Publications: DR Madubashini Peiris

( 2025 ) . A Role for High Mobility Group Box 1 (<scp>HMGB1</scp>) Release in the Pathogenesis of Gastroesophageal Reflux Disease . Neurogastroenterology &amp; Motility Article e70083 ,

( 2024 ) . The role of the gut microbiome in neuroinflammation and chemotherapy-induced peripheral neuropathy . European Journal of Pharmacology vol. 979 , Article 176818 , 176818 - 176818 .

( 2024 ) . Descriptive study of perineuronal net in enteric nervous system of humans and mice . Journal of Neurochemistry vol. 168 , ( 9 ) 1956 - 1972 .

( 2024 ) . Sensing of luminal contents and downstream modulation of GI function . JGH Open vol. 8 , ( 5 ) Article e13083 ,

( 2024 ) . Perineuronal net in the extrinsic innervation of the distal colon of mice and its remodeling in ulcerative colitis . Journal of Neurochemistry vol. 168 , ( 9 ) 1937 - 1955 .

( 2024 ) . Mucosal neuroimmune mechanisms in gastro-oesophageal reflux disease (GORD) pathogenesis . Journal of Gastroenterology vol. 59 , ( 3 ) 165 - 178 .

( 2023 ) . Identification of novel immune cell signature in gastroesophageal reflux disease: altered mucosal mast cells and dendritic cell profile . Frontiers in Immunology vol. 14 , Article 1282577 ,

( 2023 ) . GPR84 in physiology—Many functions in many tissues . British Journal of Pharmacology vol. 181 , ( 10 ) 1524 - 1535 .

( 2023 ) . Colonic motility adjustments in acute and chronic DSS-induced colitis . Life Sciences vol. 321 , Article 121642 , 121642 - 121642 .

( 2023 ) . Potential determinants of low circulating glucagon‐like peptide 2 concentrations in Zambian children with non‐responsive stunting . Experimental Physiology vol. 108 , ( 4 ) 568 - 580 .

( 2022 ) . Su1200: ESOPHAGEAL MUCOSAL AND MOLECULAR DIFFERENCES BETWEEN FUNCTIONAL HEARTBURN AND HEALTHY ASYMPTOMATIC SUBJECTS . Gastroenterology vol. 162 , ( 7 ) S - 543 .

( 2022 ) . Su1210: RNA SEQUENCING REVEALS FEW MOLECULAR DIFFERENCES IN OESOPHAGEAL MUCOSA BETWEEN PATIENTS WITH EROSIVE AND NON-EROSIVE REFLUX DISEASE . Gastroenterology vol. 162 , ( 7 )

( 2022 ) . Association Between Sex Hormone Levels and Gut Microbiota Composition and Diversity—A Systematic Review . Journal of Clinical Gastroenterology vol. 56 , ( 5 ) 384 - 392 .

( 2022 ) . The cation channel TRPM8 influences the differentiation and function of human monocytes . Journal of Leukocyte Biology vol. 112 , ( 3 ) 365 - 381 .

( 2022 ) . RNA SEQUENCING REVEALS FEW MOLECULAR DIFFERENCES IN OESOPHAGEAL MUCOSA BETWEEN PATIENTS WITH EROSIVE AND NON-EROSIVE REFLUX DISEASE . GASTROENTEROLOGY . vol. 162 , S548 - S549 .

( 2021 ) . Post-inflammatory Abdominal Pain in Patients with Inflammatory Bowel Disease During Remission: A Comprehensive Review . Crohn's &amp; Colitis 360 vol. 3 , ( 4 ) Article otab073 ,

( 2021 ) . A putative anti‐inflammatory role for TRPM8 in irritable bowel syndrome—An exploratory study . Neurogastroenterology &amp; Motility vol. 33 , ( 9 ) Article e14170 ,

( 2021 ) . Decoy bypass for appetite suppression in obese adults: role of synergistic nutrient sensing receptors GPR84 and FFAR4 on colonic endocrine cells . Gut vol. 71 , ( 5 ) 928 - 937 .

( 2021 ) . 789 HEARTBURN SENSATION IN NON-EROSIVE REFLUX DISEASE: DISTINCTIVE PATTERN OF SUPERFICIAL SENSORY NERVES EXPRESSING TRPV1 AND EPITHELIAL CELLS EXPRESSING ASIC3 RECEPTORS . Gastroenterology vol. 160 , ( 6 )

( 2021 ) . Heartburn sensation in nonerosive reflux disease: pattern of superficial sensory nerves expressing TRPV1 and epithelial cells expressing ASIC3 receptors . American Journal of Physiology-Gastrointestinal and Liver Physiology vol. 320 , ( 5 ) G804 - G815 .

( 2021 ) . Effect of Obesity on the Expression of Nutrient Receptors and Satiety Hormones in the Human Colon . Nutrients vol. 13 , ( 4 ) 1271 - 1271 .

( 2021 ) . Effect of obesity on the expression of nutrient receptors and satiety hormones in the human colon . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 33 ,

( 2021 ) . RNA sequencing of the oesophageal mucosa of patients with heartburn identifies dendritic cell population in functional heartburn . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 33 ,

( 2020 ) . Human resident gut microbe <i>Bacteroides thetaiotaomicron</i> regulates colonic neuronal innervation and neurogenic function . Gut Microbes vol. 11 , ( 6 ) 1745 - 1757 .

( 2020 ) . Sa1216 IN PATIENTS WITH HEARTBURN, SUPERFICIAL MUCOSAL AFFERENT NERVES EXPRESS TRANSIENT RECEPTOR POTENTIAL VANILLOID SUBFAMILY MEMBER-1 (TRPV1) . Gastroenterology vol. 158 , ( 6 )

( 2020 ) . Direct activation of tuft cells by transient receptor potential subfamily M member 5 (TRPM5) agonists increases colonic motility and secretion through induction of a Th2 cytokine response and mobilization of non-neuronal acetylcholine . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 32 ,

( 2020 ) . IN PATIENTS WITH HEARTBURN, SUPERFICIAL MUCOSAL AFFERENT NERVES EXPRESS TRANSIENT RECEPTOR POTENTIAL VANILLOID SUBFAMILY MEMBER-1 (TRPV1) . GASTROENTEROLOGY . vol. 158 , S315 - S316 .

( 2020 ) . Patients with heartburn express transient receptor potential vanilloid subfamily member-1 (TRPV1) on superficial afferent oesophageal nerve fibres . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 32 ,

( 2019 ) . A novel role for the extracellular matrix glycoprotein‐Tenascin‐X in gastric function . The Journal of Physiology vol. 597 , ( 6 ) 1503 - 1515 .

( 2019 ) . Conventionalisation of germ free mice with bacteriodes thetaiotaomicron induces proliferation of inhibitory motor neurones and specifically alters proximal colonic motility . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 31 ,

( 2019 ) . TRPM8 and TRPA1 mRNA expression in colonic biopsies of patients with irritable bowel syndrome and healthy controls . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 31 ,

( 2018 ) . Effects of Obesity and Gastric Bypass Surgery on Nutrient Sensors, Endocrine Cells, and Mucosal Innervation of the Mouse Colon . Nutrients vol. 10 , ( 10 ) 1529 - 1529 .

( 2018 ) . The extracellular matrix glycoprotein tenascin‐X regulates peripheral sensory and motor neurones . The Journal of Physiology vol. 596 , ( 17 ) 4237 - 4251 .

( 2018 ) . Mo1599 - Abdominal Pain in Hypermobility-Type Ehlers Danlos Syndrome is Associated with Proliferation and Hypersensitivity of Colonic Nociceptive Nerve Endings . Gastroenterology vol. 154 , ( 6 )

( 2017 ) . Exam 2: Superficial Esophageal Mucosal Afferent Nerves May Contribute to Reflux Hypersensitivity in Nonerosive Reflux Disease . Gastroenterology vol. 153 , ( 5 ) e16 - e16 .

( 2017 ) . Superficial Esophageal Mucosal Afferent Nerves May Contribute to Reflux Hypersensitivity in Nonerosive Reflux Disease . Gastroenterology vol. 153 , ( 5 ) 1230 - 1239 .

( 2017 ) . Peripheral K_V7 channels regulate visceral sensory function in mouse and human colon . Molecular Pain vol. 13 , Article 1744806917709371 ,

( 2017 ) . Innervation Pattern of the Distal Mucosal Squamous Epithelium May Underlie Hyposensitivity to Acid Reflux in Patients with Barrett’s Oesophagus . Gastroenterology . vol. 152 , S236 - S236 .

( 2017 ) . Abdominal pain in hypermobile Ehlers Danlos Syndrome (hEDS) may be associated with proliferation of colonic nociceptive nerve endings . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 29 , 13 - 13 .

( 2017 ) . Expression and neurochemical identity of sensory fibres is altered in Inflammatory Bowel Disease (IBD) . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 29 , 27 - 28 .

( 2017 ) . Long-term effects of Roux-en-Y gastric bypass surgery on colonic nutrient-sensing receptors and enteroendocrine cells . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 29 , 19 - 20 .

( 2017 ) . Multiple nutrient stimulation enhances enteroendocrine cell responses in human and mouse colon . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 29 , 20 - 21 .

( 2016 ) . Ex vivo study of human visceral nociceptors . Gut vol. 67 , ( 1 ) 86 - 96 .

( 2016 ) . 671 Molecular And Cellular Alterations in Mouse Colonic Chemosensory Mechanisms After Roux-en-Y Gastric Bypass . Gastroenterology . vol. 150 , S137 - S138 .

( 2016 ) . Sa1688 Multiple Functional Roles for the Extracellular Matrix Glycoprotein Tenascin X . Gastroenterology . vol. 150 , S346 - S346 .

( 2015 ) . TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP . Mucosal Immunology vol. 8 , ( 3 ) 491 - 504 .

( 2015 ) . Distinct afferent innervation patterns within the human proximal and distal esophageal mucosa . American Journal of Physiology-Gastrointestinal and Liver Physiology vol. 308 , ( 6 ) G525 - G531 .

( 2015 ) . CD11c Positive Dendritic Cells Express the Ion Channel TRPM8 in Human Colon, Which Regulates Immune Responses . GASTROENTEROLOGY . vol. 148 , S693 - S694 .

( 2015 ) . Nutrient-Neural Signaling in the Proximal Colon . GASTROENTEROLOGY . vol. 148 , S385 - S385 .

( 2014 ) . Mechanisms of activation of mouse and human enteroendocrine cells by nutrients . Gut vol. 64 , ( 4 ) 618 - 626 .

( 2014 ) . 13 Enhanced Perception of Proximal Gastro-Esophageal Reflux in Patients With GERD: Impaired Mucosal Integrity or Distinct Sensory Innervation? . Gastroenterology vol. 146 , ( 5 )

( 2014 ) . Activation of guanylate cyclase C inhibits human and mouse intestinal afferent mechanosensitivity but not chemosensitivity . NEUROGASTROENTEROLOGY AND MOTILITY vol. 26 , 32 - 32 .

( 2014 ) . Afferent Activation in the Proximal Colon by Enteroendocrine Mediators and Nutrients . GASTROENTEROLOGY . vol. 146 , S366 - S366 .

( 2014 ) . Amino Acid and Fatty Acid Sensing Mechanisms in the Human Colon . GASTROENTEROLOGY . vol. 146 , S492 - S492 .

( 2014 ) . Enhanced Perception of Proximal Gastro-Esophageal Reflux in Patients With GERD: Impaired Mucosal Integrity or Distinct Sensory Innervation? . GASTROENTEROLOGY . vol. 146 , S4 - S5 .

( 2014 ) . Long-Lasting \In Vitro\ Esophageal Mucosal Protection With Alginates: A Potential for Topical Mucosal Therapy in Gastroesophageal Reflux Disease . GASTROENTEROLOGY . vol. 146 , S757 - S758 .

( 2014 ) . Nutrient-Induced Reduction of IL-8 Release in Paediatric Human Ascending Colon . GASTROENTEROLOGY . vol. 146 , S783 - S783 .

( 2014 ) . Role of Kv7 Potassium Channels in Excitation of Human Colonic Afferents . GASTROENTEROLOGY . vol. 146 , S722 - S722 .

( 2013 ) . PTU-137 ‘Nutrient Sensing in the Human Gut: Investigation of the Co-Localization Rate Between Casr, T1R1 and GPR43 Receptors with Satiety Peptides in the Human Antrum, Terminal Ileum and Ascending Colon.’ . Gut . vol. 62 , A103.1 - A103 .

( 2013 ) . Gut Hypersensitivity Related Symptoms . Wiley

( 2013 ) . Anatomical Sensory Nerve Markers in Human Gut . GASTROENTEROLOGY . vol. 144 , S56 - S56 .

( 2013 ) . Extracellular Matrix Protein Tenascin-X in Nerve-Gut Interactions . GASTROENTEROLOGY . vol. 144 , S554 - S554 .

( 2013 ) . Identification of a Distinct Population of Human Visceral Nociceptors . GASTROENTEROLOGY . vol. 144 , S670 - S670 .

( 2013 ) . Specific Pathways of Nutrient Activation in Human and Mouse Enteroendocrine Eells . GASTROENTEROLOGY . vol. 144 , S374 - S374 .

( 2012 ) . Peripheral neural targets in obesity . British Journal of Pharmacology vol. 166 , ( 5 ) 1537 - 1558 .

( 2012 ) . 1104 Molecular Aspects of Nutrient Sensing in the Human Gastrointestinal Tract . Gastroenterology vol. 142 , ( 5 ) S - 199 .

( 2012 ) . Functional characterisation of human and mouse proximal colon as a site of nutrient sensing . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 24 , 151 - 151 .

( 2012 ) . Mechanical and chemical stimulation of human visceral afferents . NEUROGASTROENTEROLOGY AND MOTILITY vol. 24 , 74 - 74 .

( 2012 ) . Molecular Aspects of Nutrient Sensing in the Human Gastrointestinal Tract . GASTROENTEROLOGY . vol. 142 , S199 - S199 .

( 2011 ) . Oesophageal epithelial ASIC3 is associated with increase in severity of symptoms in patients with gastro-oesophageal reflux disease (GORD) . Gut . vol. 60 , A171 - A171 .

( 2011 ) . Human visceral afferent recordings: preliminary report . GUT vol. 60 , ( 2 ) 204 - 208 .

( 2010 ) . A novel <i>in vitro</i> model of visceral pain using the human appendix . BRITISH JOURNAL OF SURGERY vol. 97 , 31 - 32 .

( 2008 ) . Rapid, opioid-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization . J BIOL CHEM vol. 283 , ( 28 ) 19540 - 19550 .

( 2007 ) . A model of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice for the characterisation of intervention therapies . J NEUROSCI METH vol. 163 , ( 2 ) 245 - 254 .