M ( 2023 ) . Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction . Journal of Innate Immunity vol. 15 , ( 1 ) 548 - 561 .

Ward EJ, Bert S, Fanti S, Malone KM, Maughan RT, Gkantsinikoudi C, Prin F, Volpato LK et al. ( 2023 ) . Placental Inflammation Leads to Abnormal Embryonic Heart Development . Circulation vol. 147 , ( 12 ) 956 - 972 .

Granell R, Curtin JA, Haider S, Kitaba N, Mathie S, Gregory L, Yates LL, Tutino M et al. ( 2023 ) . A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies<i>ANXA1</i>as a susceptibility locus for persistent wheezing .

Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN et al. ( 2023 ) . Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis . JCI Insight vol. 8 , ( 3 ) Article e168728 ,

Perretti M, Dalli J ( 2023 ) . Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation . Annual Review of Pharmacology and Toxicology vol. 63 , ( 1 ) 449 - 469 .

Chen J, Oggero S, Cecconello C, Veng L, Jonassen T, Perretti M ( 2023 ) . RTP-026 promotes acute cardioprotection through formyl peptide receptor type 2 modulation of immune cell activation . BRITISH JOURNAL OF PHARMACOLOGY . vol. 180 , 512 - 512 .

Perretti M, Subramanian M ( 2023 ) . Resolution pharmacology − A fresh approach to the clinical management of human inflammatory diseases . Seminars in Immunology vol. 65 , Article 101669 , 101669 - 101669 .

Garrido-Mesa J, Thomas BL, Dodd J, Spana C, Perretti M, Montero-Melendez T ( 2022 ) . Pro-resolving and anti-arthritic properties of the MC1 selective agonist PL8177 . Frontiers in Immunology vol. 13 , Article 1078678 ,

Bert S, Nadkarni S, Perretti M ( 2022 ) . <scp>Neutrophil‐T</scp> cell crosstalk and the control of the host inflammatory response . Immunological Reviews vol. 314 , ( 1 ) 36 - 49 .

Oggero S, Cecconello C, Silva R, Zeboudj L, Sideris-Lampretsas G, Perretti M, Malcangio M ( 2022 ) . Dorsal root ganglia CX3CR1 expressing monocytes/macrophages contribute to arthritis pain . Brain, Behavior, and Immunity vol. 106 , 289 - 306 .

de Araújo S, de Melo Costa VR, Santos FM, de Sousa CDF, Moreira TP, Gonçalves MR, Félix FB, Queiroz-Junior CM et al. ( 2022 ) . Annexin A1-FPR2/ALX Signaling Axis Regulates Acute Inflammation during Chikungunya Virus Infection . Cells vol. 11 , ( 17 ) 2717 - 2717 .

Qin CX, Norling LV, Vecchio EA, Brennan EP, May LT, Wootten D, Godson C, Perretti M et al. ( 2022 ) . Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35 . British Journal of Pharmacology vol. 179 , ( 19 ) 4617 - 4639 .

Oggero S, Godec T, van Gorp R, Pinto AL, Schurgers LJ, Reutelingsperger C, Sever P, Norling LV et al. ( 2022 ) . Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients . Journal of Hypertension vol. 40 , ( 8 ) 1522 - 1529 .

Margraf A, Perretti M ( 2022 ) . Immune Cell Plasticity in Inflammation: Insights into Description and Regulation of Immune Cell Phenotypes . Cells vol. 11 , ( 11 ) 1824 - 1824 .

Gadipudi LL, Ramavath NN, Provera A, Reutelingsperger C, Albano E, Perretti M, Sutti S ( 2022 ) . Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis . Clinical Science vol. 136 , ( 9 ) 643 - 656 .

Hamilton A, Rizzo R, Brod S, Ono M, Perretti M, Cooper D, D'Acquisto F ( 2022 ) . The immunomodulatory effects of social isolation in mice are linked to temperature control . Brain, Behavior, and Immunity vol. 102 , 179 - 194 .

Costa VV, Sugimoto MA, Hubner J, Bonilha CS, Queiroz-Junior CM, Gonçalves-Pereira MH, Chen J, Gobbetti T et al. ( 2022 ) . Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease . eLife vol. 11 , Article e73853 ,

Ward EJ, Bert S, Fanti S, Dufton NP, Malone KM, Maughan RT, Prin F, Volpato LK et al. ( 2022 ) . Placental inflammation leads to abnormal embryonic heart development .

Ferreira TPT, Guimarães FV, Sá YAPJ, da Silva Ribeiro NB, de Arantes ACS, de Frias Carvalho V, Sousa LP, Perretti M et al. ( 2022 ) . Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice . Cells vol. 11 , ( 5 ) 759 - 759 .

Maciuszek M, Ortega-Gomez A, Maas SL, Garrido-Mesa J, Ferraro B, Perretti M, Merritt A, Nicolaes GAF et al. ( 2021 ) . Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists . European Journal of Medicinal Chemistry vol. 226 , Article 113805 , 113805 - 113805 .

Costa VV, Sugimoto MA, Hubner J, Bonilha CS, Queiroz-Junior CM, Gonçalves Pereira MH, Chen J, Gobbetti T et al. ( 2021 ) . Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease .

Man F, Nadkarni S, Kanabar V, e-Lacerda RR, Gomes Ferreira S, Federici Canova D, Perretti M, Page CP et al. ( 2021 ) . A peptide derived from chaperonin 60.1, IRL201104, inhibits LPS-induced acute lung inflammation . American Journal of Physiology-Lung Cellular and Molecular Physiology vol. 321 , ( 5 ) L803 - L813 .

das Dores Pereira R, Rabelo RAN, Leite PG, Cramer A, Botelho AFM, Cruz JS, Régis WCB, Perretti M et al. ( 2021 ) . Role of formyl peptide receptor 2 (FPR2) in modulating immune response and heart inflammation in an experimental model of acute and chronic Chagas disease . Cellular Immunology vol. 369 , Article 104427 , 104427 - 104427 .

de Paula-Silva M, da Rocha GHO, Broering MF, Queiroz ML, Sandri S, Loiola RA, Oliani SM, Vieira A et al. ( 2021 ) . Formyl Peptide Receptors and Annexin A1: Complementary Mechanisms to Infliximab in Murine Experimental Colitis and Crohn’s Disease . Frontiers in Immunology vol. 12 , Article 714138 ,

Chen J, Norling LV, Garrido Mesa J, Silva MDP, Burton SE, Reutelingsperger C, Perretti M, Cooper D ( 2021 ) . Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis . Proceedings of the National Academy of Sciences vol. 118 , ( 38 ) Article e2020385118 ,

Hamilton A, Rizzo R, Brod S, Ono M, Perretti M, Cooper D, D’Acquisto F ( 2021 ) . The Immunomodulatory Effects of Social Isolation in Mice are Linked to Temperature Control .

Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS et al. ( 2021 ) . Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation . Immunity vol. 54 , ( 9 ) 1989 - 2004.e9 .

Koenis DS, Beegun I, Jouvene CC, Aguirre GA, Souza PR, Gonzalez-Nunez M, Ly L, Pistorius K et al. ( 2021 ) . Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19 . Circulation Research vol. 129 , ( 4 )

Coenen DM, Heinzmann ACA, Oggero S, Albers HJ, Nagy M, Hagué P, Kuijpers MJE, Vanderwinden J-M et al. ( 2021 ) . Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions . Cells vol. 10 , ( 8 ) 1998 - 1998 .

Pessolano E, Belvedere R, Novizio N, Filippelli A, Perretti M, Whiteford J, Petrella A ( 2021 ) . Mesoglycan connects Syndecan‐4 and VEGFR2 through Annexin A1 and formyl peptide receptors to promote angiogenesis <i>in vitro</i> . The FEBS Journal vol. 288 , ( 22 ) 6428 - 6446 .

de Gaetano M, Tighe C, Gahan K, Zanetti A, Chen J, Newson J, Cacace A, Marai M et al. ( 2021 ) . Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A₄ Mimetics (QNX-sLXms) . Journal of Medicinal Chemistry vol. 64 , ( 13 ) 9193 - 9216 .

Marques RM, Gonzalez-Nunez M, Walker ME, Gomez EA, Colas RA, Montero-Melendez T, Perretti M, Dalli J ( 2021 ) . Loss of 15-lipoxygenase disrupts Treg differentiation altering their pro-resolving functions . Cell Death &amp; Differentiation vol. 28 , ( 11 ) 3140 - 3160 .

Thomas BL, Eldridge SE, Nosrati B, Alvarez M, Thorup A, Nalesso G, Caxaria S, Barawi A et al. ( 2021 ) . WNT3A‐loaded exosomes enable cartilage repair . Journal of Extracellular Vesicles vol. 10 , ( 7 ) Article e12088 ,

Oggero S, de Gaetano M, Marcone S, Fitzsimons S, Pinto AL, Ikramova D, Barry M, Burke D et al. ( 2021 ) . Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity . Journal of Extracellular Vesicles vol. 10 , ( 6 ) Article 12084 ,

Ito T, Shintani Y, Fields L, Shiraishi M, Podaru M, Kainuma S, Yamashita K, Kobayashi K et al. ( 2021 ) . Cell barrier function of resident peritoneal macrophages in post-operative adhesions . Nature Communications vol. 12 , ( 1 ) Article 2232 ,

Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E et al. ( 2021 ) . Corrigendum to “Activation of Melanocortin Receptors MC₁ and MC₅ Attenuates Retinal Damage in Experimental Diabetic Retinopathy” . Mediators of Inflammation vol. 2021 , ( 1 ) Article 9861434 ,

Kaneva MK, Muley MM, Krustev E, Reid AR, Souza PR, Dell’Accio F, McDougall JJ, Perretti M ( 2021 ) . Alpha‐1‐antitrypsin reduces inflammation and exerts chondroprotection in arthritis . The FASEB Journal vol. 35 , ( 5 )

Maciuszek M, Ortega-Gomez A, Maas SL, Perretti M, Merritt A, Soehnlein O, Chapman TM ( 2021 ) . Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation . European Journal of Medicinal Chemistry vol. 214 , Article 113194 , 113194 - 113194 .

Davan-Wetton CSA, Pessolano E, Perretti M, Montero-Melendez T ( 2021 ) . Senescence under appraisal: hopes and challenges revisited . Cellular and Molecular Life Sciences vol. 78 , ( 7 ) 3333 - 3354 .

Novizio N, Belvedere R, Pessolano E, Tosco A, Porta A, Perretti M, Campiglia P, Filippelli A et al. ( 2020 ) . Annexin A1 Released in Extracellular Vesicles by Pancreatic Cancer Cells Activates Components of the Tumor Microenvironment, through Interaction with the Formyl-Peptide Receptors . Cells vol. 9 , ( 12 ) 2719 - 2719 .

Fitzsimons S, Oggero S, Bruen R, McCarthy C, Strowitzki MJ, Mahon NG, Ryan N, Brennan EP et al. ( 2020 ) . microRNA-155 Is Decreased During Atherosclerosis Regression and Is Increased in Urinary Extracellular Vesicles During Atherosclerosis Progression . Frontiers in Immunology vol. 11 , Article 576516 ,

Belvedere R, Morretta E, Pessolano E, Novizio N, Tosco A, Porta A, Whiteford J, Perretti M et al. ( 2020 ) . RETRACTED: Mesoglycan exerts its fibrinolytic effect through the activation of annexin A2 . Journal of Cellular Physiology vol. 236 , ( 7 ) 4926 - 4943 .

Belvedere R, Novizio N, Pessolano E, Tosco A, Eletto D, Porta A, Campiglia P, Perretti M et al. ( 2020 ) . Heparan sulfate binds the extracellular Annexin A1 and blocks its effects on pancreatic cancer cells . Biochemical Pharmacology vol. 182 , Article 114252 , 114252 - 114252 .

Perretti M ( 2020 ) . Switching on resolution to treat RA moves closer to reality . Nature Reviews Rheumatology vol. 17 , ( 2 ) 73 - 74 .

Brouwers H, Jónasdóttir HS, Kuipers ME, Kwekkeboom JC, Auger JL, Gonzalez-Torres M, López-Vicario C, Clària J et al. ( 2020 ) . Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid . The Journal of Immunology vol. 205 , ( 10 ) 2840 - 2849 .

Souza PR, Walker ME, Goulding NJ, Dalli J, Perretti M, Norling LV ( 2020 ) . The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections . Frontiers in Immunology vol. 11 , Article 573019 ,

Perretti M, Godson C ( 2020 ) . Formyl peptide receptor type 2 agonists to kick‐start resolution pharmacology . British Journal of Pharmacology vol. 177 , ( 20 ) 4595 - 4600 .

Serhan CN, Gupta SK, Perretti M, Godson C, Brennan E, Li Y, Soehnlein O, Shimizu T et al. ( 2020 ) . The Atlas of Inflammation Resolution (AIR) . Molecular Aspects of Medicine vol. 74 , Article 100894 , 100894 - 100894 .

Serhan CN, Gupta SK, Perretti M, Godson C, Brennan E, Li Y, Soehnlein O, Shimizu T et al. ( 2020 ) . WITHDRAWN: The Atlas of Inflammation Resolution (AIR) . Molecular Aspects of Medicine Article 100893 , 100893 - 100893 .

Piras G, Rattazzi L, Paschalidis N, Oggero S, Berti G, Ono M, Bellia F, D'Addario C et al. ( 2020 ) . Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells . Brain, Behavior, and Immunity vol. 87 , 689 - 702 .

Hebeda CB, Sandri S, Benis CM, Paula-Silva MD, Loiola RA, Reutelingsperger C, Perretti M, Farsky SHP ( 2020 ) . Annexin A1/Formyl Peptide Receptor Pathway Controls Uterine Receptivity to the Blastocyst . Cells vol. 9 , ( 5 ) 1188 - 1188 .

Allen BL, Montague-Cardoso K, Simeoli R, Colas RA, Oggero S, Vilar B, McNaughton PA, Dalli J et al. ( 2020 ) . Imbalance of proresolving lipid mediators in persistent allodynia dissociated from signs of clinical arthritis . Pain vol. 161 , ( 9 ) 2155 - 2166 .

Corsiero E, Carlotti E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M ( 2020 ) . H and L Chain Affinity Maturation and/or Fab <i>N</i>-Glycosylation Influence Immunoreactivity toward Neutrophil Extracellular Trap Antigens in Rheumatoid Arthritis Synovial B Cell Clones . The Journal of Immunology vol. 204 , ( 9 ) 2374 - 2379 .

Norling LV, Perretti M ( 2020 ) . Proresolving lipid mediators enhance PMN-mediated bacterial clearance . Proceedings of the National Academy of Sciences vol. 117 , ( 17 ) 9148 - 9150 .

Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin M-B, Vinci C et al. ( 2020 ) . Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody . Frontiers in Immunology vol. 11 , Article 10 ,

Montero-Melendez T, Nagano A, Chelala C, Filer A, Buckley CD, Perretti M ( 2020 ) . Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis . Nature Communications vol. 11 , ( 1 ) Article 745 ,

McArthur S, Juban G, Gobbetti T, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa JE, Reutelingsperger CP et al. ( 2020 ) . Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation . Journal of Clinical Investigation vol. 130 , ( 3 ) 1156 - 1167 .

Belvedere R, Pessolano E, Porta A, Tosco A, Parente L, Petrella F, Perretti M, Petrella A ( 2020 ) . Mesoglycan induces the secretion of microvesicles by keratinocytes able to activate human fibroblasts and endothelial cells: A novel mechanism in skin wound healing . European Journal of Pharmacology vol. 869 , Article 172894 , 172894 - 172894 .

Serhan CN, Gupta S, Perretti M, Godson C, Brennan E, Li Y, Soehnlein O, Shimizu T et al. ( 2020 ) . The Atlas of Inflammation-Resolution (AIR) .

Machado MG, Tavares LP, Souza GVS, Queiroz‐Junior CM, Ascenção FR, Lopes ME, Garcia CC, Menezes GB et al. ( 2019 ) . The Annexin A1/FPR2 pathway controls the inflammatory response and bacterial dissemination in experimental pneumococcal pneumonia . The FASEB Journal vol. 34 , ( 2 ) 2749 - 2764 .

Sinniah A, Yazid S, Bena S, Oliani SM, Perretti M, Flower RJ ( 2019 ) . Endogenous Annexin-A1 Negatively Regulates Mast Cell-Mediated Allergic Reactions . Frontiers in Pharmacology vol. 10 , Article 1313 ,

Oggero S, de Gaetano M, Marcone S, Barry M, Montero-Melendez T, Cooper D, Norling LV, Brennan EP et al. ( 2019 ) . Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque responses .

Piras G, Rattazzi L, Paschalidis N, Oggero S, Berti G, Ono M, Bellia F, D’Addario C et al. ( 2019 ) . Immuno-<i>moodulin</i>: a new anxiogenic factor produced by autoimmune-prone T cells .

Barbosa CMV, Fock RA, Hastreiter AA, Reutelingsperger C, Perretti M, Paredes-Gamero EJ, Farsky SHP ( 2019 ) . Extracellular annexin-A1 promotes myeloid/granulocytic differentiation of hematopoietic stem/progenitor cells via the Ca2+/MAPK signalling transduction pathway . Cell Death Discovery vol. 5 , ( 1 ) Article 135 ,

Everts-Graber J, Martin KR, Thieblemont N, Mocek J, Roccabianca A, Chafey P, Le Gall M, Tacnet-Delorme P et al. ( 2019 ) . Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance . Kidney International vol. 96 , ( 2 ) 397 - 408 .

Senchenkova EY, Ansari J, Becker F, Vital SA, Al-Yafeai Z, Sparkenbaugh EM, Pawlinski R, Stokes KY et al. ( 2019 ) . Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation . Circulation vol. 140 , ( 4 ) 319 - 335 .

Pessolano E, Belvedere R, Bizzarro V, Franco P, De Marco I, Petrella F, Porta A, Tosco A et al. ( 2019 ) . Annexin A1 Contained in Extracellular Vesicles Promotes the Activation of Keratinocytes by Mesoglycan Effects: An Autocrine Loop Through FPRs . Cells vol. 8 , ( 7 ) 753 - 753 .

Salamah MF, Ravishankar D, Vaiyapuri R, Moraes LA, Patel K, Perretti M, Gibbins JM, Vaiyapuri S ( 2019 ) . The formyl peptide fMLF primes platelet activation and augments thrombus formation . Journal of Thrombosis and Haemostasis vol. 17 , ( 7 ) 1120 - 1133 .

Vago JP, Sugimoto MA, Lima KM, Negreiros-Lima GL, Baik N, Teixeira MM, Perretti M, Parmer RJ et al. ( 2019 ) . Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes . Frontiers in Immunology vol. 10 , Article 1458 ,

Bizzarro V, Belvedere R, Pessolano E, Parente L, Petrella F, Perretti M, Petrella A ( 2019 ) . Mesoglycan induces keratinocyte activation by triggering syndecan‐4 pathway and the formation of the annexin A1/S100A11 complex . Journal of Cellular Physiology vol. 234 , ( 11 ) 20174 - 20192 .

Nadkarni S, Lashin H, Hollywood J, Dasgupta B, Mason JC, Perretti M ( 2019 ) . Identification of an activated neutrophil phenotype in polymyalgia rheumatica during steroid treatment: a potential involvement of immune cell cross-talk . Clinical Science vol. 133 , ( 7 ) 839 - 851 .

Voisin M, Leoni G, Woodfin A, Loumagne L, Patel NSA, Di Paola R, Cuzzocrea S, Thiemermann C et al. ( 2019 ) . Neutrophil elastase plays a non‐redundant role in remodeling the venular basement membrane and neutrophil diapedesis post‐ischemia/reperfusion injury . The Journal of Pathology vol. 248 , ( 1 ) 88 - 102 .

Di Paola R, Fusco R, Gugliandolo E, D’Amico R, Cordaro M, Impellizzeri D, Perretti M, Cuzzocrea S ( 2019 ) . Formyl peptide receptor 1 signalling promotes experimental colitis in mice . Pharmacological Research vol. 141 , 591 - 601 .

Sugimoto MA, Vago JP, Perretti M, Teixeira MM ( 2019 ) . Mediators of the Resolution of the Inflammatory Response . Trends in Immunology vol. 40 , ( 3 ) 212 - 227 .

de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E et al. ( 2019 ) . Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms) . European Journal of Medicinal Chemistry vol. 162 , 80 - 108 .

Corsiero E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M ( 2019 ) . Characterization of calreticulin, a stromal-derived autoantigens, recognized by RA synovial recombinant monoclonal antibodies . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 49 , 773 - 774 .

Oggero S, Van Gorp R, Cooper D, Norling L, Schurgers L, Reutelinsperger C, Perretti M ( 2019 ) . Monocyte and not Neutrophil derived microvesicles are able to activate endothelial cells and smooth muscle cells and to enhance recruitment of PMN in a Flow Chamber based assay . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION . vol. 49 , 198 - 199 .

Cacace A, Chen J, de Gaetano M, Marai M, Guiry P, Gahan K, Brennan E, Perretti M et al. ( 2019 ) . Protective role of a synthetic LipoxinA4 mimetic (sLXm) in an in vivo model of sepsis . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION . vol. 49 , 140 - 141 .

Pessolano E, Belvedere R, Bizzarro V, Franco P, De Marco I, Porta A, Tosco A, Parente L et al. ( 2018 ) . Annexin A1 May Induce Pancreatic Cancer Progression as a Key Player of Extracellular Vesicles Effects as Evidenced in the In Vitro MIA PaCa-2 Model System . International Journal of Molecular Sciences vol. 19 , ( 12 ) 3878 - 3878 .

Petri MH, Thul S, Andonova T, Lindquist-Liljeqvist M, Jin H, Skenteris N-T, Arnardottir H, Maegdefessel L et al. ( 2018 ) . Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms . JACC: Basic to Translational Science vol. 3 , ( 6 ) 719 - 727 .

Salamah MF, Ravishankar D, Kodji X, Moraes LA, Williams HF, Vallance TM, Albadawi DA, Vaiyapuri R et al. ( 2018 ) . The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation . Blood Advances vol. 2 , ( 21 ) 2973 - 2985 .

Frigerio F, Pasqualini G, Craparotta I, Marchini S, van Vliet EA, Foerch P, Vandenplas C, Leclercq K et al. ( 2018 ) . n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis . Brain

Thomas BL, Perretti M ( 2018 ) . Neutrophil wrap . Nature Nanotechnology vol. 13 , ( 12 ) 1098 - 1099 .

Corsiero E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M ( 2018 ) . Characterization of a Synovial B Cell–Derived Recombinant Monoclonal Antibody Targeting Stromal Calreticulin in the Rheumatoid Joints . The Journal of Immunology vol. 201 , ( 5 ) 1373 - 1381 .

Patruno S, Garrido-Mesa J, Romano M, Perretti M, Montero-Melendez T ( 2018 ) . Ligand Bias and Its Association With Pro-resolving Actions of Melanocortin Drugs . Frontiers in Pharmacology vol. 9 , Article 919 ,

McArthur S, Gobbetti T, Juban G, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa JE, Reutelingsperger CP et al. ( 2018 ) . Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation .

Piovezan AP, Perretti M ( 2018 ) . Potential engagement of pathways of the resolution of inflammation as mechanism of action for plants on animal models . Journal of Ethnopharmacology vol. 221 , 160 - 161 .

Qin CX, Finlayson SB, Al-Sharea A, Tate M, De Blasio MJ, Deo M, Rosli S, Prakoso D et al. ( 2018 ) . Author Correction: Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo . Scientific Reports vol. 8 , ( 1 ) Article 7185 ,

Fusco R, Di Paola R, Gugliandolo E, D'Amico R, Perretti M, Cuzzocrea S ( 2018 ) . Formyl peptide receptor 1 signalling promotes experimental colitis in mice . The FASEB Journal vol. 32 , ( S1 )

Lashin HMS, Nadkarni S, Oggero S, Jones HR, Knight JC, Hinds CJ, Perretti M ( 2018 ) . Microvesicle Subsets in Sepsis Due to Community Acquired Pneumonia Compared to Faecal Peritonitis . Shock vol. 49 , ( 4 ) 393 - 401 .

Thomas BL, Jones HR, Norling LV, Headland SE, Pitzalis C, Dell'Accio F, Perretti M ( 2018 ) . Neutrophil extracellular vesicles have a cartilage protective effect during inflammatory arthritis . Osteoarthritis and Cartilage . vol. 26 , S125 - S126 .

Hebeda CB, Machado ID, Reif‐Silva I, Moreli JB, Oliani SM, Nadkarni S, Perretti M, Bevilacqua E et al. ( 2018 ) . Endogenous annexin A1 (AnxA1) modulates early‐phase gestation and offspring sex‐ratio skewing . Journal of Cellular Physiology vol. 233 , ( 9 ) 6591 - 6603 .

Rhys HI, Dell'Accio F, Pitzalis C, Moore A, Norling LV, Perretti M ( 2018 ) . Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages . EBioMedicine vol. 29 , 60 - 69 .

Maciuszek M, Chapman T, Nicoales G, Birchall K, Reutelingsperger C, Perretti M, Merritt A ( 2018 ) . Investigating the binding modes and structure-activity relationships of small molecule FPR2 agonists using receptor homology modelling . ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY . vol. 256 ,

Maisto R, Gesualdo C, Trotta MC, Rossi S, Simonelli F, Grieco P, Merlino F, Perretti M et al. ( 2018 ) . MODULATION OF DIABETIC RETINOPATHY BY MELANOCORTIN MC1 AND MC5 RECEPTOR SUBTYPES ACTIVATION IN A MOUSE MODEL OF STZ-INDUCED DIABETIC RETINOPATHY AND RETINAL CELLS CULTURE . BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY . vol. 123 , 45 - 45 .

Oggero S, Norling L, Perretti M ( 2018 ) . Microvesicles in cardiovascular inflammation: markers or mediators of cardiovascular diseases? . Proceedings for Annual Meeting of The Japanese Pharmacological Society vol. WCP2018 , ( 0 )

Perretti M, Norling LV ( 2017 ) . Actions of SPM in regulating host responses in arthritis . Molecular Aspects of Medicine vol. 58 , 57 - 64 .

Qin CX, Finlayson SB, Al-Sharea A, Tate M, De Blasio MJ, Deo M, Rosli S, Prakoso D et al. ( 2017 ) . Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo . Scientific Reports vol. 7 , ( 1 ) Article 16615 ,

Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR et al. ( 2017 ) . Resolvins suppress tumor growth and enhance cancer therapy . Journal of Experimental Medicine vol. 215 , ( 1 ) 115 - 140 .

Simeoli R, Montague K, Jones HR, Castaldi L, Chambers D, Kelleher JH, Vacca V, Pitcher T et al. ( 2017 ) . Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma . Nature Communications vol. 8 , ( 1 ) Article 1778 ,

Perretti M, MonteroMelendez T ( 2017 ) . Resolution in an ‘over-inflamed’ era . The Biochemist vol. 39 , ( 4 ) 4 - 7 .

Lima KM, Vago JP, Caux TR, Negreiros-Lima GL, Sugimoto MA, Tavares LP, Arribada RG, Carmo AAF et al. ( 2017 ) . The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1 . Journal of Biological Chemistry vol. 292 , ( 33 ) 13758 - 13773 .

Gittens BR, Bodkin JV, Nourshargh S, Perretti M, Cooper D ( 2017 ) . Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation . The Journal of Immunology vol. 198 , ( 11 ) 4458 - 4469 .

Piovezan AP, Batisti AP, Benevides MLACS, Turnes BL, Martins DF, Kanis L, Duarte ECW, Cavalheiro AJ et al. ( 2017 ) . Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways . Journal of Ethnopharmacology vol. 204 , 179 - 188 .

Perretti M, Di Filippo C, D’Amico M, Dalli J ( 2017 ) . Characterizing the anti-inflammatory and tissue protective actions of a novel Annexin A1 peptide . PLOS ONE vol. 12 , ( 4 ) e0175786 - e0175786 .

Brod S, Gobbetti T, Gittens B, Ono M, Perretti M, D’Acquisto F ( 2017 ) . The impact of environmental enrichment on the murine inflammatory immune response . JCI Insight vol. 2 , ( 7 ) Article e90723 ,

Kaneva MK, Greco KV, Headland SE, Montero-Melendez T, Mori P, Greenslade K, Pitzalis C, Moore A et al. ( 2017 ) . Identification of Novel Chondroprotective Mediators in Resolving Inflammatory Exudates . The Journal of Immunology vol. 198 , ( 7 ) 2876 - 2885 .

Gobbetti T, Dalli J, Colas RA, Federici Canova D, Aursnes M, Bonnet D, Alric L, Vergnolle N et al. ( 2017 ) . Protectin D1\n _{n-3 DPA}\n and resolvin D5\n _{n-3 DPA}\n are effectors of intestinal protection . Proceedings of the National Academy of Sciences vol. 114 , ( 15 ) 3963 - 3968 .

Petri MH, Laguna‐Fernandez A, Arnardottir H, Wheelock CE, Perretti M, Hansson GK, Bäck M ( 2017 ) . Aspirin‐triggered lipoxin A4 inhibits atherosclerosis progression in apolipoprotein E^−/− mice . British Journal of Pharmacology vol. 174 , ( 22 ) 4043 - 4054 .

Perretti M, Cooper D, Dalli J, Norling LV ( 2017 ) . Immune resolution mechanisms in inflammatory arthritis . Nature Reviews Rheumatology vol. 13 , ( 2 ) 87 - 99 .

Bruzzì S, Sutti S, Toscani A, Bozzola C, Reutelingsperger C, Kusters D, Mcarthur S, Perretti M et al. ( 2017 ) . Annexin A1 supplementation prevents the progression to fibrosis of nonalcoholic steatoepatitis (NASH) . Journal of Hepatology . vol. 66 , S608 - S608 .

Frigerio F, Colas R, Marchini S, van Vliet E, Foerch P, Aronica E, Perretti M, Dalli J et al. ( 2017 ) . PRORESOLVING ANTIINFLAMMATORY MECHANISMS ARE NOVEL POTENTIAL TARGETS AGAINST EPILEPTOGENESIS . EPILEPSIA . vol. 58 , S5 - S5 .

Nadkarni S, Smith J, Sferruzzi-Perri AN, Ledwozyw A, Kishore M, Haas R, Mauro C, Williams DJ et al. ( 2016 ) . Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy . Proceedings of the National Academy of Sciences vol. 113 , ( 52 )

Montero-Melendez T, Forfar RAE, Cook JM, Jerman JC, Taylor DL, Perretti M ( 2016 ) . Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3 . Cellular and Molecular Life Sciences vol. 74 , ( 7 ) 1335 - 1345 .

Simeoli R, Mattace Raso G, Pirozzi C, Lama A, Santoro A, Russo R, Montero‐Melendez T, Berni Canani R et al. ( 2016 ) . An orally administered butyrate‐releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium‐induced murine colitis . British Journal of Pharmacology vol. 174 , ( 11 ) 1484 - 1496 .

Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M, Serhan CN ( 2016 ) . Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation . The Journal of Immunology vol. 197 , ( 6 ) 2362 - 2368 .

Madeira MFM, Queiroz‐Junior CM, Montero‐Melendez T, Werneck SMC, Corrêa JD, Soriani FM, Garlet GP, Souza DG et al. ( 2016 ) . Melanocortin agonism as a viable strategy to control alveolar bone loss induced by oral infection . The FASEB Journal vol. 30 , ( 12 ) 4033 - 4041 .

Montero-Melendez T, Buckley CD, Filer A, Turner JD, Perretti M ( 2016 ) . AB0077 Targeting Synovial Fibroblasts with Melanocortin Drugs . Annals of the Rheumatic Diseases . vol. 75 , 923 - 923 .

Eldridge S, Nalesso G, Ismail H, Vicente-Greco K, Kabouridis P, Ramachandran M, Niemeier A, Herz J et al. ( 2016 ) . Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo . Annals of the Rheumatic Diseases vol. 75 , ( 6 ) 1228 - 1235 .

Norling L, Headland S, Dalli J, Arnardottir H, Jones H, Haworth O, Serhan C, Perretti M ( 2016 ) . SAT0026 Pro-Resolving and Cartilage-Protective Actions of Resolvin D1 in Inflammatory Arthritis . Annals of the Rheumatic Diseases . vol. 75 , 673 - 673 .

Vital SA, Becker F, Holloway PM, Russell J, Perretti M, Granger DN, Gavins FNE ( 2016 ) . Formyl-Peptide Receptor 2/3/Lipoxin A\n ₄\n Receptor Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral Inflammation . Circulation vol. 133 , ( 22 ) 2169 - 2179 .

Chen J, Kieswich JE, Chiazza F, Moyes AJ, Gobbetti T, Purvis GSD, Salvatori DCF, Patel NSA et al. ( 2016 ) . IκB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD . Journal of the American Society of Nephrology vol. 28 , ( 1 ) 94 - 105 .

Sugimoto MA, Sousa LP, Pinho V, Perretti M, Teixeira MM ( 2016 ) . Resolution of Inflammation: What Controls Its Onset? . Frontiers in Immunology vol. 7 ,

Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN et al. ( 2016 ) . Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis . JCI Insight vol. 1 , ( 5 )

Jones HR, Robb CT, Perretti M, Rossi AG ( 2016 ) . The role of neutrophils in inflammation resolution . Seminars in Immunology vol. 28 , ( 2 ) 137 - 145 .

Brancaleone V, Esposito I, Gargiulo A, Vellecco V, Asimakopoulou A, Citi V, Calderone V, Gobbetti T et al. ( 2016 ) . <scp>d</scp>‐Penicillamine modulates hydrogen sulfide (<scp>H₂S</scp>) pathway through selective inhibition of cystathionine‐γ‐lyase . British Journal of Pharmacology vol. 173 , ( 9 ) 1556 - 1565 .

Machado ID, Spatti M, Hastreiter A, Santin JR, Fock RA, Gil CD, Oliani SM, Perretti M et al. ( 2016 ) . Annexin A1 Is a Physiological Modulator of Neutrophil Maturation and Recirculation Acting on the CXCR4/CXCL12 Pathway . Journal of Cellular Physiology vol. 231 , ( 11 ) 2418 - 2427 .

Sinniah A, Yazid S, Perretti M, Solito E, Flower RJ ( 2016 ) . The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil . International Immunopharmacology vol. 32 , 87 - 95 .

Vago JP, Tavares LP, Sugimoto MA, Lima GLN, Galvão I, de Caux TR, Lima KM, Ribeiro ALC et al. ( 2016 ) . Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1 . The Journal of Immunology vol. 196 , ( 4 ) 1922 - 1932 .

Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E et al. ( 2016 ) . Activation of Melanocortin Receptors MC₁and MC₅Attenuates Retinal Damage in Experimental Diabetic Retinopathy . Mediators of Inflammation vol. 2016 , 1 - 13 .

Di Perna L, Gesualdo C, Maisto R, Di Filippo C, Perretti M, Testa F, Rossi S, D'amico M et al. ( 2016 ) . Activation of melanocortin receptors Mc1 and Mc5 attenuates retinal damage in experimental diabetic retinopathy . INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . vol. 57 ,

Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A et al. ( 2015 ) . Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis . Science Translational Medicine vol. 7 , ( 315 )

Canova DF, Pavlov AM, Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB et al. ( 2015 ) . Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response . Journal of Controlled Release vol. 217 , 284 - 292 .

Perretti M, Leroy X, Bland EJ, Montero-Melendez T ( 2015 ) . Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation . Trends in Pharmacological Sciences vol. 36 , ( 11 ) 737 - 755 .

Holloway PM, Durrenberger PF, Trutschl M, Cvek U, Cooper D, Orr AW, Perretti M, Getting SJ et al. ( 2015 ) . Both MC\n ₁\n and MC\n ₃\n Receptors Provide Protection From Cerebral Ischemia-Reperfusion–Induced Neutrophil Recruitment . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 35 , ( 9 ) 1936 - 1944 .

McArthur S, Gobbetti T, Kusters DHM, Reutelingsperger CP, Flower RJ, Perretti M ( 2015 ) . Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation . The Journal of Immunology vol. 195 , ( 3 ) 1139 - 1151 .

Haas R, Smith J, Rocher-Ros V, Nadkarni S, Montero-Melendez T, D’Acquisto F, Bland EJ, Bombardieri M et al. ( 2015 ) . Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions . PLOS Biology vol. 13 , ( 7 ) e1002202 - e1002202 .

Kusters DHM, Chatrou ML, Willems BAG, De Saint-Hubert M, Bauwens M, van der Vorst E, Bena S, Biessen EAL et al. ( 2015 ) . Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet . PLOS ONE vol. 10 , ( 6 ) e0130484 - e0130484 .

Perretti M ( 2015 ) . The resolution of inflammation: New mechanisms in patho-physiology open opportunities for pharmacology . Seminars in Immunology vol. 27 , ( 3 ) 145 - 148 .

Trentin PG, Ferreira TPT, Arantes ACS, Ciambarella BT, Cordeiro RSB, Flower RJ, Perretti M, Martins MA et al. ( 2015 ) . Annexin <scp>A1</scp> mimetic peptide controls the inflammatory and fibrotic effects of silica particles in mice . British Journal of Pharmacology vol. 172 , ( 12 ) 3058 - 3071 .

Montero-Melendez T, Gobbetti T, Cooray SN, Jonassen TEN, Perretti M ( 2015 ) . Biased Agonism as a Novel Strategy To Harness the Proresolving Properties of Melanocortin Receptors without Eliciting Melanogenic Effects . The Journal of Immunology vol. 194 , ( 7 ) 3381 - 3388 .

Amoruso A, Fresu LG, Dalli J, Miglietta D, Bardelli C, Canova DF, Perretti M, Brunelleschi S ( 2015 ) . Characterization of the anti-inflammatory properties of NCX 429, a dual-acting compound releasing nitric oxide and naproxen . Life Sciences vol. 126 , 28 - 36 .

Flower RJ, Perretti M ( 2015 ) . ‘Annexins’ themed section . British Journal of Pharmacology vol. 172 , ( 7 ) 1651 - 1652 .

Fredman G, Kamaly N, Spolitu S, Milton J, Ghorpade D, Chiasson R, Kuriakose G, Perretti M et al. ( 2015 ) . Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice . Science Translational Medicine vol. 7 , ( 275 )

Leoni G, Neumann P-A, Kamaly N, Quiros M, Nishio H, Jones HR, Sumagin R, Hilgarth RS et al. ( 2015 ) . Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair . Journal of Clinical Investigation vol. 125 , ( 3 ) 1215 - 1227 .

Petri MH, Laguna-Fernandez A, Tseng C-N, Hedin U, Perretti M, Bäck M ( 2015 ) . Aspirin-triggered 15-epi-lipoxin A4 signals through FPR2/ALX in vascular smooth muscle cells and protects against intimal hyperplasia after carotid ligation . International Journal of Cardiology vol. 179 , 370 - 372 .

Chen J, Kieswich J, Chiazza F, Gobbetti T, Patel NS, Perretti M, Collino M, Yaqoob MM et al. ( 2015 ) . THE CARDIAC DYSFUNCTION CAUSED BY SEPSIS IN ANIMALS WITH CHRONIC KIDNEY DISEASE IS ATTENUATED BY INHIBITING IκB KINASE . SHOCK . vol. 43 , 92 - 93 .

Gallo I, Rattazzi L, Piras G, Gobbetti T, Panza E, Perretti M, Dalley JW, D'Acquisto F ( 2014 ) . Formyl Peptide Receptor as a Novel Therapeutic Target for Anxiety-Related Disorders . PLoS ONE vol. 9 , ( 12 ) e114626 - e114626 .

Gobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C et al. ( 2014 ) . Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis . Proceedings of the National Academy of Sciences vol. 111 , ( 52 ) 18685 - 18690 .

Gobbetti T, Ducheix S, le Faouder P, Perez T, Riols F, Boue J, Bertrand‐Michel J, Dubourdeau M et al. ( 2014 ) . Protective effects of n‐6 fatty acids‐enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin <scp>A</scp>₄ and its receptor . British Journal of Pharmacology vol. 172 , ( 3 ) 910 - 923 .

Thompson D, McArthur S, Hislop JN, Flower RJ, Perretti M ( 2014 ) . Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor . Journal of Biological Chemistry vol. 289 , ( 52 ) 36166 - 36178 .

Machado ID, Santin JR, Drewes CC, Gil CD, Oliani SM, Perretti M, Farsky SHP ( 2014 ) . Alterations in the profile of blood neutrophil membrane receptors caused by in vivo adrenocorticotrophic hormone actions . American Journal of Physiology-Endocrinology and Metabolism vol. 307 , ( 9 ) E754 - E763 .

Dufton NP, Hannon R, Perretti M, Flower R ( 2014 ) . Quantitative Analysis of Promoter Activity by Green Fluorescent Protein (GFP) Target/Reporter Strategy in a Novel Transgenic alx/fpr-rs2 Null Mouse . Inflammation Research vol. 58 , ( S2 ) S252 - S255 .

Paul-Clark MJ, Perretti M ( 2003 ) . The enhanced anti-inflammatory properties of nitro-prednisolone (NCX-1015) is linked to post-translational modification of the glucocorticoid receptor . Inflammation Research . vol. 52 , S194 - S196 .

Paschalidis N, Huggins A, Rowbotham NJ, Furmanski AL, Crompton T, Flower RJ, Perretti M, D’Acquisto F ( 2014 ) . Role of endogenous Annexin-A1 in the regulation of thymocyte positive and negative selection . Cell Cycle vol. 9 , ( 4 ) 785 - 794 .

Greco KV, Nalesso G, Kaneva MK, Sherwood J, Iqbal AJ, Moradi-Bidhendi N, Dell’Accio F, Perretti M ( 2014 ) . Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin . Biochemical Pharmacology vol. 91 , ( 3 ) 348 - 358 .

Brancaleone V, Mitidieri E, Flower RJ, Cirino G, Perretti M ( 2014 ) . Annexin A1 Mediates Hydrogen Sulfide Properties in the Control of Inflammation . The Journal of Pharmacology and Experimental Therapeutics vol. 351 , ( 1 ) 96 - 104 .

Yona S, Heinsbroek S, Gordon S, Perretti M, Flower RJ ( 2014 ) . A novel role for Annexin 1 in macrophage phagocytosis . Inflammation Research vol. 54 , ( S2 ) S217 - S218 .

Fredman G, Ozcan L, Spolitu S, Hellmann J, Spite M, Backs J, Tabas I ( 2014 ) . Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B\n ₄\n synthesis by inhibiting a calcium-activated kinase pathway . Proceedings of the National Academy of Sciences . vol. 111 , 14530 - 14535 .

Burgmaier M, Schutters K, Willems B, van der Vorst EPC, Kusters D, Chatrou M, Norling L, Biessen EAL et al. ( 2014 ) . AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE^−/− mice . Journal of Cellular and Molecular Medicine vol. 18 , ( 10 ) 2117 - 2124 .

Montero-Melendez T, Madeira MFM, Norling LV, Alsam A, Curtis MA, da Silva TA, Perretti M ( 2014 ) . Association between Periodontal Disease and Inflammatory Arthritis Reveals Modulatory Functions by Melanocortin Receptor Type 3 . The American Journal of Pathology vol. 184 , ( 8 ) 2333 - 2341 .

Locatelli I, Sutti S, Jindal A, Vacchiano M, Bozzola C, Reutelingsperger C, Kusters D, Bena S et al. ( 2014 ) . Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice . Hepatology vol. 60 , ( 2 ) 531 - 544 .

Ahmed TJ, Kaneva MK, Pitzalis C, Cooper D, Perretti M ( 2014 ) . Resolution of inflammation: examples of peptidergic players and pathways . Drug Discovery Today vol. 19 , ( 8 ) 1166 - 1171 .

Cash JL, Norling LV, Perretti M ( 2014 ) . Resolution of inflammation: targeting GPCRs that interact with lipids and peptides . Drug Discovery Today vol. 19 , ( 8 ) 1186 - 1192 .

Montero-Melendez T, Perretti M ( 2014 ) . Connections in pharmacology: innovation serving translational medicine . Drug Discovery Today vol. 19 , ( 7 ) 820 - 823 .

Headland SE, Jones HR, D'Sa ASV, Perretti M, Norling LV ( 2014 ) . Cutting-Edge Analysis of Extracellular Microparticles using ImageStreamX Imaging Flow Cytometry . Scientific Reports vol. 4 , ( 1 ) Article 5237 ,

Hardy W, Wright F, Hawtree S, Fearon U, Veale D, Perretti M, Wilson A, Muthana M ( 2014 ) . OP0296 Hypoxia-Inducible Factor 2A Regulates Macrophage Function in Rheumatoid Arthritis . Annals of the Rheumatic Diseases . vol. 73 , 174 - 174 .

Old EA, Nadkarni S, Grist J, Gentry C, Bevan S, Kim K-W, Mogg AJ, Perretti M et al. ( 2014 ) . Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain . Journal of Clinical Investigation vol. 124 , ( 5 ) 2023 - 2036 .

Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, Infante E, Ridley AJ et al. ( 2014 ) . Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation . Nature Communications vol. 5 , ( 1 ) Article 3436 ,

Montero-Melendez T, Perretti M ( 2014 ) . Gapdh Gene Expression Is Modulated by Inflammatory Arthritis and Is not Suitable for qPCR Normalization . Inflammation vol. 37 , ( 4 ) 1059 - 1069 .

Nadkarni S, Dalli J, Hollywood J, Mason JC, Dasgupta B, Perretti M ( 2014 ) . Investigational Analysis Reveals a Potential Role for Neutrophils in Giant-Cell Arteritis Disease Progression . Circulation Research vol. 114 , ( 2 ) 242 - 248 .

Farsky SHP, Santin JR, Takahama C, Machado ID, Teixeira S, Muscara MN, Pitta IR, Solito E et al. ( 2014 ) . ANNEXIN A1 AND PPARγ ON RESOLUTION OF INFLAMMATION . BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY . vol. 115 , 286 - 286 .

Lashin H, Nadkarni S, Hinds C, Perretti M ( 2014 ) . IN PATIENTS WITH SEVERE SEPSIS MICROPARTICLE PROFILES DIFFER ACCORDING TO THE SOURCE OF INFECTION . INTENSIVE CARE MEDICINE . vol. 40 , S239 - S240 .

Nadkarni S, Dalli J, Hollywood J, Mason JC, Dasgupta B, Perretti M ( 2014 ) . NEUTROPHILS IN GCA . RHEUMATOLOGY . vol. 53 , 9 - 9 .

Bena S, Gobbetti T, D'Amico M, Flower R, Perretti M ( 2014 ) . THE CARDIOPROTECTIVE ROLE OF THE ANXA1/FPR2 PATHWAY . BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY . vol. 115 , 299 - 299 .

Ahmed TJ, Perretti M, Pitzalis C ( 2014 ) . TRANSLATIONAL MEDICINE IN RHEUMATOID ARTHRITIS: EXPLOITING MELANOCORTIN RECEPTORS . RHEUMATOLOGY . vol. 53 , 85 - 86 .

Dalli J, Norling LV, Montero‐Melendez T, Canova DF, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ et al. ( 2013 ) . Microparticle alpha‐2‐macroglobulin enhances pro‐resolving responses and promotes survival in sepsis . EMBO Molecular Medicine vol. 6 , ( 1 ) 27 - 42 .

Montero-Meléndez T, Llor X, García-Planella E, Perretti M, Suárez A ( 2013 ) . Identification of Novel Predictor Classifiers for Inflammatory Bowel Disease by Gene Expression Profiling . PLoS ONE vol. 8 , ( 10 ) e76235 - e76235 .

Cooray SN, Gobbetti T, Montero-Melendez T, McArthur S, Thompson D, Clark AJL, Flower RJ, Perretti M ( 2013 ) . Ligand-specific conformational change of the G-protein–coupled receptor ALX/FPR2 determines proresolving functional responses . Proceedings of the National Academy of Sciences vol. 110 , ( 45 ) 18232 - 18237 .

Cash JL, Bena S, Headland SE, McArthur S, Brancaleone V, Perretti M ( 2013 ) . Chemerin15 inhibits neutrophil‐mediated vascular inflammation and myocardial ischemia‐reperfusion injury through ChemR23 . EMBO reports vol. 14 , ( 11 ) 999 - 1007 .

Brancaleone V, Flower RJ, Cirino G, Perretti M ( 2013 ) . OP06 Annexin A1 (AnxA1) mediates hydrogen sulfide (H2S) effects in the control of inflammation . Nitric Oxide . vol. 31 , S21 - S22 .

Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M, Perretti M ( 2013 ) . Heterogeneity in Neutrophil Microparticles Reveals Distinct Proteome and Functional Properties . Molecular &amp; Cellular Proteomics vol. 12 , ( 8 ) 2205 - 2219 .

Godson C, Perretti M ( 2013 ) . Novel pathways in the yin-yang of immunomodulation . Current Opinion in Pharmacology vol. 13 , ( 4 ) 543 - 546 .

Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S et al. ( 2013 ) . A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation . Blood vol. 122 , ( 4 ) 608 - 617 .

Iqbal AJ, Cooper D, Vugler A, Gittens BR, Moore A, Perretti M ( 2013 ) . Endogenous Galectin-1 Exerts Tonic Inhibition on Experimental Arthritis . The Journal of Immunology vol. 191 , ( 1 ) 171 - 177 .

Dalli J, Consalvo AP, Ray V, Di Filippo C, D’Amico M, Mehta N, Perretti M ( 2013 ) . Proresolving and Tissue-Protective Actions of Annexin A1–Based Cleavage-Resistant Peptides Are Mediated by Formyl Peptide Receptor 2/Lipoxin A4 Receptor . The Journal of Immunology vol. 190 , ( 12 ) 6478 - 6487 .

Perretti M ( 2013 ) . SP0144 The Role of Omega-3 Derived Resolvins in Arthritis . Annals of the Rheumatic Diseases vol. 72 , A33 - A33 .

Norling LV, Perretti M ( 2013 ) . The role of omega-3 derived resolvins in arthritis . Current Opinion in Pharmacology vol. 13 , ( 3 ) 476 - 481 .

Nusrat A, Leoni G, Neumann P-A, Alam A, Lambeth D, Hilgarth R, Kusters D, Reutelingsperger C et al. ( 2013 ) . Annexin 1 in microparticles promotes intestinal mucosal wound repair during inflammation. (P3264) . The Journal of Immunology . vol. 190 , 136.14 - 136.14 .

Fowkes RC, Moradi-Bidhendi N, Branceleone V, Zariwala MG, Brady D, Jessop DS, Perretti M, Renshaw D ( 2013 ) . Annexin-A1 protein and its relationship to cortisol in human saliva . Psychoneuroendocrinology vol. 38 , ( 5 ) 722 - 727 .

Gobbetti T, Ducheix S, Faouder PL, Boue J, Bertrand-Michel J, Guillou H, Perretti M, Vergnolle N et al. ( 2013 ) . Tu1993 Protective Effects of N-6 Polyunsaturated Fatty Acid Diet on Intestinal Ischemia/Reperfusion Injury Are Centererd on Lipoxin A4 and Its Receptor . Gastroenterology vol. 144 , ( 5 ) S - 899 .

Norling LV, Perretti M ( 2013 ) . Control of Myeloid Cell Trafficking in Resolution . Journal of Innate Immunity vol. 5 , ( 4 ) 367 - 376 .

Ortega‐Gómez A, Perretti M, Soehnlein O ( 2013 ) . Resolution of inflammation: an integrated view . EMBO Molecular Medicine vol. 5 , ( 5 ) 661 - 674 .

Patel HB, Bombardieri M, Pitzalis C, Perretti M ( 2013 ) . Activation of Melanocortin Receptor 3 as a new strategy to control experimental and rheumatoid arthritis . The FASEB Journal . vol. 27 ,

Cooray SN, Clark A, Flower R, Perretti M ( 2013 ) . Agonist‐induced conformational change of the Formyl Peptide Receptors . The FASEB Journal . vol. 27 ,

Eldridge S, Vicent-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P, Dell'Accio F ( 2013 ) . Agrin expression is downregulated in OA and is required for chondrocyte differentiation . Osteoarthritis and Cartilage vol. 21 , S112 - S113 .

Ryan SM, McMorrow J, Umerska A, Patel HB, Kornerup KN, Tajber L, Murphy EP, Perretti M et al. ( 2013 ) . An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis . Journal of Controlled Release vol. 167 , ( 2 ) 120 - 129 .

Thompson D, Perretti M ( 2013 ) . Differential Trafficking of the FPR2/ALX receptor in response to endogenous or synthetic ligands . The FASEB Journal . vol. 27 ,

Leoni G, Neumann P, Alam A, Hilgarth RS, Lambeth DJ, Kusters D, Reutelingsperger C, Perretti M et al. ( 2013 ) . Epithelial wound repair: insights into the multifaceted roles of Annexin A1 . The FASEB Journal . vol. 27 ,

Gittens B, Perretti M, Cooper D ( 2013 ) . Investigating Novel Roles for Exogenous and Endogenous Galectin‐3 in Controlling Vascular Inflammation . The FASEB Journal . vol. 27 ,

Martin K, Perretti M, Ahluwalia A ( 2013 ) . Kinin B1 receptor regulates inflammatory cell recruitment during low laminar shear stress . The FASEB Journal . vol. 27 ,

Perretti M, Bena S, Brancaleone V, Flower RJ ( 2013 ) . Modulation of the receptor ALX/FPR2 in vascular inflammation . The FASEB Journal . vol. 27 ,

Perretti M, Dalli J, Norling LV, Melendez TM, Hinds C ( 2013 ) . Neutrophil Microparticles are heterogenous in content and function . The FASEB Journal . vol. 27 ,

Headland SE, Dell'Accio F, Perretti M ( 2013 ) . Neutrophil‐Derived Microparticles as Novel Effectors in Joint Disease . The FASEB Journal . vol. 27 ,

Norling LV, Perretti M ( 2013 ) . Omega‐3 derived Resolvin D1 reduces the severity of inflammatory arthritis . The FASEB Journal . vol. 27 ,

Farsky SHP, Machado ID, Santin JR, Ferraz VP, Gil CD, Oliani SM, Perretti M ( 2013 ) . Role of cytosolic glucocorticoid receptor and Annexin‐A1 on neutrophil traffic from bone marrow into blood: SDF‐ 1alpha/CXCR‐4/CXCR‐2 axis . The FASEB Journal . vol. 27 ,

Rhodes DH, Pini M, Castellanos KJ, Montero‐Melendez T, Cooper D, Perretti M, Fantuzzi G ( 2013 ) . Adipose tissue‐specific modulation of galectin expression in lean and obese mice: Evidence for regulatory function . Obesity vol. 21 , ( 2 ) 310 - 319 .

Pang J, Rhodes DH, Pini M, Akasheh RT, Castellanos KJ, Cabay RJ, Cooper D, Perretti M et al. ( 2013 ) . Increased Adiposity, Dysregulated Glucose Metabolism and Systemic Inflammation in Galectin-3 KO Mice . PLoS ONE vol. 8 , ( 2 ) e57915 - e57915 .

Al-Kashi A, Montero-Melendez T, Moradi-Bidhendi N, Gilligan JP, Mehta N, Perretti M ( 2013 ) . The Calcitonin and Glucocorticoids Combination: Mechanistic Insights into Their Class–Effect Synergy in Experimental Arthritis . PLoS ONE vol. 8 , ( 2 ) e54299 - e54299 .

Gil CD, La M, Perretti M, Oliani SM ( 2013 ) . Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin‐1 and galectin‐3 . Cell Biology International vol. 30 , ( 4 ) 338 - 344 .

Oliani SM, Lim LHK, Christian HC, Pell K, Das AM, Perretti M ( 2013 ) . MORPHOLOGICAL ALTERATION OF PERITONEAL MAST CELLS AND MACROPHAGES IN THE MOUSE PERITONEAL CAVITY DURING THE EARLY PHASES OF AN ALLERGIC INFLAMMATORY REACTION . Cell Biology International vol. 25 , ( 8 ) 795 - 803 .

Mathie SA, Bena S, Mondae M, Davda D, O'Donnell VB, Perretti M, Lloyd CM ( 2013 ) . Activation of annexin A1-FPR2 axis promotes resolution of house dust mite induced airway hyper-reactivity . IMMUNOLOGY . vol. 140 , 82 - 83 .

Perretti M, D’Acquisto F, Flower RJ ( 2013 ) . Annexin-A1 Peptide Ac2–26 . Handbook of Biologically Active Peptides , Elsevier

Sampaio ALF, Dalli J, Brancaleone V, D'Acquisto F, Perretti M, Wheatley C ( 2013 ) . Biphasic Modulation of NOS Expression, Protein and Nitrite Products by Hydroxocobalamin Underlies Its Protective Effect in Endotoxemic Shock: Downstream Regulation of COX-2, IL-1<mml:math xmlns:mml=\http://www.w3.org/1998/Math/MathML\ id=\M1\><mml:mrow><mml:mi mathvariant=\bold-italic\>β</mml:mi></mml:mrow></mml:math>, TNF-<mml:math xmlns:mml=\http://www.w3.org/1998/Math/MathML\ id=\M2\><mml:mrow><mml:mi mathvariant=\bold-italic\>α</mml:mi></mml:mrow></mml:math>, IL-6, and HMGB1 Expression . Mediators of Inflammation vol. 2013 , 1 - 20 .

Perretti M, D’Acquisto F, Flower RJ ( 2013 ) . Chapter 86 Annexin-A1 Peptide Ac2–26 . Handbook of Biologically Active Peptides , Elsevier

Ahmed TJ, Montero-Melendez T, Perretti M, Pitzalis C ( 2013 ) . Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides . International Journal of Inflammation vol. 2013 , 1 - 10 .

Gobbetti T, Ducheix S, Le Faouder P, Boue J, Bertrand-Michel J, Guillou H, Perretti M, Vergnolle N et al. ( 2013 ) . Protective Effects of N-6 Polyunsaturated Fatty Acid Diet on Intestinal Ischemia/Reperfusion Injury Are Centererd on Lipoxin A4 and Its Receptor . GASTROENTEROLOGY . vol. 144 , S899 - S899 .

Viiri LE, Full LE, Navin TJ, Begum S, Didangelos A, Astola N, Berge RK, Seppälä I et al. ( 2013 ) . Smooth muscle cells in human atherosclerosis: Proteomic profiling reveals differences in expression of Annexin A1 and mitochondrial proteins in carotid disease . Journal of Molecular and Cellular Cardiology vol. 54 , 65 - 72 .

Leoni G, Alam A, Neumann P-A, Lambeth JD, Cheng G, McCoy J, Hilgarth RS, Kundu K et al. ( 2012 ) . Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair . Journal of Clinical Investigation vol. 123 , ( 1 ) 443 - 454 .

Montero-Melendez T, Dalli J, Perretti M ( 2012 ) . Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors . Cell Death &amp; Differentiation vol. 20 , ( 4 ) 567 - 575 .

Patel HB, Kornerup KN, Sampaio ALF, D'Acquisto F, Seed MP, Girol AP, Gray M, Pitzalis C et al. ( 2012 ) . The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis . Annals of the Rheumatic Diseases vol. 71 , ( 11 ) 1872 - 1880 .

Kosicka A, Cunliffe AD, Mackenzie R, Zariwala MG, Perretti M, Flower RJ, Renshaw D ( 2012 ) . Attenuation of plasma annexin A1 in human obesity . The FASEB Journal vol. 27 , ( 1 ) 368 - 378 .

Schutters K, Kusters DHM, Chatrou MLL, Montero-Melendez T, Donners M, Deckers NM, Krysko DV, Vandenabeele P et al. ( 2012 ) . Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells . Cell Death &amp; Differentiation vol. 20 , ( 1 ) 49 - 56 .

Cardini S, Dalli J, Fineschi S, Perretti M, Lungarella G, Lucattelli M ( 2012 ) . Genetic Ablation of the <i>Fpr1</i> Gene Confers Protection from Smoking-Induced Lung Emphysema in Mice . American Journal of Respiratory Cell and Molecular Biology vol. 47 , ( 3 ) 332 - 339 .

Perretti M ( 2012 ) . Editorial: To resolve or not to resolve: Annexin A1 pushes resolution on track . Journal of Leukocyte Biology vol. 92 , ( 2 ) 245 - 247 .

Norling LV, Dalli J, Flower RJ, Serhan CN, Perretti M ( 2012 ) . Resolvin D1 Limits Polymorphonuclear Leukocyte Recruitment to Inflammatory Loci . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 32 , ( 8 ) 1970 - 1978 .

Perretti M, Szabó C, Thiemermann C ( 2012 ) . Effect of interleukin‐4 and interleukin‐10 on leucocyte migration and nitric oxide production in the mouse . British Journal of Pharmacology vol. 116 , ( 4 ) 2251 - 2257 .

Thiemermann C, Wu C, Szabó C, Perretti M, Vane JR ( 2012 ) . Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock . British Journal of Pharmacology vol. 110 , ( 1 ) 177 - 182 .

Perretti M, Becherucci C, Scapigliati G, Parente L ( 2012 ) . The effect of adrenalectomy on interleukin‐1 release <i>in vitro</i> and <i>in vivo</i> . British Journal of Pharmacology vol. 98 , ( 4 ) 1137 - 1142 .

Bena S, Brancaleone V, Wang JM, Perretti M, Flower RJ ( 2012 ) . Annexin A1 Interaction with the FPR2/ALX Receptor . Journal of Biological Chemistry vol. 287 , ( 29 ) 24690 - 24697 .

Vong L, Ferraz JGP, Dufton N, Panaccione R, Beck PL, Sherman PM, Perretti M, Wallace JL ( 2012 ) . Up-Regulation of Annexin-A1 and Lipoxin A4 in Individuals with Ulcerative Colitis May Promote Mucosal Homeostasis . PLoS ONE vol. 7 , ( 6 ) e39244 - e39244 .

Clark AK, Grist J, Al‐Kashi A, Perretti M, Malcangio M ( 2012 ) . Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen‐induced arthritis model . Arthritis &amp; Rheumatism vol. 64 , ( 6 ) 2038 - 2047 .

Kabouridis PS, Pimentel TA, Brancaleone V, D’Acquisto F, Oliani SM, Perretti M, Jury EC ( 2012 ) . Distinct localization of T cell Agrin during antigen presentation – evidence for the expression of Agrin receptor(s) in antigen‐presenting cells . The FEBS Journal vol. 279 , ( 13 ) 2368 - 2380 .

Liverani E, Banerjee S, Roberts W, Naseem KM, Perretti M ( 2012 ) . Prednisolone exerts exquisite inhibitory properties on platelet functions . Biochemical Pharmacology vol. 83 , ( 10 ) 1364 - 1373 .

Leinster DA, Kulbe H, Everitt G, Thompson R, Perretti M, Gavins FNE, Cooper D, Gould D et al. ( 2012 ) . The peritoneal tumour microenvironment of high‐grade serous ovarian cancer . The Journal of Pathology vol. 227 , ( 2 ) 136 - 145 .

Vincent TL, Williams RO, Maciewicz R, Silman A, Garside P ( 2012 ) . Mapping pathogenesis of arthritis through small animal models . Rheumatology vol. 51 , ( 11 ) 1931 - 1941 .

Cooper D, Iqbal AJ, Gittens BR, Cervone C, Perretti M ( 2012 ) . The effect of galectins on leukocyte trafficking in inflammation: sweet or sour? . Annals of the New York Academy of Sciences vol. 1253 , ( 1 ) 181 - 192 .

Pieretti S, di Giannuario A, Colucci M, Mastriota M, Perretti M ( 2012 ) . 297 INVESTIGATION OF THE ROLE OF FORMYL PEPTIDE RECEPTOR IN ACUTE NOCICEPTION USING GENE‐DEFICIENT MICE . European Journal of Pain vol. 13 , ( S1 )

de Lima CB, Tamura EK, Montero-Melendez T, Palermo-Neto J, Perretti M, Markus RP, Farsky SHP ( 2012 ) . Actions of translocator protein ligands on neutrophil adhesion and motility induced by G-protein coupled receptor signaling . Biochemical and Biophysical Research Communications vol. 417 , ( 2 ) 918 - 923 .

Dalli J, Montero-Melendez T, McArthur S, Perretti M ( 2012 ) . Annexin A1 N-Terminal Derived Peptide Ac2-26 Exerts Chemokinetic Effects on Human Neutrophils . Frontiers in Pharmacology vol. 3 ,

Vessillier S, Adams G, Montero-Melendez T, Jones R, Seed M, Perretti M, Chernajovsky Y ( 2012 ) . Molecular engineering of short half-life small peptides (VIP, αMSH and γ3MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics . Annals of the Rheumatic Diseases vol. 71 , ( 1 ) 143 - 149 .

Headland SE, Perretti M ( 2012 ) . NEUTROPHIL MICROPARTICLES AS POTENTIAL NOVEL EFFECTORS OF JOINT DISEASE . RHEUMATOLOGY . vol. 51 , 47 - 47 .

Headland S, Perretti M ( 2012 ) . Neutrophil microparticles as novel effectors of joint disease . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 93 , A30 - A30 .

Norling L, Dalli J, Flower R, Serhan C, Perretti M ( 2012 ) . RESOLVIN D1 LIMITS PMN RECRUITMENT TO INFLAMMATORY LOCI: RECEPTOR DEPENDENT BIOACTIONS . RHEUMATOLOGY . vol. 51 , 47 - 48 .

Patel HB, Kornerup KN, Sampaio ALF, Acquisto FD, Seed MP, Girol AP, Gray M, Pitzalis C et al. ( 2012 ) . The impact of endogenous annexin A1 on glucocorticoid control of in ammatory arthritis . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , ( 11 ) 1872 - 1880 .

Greco KV, Iqbal AJ, Rattazzi L, Nalesso G, Moradi-Bidhendi N, Moore AR, Goldring MB, Dell’Accio F et al. ( 2011 ) . High density micromass cultures of a human chondrocyte cell line: A reliable assay system to reveal the modulatory functions of pharmacological agents . Biochemical Pharmacology vol. 82 , ( 12 ) 1919 - 1929 .

Colom B, Poitelon Y, Huang W, Woodfin A, Averill S, Carro UD, Zambroni D, Brain SD et al. ( 2011 ) . Schwann cell‐specific JAM‐C‐deficient mice reveal novel expression and functions for JAM‐C in peripheral nerves . The FASEB Journal vol. 26 , ( 3 ) 1064 - 1076 .

Nadkarni S, Cooper D, Brancaleone V, Bena S, Perretti M ( 2011 ) . Activation of the Annexin A1 Pathway Underlies the Protective Effects Exerted by Estrogen in Polymorphonuclear Leukocytes . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 31 , ( 11 ) 2749 - 2759 .

Di Filippo C, Perretti M, Rossi F, Ferraraccio F, Motterlini R, D’Amico M ( 2011 ) . Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3) . Naunyn-Schmiedeberg's Archives of Pharmacology vol. 385 , ( 2 ) 137 - 144 .

Damazo AS, Sampaio ALF, Nakata CMAG, Flower RJ, Perretti M, Oliani SM ( 2011 ) . Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis . BMC Immunology vol. 12 , ( 1 ) Article 59 ,

Dalli J, Jones CP, Cavalcanti DM, Farsky SH, Perretti M, Rankin SM ( 2011 ) . Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow . The FASEB Journal vol. 26 , ( 1 ) 387 - 396 .

Patel HB, Montero-Melendez T, Greco KV, Perretti M ( 2011 ) . Melanocortin receptors as novel effectors of macrophage responses in inflammation . Frontiers in immunology vol. 2 ,

Ingegnoli F, Blades M, Manzo A, Wahid S, Perretti M, Panay G, Pitzalis C ( 2011 ) . Role of cell migration in the pathogenesis of rheumatoid arthritis: in vivo studies in SCID mice transplanted with human synovial membrane . Reumatismo vol. 54 , ( 2 )

Montero-Melendez T, Patel HB, Seed M, Nielsen S, Jonassen TEN, Perretti M ( 2011 ) . The Melanocortin Agonist AP214 Exerts Anti-Inflammatory and Proresolving Properties . The American Journal of Pathology vol. 179 , ( 1 ) 259 - 269 .

Roviezzo F, Brancaleone V, De Gruttola L, Vellecco V, Bucci M, D'Agostino B, Cooper D, Sorrentino R et al. ( 2011 ) . Sphingosine-1-Phosphate Modulates Vascular Permeability and Cell Recruitment in Acute Inflammation In Vivo . J PHARMACOL EXP THER vol. 337 , ( 3 ) 830 - 837 .

Maione F, Cicala C, Liverani E, Mascolo N, Perretti M, D'Acquisto F ( 2011 ) . IL-17A increases ADP-induced platelet aggregation . BIOCHEM BIOPH RES CO vol. 408 , ( 4 ) 658 - 662 .

Norling LV, Spite M, Yang R, Flower RJ, Perretti M, Serhan CN ( 2011 ) . Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing . The Journal of Immunology vol. 186 , ( 10 ) 5543 - 5547 .

Velmurugan S, Kapil V, McKnight AHO, Aboud Z, Davies S, Milsom AB, Pearl V, Liverani E et al. ( 2011 ) . P54. Dietary nitrate attenuates platelet reactivity: Role of the erythrocyte and influence of sex . Nitric Oxide . vol. 24 , S35 - S36 .

Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL, Perretti M, Hobbs AJ et al. ( 2011 ) . Suppression of Endothelial P-Selectin Expression Contributes to Reduced Cell Trafficking in Females An Effect Independent of NO and Prostacyclin . ARTERIOSCL THROM VAS vol. 31 , ( 5 ) 1075 - 1083 .

Brancaleone V, Dalli J, Bena S, Flower RJ, Cirino G, Perretti M ( 2011 ) . Evidence for an Anti-Inflammatory Loop Centered on Polymorphonuclear Leukocyte Formyl Peptide Receptor 2/Lipoxin A(4) Receptor and Operative in the Inflamed Microvasculature . J IMMUNOL vol. 186 , ( 8 ) 4905 - 4914 .

Iqbal AJ, Sampaio ALF, Maione F, Greco KV, Niki T, Hirashima M, Perretti M, Cooper D ( 2011 ) . Endogenous Galectin-1 and Acute Inflammation Emerging Notion of a Galectin-9 Pro-Resolving Effect . AM J PATHOL vol. 178 , ( 3 ) 1201 - 1209 .

Gavins FNE, Li G, Russell J, Perretti M, Granger DN ( 2011 ) . Microvascular thrombosis and CD40/CD40L signaling . J THROMB HAEMOST vol. 9 , ( 3 ) 574 - 581 .

Dufton N, Hannon R, Brancaleone V, Dalli J, Patel HB, Gray M, D'Acquisto F, Buckingham JC et al. ( 2011 ) . Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation (vol 184, pg 2611, 2010) . J IMMUNOL vol. 186 , ( 4 ) 2684 - 2685 .

Allegra M, D’Acquisto F, Tesoriere L, Livrea MA, Perretti M ( 2011 ) . Cross-talk between minimally primed HL-60 cells and resting HUVEC reveals a crucial role for adhesion over extracellularly released oxidants . Biochemical Pharmacology vol. 81 , ( 3 ) 396 - 401 .

Colucci M, Mastriota M, Maione F, Di Giannuario A, Mascolo N, Palmery M, Severini C, Perretti M et al. ( 2011 ) . Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids . Peptides vol. 32 , ( 2 ) 266 - 271 .

Montero-Melendez T, Patel HB, Perretti M ( 2011 ) . Role of Melanocortin Receptors in the Regulation of Gouty Inflammation . Current Rheumatology Reports vol. 13 , ( 2 ) 138 - 145 .

Greco KV, Moore A, Dell'Accio F, Perretti M ( 2011 ) . 3D CULTURES OF C-28/I2 CHONDROCYTES TO STUDY CHONDROCYTE BIOLOGY AND THERAPEUTIC DEVELOPMENT . INFLAMMATION RESEARCH . vol. 60 , 283 - 283 .

Brancaleone V, Sampaio AL, Cirino G, Flower RJ, Perretti M ( 2011 ) . A NOVEL CROSS-TALK IN RESOLUTION: H2S ACTIVATES THE ANNEXIN A1 PATHWAY . INFLAMMATION RESEARCH . vol. 60 , 291 - 293 .

Pimentel TA, Sampaio ALF, D'Acquisto F, Perretti M, Oliani SM ( 2011 ) . An essential role for mast cells as modulators of neutrophils influx in collagen-induced arthritis in the mouse . LAB INVEST vol. 91 , ( 1 ) 33 - 42 .

Nadkarni S, Hollywood J, Mason JC, Dasgupta B, Perretti M ( 2011 ) . Annexin-A1: A Potential Novel Biomarker in Giant Cell Arteritis . ARTHRITIS AND RHEUMATISM . vol. 63 , S593 - S593 .

Spurr L, Nadkarni S, Pederzoli-Ribeil M, Goulding NJ, Perretti M, D'Acquisto F ( 2011 ) . Comparative analysis of Annexin A1-formyl peptide receptor 2/ALX expression in human leukocyte subsets . INT IMMUNOPHARMACOL vol. 11 , ( 1 ) 55 - 66 .

Norling LV, Spite M, Yang R, Flower RJ, Perretti M, Serhan CN ( 2011 ) . Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing . JOURNAL OF IMMUNOLOGY vol. 186 , ( 10 ) 5543 - 5547 .

Iqbal AJ, Cooper D, Vugler AD, Moore A, Perretti M ( 2011 ) . ENDOGENOUS GALECTIN-1 INHIBITS EXPERIMENTAL ARTHRITIS: A POTENTIAL SWEET THERAPEUTIC TARGET? . INFLAMMATION RESEARCH . vol. 60 , 186 - 187 .

Rhodes D, Pini M, Montero-Melendez T, Perretti M, Fantuzzi G ( 2011 ) . EXPRESSION OF ANNEXIN A1 IN ADIPOSE TISSUE IS DISSOCIATED FROM MACROPHAGE INFILTRATION DURING DEVELOPMENT OF OBESITY IN MICE . INFLAMMATION RESEARCH . vol. 60 , 261 - 261 .

Cooper D, Iqbal AJ, Niki T, Hirashima M, Perretti M ( 2011 ) . GALECTIN-9: SWEETENING LEUKOCYTE RECRUITMENT . INFLAMMATION RESEARCH . vol. 60 , 87 - 88 .

Perretti M ( 2011 ) . GLUCOCORTICOIDS CUT SHORT THE CONCERT OF INFLAMMATION THROUGH THE RELEASE OF ANNEXIN A1 . INFLAMMATION RESEARCH . vol. 60 , 16 - 17 .

Ryan SM, Patel HB, Kornerup KN, Tajber L, Umerska A, Perretti M, Brayden DJ ( 2011 ) . Intra-articular delivery of salmon calcitonin nanocomplexes to the K/BXN murine model for treatment of osteoarthritis . 24th European Conference on Biomaterials Annual Conference of the European Society for Biomaterials .

Montero-Melendez T, Jonassen T, Seed M, Perretti M ( 2011 ) . MC3 AGONISTS AS NOVEL PRO-RESOLVING THERAPEUTICS . INFLAMMATION RESEARCH . vol. 60 , 269 - 269 .

Greco KV, Montero-Melendez T, Patel H, Perretti M ( 2011 ) . MELANOCORTIN RECEPTOR AGONISTS ARE NOVEL CHONDROPROTECTIVE THERAPEUTICS . INFLAMMATION RESEARCH . vol. 60 , 273 - 273 .

Vessillier S, Adams G, Montero-Melendez T, Jones R, Seed MP, Perretti M, Chernajovsky Y ( 2011 ) . MOLECULAR ENGINEERING OF SHORT HALF LIFE SMALL PEPTIDES (VIP, αMSH AND γ3MSH) INTO LATENT ASSOCIATED PEPTIDE (LAP) RESULTS IN TARGETED ANTI-INFLAMMATORY AND ANTI-RHEUMATIC THERAPEUTICS . INFLAMMATION RESEARCH . vol. 60 , 43 - 43 .

Patel HB, Montero-Melendez T, Greco KV, Perretti M ( 2011 ) . Melanocortin Receptors as Novel Effectors of Macrophage Responses in Inflammation . Frontiers in Immunology vol. 2 ,

Norling LV, Dalli J, Serhan CN, Perretti M ( 2011 ) . RESOLVIN D1 LIMITS PMN RECRUITMENT TO INFLAMMATORY LOCI: RECEPTOR DEPENDENT BIOACTIONS . INFLAMMATION RESEARCH . vol. 60 , 60 - 60 .

Maione F, Paschalidis N, Iqbal AJ, Crompton T, Perretti M, D'Acquisto F ( 2010 ) . Analysis of the inflammatory response in HY-TCR transgenic mice highlights the pathogenic potential of CD4(-)CD8(-) T cells . AUTOIMMUNITY vol. 43 , ( 8 ) 672 - 681 .

Patel HB, Bombardieri M, Sampaio ALF, D'Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C et al. ( 2010 ) . Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis . FASEB J vol. 24 , ( 12 ) 4835 - 4843 .

Pederzoli-Ribeil M, Maione F, Cooper D, Al-Kashi A, Dalli J, Perretti M, D'Acquisto F ( 2010 ) . Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature . BLOOD vol. 116 , ( 20 ) 4288 - 4296 .

Maderna P, Cottell DC, Toivonen T, Dufton N, Dalli J, Perretti M, Godson C ( 2010 ) . FPR2/ALX receptor expression and internalization are critical for lipoxin A(4) and annexin-derived peptide-stimulated phagocytosis . FASEB J vol. 24 , ( 11 ) 4240 - 4249 .

Canaider ( 2010 ) . Human RCAN3 gene expression and cell growth in endothelial cells . International Journal of Molecular Medicine vol. 26 , ( 6 )

Perretti M, Dalli J, Bolla M, Padron J ( 2010 ) . 561 THE CINOD NCX 429 INHIBITS MICROVASCULAR INFLAMMATION THROUGH ITS NO-RELEASING PROPERTIES . Osteoarthritis and Cartilage . vol. 18 , S251 - S251 .

Renshaw D, Montero-Melendez T, Dalli J, Kamal A, Brancaleone V, D'Acquisto F, Cirino G, Perretti M ( 2010 ) . Downstream Gene Activation of the Receptor ALX by the Agonist Annexin A1 . PLOS ONE vol. 5 , ( 9 ) Article e12771 ,

Yazid S, Leoni G, Getting SJ, Cooper D, Solito E, Perretti M, Flower RJ ( 2010 ) . Antiallergic Cromones Inhibit Neutrophil Recruitment Onto Vascular Endothelium via Annexin-A1 Mobilization . ARTERIOSCL THROM VAS vol. 30 , ( 9 ) 1718 - U103 .

Patel HB, Bombardieri M, Sampaio ALF, D’Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C et al. ( 2010 ) . Anti‐inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis . The FASEB Journal vol. 24 , ( 12 ) 4835 - 4843 .

Dufton N, Perretti M ( 2010 ) . Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists . PHARMACOL THERAPEUT vol. 127 , ( 2 ) 175 - 188 .

Sampaio ALF, Zahn G, Leoni G, Vossmeyer D, Christner C, Marshall JF, Perretti M ( 2010 ) . Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis . J LEUKOCYTE BIOL vol. 87 , ( 5 ) 877 - 884 .

Leoni G, Voisin MB, Carlson K, Getting SJ, Nourshargh S, Perretti M ( 2010 ) . The melanocortin MC1 receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature . BRIT J PHARMACOL vol. 160 , ( 1 ) 171 - 180 .

Semple F, Webb S, Li H, Patel HB, Perretti M, Jackson IJ, Gray M, Davidson DJ et al. ( 2010 ) . Human β‐defensin 3 has immunosuppressive activity <i>in vitro</i> and <i>in vivo</i> . European Journal of Immunology vol. 40 , ( 4 ) 1073 - 1078 .

Di Filippo C, Monopoli A, Ongini E, Perretti M, D’Amico M ( 2010 ) . The cardio-protective properties of NCX-6550, a nitric oxide donating pravastatin, in the mouse . Microcirculation

Dufton N, Hannon R, Brancaleone V, Dalli J, Patel HB, Gray M, D'Acquisto F, Buckingham JC et al. ( 2010 ) . Anti-Inflammatory Role of the Murine Formyl-Peptide Receptor 2: Ligand-Specific Effects on Leukocyte Responses and Experimental Inflammation . J IMMUNOL vol. 184 , ( 5 ) 2611 - 2619 .

Särndahl E, Bergström I, Nijm J, Forslund T, Perretti M, Jonasson L ( 2010 ) . Enhanced neutrophil expression of annexin-1 in coronary artery disease . Metabolism vol. 59 , ( 3 ) 433 - 440 .

CAO TV, LA M, GETTING SJ, DAY AJ, PERRETTI M ( 2010 ) . Inhibitory Effects of TSG‐6 Link Module on Leukocyte–Endothelial Cell Interactions <i>In Vitro</i> and <i>In Vivo</i> . Microcirculation vol. 11 , ( 7 ) 615 - 624 .

PERRETTI M, AHLUWALIA A ( 2010 ) . The Microcirculation and Inflammation: Site of Action for Glucocorticoids . Microcirculation vol. 7 , ( 3 ) 147 - 161 .

Dalli J, Cavalcanti DM, Farksy SH, Rankin S, Flower RJ, Perretti M ( 2010 ) . Abnormalities in annexin a1 null bone marrow cells: evidence for failure of clearance of apoptotic neutrophils . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION . vol. 40 , 49 - 49 .

Dalli J, Rosignoli G, Hayhoe RPG, Edelman A, Perretti M ( 2010 ) . CFTR Inhibition Provokes an Inflammatory Response Associated with an Imbalance of the Annexin A1 Pathway . AMERICAN JOURNAL OF PATHOLOGY vol. 177 , ( 1 ) 176 - 186 .

Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D, Perretti M ( 2010 ) . Human RCAN3 gene expression and cell growth in endothelial cells . INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE vol. 26 , ( 6 ) 913 - 918 .

Cooper D, Ilarregui JM, Pesoa SA, Croci DO, Perretti M, Rabinovich GA ( 2010 ) . MULTIPLE FUNCTIONAL TARGETS OF THE IMMUNOREGULATORY ACTIVITY OF GALECTIN-1: CONTROL OF IMMUNE CELL TRAFFICKING, DENDRITIC CELL PHYSIOLOGY, AND T-CELL FATE . vol. 480 ,

Patel HB, Leoni G, Melendez TM, Sampaio ALF, Perretti M ( 2010 ) . Melanocortin Control of Cell Trafficking in Vascular Inflammation . Advances in Experimental Medicine and Biology , Springer New York

Brancaleone V, Dalli J, Perretti M ( 2010 ) . Mobilization of Annexin A1 in human polymorphonuclear leukocytes (PMN) . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION . vol. 40 , 36 - 37 .

Nadkarni S, Brancaleone V, Bena S, Perretti M ( 2010 ) . Protective effect of oestrogen is mediated by the anti-inflammatory protein annexin-A1 . IMMUNOLOGY . vol. 131 , 165 - 166 .

Hunter C, Kadakia TB, Cooper D, Perretti M, Schwartz RC, Brown SB ( 2010 ) . Selective Inhibitors of Kv11.1 Regulate IL-6 Expression by Macrophages in Response to TLR/IL-1R Ligands . The Scientific World JOURNAL vol. 10 , 1580 - 1596 .

Pederzoli-Ribeil M, Maione F, Al-Kashi A, Dalli J, Perretti M, D'Acquisto F ( 2010 ) . \Super\ Annexin-A1: a novel tool to regulate neutrophil-driven inflammation? . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION . vol. 40 , 47 - 47 .

Paschalidis N, Iqbal AJ, Maione F, Wood EG, Perretti M, Flower RJ, D'Acquisto F ( 2009 ) . Modulation of experimental autoimmune encephalomyelitis by endogenous Annexin A1 . J NEUROINFLAMM vol. 6 , Article 33 ,

Duchene J, Cayla C, Vessillier S, Scotland R, Yamashiro K, Lecomte F, Syed I, Vo P et al. ( 2009 ) . Laminar Shear Stress Regulates Endothelial Kinin B1 Receptor Expression and Function Potential Implication in Atherogenesis . ARTERIOSCL THROM VAS vol. 29 , ( 11 ) 1757 - 1763 .

Perretti M, Dalli J ( 2009 ) . Exploiting the Annexin A1 pathway for the development of novel anti-inflammatory therapeutics . BRIT J PHARMACOL vol. 158 , ( 4 ) 936 - 946 .

Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M et al. ( 2009 ) . Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis . Nature vol. 461 , ( 7268 ) 1287 - 1291 .

McColl A, Bournazos S, Franz S, Perretti M, Morgan BP, Haslett C, Dransfield I ( 2009 ) . Glucocorticoids Induce Protein S-Dependent Phagocytosis of Apoptotic Neutrophils by Human Macrophages . The Journal of Immunology vol. 183 , ( 3 ) 2167 - 2175 .

Norling LV, Perretti M, Cooper D ( 2009 ) . Endogenous galectins and the control of the host inflammatory response . J ENDOCRINOL vol. 201 , ( 2 ) 169 - 184 .

Piqueras L, Sanz MJ, Perretti M, Morcillo E, Norling L, Mitchell JA, Li Y, Bishop-Bailey D ( 2009 ) . Activation of PPARβ/δ inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release . Journal of Leukocyte Biology vol. 86 , ( 1 ) 115 - 122 .

Huggins A, Paschalidis N, Flower RJ, Perretti M, D'Acquisto F ( 2009 ) . Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation . FASEB J vol. 23 , ( 4 ) 985 - 996 .

Tripatara P, Patel NSA, Brancaleone V, Renshaw D, Rocha J, Sepodes B, Mota-Filipe H, Perretti M et al. ( 2009 ) . Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: An in vivo study . EUR J PHARMACOL vol. 606 , ( 1-3 ) 205 - 209 .

Maione F, Paschalidis N, Mascolo N, Dufton N, Perretti M, Dacquisto F ( 2009 ) . Interleukin 17 sustains rather than induces inflammation . BIOCHEM PHARMACOL vol. 77 , ( 5 ) 878 - 887 .

Ahluwalia A, De Felipe C, O'Brien J, Hunt SP, Perretti M ( 2009 ) . Impaired IL‐1<i>β</i>‐induced neutrophil accumulation in tachykinin NK₁ receptor knockout mice . British Journal of Pharmacology vol. 124 , ( 6 ) 1013 - 1015 .

Ajuebor MN, Gibbs L, Flower RJ, Das AM, Perretti M ( 2009 ) . Investigation of the functional role played by the chemokine monocyte chemoattractant protein‐1 in interleukin‐1‐induced murine peritonitis . British Journal of Pharmacology vol. 125 , ( 2 ) 319 - 326 .

Teixeira MM, Das AM, Miotla JM, Perretti M, Hellewell PG ( 2009 ) . The role of lipocortin‐1 in the inhibitory action of dexamethasone on eosinophil trafficking in cutaneous inflammatory reactions in the mouse . British Journal of Pharmacology vol. 123 , ( 3 ) 538 - 544 .

Hecht I, Rong J, Sampaio ALF, Hermesh C, Rutledge C, Shemesh R, Toporik A, Beiman M et al. ( 2009 ) . A Novel Peptide Agonist of Formyl-Peptide Receptor-Like 1 (ALX) Displays Anti-Inflammatory and Cardioprotective Effects . The Journal of Pharmacology and Experimental Therapeutics vol. 328 , ( 2 ) 426 - 434 .

D'Acquisto F, Perretti M, Flower RJ ( 2009 ) . Annexin‐A1: a pivotal regulator of the innate and adaptive immune systems . British Journal of Pharmacology vol. 155 , ( 2 ) 152 - 169 .

Yona S, Heinsbroek SEM, Peiser L, Gordon S, Perretti M, Flower RJ ( 2009 ) . Impaired phagocytic mechanism in annexin 1 null macrophages . British Journal of Pharmacology vol. 148 , ( 4 ) 469 - 477 .

McLean PG, Perretti M, Ahluwalia A ( 2009 ) . Inducible expression of the kinin B₁ receptor in the endotoxemic heart: mechanisms of des‐Arg⁹bradykinin‐induced coronary vasodilation . British Journal of Pharmacology vol. 128 , ( 2 ) 275 - 282 .

Solito E, De Coupade C, Canaider S, Goulding NJ, Perretti M ( 2009 ) . Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase‐3 activation . British Journal of Pharmacology vol. 133 , ( 2 ) 217 - 228 .

Sampaio ALF, Leoni G, Marshall JF, Perretti M ( 2009 ) . A role for α5β1 integrin in leukocyte accumulation in acute peritonitis . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION . vol. 39 , 22 - 23 .

Patel HB, Bombardieri M, Pitzalis C, Perretti M ( 2009 ) . Activation of melanocortin receptor type 3 as a new strategy to control experimental and rheumatoid arthritis . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION vol. 39 , 29 - 29 .

Perretti M, D'Acquisto F ( 2009 ) . Annexin A1 and glucocorticoids as effectors of the resolution of inflammation . NAT REV IMMUNOL vol. 9 , ( 1 ) 62 - 70 .

Laukoetter MG, Babbin BA, Nava P, Koch S, Lee WY, Capaldo CT, Peatman E, Severson EA et al. ( 2009 ) . Annexin A1 regulates intestinal mucosal injury, inflammation, and repair . Deutsche Gesellschaft für Chirurgie , Springer Berlin Heidelberg

Pederzoli-Ribeil M, Maione F, Perretti M, D'Acquisto F ( 2009 ) . Annexin-A1, a novel pathway effector of neutrophil behavior in Wegener disease? . APMIS . vol. 117 , 118 - 118 .

Gastardelo TS, Damazo AS, Dalli J, Flower RJ, Perretti M, Oliani SM ( 2009 ) . Functional and Ultrastructural Analysis of Annexin A1 and Its Receptor in Extravasating Neutrophils during Acute Inflammation . The American Journal of Pathology vol. 174 , ( 1 ) 177 - 183 .

Pederzoli-Ribeil M, Maione F, Perretti M, D'Acquisto F ( 2009 ) . The impact of Annexin-A1 cleavage on neutrophil behaviour during vascular inflammation . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION vol. 39 , 37 - 37 .

Perretti M, Dufton N, Patel HB, Hannon R, Flower RJ ( 2009 ) . The role of ALX/FPRL-1 in inflammation and its impact on Annexin A1 biology . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION . vol. 39 , 24 - 24 .

Getting SJ, Riffo-Vasquez Y, Pitchford S, Kaneva M, Grieco P, Page CP, Perretti M, Spina D ( 2008 ) . A role for MC3R in modulating lung inflammation . Pulmonary Pharmacology &amp; Therapeutics vol. 21 , ( 6 ) 866 - 873 .

Leoni G, Patel HB, Sampaio ALF, Gavins FNE, Murray JF, Grieco P, Getting SJ, Perretti M ( 2008 ) . Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion . FASEB J vol. 22 , ( 12 ) 4228 - 4238 .

Oliani SM, Ciocca GAP, Pimentel TA, Damazo AS, Gibbs L, Perretti M ( 2008 ) . Fluctuation of annexin-A1 positive mast cells in chronic granulomatous inflammation . Inflammation Research vol. 57 , ( 10 ) 450 - 456 .

Babbin BA, Laukoetter MG, Nava P, Koch S, Lee WY, Capaldo CT, Peatman E, Severson EA et al. ( 2008 ) . Annexin A1 Regulates Intestinal Mucosal Injury, Inflammation, and Repair . The Journal of Immunology vol. 181 , ( 7 ) 5035 - 5044 .

Dalli J, Norling LV, Renshaw D, Cooper D, Leung K-Y, Perretti M ( 2008 ) . Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles . Blood vol. 112 , ( 6 ) 2512 - 2519 .

D'Acquisto F, Perretti M ( 2008 ) . Overview of the Role of Annexin 1 in the Innate and Adaptive Immune Response . Immunology‚ Endocrine &amp; Metabolic Agents in Medicinal Chemistry vol. 8 , ( 3 ) 252 - 258 .

Sarndahl E, Bergstrom I, Nijm J, Perretti M, Jonasson L ( 2008 ) . ENHANCED NEUTROPHIL EXPRESSION OF ANNEXIN-1 IN CORONARY ARTERY DISEASE . Atherosclerosis Supplements vol. 9 , ( 1 ) 15 - 15 .

D'Acquisto F, Paschalidis N, Raza K, Buckley CD, Flower RJ, Perretti M ( 2008 ) . Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid arthritis CD4(+) T cells . RHEUMATOLOGY vol. 47 , ( 5 ) 636 - 639 .

Cooper D, Norling LV, Perretti M ( 2008 ) . Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow . Journal of Leukocyte Biology vol. 83 , ( 6 ) 1459 - 1466 .

Martin GR, Perretti M, Flower RJ, Wallace JL ( 2008 ) . Annexin-1 modulates repair of gastric mucosal injury . American Journal of Physiology-Gastrointestinal and Liver Physiology vol. 294 , ( 3 ) G764 - G769 .

Dasgupta B, Dalli J, Norling L, Pederzoli-Ribeil M, Hollywood J, D'Acquisto F, Perretti M ( 2008 ) . Altered expression of annexin 1 and its receptor in neutrophils of patients with giant cell arteritis (GCA) and ANCA associated vasculitis (AAV) . RHEUMATOLOGY . vol. 47 , II99 - II99 .

Dufton N, Buckingham J, Perretti M, Flower R ( 2008 ) . Initial characterisation of the novel transgenic, the <i>alx/fpr-rs2</i> null mouse . FUNDAMENTAL & CLINICAL PHARMACOLOGY vol. 22 , 48 - 48 .

Finney SJ, Anning PB, Cao TV, Perretti M, Evans TW, Burke-Gaffney A ( 2007 ) . Butanol-extracted lipoteichoic acid induces in vivo leukocyte adhesion . Biochemical and Biophysical Research Communications vol. 364 , ( 4 ) 831 - 837 .

O'Sullivan TP, Vallin KSA, Ali Shah ST, Fakhry J, Maderna P, Scannell M, Sampaio ALF, Perretti M et al. ( 2007 ) . Aromatic Lipoxin A₄and Lipoxin B₄Analogues Display Potent Biological Activities . Journal of Medicinal Chemistry vol. 50 , ( 24 ) 5894 - 5902 .

Norling LV, Sampaio ALF, Cooper D, Perretti M ( 2007 ) . Inhibitory control of endothelial galectin‐1 on<i>in vitro</i>and<i>in vivo</i>lymphocyte trafficking . The FASEB Journal vol. 22 , ( 3 ) 682 - 690 .

D'Acquisto F, Paschalidis N, Sampaio ALF, Merghani A, Flower RJ, Perretti M ( 2007 ) . Impaired T cell activation and increased Th2 lineage commitment in Annexin‐1‐deficient T cells . European Journal of Immunology vol. 37 , ( 11 ) 3131 - 3142 .

Yona S, Lin H, Dri P, Davies JQ, Hayhoe RPG, Lewis SM, Heinsbroek SEM, Brown KA et al. ( 2007 ) . Ligation of the adhesion‐GPCR EMR2 regulates human neutrophil function . The FASEB Journal vol. 22 , ( 3 ) 741 - 751 .

Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A ( 2007 ) . A novel inflammatory pathway recruitment: Role for the kinin chemokine CXCL5 . J IMMUNOL vol. 179 , ( 7 ) 4849 - 4856 .

Vong L, D'Acquisto F, Pederzoli-Ribeil M, Lavagno L, Flower RJ, Witko-Sarsat V, Perretti M ( 2007 ) . Annexin 1 Cleavage in Activated Neutrophils . Journal of Biological Chemistry vol. 282 , ( 41 ) 29998 - 30004 .

Perretti M, Mancini L ( 2007 ) . Potential of calcitonin as a novel cotreatment for arthritis . Future Rheumatology vol. 2 , ( 5 ) 493 - 496 .

Gavins FNE, Dalli J, Flower RJ, Granger DN, Perretti M ( 2007 ) . Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation . FASEB J vol. 21 , ( 8 ) 1751 - 1758 .

Urquhart P, Rosignoli G, Cooper D, Motterlini R, Perretti M ( 2007 ) . Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flow . J PHARMACOL EXP THER vol. 321 , ( 2 ) 656 - 662 .

Mancini L, Paul-Clark MJ, Rosignoli G, Hannon R, Martin JE, Macintyre I, Perretti M ( 2007 ) . Calcitonin and Prednisolone Display Antagonistic Actions on Bone and Have Synergistic Effects in Experimental Arthritis . The American Journal of Pathology vol. 170 , ( 3 ) 1018 - 1027 .

Giner RM, Mancini L, Kamal AM, Perretti M ( 2007 ) . Uneven modulation of the annexin 1 system in osteoblast-like cells by dexamethasone . Biochemical and Biophysical Research Communications vol. 354 , ( 2 ) 414 - 419 .

D'Acquisto F, Merghani A, Lecona E, Rosignoli G, Raza K, Buckley CD, Flower RJ, Perretti M ( 2007 ) . Annexin-1 modulates T-cell activation and differentiation . BLOOD vol. 109 , ( 3 ) 1095 - 1102 .

Perretti M ( 2007 ) . Glucocorticoids in innate immunity: more transactivation than transrepression! . Blood vol. 109 , ( 3 ) 852 - 853 .

Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, O'Neill LAJ, Perretti M, Rossi AG et al. ( 2007 ) . Resolution of in flammation: state of the art, definitions and terms . The FASEB Journal vol. 21 , ( 2 ) 325 - 332 .

John CD, Sahni V, Mehet D, Morris JF, Christian HC, Perretti M, Flower RJ, Solito E et al. ( 2007 ) . Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides . The FASEB Journal vol. 21 , ( 4 ) 1037 - 1046 .

Piqueras L, Norlyng L, Perretti M, Li Y, Sanz MJ, Real JT, Warner T, Bishop-Bayley D ( 2007 ) . PPARb inhibits neutrophil-endothelium interactions under flow . INFLAMMATION RESEARCH . vol. 56 , S453 - S454 .

Getting SJ, Lam CW, Leoni G, Gavins FNE, Grieco P, Perretti M ( 2006 ) . [d-Trp8]-γ-Melanocyte-Stimulating Hormone Exhibits Anti-Inflammatory Efficacy in Mice Bearing a Nonfunctional MC1R (Recessive Yellow e/e Mouse) . Molecular Pharmacology vol. 70 , ( 6 ) 1850 - 1855 .

Sawmynaden P, Perretti M ( 2006 ) . Glucocorticoid upregulation of the annexin-A1 receptor in leukocytes . BIOCHEM BIOPH RES CO vol. 349 , ( 4 ) 1351 - 1355 .

Getting SJ, Lam CW, Chen AS, Grieco P, Perretti M ( 2006 ) . Melanocortin 3 receptors control crystal‐induced inflammation . The FASEB Journal vol. 20 , ( 13 ) 2234 - 2241 .

Renshaw D, Urquhart P, Perretti M ( 2006 ) . Therapeutic Exploitation of Endogenous Anti-Inflammatory Mechanisms:Old and New Leads . Anti-Inflammatory &amp; Anti-Allergy Agents in Medicinal Chemistry vol. 5 , ( 4 ) 289 - 305 .

Kamal AM, Hayhoe RPG, Paramasivam A, Cooper D, Flower RJ, Solito E, Perretti M ( 2006 ) . Antiflammin-2 activates the human formyl-peptide receptor like 1 . THESCIENTIFICWORLDJO vol. 6 , 1375 - 1384 .

CASSATELLA M, PERRETTI M ( 2006 ) . ImmunomodulationThe promises of immunopharmacology for the development of new drugs . Current Opinion in Pharmacology vol. 6 , ( 4 ) 376 - 378 .

Babbin BA, Lee WY, Parkos CA, Winfree LM, Akyildiz A, Perretti M, Nusrat A ( 2006 ) . Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors . J BIOL CHEM vol. 281 , ( 28 ) 19588 - 19599 .

Perretti M, D'Acquisto F ( 2006 ) . Novel Aspects of Annexin 1 and Glucocorticoid Biology: Intersection with Nitric Oxide and the Lipoxin Receptor . Inflammation &amp; Allergy-Drug Targets vol. 5 , ( 2 ) 107 - 114 .

Damazo AS, Yona S, Flower RJ, Perretti M, Oliani SM ( 2006 ) . Spatial and Temporal Profiles for Anti-Inflammatory Gene Expression in Leukocytes during a Resolving Model of Peritonitis . The Journal of Immunology vol. 176 , ( 7 ) 4410 - 4418 .

Babbin BA, Lee W, Winfree LM, Akyildiz A, Parkos CA, Perretti M, Nusrat A ( 2006 ) . Annexin I regulates epithelial cell migration by signaling through formyl peptide receptors . The FASEB Journal . vol. 20 ,

Vong L, D’Acquisto F, Flower RJ, Witko‐Sarsat V, Perretti M ( 2006 ) . Cleavage of Annexin‐A1 by Proteinase 3: a possible cause of Wegener’s vasculitis? . The FASEB Journal . vol. 20 ,

Renshaw D, Dalli J, Kamal A, Perretti M ( 2006 ) . Disinct patterns of gene expression induced by annexin 1 activation of the ALXR receptor in HEK293 cells . The FASEB Journal . vol. 20 ,

Norling LV, Cooper D, Perretti M ( 2006 ) . Endogenous Galectn‐1 inhibits lymphocyte‐endothelial cell interactions as determined by small interference RNA . The FASEB Journal . vol. 20 ,

Renshaw D, Sawmynadan P, Dalli J, Perretti M ( 2006 ) . Glueocorticoid regulated expression of the anti-inflammatory receptor ALXR . FASEB JOURNAL . vol. 20 , A645 - A645 .

Duchene J, Lecomte F, Perretti M, Ahluwalia A ( 2006 ) . INFLAMMATORY CHEMOKINE CXCL5 EXPRESSION BY ENDOTHELIAL CELLS IS DEPENDENT UPON KININ B1 RECEPTOR ACTIVATION . The FASEB Journal . vol. 20 ,

Hayhoe RPG, Cooper D, Perretti M ( 2006 ) . The anti‐adhesive effects of annexin 1 on neutrophil‐endothelial interactions under flow . The FASEB Journal . vol. 20 ,

Hayhoe RPG, Kamal AM, Solito E, Flower RJ, Cooper D, Perretti M ( 2006 ) . Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement . Blood vol. 107 , ( 5 ) 2123 - 2130 .

Gil CD, Cooper D, Rosignoli G, Perretti M, Oliani SM ( 2006 ) . Inflammation-induced modulation of cellular galectin-1 and-3 expression in a model of rat peritonitis . INFLAMM RES vol. 55 , ( 3 ) 99 - 107 .

Lam CW, Perretti M, Getting SJ ( 2006 ) . Melanocortin receptor signaling in RAW264.7 macrophage cell line . PEPTIDES vol. 27 , ( 2 ) 404 - 412 .

Getting SJ, Di Filippo C, D'Amico M, Perretti M ( 2006 ) . The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage . European Journal of Pharmacology vol. 532 , ( 1-2 ) 138 - 144 .

Perretti M, GETTING SJ, Spina D, Riffo-Vasquez Y, Page C, Pitchford S, Grieco P ( 2006 ) . A role for MC3R in modulating eosinophil migration in allergic inflammation . Am J Pathol .

Flower RJ, Perretti M, D'Acquisto F, Buckingham JC ( 2006 ) . Annexin 1, anti-inflammatory drugs and the neuroendocrine-immune interface . ACTA PHARMACOLOGICA SINICA vol. 27 , 13 - 14 .

D'Acquisto F, Merghani A, Lecona E, Guglielmo R, Vo P, Raza K, Buckley C, Flower RJ et al. ( 2006 ) . Annexin A1: a novel target of the immunosuppressive effects of glucocorticoids in autoimmune diseases . FASEB JOURNAL . vol. 20 , A1376 - A1376 .

Flower RJ, Ayoub S, Perretti M ( 2006 ) . Anti-inflammatory and analgesic aspects of the annexin A1 system . ACTA PHARMACOLOGICA SINICA vol. 27 , ( 9 ) 1272 - 1272 .

Urquhart P, Cooper D, Motterlini R, Perretti M ( 2006 ) . CO-releasing molecules modulate leukocyte/endothelial cell adhesion: under static and flow studies . FASEB JOURNAL . vol. 20 , A1321 - A1321 .

Allegra M, Tesoriere L, D'acquisto F, Perretti M, Livrea M ( 2006 ) . Indicaxanthin and betanin suppress LPS-induced NF-κB activation and modulate the levels of inflammatory mediators iNOS, COX-2 and PGE2 in macrophages . FREE RADICAL RESEARCH . vol. 40 , S113 - S113 .

Moraes LA, Paul-Clark MJ, Rickman A, Flower RJ, Goulding NJ, Perretti M ( 2005 ) . Ligand-specific glucocorticoid receptor activation in human platelets . BLOOD vol. 106 , ( 13 ) 4167 - 4175 .

Bensalem N, Ventura AP, Vallée B, Lipecka J, Tondelier D, Davezac N, Santos AD, Perretti M et al. ( 2005 ) . Down-regulation of the Anti-inflammatory Protein Annexin A1 in Cystic Fibrosis Knock-out Mice and Patients . Molecular &amp; Cellular Proteomics vol. 4 , ( 10 ) 1591 - 1601 .

Gavins FNE, Sawmynaden P, Chatterjee BE, Perretti M ( 2005 ) . A twist in anti-inflammation: Annexin 1 acts via the lipoxin A(4) receptor . PROSTAG LEUKOTR ESS vol. 73 , ( 3-4 ) 211 - 219 .

Chatterjee BE, Yona S, Rosignoli G, Young RE, Nourshargh S, Flower RJ, Perretti M ( 2005 ) . Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro . J LEUKOCYTE BIOL vol. 78 , ( 3 ) 639 - 646 .

GILROY D, PERRETTI M ( 2005 ) . Aspirin and steroids: new mechanistic findings and avenues for drug discovery . Current Opinion in Pharmacology vol. 5 , ( 4 ) 405 - 411 .

Marchand F, Perretti M, McMahon SB ( 2005 ) . Role of the Immune system in chronic pain . Nature Reviews Neuroscience vol. 6 , ( 7 ) 521 - 532 .

Bandeira-Melo C, Bonavita AGC, Diaz BL, Silva PMRE, Carvalho VF, Jose PJ, Flower RJ, Perretti M et al. ( 2005 ) . A novel effect for annexin 1-derived peptide Ac2-26: Reduction of allergic inflammation in the rat . J PHARMACOL EXP THER vol. 313 , ( 3 ) 1416 - 1422 .

Damazo AS, Yona S, D'Acquisto F, Flower RJ, Oliani SM, Perretti M ( 2005 ) . Critical Protective Role for Annexin 1 Gene Expression in the Endotoxemic Murine Microcirculation . The American Journal of Pathology vol. 166 , ( 6 ) 1607 - 1617 .

Maderna P, Yona S, Perretti M, Godson C ( 2005 ) . Modulation of Phagocytosis of Apoptotic Neutrophils by Supernatant from Dexamethasone-Treated Macrophages and Annexin-Derived Peptide Ac2–26 . The Journal of Immunology vol. 174 , ( 6 ) 3727 - 3733 .

Flower RJ, Perretti M ( 2005 ) . Controlling inflammation: a fat chance? . J EXP MED vol. 201 , ( 5 ) 671 - 674 .

Basoni C, Nobles M, Grimshaw A, Desgranges C, Davies D, Perretti M, Kramer IM, Genot E ( 2005 ) . Inhibitory control of TGF‐β1 on the activation of Rap1, CD11b, and transendothelial migration of leukocytes . The FASEB Journal vol. 19 , ( 7 ) 1 - 25 .

Kamal AM, Flower RJ, Perretti M ( 2005 ) . An overview of the effects of annexin 1 on cells involved in the inflammatory process . MEMORIAS DO INSTITUTO OSWALDO CRUZ vol. 100 , 39 - 47 .

Zanardo RCO, Perretti M, Wallace JL ( 2005 ) . Annexin-1 is an endogenous gastroprotective factor against indomethacin-induced damage . American Journal of Physiology-Gastrointestinal and Liver Physiology vol. 288 , ( 3 ) G481 - G486 .

McLean PG, Perretti M, Ahluwalia A ( 2005 ) . Kinin B₁receptors as novel anti-inflammatory targets . Emerging Therapeutic Targets vol. 4 , ( 2 ) 127 - 141 .

Lam CW, Getting SJ, Perretti M ( 2005 ) . In Vitro and In Vivo Induction of Heme Oxygenase 1 in Mouse Macrophages following Melanocortin Receptor Activation . The Journal of Immunology vol. 174 , ( 4 ) 2297 - 2304 .

Yona S, Ward B, Buckingham JC, Perretti M, Flower RJ ( 2005 ) . Macrophage biology in the Anx-A1(-/-) mouse . PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS vol. 72 , ( 2 ) 95 - 103 .

Yona S, Heinsbroek S, Gordon S, Perretti M, Flow RJ ( 2005 ) . A novel role for Annexin 1 in macrophage phagocytosis . INFLAMMATION RESEARCH . vol. 54 , S100 - S100 .

Kamal AM, Flower RJ, Perretti M ( 2005 ) . An overview of the effects of annexin 1 on cells involved in the inflammatory process . Memorias do Instituto Oswaldo Cruz . vol. 100 , 39 - 48 .

Gavins FN, Granger N, Perretti M ( 2005 ) . Annexin 1 Peptide Protects against Focal Cerebral Ischaemia-Reperfusion Injury in Mice . INFLAMMATION RESEARCH . vol. 54 , S167 - S167 .

Perretti M, Mancini L, Paul-Clark MJ, Hannon R, Macintyre I ( 2005 ) . Calcitonin (CT) and glucocorticoids (GC) have contrasting effects on the RANKL/OPG system in osteoblast-like cells . FASEB JOURNAL . vol. 19 , A93 - A93 .

MacIntyre I, Mancini L, Perretti M ( 2005 ) . Calcitonin abolishes collagen-induced arthritis . JOURNAL OF BONE AND MINERAL RESEARCH . vol. 20 , S198 - S199 .

Duchene J, Perretti M, Ahluwalia A ( 2005 ) . Chemokine involvement in kinin B1 receptor-mediated leukocyte recruitment . FASEB JOURNAL . vol. 19 , A1512 - A1513 .

Perretti M, Damazo AS, Yona S, D'acquisto F, Oliani SM, Flower RJ ( 2005 ) . Critical protective role for annexin 1 gene expression in mouse endotoxemia . FASEB JOURNAL . vol. 19 , A1221 - A1222 .

Cooper D, Hayhoe RPG, Perretti M ( 2005 ) . Effect of annexin 1 in an in vitro model of human neutrophil-endothelial interaction under flow . FASEB JOURNAL . vol. 19 , A1522 - A1522 .

Perretti M, Gavins FNE, Kamal AM, D'Amico M, Oliani SM ( 2005 ) . Formyl-peptide receptor is not involved in the protection afforded by annexin 1 in marine acute myocardial infarct . FASEB JOURNAL . vol. 19 , A707 - A707 .

Cooper D, Perretti M ( 2005 ) . Galectin-1 inhibits neutrophil rolling in a carbohydrate-dependent manner . FASEB JOURNAL . vol. 19 , A1512 - A1512 .

Perretti M, Chatterjee BE, Yona S, Flower RJ ( 2005 ) . Higher degree of neutrophil activation in vitro and within the microcirculation in absence of annexin 1 (Anx-A1) gene . FASEB JOURNAL . vol. 19 , A1262 - A1262 .

Perretti M, Lam CW, Getting SJ ( 2005 ) . In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation . FASEB JOURNAL . vol. 19 , A1421 - A1421 .

Kamal AM, Sawmynaden P, Perretti M ( 2005 ) . Interaction of annexin 1 (Anx-A1) and its bioactive peptides with receptors of the human FPR family . FASEB JOURNAL . vol. 19 , A1513 - A1513 .

Perretti M, Lam CW, Getting SJ, Di Filippo C, D'Amico M ( 2005 ) . MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct . FASEB JOURNAL . vol. 19 , A485 - A485 .

Alam CAS, Seed MP, Freemantle C, Brown J, Perretti M, Carrier M, Divwedi A, West DC et al. ( 2005 ) . The inhibition of neutrophil-endothelial cell adhesion by hyaluronan independent of CD44 . InflammoPharmacology vol. 12 , ( 5-6 ) 535 - 550 .

Gavins FNE, Kamal AM, D'Amico M, Oliani SM, Perretti M ( 2004 ) . Formyl-peptide receptor is not involved in the protection afforded by annexin 1 in murine acute myocardial infarct . FASEB J vol. 18 , ( 13 ) 100 - + .

Getting SJ, Di Filippo C, Christian HC, Lam CW, Rossi F, D'Amico M, Perretti M ( 2004 ) . MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct . Journal of Leukocyte Biology vol. 76 , ( 4 ) 845 - 853 .

Di Filippo C, Rossi F, Ongini E, Del Soldato P, Perretti M, D’Amico M ( 2004 ) . The Distinct Alterations Produced in Cardiovascular Functions by Prednisolone and Nitro-prednisolone (NCX-1015) in the Rat Highlight a Causal Role for Endothelin-1 . The Journal of Pharmacology and Experimental Therapeutics vol. 310 , ( 3 ) 1133 - 1141 .

Perretti M, Flower RJ ( 2004 ) . Annexin 1 and the biology of the neutrophil . JOURNAL OF LEUKOCYTE BIOLOGY vol. 76 , ( 1 ) 25 - 29 .

Yona S, Buckingham JC, Perretti M, Flower RJ ( 2004 ) . Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages . BRIT J PHARMACOL vol. 142 , ( 5 ) 890 - 898 .

MARTIN JE, Flower RJ, Perretti M, Hannon R, Getting SJ, Gavins FNE, Christian HC, Parente L et al. ( 2004 ) . The Annexin 1-/- Mouse: Phenotypic Studies . Annexins vol. 1 , ( 2 ) 109 - 120 .

Perretti M, Solito E ( 2004 ) . Annexin 1 and neutrophil apoptosis . BIOCHEMICAL SOCIETY TRANSACTIONS vol. 32 , 507 - 510 .

Gilroy DW, Lawrence T, Perretti M, Rossi AG ( 2004 ) . Inflammatory resolution: New opportunities for drug discovery . NAT REV DRUG DISCOV vol. 3 , ( 5 ) 401 - 416 .

Pieretti S, Di Giannuario A, De Felice M, Perretti M, Cirino G ( 2004 ) . Stimulus-dependent specificity for annexin 1 inhibition of the inflammatory nociceptive response: the involvement of the receptor for formylated peptides . Pain vol. 109 , ( 1 ) 52 - 63 .

Young RE, Thompson RD, Larbi KY, La M, Roberts CE, Shapiro SD, Perretti M, Nourshargh S ( 2004 ) . Neutrophil Elastase (NE)-Deficient Mice Demonstrate a Nonredundant Role for NE in Neutrophil Migration, Generation of Proinflammatory Mediators, and Phagocytosis in Response to Zymosan Particles In Vivo . The Journal of Immunology vol. 172 , ( 7 ) 4493 - 4502 .

Yang YH, Morand EF, Getting SJ, Paul‐Clark M, Liu DL, Yona S, Hannon R, Buckingham JC et al. ( 2004 ) . Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen‐induced arthritis . Arthritis &amp; Rheumatism vol. 50 , ( 3 ) 976 - 984 .

Moraes LA, Giner RM, Paul‐Clark MJ, Perretti M, Perrett D ( 2004 ) . An isocratic HPLC method for the quantitation of eicosanoids in human platelets . Biomedical Chromatography vol. 18 , ( 1 ) 64 - 68 .

Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A, Perretti M, Moncada S, Hobbs AJ ( 2004 ) . Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment . Proceedings of the National Academy of Sciences vol. 101 , ( 5 ) 1386 - 1391 .

PERRETTI M, Oliani SM, Takahashi HK, Damazo AS, Paul-Clark MJ, Straus AH ( 2004 ) . Analysis of annexin 1 expression in rat trachea: study of mast cell heterogeneity . ANNEXINS vol. 1 , 12 - 18 .

Smith T, Perretti M, Patton JT, Sarkar A, Magnani JL ( 2004 ) . Pan-selectin glycomimetic inhibitors inhibit rolling and neutrophil migration in mouse models of inflammation . GLYCOBIOLOGY . vol. 14 , 1202 - 1203 .

Baraldi PG, Romagnoli R, del Carmen Nuñez M, Perretti M, Paul-Clark MJ, Ferrario M, Govoni M, Benedini F et al. ( 2003 ) . Synthesis of Nitro Esters of Prednisolone, New Compounds Combining Pharmacological Properties of Both Glucocorticoids and Nitric Oxide . Journal of Medicinal Chemistry vol. 47 , ( 3 ) 711 - 719 .

Perretti M ( 2003 ) . The annexin 1 receptor(s): is the plot unravelling? . Trends in Pharmacological Sciences vol. 24 , ( 11 ) 574 - 579 .

La M, Cao TV, Cerchiaro G, Chilton K, Hirabayashi J, Kasai K-I, Oliani SM, Chernajovsky Y et al. ( 2003 ) . A Novel Biological Activity for Galectin-1 . The American Journal of Pathology vol. 163 , ( 4 ) 1505 - 1515 .

Paul-Clark MJ, Roviezzo F, Flower RJ, Cirino G, Soldato PD, Adcock IM, Perretti M ( 2003 ) . Glucocorticoid Receptor Nitration Leads to Enhanced Anti-Inflammatory Effects of Novel Steroid Ligands . The Journal of Immunology vol. 171 , ( 6 ) 3245 - 3252 .

Getting SJ, Schiöth HB, Perretti M ( 2003 ) . Dissection of the Anti-Inflammatory Effect of the Core and C-Terminal (KPV) α-Melanocyte-Stimulating Hormone Peptides . The Journal of Pharmacology and Experimental Therapeutics vol. 306 , ( 2 ) 631 - 637 .

Solito E, Kamal A, Russo-Marie F, Buckingham JC, Marullo S, Perretti M ( 2003 ) . A novel calcium‐dependent proapoptotic effect of annexin 1 on human neutrophils . The FASEB Journal vol. 17 , ( 11 ) 1 - 27 .

Gavins FNE, Yona S, Kamal AM, Flower RJ, Perretti M ( 2003 ) . Leukocyte antiadhesive actions of annexin 1: ALYR- and FPR-related anti-inflammatory mechanisms . BLOOD vol. 101 , ( 10 ) 4140 - 4147 .

Perretti M, Paul-Clark MJ, Mancini L, Flower RJ ( 2003 ) . Generation of innovative anti-inflammatory and anti-arthritic glucocorticoid derivatives that release NO: the nitro-steroids . Digestive and Liver Disease vol. 35 , S41 - S48 .

Perretti M, Gavins FNE ( 2003 ) . Annexin 1: An endogenous anti-inflammatory protein . NEWS PHYSIOL SCI vol. 18 , 60 - 64 .

Getting SJ, Christian HC, Lam CW, Gavins FNE, Flower RJ, Schiöth HB, Perretti M ( 2003 ) . Redundancy of a Functional Melanocortin 1 Receptor in the Anti-inflammatory Actions of Melanocortin Peptides: Studies in the Recessive Yellow (e/e) Mouse Suggest an Important Role for Melanocortin 3 Receptor . The Journal of Immunology vol. 170 , ( 6 ) 3323 - 3330 .

Parente L, Perretti M ( 2003 ) . Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight . BIOCHEM PHARMACOL vol. 65 , ( 2 ) 153 - 159 .

Gavins FNE, Flower RJ, Perretti M ( 2003 ) . A Boc-sensitive receptor, distinct from FPR, mediates the anti-inflammatory action of an annexin 1 peptide in the mouse heart . FASEB JOURNAL . vol. 17 , A1074 - A1074 .

Solito E, Kamal A, Russo-Marie F, Buckingham JC, Marullo S, Perretti M ( 2003 ) . A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils . FASEB Journal Official Publication of the Federation of American Societies for Experimental Biology . vol. 17 , 1544 - 1546 .

Gavins FNE, Gao JL, Murphy PM, Flower RJ, Perretti M ( 2003 ) . An annexin 1 peptide reduces myocardial ischaemia reperfusion in the mouse . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U9 - U9 .

Kamal AM, Giner RM, Paramasivam AM, Perretti M ( 2003 ) . Annexin 1 interactions with receptors of the formylated peptide family . FASEB JOURNAL . vol. 17 , A638 - A638 .

Paul-Clark MJ, Getting SJ, Flower RJ, Del Soldato P, Perretti M ( 2003 ) . Anti-arthritic properties of an NO-donating glucocorticoid, NCX-1015 . FASEB JOURNAL . vol. 17 , A1061 - A1061 .

Foster P, Mathur A, McLean P, Perretti M, Moncada S, Ahluwalia A, Hobbs A ( 2003 ) . Anti-leukocyte properties of a novel non NO-based soluble guanylate cyclase activator, BAY 41-2272 . FASEB JOURNAL . vol. 17 , A1052 - A1052 .

Goulding NJ, Rickford AKB, Sherratt KM, Paul-Clark MJ, Flower RJ, Perretti M ( 2003 ) . Characterisation of a novel glucocorticoid receptor inhuman platelets . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U61 - U61 .

Paul-Clark MJ, Getting SJ, Roviezzo F, Del Soldato P, Flower RJ, Perretti M ( 2003 ) . Effects of a novel NO-releasing glucocorticoid (NCX-1015) in a rat model of gout . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U38 - U38 .

La M, Chilton K, Hirabayashi J, Kasai K, Chernajovsky Y, Perretti M ( 2003 ) . Evidence for specific Galectin-1 binding proteins on human neutrophil . FASEB JOURNAL . vol. 17 , A796 - A796 .

Solito E, Perretti M ( 2003 ) . Exogenous annexin 1 promotes human neutrophil apoptosis . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U7 - U7 .

Mancini L, Paul-Clark MJ, Hannon R, MacIntyre I, Perretti M ( 2003 ) . Glucocorticoid modulation of RANKL and osteoprotegerin in osteoblast cell lines . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U61 - U61 .

Oliani SM, Damazo AS, Paul-Clark MJ, Perretti M ( 2003 ) . Mast cell heterogeneity: analysis of annexin 1 expression in rat trachea . FASEB JOURNAL . vol. 17 , A1070 - A1070 .

Getting SJ, Lam CW, Christian HC, Flower RJ, Schioth H, Perretti M ( 2003 ) . Melanocortin agonists possess anti-inflammatory effect in mice with a non-funetional MC1-R (recessive yellow e/e mice) . FASEB JOURNAL . vol. 17 , A1069 - A1069 .

Getting SJ, Lam CW, Christian HC, Gavins FNE, Flower RJ, Schiöth HB, Perretti M ( 2003 ) . Melanocortin agonists possess anti-inflammatory effects in mice with a non-functional MC1-R (recessive yellow e/e) . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U6 - U6 .

Perretti M, Getting SJ ( 2003 ) . Migration of Specific Leukocyte Subsets in Response to Cytokine or Chemokine Application In Vivo . Inflammation Protocols , vol. 225 , Springer Nature

Young RE, Thompson RD, Larbi KY, La M, Roberts C, Shapir SD, Perretti M, Nourshargh S ( 2003 ) . Neutrophil elastase (NE) plays a non-redundant role in zymosan-induced leukocyte migration . FASEB JOURNAL . vol. 17 , A1188 - A1188 .

Getting SJ, Di Filippo C, Lam CW, Rossi F, Flower RJ, D'Amico M, Perretti M ( 2003 ) . Protective role of melanocortin type 3 receptor in myocardial ischaemia-reperfusion injury in mice . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U72 - U72 .

Vo PA, Syed I, McLean P, Bascands JL, Perretti M, Ahluwalia A ( 2003 ) . Regulation of kinin B1 receptors in emlothelial cells by laminar shear stress . FASEB JOURNAL . vol. 17 , A1056 - A1056 .

Getting SJ, Mahoney DJ, Cao T, Rugg MS, Fries E, Milner CM, Perretti M, Day AJ ( 2002 ) . The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha-inhibitor-independent manner . J BIOL CHEM vol. 277 , ( 52 ) 51068 - 51076 .

Hannon R, Croxtall JD, Getting SJ, Roviezzo F, Yona S, Paul-Clark MJ, Gavins FNE, Perretti M et al. ( 2002 ) . Aberrant inflammation and resistance to glucocorticoids in Annexin 1(-/-) Mouse . FASEB J vol. 16 , ( 14 ) 253 - + .

Roviezzo F, Getting SJ, Paul-Clark MJ, Yona S, Gavins FNE, Perretti M, Hannon R, Croxtall JD et al. ( 2002 ) . The annexin-1 knockout mouse: What it tells us about the inflammatory response . Journal of Physiology and Pharmacology . vol. 53 , 541 - 553 .

Fiorucci S, Antonelli E, Distrutti E, Del Soldato P, Flower RJ, Clark MJP, Morelli A, Perretti M et al. ( 2002 ) . NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice . Proceedings of the National Academy of Sciences vol. 99 , ( 24 ) 15770 - 15775 .

Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ, Solito E, Serhan CN ( 2002 ) . Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor . Nature Medicine vol. 8 , ( 11 ) 1296 - 1302 .

Getting SJ, Christian HC, Flower RJ, Perretti M ( 2002 ) . Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis . ARTHRITIS RHEUM vol. 46 , ( 10 ) 2765 - 2775 .

Oliani SM, Damazo AS, Perretti M ( 2002 ) . Annexin 1 localisation in tissue eosinophils as detected by electron microscopy . MEDIAT INFLAMM vol. 11 , ( 5 ) 287 - 292 .

Perretti M, Ingegnoli F, Wheller SK, Blades MC, Solito E, Pitzalis C ( 2002 ) . Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model . J IMMUNOL vol. 169 , ( 4 ) 2085 - 2092 .

Gibbs L, Carollo MG, Damazo AS, Oliani SM, Perretti M ( 2002 ) . Time-dependent expression of annexin 1 in a model of chronic granulomatous inflammation . Inflammation Research vol. 51 , ( 6 ) 300 - 306 .

Verdini AS, Silvestri S, Becherucci C, Longobardi MG, Parente L, Peppoloni S, Perretti M, Pileri P et al. ( 2002 ) . Immunostimulation by a partially modified retro-inverso-tuftsin analog containing Thr1.sum..psi.[NHCO](R,S)Lys2 modification . Journal of Medicinal Chemistry vol. 34 , ( 12 ) 3372 - 3379 .

Blades MC, Manzo A, Ingegnoli F, Taylor PR, Panayi GS, Irjala H, Jalkanen S, Haskard DO et al. ( 2002 ) . Stromal Cell-Derived Factor 1 (CXCL12) Induces Human Cell Migration into Human Lymph Nodes Transplanted into SCID Mice . The Journal of Immunology vol. 168 , ( 9 ) 4308 - 4317 .

Ajuebor MN, Swain MG, Perretti M ( 2002 ) . Chemokines as novel therapeutic targets in inflammatory diseases . Biochemical Pharmacology vol. 63 , ( 7 ) 1191 - 1196 .

Calatayud S, Mitchell JA, Perretti M, Giuliano F, Warner TD ( 2002 ) . Effects of cyclooxygenase-1/cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery . European Journal of Pharmacology vol. 440 , ( 1 ) 71 - 77 .

Malcangio M, Getting S, Grist J, Cunningham JR, Bradbury EJ, Issa PC, Lever IJ, Pezet S et al. ( 2002 ) . A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones . The FASEB Journal vol. 16 , ( 7 ) 730 - 732 .

Blades MC, Ingegnoli F, Wheller SK, Manzo A, Wahid S, Panayi GS, Perretti M, Pitzalis C ( 2002 ) . Stromal cell–derived factor 1 (CXCL12) induces monocyte migration into human synovium transplanted onto SCID Mice . Arthritis &amp; Rheumatism vol. 46 , ( 3 ) 824 - 836 .

Carollo M, Getting SJ, Delaney S, Christie MI, Perretti M ( 2002 ) . Characterization of CXC and CC chemokine expression in a murine model of chronic granuloma . INFLAMM RES . vol. 51 , 110 - 111 .

Paul-Clark MJ, Mancini L, Del Soldato P, Flower RJ, Perretti M ( 2002 ) . Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis . Proceedings of the National Academy of Sciences vol. 99 , ( 3 ) 1677 - 1682 .

Getting SJ, Flower RJ, Perretti M ( 2002 ) . A molecular mechanism for the clinical efficacy of ACTH in controlling human gout: activation of melanocortin type 3 receptor . FASEB JOURNAL . vol. 16 , A591 - A591 .

Malcangio M, Getting SJ, Grist J, Cunningham JR, Bradbury EJ, Charbel Issa P, Lever IJ, Pezet S et al. ( 2002 ) . A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones . FASEB Journal Official Publication of the Federation of American Societies for Experimental Biology vol. 16 , ( 7 ) 730 - 732 .

Getting SJ, Flower RJ, Perretti M ( 2002 ) . Activation of melanocortin type 3 receptor as a novel mechanism for ACTH efficacy in gouty arthritis . BRITISH JOURNAL OF PHARMACOLOGY . vol. 135 ,

Yona S, Perretti M, Buckingham JC, Morris JF, Flower RJ ( 2002 ) . Altered degree of activation and steroid inhibition in leukocytes from annexin 1 null mice . BRITISH JOURNAL OF PHARMACOLOGY . vol. 137 ,

Perretti M, La M, Solito E ( 2002 ) . Annexin 1 interacts with L-selectin following neutrophil adhesion to endothelial cells . FASEB JOURNAL . vol. 16 , A1049 - A1049 .

Gavins FNE, Gao JL, Murphy PM, Tailor A, Granger DN, Flower RJ, Perretti M ( 2002 ) . Annexin 1 peptide inhibits ischaemia reperfusion (IR)-induced leukocyte adhesion and emigration: Receptors involved . FASEB JOURNAL . vol. 16 , A598 - A599 .

Gavins FNE, Gao J, Murphy PM, Flower RJ, Perretti M ( 2002 ) . Annexin 1 peptide protects against ischaemia reperfusion in the mouse mesentery . BRITISH JOURNAL OF PHARMACOLOGY . vol. 135 ,

Yang YH, Getting SJ, Paul-Clark M, Liu DL, Perretti M, Flower RJ, Morand EF ( 2002 ) . Annexin I -/- mice are resistant to the anti-inflammatory effect of glucocorticoids . ARTHRITIS AND RHEUMATISM . vol. 46 , S388 - S388 .

La M, Cao T, Chernajovsky Y, Perretti M ( 2002 ) . Effect of galectin-1 on neutrophil chemotaxis <i>in vitro</i> and migration <i>in vivo</i> . BRITISH JOURNAL OF PHARMACOLOGY . vol. 135 ,

Perretti M, GETTING SJ, Cunningham JR, Bradbury EJ, Malcangio M, Pezet S, Grist J, Lever IJ ( 2002 ) . Functional evidence that somatostatin release contributes to GDNF anti-hyperalgesic and anti-inflammatory properties . FASEB J . vol. 16 , 730 - 732 .

La M, Cao T, Hirabayashi J, Kasai K, Chernajovsky Y, Perretti M ( 2002 ) . Galectin-1 inhibits neutrophil chemotaxis in vitro and migration in vivo: Indication for a novel endogenous anti-inflammatory loop . FASEB JOURNAL . vol. 16 , A598 - A598 .

Cao T, Day AJ, Perretti M ( 2002 ) . Link tumor necrosis factor stimulatory gene-6 (LINK_TSG6) has neutrophil anti-migratory effects <i>in-vivo</i> . BRITISH JOURNAL OF PHARMACOLOGY . vol. 135 ,

Perretti M, Blades MC, Wheller SK, Wahid S, Solito E, Pitzalis C ( 2002 ) . Monocytic cells over-expressing annexin 1 have reduced transmigration in vitro and elicitation in vivo . FASEB JOURNAL . vol. 16 , A598 - A598 .

Pitzalis C, Pipitone N, Perretti M ( 2002 ) . Regulation of leukocyte-endothelial interactions by glucocorticoids . NEUROENDOCRINE IMMUNE BASIS OF THE RHEUMATIC DISEASES II, PROCEEDINGS . vol. 966 , 108 - 118 .

PERRETTI M, Manzo A, Wheller SK, Ingegnoli F, Blades MC, Petzalis C, Wahid S, Panayi GS ( 2002 ) . Stromal cell derived factor-1 (CXCL 12) induces monocyte migration into human synovium transplanted onto SCID mice . ARTH RHEUM vol. 46 , 824 - 836 .

Roviezzo F, Getting SJ, Paul-Clark MJ, Yona S, Gavins FNE, Perretti M, Hannon R, Croxtall JD et al. ( 2002 ) . The annexin-1 knockout mouse: What it tells us about the inflammatory response . JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY . vol. 53 , 541 - 553 .

AJUEBOR, VIRÁG, FLOWER, PERRETTI, SZABÓ ( 2001 ) . Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan‐induced inflammation . Immunology vol. 95 , ( 4 ) 625 - 630 .

Allcock GH, Allegra M, Flower RJ, Perretti M ( 2001 ) . Neutrophil accumulation induced by bacterial lipopolysaccharide: effects of dexamethasone and annexin 1 . Clinical and Experimental Immunology vol. 123 , ( 1 ) 62 - 67 .

Carollo M, Hogaboam CM, Kunkel SL, Delaney S, Christie MI, Perretti M ( 2001 ) . Analysis of the temporal expression of chemokines and chemokine receptors during experimental granulomatous inflammation: role and expression of MIP-1 alpha and MCP-1 . BRIT J PHARMACOL vol. 134 , ( 6 ) 1166 - 1179 .

Mabley JG, Jagtap P, Perretti M, Getting SJ, Salzman AL, Virág L, Szabó É, Soriano FG et al. ( 2001 ) . Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase . Inflammation Research vol. 50 , ( 11 ) 561 - 569 .

La M, Tailor A, D'Amico M, Flower RJ, Perretti M ( 2001 ) . Analysis of the protection afforded by annexin 1 in ischaemia-reperfusion injury: focus on neutrophil recruitment . EUROPEAN JOURNAL OF PHARMACOLOGY vol. 429 , ( 1-3 ) 263 - 278 .

La M, D'Amico M, Bandiera S, Filippo CD, Oliani SM, Gavins FNE, Flower RJ, Perretti M ( 2001 ) . Annexin 1 peptides protect against experimental myocardial ischemia‐reperfusion: analysis of their mechanism of action . The FASEB Journal . vol. 15 , 2247 - 2256 .

de Coupade C, Ajuebor MN, Russo-Marie F, Perretti M, Solito E ( 2001 ) . Cytokine modulation of liver annexin 1 expression during experimental endotoxemia . AM J PATHOL vol. 159 , ( 4 ) 1435 - 1443 .

Getting SJ, Perretti M ( 2001 ) . Arthritic diseases: Melanocortin type 3 receptor agonists as potential therapeutics . Current Opinion in Investigational Drugs vol. 2 , ( 8 ) 1064 - 1069 .

Damazo AS, Tavares de Lima W, Perretti M, Oliani SM ( 2001 ) . Pharmacological modulation of allergic inflammation in the rat airways and association with mast cell heterogeneity . European Journal of Pharmacology vol. 426 , ( 1-2 ) 123 - 130 .

Henderson RB, Lim LHK, Tessier PA, Gavins FNE, Mathies M, Perretti M, Hogg N ( 2001 ) . The Use of Lymphocyte Function–Associated Antigen (Lfa)-1–Deficient Mice to Determine the Role of Lfa-1, Mac-1, and α4 Integrin in the Inflammatory Response of Neutrophils . The Journal of Experimental Medicine vol. 194 , ( 2 ) 219 - 226 .

Perretti M, Getting SJ, Solito E, Murphy PM, Gao J-L ( 2001 ) . Involvement of the Receptor for Formylated Peptides in the in Vivo Anti-Migratory Actions of Annexin 1 and its Mimetics . The American Journal of Pathology vol. 158 , ( 6 ) 1969 - 1973 .

Diaz B, Barreto E, Cordeiro R, Perretti M, Martins M, Silva P ( 2001 ) . Enhanced serum glucocorticoid levels mediate the reduction of serosal mast cell numbers in diabetic rats . Life Sciences vol. 68 , ( 26 ) 2925 - 2932 .

Allegra M, Furtmuller PG, Regelsberger G, Turco-Liveri ML, Tesoriere L, Perretti M, Livrea RA, Obinger C ( 2001 ) . Mechanism of reaction of melatonin with human myeloperoxidase . BIOCHEM BIOPH RES CO vol. 282 , ( 2 ) 380 - 386 .

Oliani SM, Paul-Clark MJ, Christian HC, Flower RJ, Perretti M ( 2001 ) . Neutrophil Interaction with Inflamed Postcapillary Venule Endothelium Alters Annexin 1 Expression . The American Journal of Pathology vol. 158 , ( 2 ) 603 - 615 .

La M, Bandiera S, Flower RJ, Perretti M ( 2001 ) . Annexin-1-derived peptides protect against myocardial ischaemia reperfusion injury . BRITISH JOURNAL OF PHARMACOLOGY . vol. 133 , U20 - U20 .

Oliani SM, Perretti M ( 2001 ) . Cell localization of the anti-inflammatory protein annexin 1 during experimental inflammatory response . ADVANCES IN MICROANATOMY OF CELLS AND TISSUES, BIOPHYSICAL AND BIOCHEMICAL CORRELATES . vol. 7 , 69 - 77 .

Calatayud S, Allcock GH, Perretti M, Mitchell JA, Warner TD ( 2001 ) . Comparison of the effects of the selective COX-2 inhibitor, DFP, and indomethacin on leukocyte-endothelial cell interactions in the rat mesentery . BRITISH JOURNAL OF PHARMACOLOGY . vol. 133 , U102 - U102 .

Blades MC, Ingegnoli F, Manzo A, Wahid S, Haskard D, Panayi G, Perretti M, Pitzalis C ( 2001 ) . Development of a new model to investigate lymphocyte migration into human peripheral lymph nodes (HPLN) transplanted into SCID mice . RHEUMATOLOGY vol. 40 , 66 - 66 .

Mabley J, Virag L, Jagtap P, Szabo E, Prendergast R, Perretti M, Getting S, Szabo C ( 2001 ) . Effect of a novel poly (ADP-ribose) polymerase (PARP) inhibitor in rodent models of local inflammation . FASEB JOURNAL . vol. 15 , A242 - A242 .

Getting SJ, Flower RJ, Perretti M ( 2001 ) . Effect of melanocortin agonists on joint inflammation . BRITISH JOURNAL OF PHARMACOLOGY . vol. 133 , U19 - U19 .

Pitzalis C, Pipitone N, Perretti M ( 2001 ) . Glucocorticoids and leukocyte adhesion . Glucocorticoids , Birkhäuser Basel

Mancini L, MacIntyre I, Perretti M ( 2001 ) . Glucocorticoids modulate osteoprotegerin/osteoprotegerin ligand and osteoclast activity . BONE . vol. 28 , S161 - S162 .

Perretti M, Wheller SK, Getting SJ, Gao JL ( 2001 ) . Interaction with the formylated receptor (FPR) is at the basis of annexin 1 anti-inflammatory effects . FASEB JOURNAL . vol. 15 , A681 - A681 .

Perretti M, Wheller SK, Getting SJ, Gao JL ( 2001 ) . Involvement of FPR in the anti-inflammatory action of annexin-1 . BRITISH JOURNAL OF PHARMACOLOGY . vol. 133 , U105 - U105 .

Goulding NJ, Rajakulendran S, Goulding PN, Perretti M, Flower RJ, Guyre PM ( 2001 ) . Monocyte CD163 expression is regulated by glucocorticoids and lipopolysaccharide but not by chemokines . BRITISH JOURNAL OF PHARMACOLOGY . vol. 133 , U100 - U100 .

Getting SJ, Allcock GH, Flower R, Perretti M ( 2001 ) . Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties . J LEUKOCYTE BIOL vol. 69 , ( 1 ) 98 - 104 .

Paul-Clark M, Del Soldato P, Fiorucci S, Flower RJ, Perretti M ( 2000 ) . 21-NO-prednisolone is a novel nitric oxide-releasing derivative of prednisolone with enhanced anti-inflammatory properties . BRIT J PHARMACOL vol. 131 , ( 7 ) 1345 - 1354 .

Mancini L, Moradi-Bidhendi N, Brandi ML, Perretti M, MacIntyre I ( 2000 ) . Modulation of the Effects of Osteoprotegerin (OPG) Ligand in a Human Leukemic Cell Line by OPG and Calcitonin . Biochemical and Biophysical Research Communications vol. 279 , ( 2 ) 391 - 397 .

McLean P ( 2000 ) . Kinin B1 receptors and the cardiovascular system: regulation of expression and function . Cardiovascular Research vol. 48 , ( 2 ) 194 - 210 .

D'Amico M, Di Filippo C, La M, Solito E, McLean PG, Flower RJ, Oliani SM, Perretti M ( 2000 ) . Lipocortin 1 reduces myocardial ischemia-reperfusion injury by affecting local leukocyte recruitment . FASEB J vol. 14 , ( 13 ) 1867 - 1869 .

Oliani SM, Christian HC, Manston J, Flower RJ, Perretti M ( 2000 ) . An immunocytochemical and in situ hybridization analysis of annexin 1 expression in rat mast cells: Modulation by inflammation and dexamethasone . LAB INVEST vol. 80 , ( 9 ) 1429 - 1438 .

McLean PG, Ahluwalia A, Perretti M ( 2000 ) . Association between Kinin B1 Receptor Expression and Leukocyte Trafficking across Mouse Mesenteric Postcapillary Venules . The Journal of Experimental Medicine vol. 192 , ( 3 ) 367 - 380 .

PERRETTI M ( 2000 ) . Heparin and inflammation: a new use for an old GAG? . Gut vol. 47 , ( 1 ) 14 - 15 .

Lim LHK, Flower RJ, Perretti M, Das AM ( 2000 ) . Glucocorticoid receptor activation reduces CD11b and CD49d levels on murine eosinophils - Characterization and functional relevance . AM J RESP CELL MOL vol. 22 , ( 6 ) 693 - 701 .

Getting SJ, Perretti M ( 2000 ) . MC3-R as a novel target for antiinflammatory therapy . Drug News and Perspectives vol. 13 , ( 1 ) 19 - 27 .

Mancini L, MacIntyre L, Brandi ML, Perretti M ( 2000 ) . Analysis of osteoprotegerin ligand effects on the FLG 29.1 pre-osteoclastic cell line . BRITISH JOURNAL OF PHARMACOLOGY . vol. 131 , U15 - U15 .

Perretti M, Christian H, Wheller SK, Aiello I, Mugridge KG, Morris JF, Flower RJ, Goulding NJ ( 2000 ) . Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis . CELL BIOL INT vol. 24 , ( 3 ) 163 - 174 .

Carollo M, Christie MI, Perretti M ( 2000 ) . Expression of MIP-2, KC and MCR-1 and their receptors in chronic granulomatous inflammation . BRITISH JOURNAL OF PHARMACOLOGY . vol. 131 , U13 - U13 .

Canaider S, Solito E, de Coupade C, Flower RJ, Russo-Marie F, Goulding NJ, Perretti M ( 2000 ) . Increased apoptosis in U937 cells over-expressing lipocortin 1 (annexin I) . LIFE SCI vol. 66 , ( 18 ) PL265 - PL270 .

Getting SJ, Flower RJ, Perretti M ( 1999 ) . Agonism at melanocortin receptor type 3 on macrophages inhibits neutrophil influx . INFLAMMATION RESEARCH . vol. 48 , S140 - S141 .

Tailor A, Tomlinson A, Salas A, Panes J, Granger DN, Flower RJ, Perretti M ( 1999 ) . Dexamethasone inhibition of leucocyte adhesion to rat mesenteric postcapillary venules: role of intercellular adhesion molecule 1 and KC . GUT vol. 45 , ( 5 ) 705 - 712 .

Das AM, Ajuebor MN, Flower RJ, Perretti M, McColl SR ( 1999 ) . Contrasting roles for RANTES and macrophage inflammatory protein-1 alpha (MIP-1 alpha) in a murine model of allergic peritonitis . CLIN EXP IMMUNOL vol. 117 , ( 2 ) 223 - 229 .

Getting SJ, Gibbs L, Clark AJL, Flower RJ, Perretti M ( 1999 ) . POMC gene-derived peptides activate melanocortin type 3 receptor or murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation . J IMMUNOL vol. 162 , ( 12 ) 7446 - 7453 .

Perretti M, Wheller SK, Flower RJ, Wahid S, Pitzalis C ( 1999 ) . Modulation of cellular annexin I in human leukocytes infiltrating DTH skin reactions . J LEUKOCYTE BIOL vol. 65 , ( 5 ) 583 - 589 .

Ahluwalia A, Perretti M ( 1999 ) . B1 receptors as a new inflammatory target. Could this B the 1? . Trends in Pharmacological Sciences vol. 20 , ( 3 ) 100 - 104 .

Minghetti L, Nicolini A, Polazzi E, Greco A, Perretti M, Parente L, Levi G ( 1999 ) . Down-regulation of microglial cyclo-oxygenase-2 and inducible nitric oxide synthase expression by lipocortin 1 . BRIT J PHARMACOL vol. 126 , ( 6 ) 1307 - 1314 .

Ajuebor MN, Das AM, Virág L, Szabó C, Perretti M ( 1999 ) . Regulation of Macrophage Inflammatory Protein-1α Expression and Function by Endogenous Interleukin-10 in a Model of Acute Inflammation . Biochemical and Biophysical Research Communications vol. 255 , ( 2 ) 279 - 282 .

Ajuebor MN, Das AM, Virag L, Flower RJ, Szabo C, Perretti M ( 1999 ) . Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: Evidence for an inhibitory loop involving endogenous IL-10 . J IMMUNOL vol. 162 , ( 3 ) 1685 - 1691 .

Getting SJ, Flower RJ, Perretti M ( 1999 ) . Agonism at melanocortin receptor type 3 on macrophages inhibits neutrophil influx . Inflammation Research . vol. 48 , S140 - S141 .

Euzger HS, Flower RJ, Goulding NJ, Perretti M ( 1999 ) . Differential modulation of annexin I binding sites on monocytes and neutrophils . MEDIAT INFLAMM vol. 8 , ( 1 ) 53 - 62 .

Ruetten H, Thiemermann C, Perretti M ( 1999 ) . Upregulation of ICAM‐1 Expression on J774.2 Macrophages by Endotoxin Involves Activation of NF‐κB but not Protein Tyrosine Kinase: Comparison to Induction of iNOS . Mediators of Inflammation vol. 8 , ( 2 ) 77 - 84 .

Goulding NJ, Euzger HS, Butt SK, Perretti M ( 1998 ) . Novel pathways for glucocorticoid effects on neutrophils in chronic inflammation . Inflammation Research . vol. 47 , 158 - 165 .

Lim LHK, Solito E, Russo-Marie F, Flower RJ, Perretti M ( 1998 ) . Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: Effect of lipocortin 1 . P NATL ACAD SCI USA vol. 95 , ( 24 ) 14535 - 14539 .

Perretti M ( 1998 ) . Lipocortin 1 and Chemokine Modulation of Granulocyte and Monocyte Accumulation in Experimental Inflammation . General Pharmacology: The Vascular System vol. 31 , ( 4 ) 545 - 552 .

Das AM, Flower RJ, Perretti M ( 1998 ) . Resident mast cells are important for eotaxin-induced eosinophil accumulation in vivo . J LEUKOCYTE BIOL vol. 64 , ( 2 ) 156 - 162 .

Pistritto G, Mancuso C, Tringali G, Perretti M, Preziosi P, Navarra P ( 1998 ) . The relative contribution of constitutive and inducible cyclooxygenase activity to lipopolysaccharide-induced prostaglandin production by primary cultures of rat hypothalamic astrocytes . Neuroscience Letters vol. 246 , ( 1 ) 45 - 48 .

Bryant CE, Perretti M, Flower RJ ( 1998 ) . Suppression by dexamethasone of inducible nitric oxide synthase protein expression in vivo - A possible role for lipocortin 1 . BIOCHEM PHARMACOL vol. 55 , ( 3 ) 279 - 285 .

Ajuebor MN, Flower RJ, Hannon R, Christie M, Bowers K, Verity A, Perretti M ( 1998 ) . Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model . J LEUKOCYTE BIOL vol. 63 , ( 1 ) 108 - 116 .

Das AM, Lim LHK, Flower RJ, Perretti M ( 1997 ) . Dexamethasone reduces cell surface levels of CD11b on human eosinophils . MEDIAT INFLAMM vol. 6 , ( 5-6 ) 363 - 367 .

Cuzzocrea S, Tailor A, Zingarelli B, Salzman AL, Flower RJ, Szabo C, Perretti M ( 1997 ) . Lipocortin 1 protects against splanchnic artery occlusion and reperfusion injury by affecting neutrophil migration . J IMMUNOL vol. 159 , ( 10 ) 5089 - 5097 .

Perretti M ( 1997 ) . Endogenous mediators that inhibit the leukocyte– endothelium interaction . Trends in Pharmacological Sciences vol. 18 , ( 11 ) 418 - 425 .

Szabo C, Lim LHK, Cuzzocrea S, Getting SJ, Zingarelli B, Flower RJ, Salzman AL, Perretti M ( 1997 ) . Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects . J EXP MED vol. 186 , ( 7 ) 1041 - 1049 .

Getting SJ, Flower RJ, Parente L, DeMedicis R, Lussier A, Woliztky BA, Martins MA, Perretti M ( 1997 ) . Molecular determinants of monosodium urate crystal-induced murine peritonitis: A role for endogenous mast cells and a distinct requirement for endothelial-derived selectins . J PHARMACOL EXP THER vol. 283 , ( 1 ) 123 - 130 .

Tailor A, Flower RJ, Perretti M ( 1997 ) . Dexamethasone inhibits leukocyte emigration in rat mesenteric post-capillary venules: An intravital microscopy study . J LEUKOCYTE BIOL vol. 62 , ( 3 ) 301 - 308 .

Das AM, Flower RJ, Perretti M ( 1997 ) . Eotaxin-induced eosinophil migration in the peritoneal cavity of ovalbumin-sensitized mice - Mechanism of action . J IMMUNOL vol. 159 , ( 3 ) 1466 - 1473 .

Wheller SK, Perretti M ( 1997 ) . Dexamethasone inhibits cytokine-induced intercellular adhesion molecule-1 up-regulation on endothelial cell lines . European Journal of Pharmacology vol. 331 , ( 1 ) 65 - 71 .

Ferreira SH, Cunha FQ, Lorenzetti BB, Michelin MA, Perretti M, Flower RJ, Poole S ( 1997 ) . Role of lipocortin-1 in the anti-hyperalgesic actions of dexamethasone . BRIT J PHARMACOL vol. 121 , ( 5 ) 883 - 888 .

Das AM, Flower RJ, Hellewell PG, Teixeira MM, Perretti M ( 1997 ) . A novel murine model of allergic inflammation to study the effect of dexamethasone on eosinophil recruitment . BRIT J PHARMACOL vol. 121 , ( 1 ) 97 - 104 .

Getting SJ, Flower RJ, Perretti M ( 1997 ) . Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1 . BRIT J PHARMACOL vol. 120 , ( 6 ) 1075 - 1082 .

Tailor A, Das AM, Getting SJ, Flower RJ, Perretti M ( 1997 ) . Subacute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes . BIOCHEM BIOPH RES CO vol. 231 , ( 3 ) 675 - 678 .

Perretti M, Croxtall JD, Wheller SK, Goulding NJ, Hannon R, Flower RJ ( 1996 ) . Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration . NAT MED vol. 2 , ( 11 ) 1259 - 1262 .

Harris JG, Flower RJ, Watanabe K, Tsurufuji S, Wolitzky BA, Perretti M ( 1996 ) . Relative Contribution of the Selectins in the Neutrophil Recruitment Caused by the Chemokine Cytokine-Induced Neutrophil Chemoattractant (CINC) . Biochemical and Biophysical Research Communications vol. 224 , ( 3 ) 878 - 879 .

Perretti M, Wheller SK, Harris JG, Flower RJ ( 1996 ) . Modulation of ICAM-1 levels on U-937 cells and mouse macrophages by interleukin-1 beta and dexamethasone . BIOCHEM BIOPH RES CO vol. 223 , ( 1 ) 112 - 117 .

Perretti M, Flower RJ ( 1996 ) . Measurement of lipocortin 1 levels in murine peripheral blood leukocytes by flow cytometry: Modulation by glucocorticoids and inflammation . BRIT J PHARMACOL vol. 118 , ( 3 ) 605 - 610 .

Harris JG, Flower RJ, Watanabe K, Tsurufuji S, Wolitzky BA, Perretti M ( 1996 ) . Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC) . BIOCHEM BIOPH RES CO vol. 221 , ( 3 ) 692 - 696 .

Malcangio M, Bowery NG, Flower RJ, Perretti M ( 1996 ) . Effect of interleukin-1 beta on the release of substance P from rat isolated spinal cord . EUR J PHARMACOL vol. 299 , ( 1-3 ) 113 - 118 .

Perretti M, Ahluwalia A, Harris JG, Harris HJ, Wheller SK, Flower RJ ( 1996 ) . Acute inflammatory response in the mouse: Exacerbation by immunoneutralization of lipocortin 1 . BRIT J PHARMACOL vol. 117 , ( 6 ) 1145 - 1154 .

Ahluwalia A, Perretti M ( 1996 ) . Involvement of bradykinin B1 receptors in the polymorphonuclear leukocyte accumulation induced by IL-1 beta in vivo in the mouse . The Journal of Immunology vol. 156 , ( 1 ) 269 - 274 .

Mugridge KG, Perretti M, Ghiara P, Galeotti CL, Melli M, Parente L ( 1995 ) . Gastric antisecretory and anti-ulcer actions of IL-1 in rat involve different IL-1 receptor types . American Journal of Physiology-Gastrointestinal and Liver Physiology vol. 269 , ( 5 ) G763 - G769 .

PERRETTI M, WHELLER SK, CHOUDHURY Q, CROXTALL JD, FLOWER RJ ( 1995 ) . SELECTIVE-INHIBITION OF NEUTROPHIL FUNCTION BY A PEPTIDE DERIVED FROM LIPOCORTIN-1 N-TERMINUS . BIOCHEM PHARMACOL vol. 50 , ( 7 ) 1037 - 1042 .

HARRIS JG, FLOWER RJ, PERRETTI M ( 1995 ) . ENDOGENOUS CORTICOSTEROIDS MEDIATE THE NEUTROPHILIA CAUSED BY PLATELET-ACTIVATING-FACTOR IN THE MOUSE . EUR J PHARMACOL vol. 283 , ( 1-3 ) 9 - 18 .

Klemm P, Harris HJ, Perretti M ( 1995 ) . Effect of rolipram in a murine model of acute inflammation: comparison with the corticoid dexamethasone . European Journal of Pharmacology vol. 281 , ( 1 ) 69 - 74 .

Palmi M, Frosini M, Sgaragli GP, Becherucci C, Perretti M, Parente L ( 1995 ) . Inhibition of interleukin-1β-induced pyresis in the rabbit by peptide 204–212 of lipocortin 5 . European Journal of Pharmacology vol. 281 , ( 1 ) 97 - 99 .

MANCUSO F, FLOWER RJ, PERRETTI M ( 1995 ) . LEUKOCYTE TRANSMIGRATION, BUT NOT ROLLING OR ADHESION, IS SELECTIVELY INHIBITED BY DEXAMETHASONE IN THE HAMSTER POST-CAPILLARY VENULE - INVOLVEMENT OF ENDOGENOUS LIPOCORTIN-1 . J IMMUNOL vol. 155 , ( 1 ) 377 - 386 .

HARRIS JG, FLOWER RJ, PERRETTI M ( 1995 ) . ALTERATION OF NEUTROPHIL TRAFFICKING BY A LIPOCORTIN-1 N-TERMINUS PEPTIDE . EUR J PHARMACOL vol. 279 , ( 2-3 ) 149 - 157 .

WU CC, CROXTALL JD, PERRETTI M, BRYANT CE, THIEMERMANN C, FLOWER RJ, VANE JR ( 1995 ) . LIPOCORTIN-1 MEDIATES THE INHIBITION BY DEXAMETHASONE OF THE INDUCTION BY ENDOTOXIN OF NITRIC-OXIDE SYNTHASE IN THE RAT . P NATL ACAD SCI USA vol. 92 , ( 8 ) 3473 - 3477 .

Perretti M, Flower RJ ( 1995 ) . Anti-Inflammatory Lipocortin-Derived Peptides . Novel Molecular Approaches to Anti-Inflammatory Therapy ,

PERRETTI M, FLOWER RJ ( 1995 ) . Anti-inflammatory lipocortin-derived peptides . NOVEL MOLECULAR APPROACHES TO ANTI-INFLAMMATORY THERAPY . vol. 46 , 131 - 138 .

Ahluwalia A, Perretti M ( 1994 ) . Calcitonin gene-related peptides modulate the acute inflammatory response induced by interleukin-1 in the mouse . European Journal of Pharmacology vol. 264 , ( 3 ) 407 - 415 .

PERRETTI M, HARRIS JG, FLOWER RJ ( 1994 ) . A ROLE FOR ENDOGENOUS HISTAMINE IN INTERLEUKIN-8-INDUCED NEUTROPHIL INFILTRATION INTO MOUSE AIR-POUCH - INVESTIGATION OF THE MODULATORY ACTION OF SYSTEMIC AND LOCAL DEXAMETHASONE . BRIT J PHARMACOL vol. 112 , ( 3 ) 801 - 808 .

PERRETTI M, FLOWER RJ ( 1994 ) . CYTOKINES, GLUCOCORTICOIDS AND LIPOCORTINS IN THE CONTROL OF NEUTROPHIL MIGRATION . PHARMACOL RES vol. 30 , ( 1 ) 53 - 59 .

Ahluwalia A, Perretti M ( 1994 ) . Anti-inflammatory effect of prostanoids in mouse and rat skin: evidence for a role of EP3-receptors . The Journal of Pharmacology and Experimental Therapeutics vol. 268 , ( 3 ) 1526 - 1531 .

Perretti M ( 1994 ) . Lipocortin-derived peptides . Biochemical Pharmacology vol. 47 , ( 6 ) 931 - 938 .

Szabó C, Thiemermann C, Wu CC, Perretti M, Vane JR ( 1994 ) . Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo . Proceedings of the National Academy of Sciences vol. 91 , ( 1 ) 271 - 275 .

PERRETTI M, AHLUWALIA A, HARRIS JG, GOULDING NJ, FLOWER RJ ( 1993 ) . LIPOCORTIN-1 FRAGMENTS INHIBIT NEUTROPHIL ACCUMULATION AND NEUTROPHIL-DEPENDENT EDEMA IN THE MOUSE - A QUALITATIVE COMPARISON WITH AN ANTI-CD11B MONOCLONAL-ANTIBODY . J IMMUNOL vol. 151 , ( 8 ) 4306 - 4314 .

PERRETTI M, DUNCAN GS, FLOWER RJ, PEERS SH ( 1993 ) . SERUM CORTICOSTERONE, INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR IN RAT EXPERIMENTAL ENDOTOXEMIA - COMPARISON BETWEEN LEWIS AND WISTAR STRAINS . BRIT J PHARMACOL vol. 110 , ( 2 ) 868 - 874 .

PERRETTI M, AHLUWALIA A, FLOWER RJ, MANZINI S ( 1993 ) . ENDOGENOUS TACHYKININS PLAY A ROLE IN IL-1-INDUCED NEUTROPHIL ACCUMULATION - INVOLVEMENT OF NK-1 RECEPTORS . IMMUNOLOGY vol. 80 , ( 1 ) 73 - 77 .

PERRETTI M, FLOWER RJ, GOULDING NJ ( 1993 ) . THE ABILITY OF MURINE LEUKOCYTES TO BIND LIPOCORTIN-1 IS LOST DURING ACUTE-INFLAMMATION . BIOCHEM BIOPH RES CO vol. 192 , ( 2 ) 345 - 350 .

CIRINO G, CICALA C, SORRENTINO L, CILIBERTO G, ARPAIA G, PERRETTI M, FLOWER RJ ( 1993 ) . ANTIINFLAMMATORY ACTIONS OF AN N-TERMINAL PEPTIDE FROM HUMAN LIPOCORTIN-1 . BRIT J PHARMACOL vol. 108 , ( 3 ) 573 - 574 .

Da Silva JAP, Peers SH, Perretti M, Willoughby DA ( 1993 ) . Sex steroids affect glucocorticoid response to chronic inflammation and to interleukin-1 . Journal of Endocrinology vol. 136 , ( 3 ) 389 - 397 .

Mugridge KG, Becherucci C, Parente L, Perretti M ( 1993 ) . Inhibition of smooth muscle contraction and platelet aggregation by peptide 204–212 of lipocortin 5: an attempt to define some structure requirements . Mediators of Inflammation vol. 2 , ( 2 ) 103 - 107 .

PERRETTI M, FLOWER RJ ( 1993 ) . MODULATION OF IL-1-INDUCED NEUTROPHIL MIGRATION BY DEXAMETHASONE AND LIPOCORTIN-1 . J IMMUNOL vol. 150 , ( 3 ) 992 - 999 .

Becherucci C, Perretti M, Solito E, Galeotti CL, Parente L ( 1993 ) . Conceivable difference in the anti‐inflammatory mechanisms of lipocortins 1 and 5 . Mediators of Inflammation vol. 2 , ( 2 ) 109 - 113 .

PERRETTI M, APPLETON I, PARENTE L, FLOWER RJ ( 1993 ) . PHARMACOLOGY OF INTERLEUKIN-1-INDUCED NEUTROPHIL MIGRATION . AGENTS AND ACTIONS . vol. 38 , C64 - C65 .

Croxtall J, Flower R, Perretti M ( 1992 ) . The role of lipocortin 1 in the regulation of A549 cell proliferation and leukocyte migration . Journal of Lipid Mediators . vol. 6 , 295 - 302 .

DOUGLAS GJ, FLOWER RJ, PARENTE L, PERRETTI M ( 1992 ) . PEPTIDE-204-212 OF LIPOCORTIN-5 INHIBITS THE GENERATION OF A PROSTACYCLIN-LIKE FACTOR FROM RAT AORTA PREPARATIONS INVITRO . PROSTAGLANDINS vol. 44 , ( 5 ) 381 - 388 .

Parente L, Perretti M, Wallace JL, Mugridge KG ( 1992 ) . Mechanism of the protective action of interleukin-1 in the experimental gastric damage in the rat . Pharmacological Research vol. 26 , 28 - 29 .

Perretti M, Mugridge KG, Wallace JL, Parente L ( 1992 ) . Reduction of aspirin-induced gastric damage in rats by interleukin-1 beta: possible involvement of endogenous corticosteroids . The Journal of Pharmacology and Experimental Therapeutics vol. 261 , ( 3 ) 1238 - 1247 .

Becherucci C, Perretti M, Nencioni L, Silvestri S, Parente L ( 1992 ) . Anti-inflammatory effect of tuftsin and its retro-inverso analogue in rat adjuvant arthritis . Agents and Actions vol. 36 , ( S1 ) C115 - C117 .

PERRETTI M, SOLITO E, PARENTE L ( 1992 ) . EVIDENCE THAT ENDOGENOUS INTERLEUKIN-1 IS INVOLVED IN LEUKOCYTE MIGRATION IN ACUTE EXPERIMENTAL INFLAMMATION IN RATS AND MICE . AGENTS ACTIONS vol. 35 , ( 1-2 ) 71 - 78 .

PERRETTI M, BECHERUCCI C, MUGRIDGE KG, SOLITO E, SILVESTRI S, PARENTE L ( 1991 ) . A NOVEL ANTIINFLAMMATORY PEPTIDE FROM HUMAN LIPOCORTIN-5 . BRIT J PHARMACOL vol. 103 , ( 2 ) 1327 - 1332 .

Mugridge KG, Perretti M, Ghiara P, Parente L ( 1991 ) . α-melanocyte-stimulating hormone reduces interleukin-lβ effects on rat stomach preparations possibly through interference with a type I receptor . European Journal of Pharmacology vol. 197 , ( 2-3 ) 151 - 155 .

Piaz VD, Ciciani G, Turco G, Giovannoni MP, Miceli M, Pirisino R, Perretti M ( 1991 ) . 5-Acyl-6-aryl-4-nitro-3(2H)pyridazinones and Related 4-Amino Compounds: Synthesis and Pharmacological Evaluation . Journal of Pharmaceutical Sciences vol. 80 , ( 4 ) 341 - 348 .

Mugridge KG, Perretti M, Parente L ( 1991 ) . 5-Lipoxygenase activation may facilitate an interleukin-1 transduction signal . Advances in Prostaglandin Thromboxane and Leukotriene Research vol. 21 B , 517 - 520 .

Perretti M, Mugridge KG, Becherucci C, Parente L ( 1991 ) . Evidence that interleukin-1 and lipoxygenase metabolites mediate the lethal effect of complete Freund's adjuvant in adrenalectomized rats . Lymphokine and Cytokine Research vol. 10 , ( 4 ) 239 - 243 .

BECHERUCCI C ( 1990 ) . Purification and biological activity of human lipocortin 2 . Pharmacological Research vol. 22 , 29 - 30 .

Perretti M, Mugridge KG, Becherucci C, Silvestri S, Parente L ( 1990 ) . Antiulcer property of human recombinant interleukin-1β . Pharmacological Research vol. 22 , 392 - 392 .

Becherucci C, Perretti M, Galeotti C, Parente L ( 1990 ) . Different anti-inflammatory effects of lipocortins 1 and 5 . Pharmacological Research vol. 22 , 34 - 34 .

Parente L, Mugridge KG, Perretti M, Solito E ( 1990 ) . In vitro and in vivo activation of phospholipase A2 by interleukin-1 . Pharmacological Research vol. 22 , 378 - 378 .

Perretti M, Nuti S, Parente L ( 1990 ) . Investigation of rat mast cell degranulation using flow cytometry . Journal of Pharmacological Methods vol. 23 , ( 3 ) 187 - 194 .

PARENTE L, BECHERUCCI C, PERRETTI M, SOLITO E, MUGRIDGE KG, GALEOTTI CL, RAUGEI G, MELLI M et al. ( 1990 ) . ARE THE LIPOCORTINS THE 2ND MESSENGERS OF THE ANTIINFLAMMATORY ACTION OF GLUCOCORTICOIDS . CYTOKINES AND LIPOCORTINS IN INFLAMMATION AND DIFFERENTIATION vol. 349 , 55 - 68 .

Mugridge KG, Perretti M, Becherucci C, Parente L ( 1990 ) . Persistent effects of interleukin-1 on smooth muscle preparations from adrenalectomized rats: implications for increased phospholipase-A2 activity via stimulation of 5-lipoxygenase . The Journal of Pharmacology and Experimental Therapeutics vol. 256 , ( 1 ) 29 - 37 .

Becherucci C, Donati D, Perretti M, Parente L ( 1989 ) . The release of interleukin-1-like activity by macrophages in two models of immunological inflammation in the rat . Agents and Actions vol. 28 , ( 3-4 ) 243 - 247 .

Perretti M, Becherucci C, Parente L ( 1988 ) . Interleukin-1 release by macrophages from adrenalectomized (ADX) and shamoperated (SHO) rats . Pharmacological Research Communications vol. 20 , 299 - 299 .

Becherucci C, Donati D, Perretti M, Parente L ( 1988 ) . Interleukin-1 release by rat macrophages in experimental immunological inflammation . Pharmacological Research Communications vol. 20 , 29 - 29 .

Ignesti G, Perretti M, Buffoni F ( 1988 ) . Induction and quail liver diamine oxidase (histaminase). Part I: Interference of spermidine synthase on the diamine oxidase activity assay using putrescine as substrate . Agents and Actions vol. 25 , ( 1-2 ) 37 - 42 .

Ignesti G, Buffoni F, Perretti M, Cintelli A ( 1988 ) . Induction and quail liver diamine oxidase (histaminase). Part II: Different responses to the inducers . Agents and Actions vol. 25 , ( 1-2 ) 43 - 47 .

Ignesti G, Perretti M, Buffoni F ( 1986 ) . Diamine oxidase activity in Japanese quail liver induced with Aroclor 1254 . Agents and Actions vol. 18 , ( 1-2 ) 41 - 43 .

Bombardieri G, Bevilacqua E, Conti LR, Innocenti P, Perretti MA ( 1981 ) . Plasma amine oxidases in Wilson's disease . Life Sciences vol. 29 , ( 2 ) 117 - 120 .

Perretti M, Flower RJ . Anti-inflammatory glucocorticoids and annexin 1 . Progress in Inflammation Research , Birkhäuser Basel

Perretti M, Getting SJ . Migration of Specific Leukocyte Subsets in Response to Cytokine or Chemokine Application In Vivo . Inflammation Protocols , Humana Press

Perretti M, D'Acquisto F, Flower RJ . Treatment . no. WO2009GB02810 20091202 ,