Publications: PROF Rupert Pearse

Jhanji S, Booth K, Hiller L, Braun J, Dunn J, Eggleston L, Fenton-May L, Frempong S et al. ( 2026 ) . Total Intravenous vs Volatile Inhalational Anesthesia for Major Noncardiac Surgery: A Randomized Clinical Trial . JAMA: The Journal of the American Medical Association vol. 336 , ( 12 ) 1039 - 1049 .

Abbott TEF, Dias P, Vairale J, Begum S, Khan K, Fowler AJ, Kaura V, Pearse RM et al. ( 2026 ) . Safety of routine antimicrobial prophylaxis for surgery (SAPPHIRE): a prospective multi-centre cohort study . EClinicalMedicine vol. 99 ,

Fadipe C, Duys R, Bedwell GJ, Barker P, Barabona G, Biccard BM, Ellis R, Hewit-Smith A et al. ( 2026 ) . Improving surgical patients’ safety in African hospitals: exploring healthcare professionals’ experiences of Phase 1 of the ‘5Rs to Rescue’ programme . International Journal for Quality in Health Care vol. 38 , ( 3 )

Frempong S, Kandiyali R, Mason J, Hiller L, Dunn J, Booth K, Moonesinghe R, Pearse R et al. ( 2026 ) . Cost‐effectiveness analysis of total intravenous vs. inhalation anaesthesia among adults aged ≥ 50 y undergoing major non‐cardiac surgery . Anaesthesia vol. 81 , ( 10 ) 1378 - 1385 .

Committee ACIOSIW, Bedwell GJ, Parker R, Madden VJ, Scribante J, Elhadi M, Ademuyiwa AO, Osinaike B et al. ( 2026 ) . One in seven has severe pain: a point-prevalence study of hospitalised patients across Africa . Pain vol. 167 , ( 10 ) 2422 - 2438 .

Wijeysundera DN, Cuthbertson BH, Duceppe E, Abbott TEF, Pearse RM, Myles PS, Xu K, Daza JF et al. ( 2026 ) . Prognostic value of the Duke Activity Status Index for preoperative cardiac risk stratification: an international pooled cohort study . EClinicalMedicine vol. 96 ,

Belachew FK, Ambese TY, Dersso D, Daniel S, Demelash A, Kifle K, Nora WT, Buno E et al. ( 2026 ) . Critical care capacity in Africa: postpandemic ICU capacity, service readiness and patient profiles across public and private hospitals in Ethiopia . BMJ Global Health vol. 11 , ( 3 )

Crowther M, Dyer R, Bishop D, Bulamba F, Maswime S, Pearse R, Biccard B, Investigators OBOTAPFPACCR ( 2026 ) . Cross-sectional Survey to Assess Hospital System Readiness for Hemorrhage During and After Cesarean Delivery in Africa . Obstetric Anesthesia Digest vol. 46 , ( 1 ) 9 - 10 .

Fazzini B, Kelly E, Mathieson G, Pearse R, Puthucheary Z, Stephens T ( 2026 ) . Beyond measures, what matters? Acceptability of advanced monitoring for acute respiratory failure during non-invasive respiratory support: perceptions from patients and critical care practitioners . Conference: Respiratory Failure and Mechanical Ventilation

Fowler AJ, Abbott TEF, Harrison EM, Gillies M, Prowle JR, Cromwell D, Pearse RM ( 2026 ) . Long-term outcomes for patients at high risk of death after surgery in the UK: a retrospective cohort study . The Lancet Public Health vol. 11 , ( 3 ) e187 - e196 .

Thomas C, Pearse RM ( 2025 ) . Corrigendum to ‘Socioeconomic deprivation and health inequity: independently associated with postoperative outcomes, and does this matter?’ (Br J Anaesth 2025; 135: 1141–3) . British Journal of Anaesthesia vol. 136 , ( 2 )

Vermeulen TD, Hemmes SNT, Blok S, Schultz MJ, Hiesmayr M, Mills GH, Putensen C, Schmid W et al. ( 2025 ) . Pulmonary complications following urological, gastrointestinal and gynaecological abdominal Surgery––A post-hoc analysis of an observational study in 29 countries . Anaesthesia Critical Care & Pain Medicine vol. 45 , ( 4 )

Althonayan J, Fowler AJ, Allin B, Sogbodjor A, Bradnock T, Orban N, Dobbs TD, Knight M et al. ( 2025 ) . Trends in Paediatric surgerical volume and associated mortality in England: a nationwide study over an eight year period . BJA Open vol. 16 ,

Dhesi JK, Partridge JSL, Strasser BC, Bearne L, Hall N, Healey A, Houghton JSM, Magill L et al. ( 2025 ) . Perioperative Medicine for Older People Undergoing Surgery Scale Up (POPS-SUp): study protocol . BJS Open vol. 9 , ( 6 )

Thomas C, Pearse RM ( 2025 ) . Socioeconomic deprivation and health inequity: independently associated with postoperative outcomes, and does this matter? . British Journal of Anaesthesia vol. 135 , ( 5 ) 1141 - 1143 .

Dias P, Walshaw E, Flatau S, O'Grady E, Hopkins PM, Garvey LH, Littlejohns A, Rousseau N et al. ( 2025 ) . Penicillin allergy risk stratification tool for use by non‐allergists in the peri‐operative setting: an agreement study and qualitative process evaluation . Anaesthesia vol. 81 , ( 2 ) 222 - 231 .

Gordeev VS, Assefa E, Pearse R, Edwards M, Mihaylova B ( 2025 ) . Health-related quality of life after emergency abdominal surgery . World Journal of Emergency Surgery vol. 20 , ( 1 )

Silversides JA, Savic L, Hiller L, Hopkins A, Booth K, Dorey J, Smithson R, Mason J et al. ( 2025 ) . Sugammadex or Neostigmine for prevention of post-operative pulmonary complications after major abdominal or thoracic surgery: study protocol for the SINFONIA (Sugammadex for preventioN oF pOst-operative pulmonary complIcAtions) randomised controlled superiority trial . Trials vol. 26 , ( 1 )

Watson S-L, Fowler AJ, Pearse RM, Abbott TEF ( 2025 ) . The financial cost of postoperative complications: a prospective cohort study with linked health systems data . British Journal of Anaesthesia vol. 135 , ( 6 ) 1753 - 1760 .

Giannas E, Patel A, Dias P, Heath RJ, Sinclair R, Surman K, Milton A, Middleditch A et al. ( 2025 ) . Perioperative management of renin–angiotensin system inhibitors in patients undergoing elective major noncardiac surgery: a mixed model investigation using systematic review, meta-analysis, multicentre service evaluation, and national survey . British Journal of Anaesthesia vol. 135 , ( 4 ) 861 - 869 .

Abbott TEF, Watson S-L, Begum S, Dias P, Haviland JS, Glasbey J, Ismail L, Love S et al. ( 2025 ) . Platform trials—an emerging methodology for perioperative medicine: a narrative review . Perioperative Medicine vol. 14 , ( 1 )

Bulamba F, Stephens T, Hewitt-Smith A, Abbott TEF, Patel A, Mugabe K, Musaba MW, Nakibuule J et al. ( 2025 ) . Incidence, treatment and outcomes of postpartum haemorrhage among women admitted at a large regional referral hospital in eastern Uganda: a one-year prospective observational study . International Journal of Obstetric Anesthesia vol. 64 ,

Savic L, Mistry A, Savic S, Arumugakani G, Pearse R, Garvey LH, Hopkins PM, Rousseau N ( 2025 ) . Understanding patient perceptions, knowledge, and experience of perioperative allergic reactions: a qualitative interview study . British Journal of Anaesthesia vol. 135 , ( 3 ) 737 - 745 .

Janssen H, Dias P, Hiller L, Hewson R, Pearse RM, Oliver NS, Jhanji S, Ackland GL et al. ( 2025 ) . Glucose variability and mode of anaesthesia in major noncardiac surgery (GlucoVITAL): study protocol for a randomised controlled trial . BJA Open vol. 14 ,

Group PTM, Ademuyiwa A, Bhangu A, Bhatt A, Biccard B, Chakrabortee S, Crawford R, Dhiman J et al. ( 2025 ) . PErioperative respiratory care aNd outcomes for patients underGoing hIgh risk abdomiNal surgery (PENGUIN): a randomised international internal pilot trial . BJA Open vol. 14 ,

Alvarez A, Bagshaw S, Biccard B, Boccalatte L, Borunda D, Calvache JA, Carmona MJC, Castillo-Huerta NM et al. ( 2025 ) . Patient outcomes after surgery in 17 Latin American countries (LASOS): a 7 day prospective cohort study . The Lancet Global Health vol. 13 , ( 4 ) e635 - e645 .

Harji DP, Griffiths B, Stocken D, Pearse R, Blazeby J, Brown JM ( 2025 ) . Key interventions and outcomes in perioperative care pathways in emergency laparotomy: a systematic review . World Journal of Emergency Surgery vol. 20 , ( 1 )

Baker T, Scribante J, Elhadi M, Ademuyiwa A, Osinaike B, Owoo C, Sottie D, Khalid K et al. ( 2025 ) . The African Critical Illness Outcomes Study (ACIOS): a point prevalence study of critical illness in 22 nations in Africa . The Lancet vol. 405 , ( 10480 ) 715 - 724 .

Hewitt-Smith A, Bulamba F, Patel A, Nanimambi J, Adong LR, Emacu B, Kabaleta M, Khanyalano J et al. ( 2025 ) . Corrigendum to ‘Family supplemented patient monitoring after surgery (SMARTER): a pilot stepped-wedge cluster-randomised trial’ (Br J Anaesth 2024; 133: 846–52) . British Journal of Anaesthesia vol. 134 , ( 4 )

Pinto BB, Shelley B, Dias P, Begum S, Ennahdi-Elidrissi F, Abbott TEF, Hewson R, Patel A et al. ( 2025 ) . Targeted heart rate control using the funny current inhibitor ivabradine to reduce morbidity in patients undergoing noncardiac surgery: study protocol for a phase 2a, triple-blind, placebo-controlled randomised trial . BJA Open vol. 13 ,

Abani O, Abbas A, Abbas F, Abbas J, Abbas K, Abbas M, Abbasi S, Abbass H et al. ( 2025 ) . Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial . EClinicalMedicine vol. 81 ,

Lloyd P, Fowler AJ, Wozniak A, Rattenberry W, Scott S, Tripurneni V, Earl M, Pearse RM et al. ( 2024 ) . Environmental impact of commonly used anaesthetic agents: systematic literature review with narrative synthesis . BJA Open vol. 13 ,

Janssen HJ, Pearse R, Giannas E, Patel A, Dias P, ABBOTT T, Ackland G ( 2024 ) . Perioperative management of renin-angiotensin aldosterone-system inhibitors in patients undergoing elective major non-cardiac surgery: A mixed model investigation of systematic review, meta-analysis, multicentre service evaluation and national survey .

Edwards M, Pearse R, Kahan B, Hamborg T, Priyadarshini G, MacDonald N, Mihaylova B, Gordeev V et al. ( 2024 ) . Cardiac output-guided haemodynamic therapy for patients undergoing major gastrointestinal surgery: OPTIMISE II randomised clinical trial . The BMJ vol. 387 ,

Vickery NJ, Fowler AJ, Prowle J, Pearse R ( 2024 ) . Association between multimorbidity and quality of life after hip replacement surgery: analysis of routinely collected patient-reported outcomes . British Journal of Anaesthesia vol. 134 , ( 1 ) 203 - 211 .

Crowther M, Dyer RA, Bishop DG, Bulamba F, Maswime S, Pearse RM, Biccard BM, Investigators OBOTAPFPACCR ( 2024 ) . Cross-Sectional Survey to Assess Hospital System Readiness for Hemorrhage During and After Cesarean Delivery in Africa . Anesthesia & Analgesia vol. 141 , ( 3 ) 456 - 463 .

Giannas E, Dias P, Janssen H, Ackland G, Pearse R, Abbott T ( 2024 ) . Clinical management of stopping or continuing perioperative angiotensin II converting enzyme inhibitors and/or angiotensin receptor blockers: a survey of clinical opinion . BJA Open vol. 12 ,

Kifle F, Iverson KR, Belay E, Teko EB, Dawit A, Deneke A, Biccard B, Kifleyohanes T et al. ( 2024 ) . Towards Establishing a National Perioperative Quality Improvement Network in LMICs: Implementation Experiences From Ethiopia . Annals of Surgery Open vol. 5 , ( 3 )

Watson S-L, Fowler AJ, Dias P, Biccard B, Wan YI, Pearse RM, Abbott TEF ( 2024 ) . The lifetime risk of surgery in England: a nationwide observational cohort study . British Journal of Anaesthesia vol. 133 , ( 4 ) 768 - 775 .

Hewitt-Smith A, Bulamba F, Patel A, Nanimambi J, Adong LR, Emacu B, Kabaleta M, Khanyalano J et al. ( 2024 ) . Family supplemented patient monitoring after surgery (SMARTER): a pilot stepped-wedge cluster-randomised trial . British Journal of Anaesthesia vol. 133 , ( 4 ) 846 - 852 .

Hussain N, Jovaisa T, Puthucheary Z, Pearse R, Phull MK ( 2024 ) . Peripherally administered vasopressors in critically ill adult patients: A survey of UK healthcare professional practices, attitudes and experiences . Journal of the Intensive Care Society vol. 25 , ( 4 ) 391 - 398 .

Yeung J, Jhanji S, Braun J, Dunn J, Eggleston L, Frempong S, Hiller L, Jacques C et al. ( 2024 ) . Volatile vs Total intravenous Anaesthesia for major non-cardiac surgery: a pragmatic randomised triaL (VITAL) . Trials vol. 25 , ( 1 )

Torborg A, Meyer H, El Fiky M, Fawzy M, Elhadi M, Ademuyiwa AO, Osinaike BB, Hewitt-Smith A et al. ( 2024 ) . Outcomes after surgery for children in Africa (ASOS-Paeds): a 14-day prospective observational cohort study . The Lancet vol. 403 , ( 10435 ) 1482 - 1492 .

Hughes G, Stephens TJ, Seuren LM, Pearse RM, Shaw SE ( 2024 ) . Clinical context and communication in shared decision-making about major surgery: Findings from a qualitative study with colorectal, orthopaedic and cardiac patients . Health An Interdisciplinary Journal for the Social Study of Health Illness and Medicine vol. 29 , ( 2 ) 200 - 219 .

Harji DP, Griffiths B, Stocken D, Pearse R, Blazeby J, Brown JM ( 2024 ) . Protocolized care pathways in emergency general surgery: a systematic review and meta-analysis . British Journal of Surgery vol. 111 , ( 3 )

Kachapila M, Monahan M, Ademuyiwa AO, Adinoyi YM, Biccard BM, George C, Ghosh DN, Glasbey J et al. ( 2024 ) . Erratum to ‘Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries’ [BJA Open 7 (2023) 100207] . BJA Open vol. 10 ,

Janssen H, Jhanji S, Oliver NS, Ackland GL, Investigators FTG, Korbonits M, Henson S, Yeung J et al. ( 2024 ) . Ward monitoring 4.0: real-time metabolic insights from continuous glucose monitoring into perioperative organ dysfunction . British Journal of Anaesthesia vol. 132 , ( 5 ) 843 - 848 .

Davies TW, Watson N, Pilkington JJ, McClelland TJ, Azzopardi G, Pearse RM, Prowle J, Puthucheary Z ( 2024 ) . Creatine supplementation for optimization of physical function in the patient at risk of functional disability: A systematic review and meta‐analysis . Journal of Parenteral and Enteral Nutrition vol. 48 , ( 4 ) 389 - 405 .

Kachapila M, Monahan M, Ademuyiwa AO, Adinoyi YM, Biccard BM, George C, Ghosh DN, Glasbey J et al. ( 2024 ) . Erratum to “Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries” [BJA Open 7 (2023) 100207] . BJA Open vol. 9 ,

Glasbey J, Ademuyiwa A, Bhatt A, Biccard B, Blazeby J, Brocklehurst P, Chakrabortee S, Ingabire JCA et al. ( 2024 ) . Accuracy of the Wound Healing Questionnaire in the diagnosis of surgical-site infection after abdominal surgery in low- and middle-income countries . British Journal of Surgery vol. 111 , ( 2 )

del Arroyo AG, Patel A, Abbott TEF, Begum S, Dias P, Somanath S, Middleditch A, Cleland S et al. ( 2024 ) . Preoperative N-terminal pro-B-type natriuretic peptide and myocardial injury after stopping or continuing renin–angiotensin system inhibitors in noncardiac surgery: a prespecified analysis of a phase 2 randomised controlled multicentre trial . British Journal of Anaesthesia vol. 132 , ( 5 ) 857 - 866 .

Prowle JR, Croal B, Abbott TEF, Cuthbertson BH, Wijeysundera DN, Myles PS, Shulman MA, Wallace S et al. ( 2024 ) . Cystatin C or creatinine for pre-operative assessment of kidney function and risk of post-operative acute kidney injury: a secondary analysis of the METS cohort study . Clinical Kidney Journal vol. 17 , ( 1 )

Gerber C, Bishop DG, Dyer RA, Maswime S, Rodseth RN, van Dyk D, Kluyts H-L, Mbwele B et al. ( 2024 ) . Method of Anesthesia and Perioperative Risk Factors, Maternal Anesthesia Complications, and Neonatal Mortality Following Cesarean Delivery in Africa: A Substudy of a 7-Day Prospective Observational Cohort Study . Anesthesia & Analgesia vol. 138 , ( 6 ) 1275 - 1284 .

Booth J, Fowler AJ, Pearse R, Dias P, Wan YI, Witton R, Abbott TEF ( 2024 ) . Dental Surgical Activity in Hospitals during COVID-19: A Nationwide Observational Cohort Study . JDR Clinical & Translational Research vol. 9 , ( 4 ) 387 - 397 .

Page A, Langan A, Wan YI, McNelly A, Prowle J, Pearse R, Puthucheary Z ( 2023 ) . Association between energy surplus and intensive care unit length of stay in critically ill patients: A retrospective cohort study . Journal of Parenteral and Enteral Nutrition vol. 48 , ( 2 ) 206 - 214 .

Hughes G, Shaw SE, Pearse RM, Stephens TJ ( 2023 ) . Opportunities for shared decision-making about major surgery with high-risk patients: the switch from ‘fixing the problem’ to undertaking shared decision-making. Response to Br J Anaesth 2023; 131: e152–3 . British Journal of Anaesthesia vol. 132 , ( 2 )

Ludwiczak A, Stephens TJ, Prowle J, Pearse R, Osman M ( 2023 ) . Supporting effective shared decision‐making in surgical context: Why framing of choices matters for high‐risk patients and clinicians . Colorectal Disease vol. 26 , ( 1 ) 110 - 119 .

Davies TW, Kelly E, van Gassel RJJ, van de Poll MCG, Gunst J, Casaer MP, Christopher KB, Preiser JC et al. ( 2023 ) . A systematic review and meta-analysis of the clinimetric properties of the core outcome measurement instruments for clinical effectiveness trials of nutritional and metabolic interventions in critical illness (CONCISE) . Critical Care vol. 27 , ( 1 )

van Lier F, Hoeks S, Pearse RM ( 2023 ) . Prediction, prognosis, and professionalism in perioperative medicine . British Journal of Anaesthesia vol. 132 , ( 1 ) 13 - 14 .

Ackland GL, Patel A, Abbott TEF, Begum S, Dias P, Crane DR, Somanath S, Middleditch A et al. ( 2023 ) . Discontinuation vs. continuation of renin–angiotensin system inhibition before non-cardiac surgery: the SPACE trial . European Heart Journal vol. 45 , ( 13 ) 1146 - 1155 .

Wan YI, Smuk M, Pearse RM, Paparini S, Apea VJ, Orkin CM ( 2023 ) . Clinical research in the NHS: a cross-sectional study of research engagement during the monkeypox pandemic . BMJ Leader vol. 7 , ( Suppl 2 )

Roshanov PS, Chan MTV, Borges FK, Conen D, Wang CY, Xavier D, Berwanger O, Marcucci M et al. ( 2023 ) . One-year Outcomes after Discharge from Noncardiac Surgery and Association between Predischarge Complications and Death after Discharge: Analysis of the VISION Prospective Cohort Study . Anesthesiology vol. 140 , ( 1 ) 8 - 24 .

Harji D, Griffiths B, Stocken D, Pearse R, Blazeby J, Brown J ( 2023 ) . SP9.9 Protocolised Care Pathways in Emergency General Surgery: A systematic review and meta-analysis . British Journal of Surgery vol. 110 , ( Supplement_6 )

Torrance HD, Zhang P, Longbottom ER, Mi Y, Whalley JP, Allcock A, Kwok AJ, Cano-Gamez E et al. ( 2023 ) . A Transcriptomic Approach to Understand Patient Susceptibility to Pneumonia After Abdominal Surgery . Annals of Surgery vol. 279 , ( 3 ) 510 - 520 .

Torrance HD, Zhang P, Longbottom ER, Mi Y, Whalley JP, Allcock A, Kwok AJ, Cano-Gamez E et al. ( 2023 ) . A Transcriptomic Approach to Understand Patient Susceptibility to Pneumonia After Abdominal Surgery . Annals of Surgery vol. 279 , ( 3 ) 510 - 520 .

Andrew BY, Brookhart MA, Pearse R, Raghunathan K, Krishnamoorthy V ( 2023 ) . Propensity score methods in observational research: brief review and guide for authors . British Journal of Anaesthesia vol. 131 , ( 5 ) 805 - 809 .

Kachapila M, Monahan M, Ademuyiwa AO, Adinoyi YM, Biccard BM, George C, Ghosh DN, Glasbey J et al. ( 2023 ) . Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries . BJA Open vol. 7 ,

Fowler AJ, Wahedally MAH, Abbott TEF, Prowle JR, Cromwell DA, Pearse RM ( 2023 ) . Long-term disease interactions amongst surgical patients: a population cohort study . British Journal of Anaesthesia vol. 131 , ( 2 ) 407 - 417 .

Fowler AJ, Brayne AB, Pearse RM, Prowle JR ( 2023 ) . Long-term healthcare use after postoperative complications: an analysis of linked primary and secondary care routine data . BJA Open vol. 7 ,

Haines RW, Fowler AJ, Liang K, Pearse RM, Larsson AO, Puthucheary Z, Prowle JR ( 2023 ) . Comparison of Cystatin C and Creatinine in the Assessment of Measured Kidney Function during Critical Illness . Clinical Journal of the American Society of Nephrology vol. 18 , ( 8 ) 997 - 1005 .

Edwards MR, Forbes G, Walker N, Morton DG, Mythen MG, Murray D, Anderson I, Mihaylova B et al. ( 2023 ) . Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery . Trials vol. 24 , ( 1 )

Shaw SE, Hughes G, Pearse R, Avagliano E, Day JR, Edsell ME, Edwards JA, Everest L et al. ( 2023 ) . Opportunities for shared decision-making about major surgery with high-risk patients: a multi-method qualitative study . British Journal of Anaesthesia vol. 131 , ( 1 ) 56 - 66 .

Wan YI, Puthucheary ZA, Pearse RM, Prowle JR ( 2023 ) . Characterising biological mechanisms underlying ethnicity-associated outcomes in COVID-19 through biomarker trajectories: a multicentre registry analysis . British Journal of Anaesthesia vol. 131 , ( 3 ) 491 - 502 .

Abani O, Abbas A, Abbas F, Abbas J, Abbas K, Abbas M, Abbasi S, Abbass H et al. ( 2023 ) . Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet vol. 401 , ( 10387 ) 1499 - 1507 .

Duceppe E, Borges FK, Conen D, Tiboni M, Chan MTV, Patel A, Sessler DI, Kavsak PA et al. ( 2023 ) . Association of Preoperative Growth Differentiation Factor-15 Concentrations and Postoperative Cardiovascular Events after Major Noncardiac Surgery . Anesthesiology vol. 138 , ( 5 ) 508 - 522 .

Glasbey J, Glasbey J, Ademuyiwa A, Bhatt A, Biccard B, Blazeby J, Brocklehurst P, Chakrabortee S et al. ( 2023 ) . Adaptation of the Wound Healing Questionnaire universal-reporter outcome measure for use in global surgery trials (TALON-1 study): mixed-methods study and Rasch analysis . British Journal of Surgery vol. 110 , ( 6 ) 685 - 700 .

McClelland TJ, Fowler AJ, Davies TW, Pearse R, Prowle J, Puthucheary Z ( 2023 ) . Can pioglitazone be used for optimization of nutrition in critical illness? A systematic review . Journal of Parenteral and Enteral Nutrition vol. 47 , ( 4 ) 459 - 475 .

Borges FK, Duceppe E, Heels-Ansdell D, Patel A, Sessler DI, Tandon V, Chan M, Pearse R et al. ( 2023 ) . High-sensitivity Troponin I Predicts Major Cardiovascular Events after Non-Cardiac Surgery: A Vascular Events in Non-Cardiac Surgery Patients Cohort Evaluation (VISION) Substudy . Clinical Chemistry vol. 69 , ( 5 ) 492 - 499 .

Fowler AJ, Brayne A, Pearse RM, Prowle JR ( 2023 ) . Long-term healthcare use after postoperative complications: a prospective analysis of linked primary and secondary care routine data .

Jackson AIR, Boney O, Pearse RM, Kurz A, Cooper DJ, van Klei WA, Cabrini L, Miller TE et al. ( 2023 ) . Systematic reviews and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: mortality, morbidity, and organ failure . British Journal of Anaesthesia vol. 130 , ( 4 ) 404 - 411 .

Duceppe E, Borges FK, Tiboni M, Pearse R, Chan MTV, Srinathan S, Kavsak PA, Garg AX et al. ( 2023 ) . High-Sensitivity Cardiac Troponin I Thresholds to Identify Myocardial Injury After Noncardiac Surgery: A Cohort Study . Canadian Journal of Cardiology vol. 39 , ( 3 ) 311 - 318 .

Toal CM, Fowler AJ, Pearse RM, Puthucheary Z, Prowle JR, Wan YI ( 2022 ) . Health Resource Utilisation and Disparities: an Ecological Study of Admission Patterns Across Ethnicity in England Between 2017 and 2020 . Journal of Racial and Ethnic Health Disparities vol. 10 , ( 6 ) 2872 - 2881 .

Kluyts H, Bedwell GJ, Bedada AG, Fadalla T, Hewitt‐Smith A, Mbwele BA, Mrara B, Omigbodun A et al. ( 2022 ) . Determining the Minimum Dataset for Surgical Patients in Africa: A Delphi Study . World Journal of Surgery vol. 47 , ( 3 ) 581 - 592 .

Surgery NGHUOG, Glasbey JC, Abbott TE, Ademuyiwa A, Adisa A, AlAmeer E, Alshryda S, Arnaud AP et al. ( 2022 ) . Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries . The Lancet vol. 400 , ( 10363 ) 1607 - 1617 .

Paterson A, Maswime S, Hardy A, Pearse RM, Biccard BM, group ICWTASOGAISO ( 2022 ) . Postoperative outcomes associated with surgical care for women in Africa: an international risk-adjusted analysis of prospective observational cohorts . BJA Open vol. 4 ,

Fowler AJ, Trivedi B, Boomla K, Pearse R, Prowle J ( 2022 ) . Change in healthcare utilisation after surgical treatment: observational study of routinely collected patient data from primary and secondary care . British Journal of Anaesthesia vol. 129 , ( 6 ) 889 - 897 .

Stephens TJ, Pearse RM ( 2022 ) . The limitations of shared decision-making in surgery . British Journal of Surgery vol. 109 , ( 11 ) 1051 - 1052 .

Bedwell GJ, Dias P, Hahnle L, Anaeli A, Baker T, Beane A, Biccard BM, Bulamba F et al. ( 2022 ) . Barriers to Quality Perioperative Care Delivery in Low- and Middle-Income Countries: A Qualitative Rapid Appraisal Study . Anesthesia & Analgesia vol. 135 , ( 6 ) 1217 - 1232 .

Hajjar LA, Quintão VC, Vieira APZ, Nakada LN, Pearse RM, Ramirez MBD, la Medina AR, Alvarez A et al. ( 2022 ) . Latin American surgical outcomes study: study protocol for a multicentre international observational cohort study of patient outcomes after surgery in Latin American countries . BJA Open vol. 3 ,

Fowler AJ, Wan YI, Prowle JR, Chew M, Campbell D, Cuthbertson B, Wijeysundera DN, Pearse R et al. ( 2022 ) . Long-term mortality following complications after elective surgery: a secondary analysis of pooled data from two prospective cohort studies . British Journal of Anaesthesia vol. 129 , ( 4 ) 588 - 597 .

Davies TW, van Gassel RJJ, van de Poll M, Gunst J, Casaer MP, Christopher KB, Preiser JC, Hill A et al. ( 2022 ) . Core outcome measures for clinical effectiveness trials of nutritional and metabolic interventions in critical illness: an international modified Delphi consensus study evaluation (CONCISE) . Critical Care vol. 26 , ( 1 )

Daza JF, Cuthbertson BH, Myles PS, Shulman MA, Wijeysundera DN, Cuthbertson BH, Wijeysundera DN, Pearse RM et al. ( 2022 ) . Measurement properties of the WHO Disability Assessment Schedule 2.0 for evaluating functional status after inpatient surgery . British Journal of Surgery vol. 109 , ( 10 ) 968 - 976 .

Abani O, Abbas A, Abbas F, Abbas J, Abbas K, Abbas M, Abbasi S, Abbass H et al. ( 2022 ) . Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis . The Lancet vol. 400 , ( 10349 ) 359 - 368 .

Collaborative SCAT, Kouli O, Murray V, Bhatia S, Cambridge W, Kawka M, Shafi S, Knight et al. ( 2022 ) . Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study . The Lancet Digital Health vol. 4 , ( 7 ) e520 - e531 .

Glasbey J, Trout I, Adeyeye V, Ademuyiwa A, Adisa A, Bhatt A, Biccard B, Brocklehurst P et al. ( 2022 ) . Use of Telemedicine for Postdischarge Assessment of the Surgical Wound . Annals of Surgery vol. 277 , ( 6 ) e1331 - e1347 .

Patel J, Tolppa T, Biccard BM, Fazzini B, Haniffa R, Marletta D, Moonesinghe R, Pearse R et al. ( 2022 ) . Perioperative Care Pathways in Low‐ and Lower‐Middle‐Income Countries: Systematic Review and Narrative Synthesis . World Journal of Surgery vol. 46 , ( 9 ) 2102 - 2113 .

Calvache JA, Delgado M, Stefani LC, Biccard B, Pearse RM ( 2022 ) . The need for a joint response. Perioperative mortality in Latin America and the time for LASOS Study . Colombian Journal of Anesthesiology vol. 50 , ( 3 )

Fowler AJ, Dias P, Hui S, Cashmore R, Laloo R, Ahmad AN, Gillies MA, Wan YI et al. ( 2022 ) . Liberal or restrictive antimicrobial prophylaxis for surgical site infection: systematic review and meta-analysis of randomised trials . British Journal of Anaesthesia vol. 129 , ( 1 ) 104 - 113 .

Fazzini B, Fowler AJ, Pearse R, Puthucheary Z ( 2022 ) . Adjusting meta-analysis data to reduce heterogeneity: the need for objective evaluation of observational studies. Response to Br J Anaesth 2022; 128: e303-5 . British Journal of Anaesthesia vol. 129 , ( 1 ) e10 - e12 .

Ripollés-Melchor J, Abad-Motos A, Cecconi M, Pearse R, Jaber S, Slim K, Francis N, Spinelli A et al. ( 2022 ) . Association between use of enhanced recovery after surgery protocols and postoperative complications in colorectal surgery in Europe: The EuroPOWER international observational study . Journal of Clinical Anesthesia vol. 80 ,

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Abeles RD, Pearse R, Powell-Tuck J ( 2021 ) . Initiation of nutrition in the intensive care unit and the reasons for its delay: a prospective audit . Proceedings of The Nutrition Society vol. 67 , ( OCE3 )

Pearse R, Ranieri M, Abbott T, Pakats M-L, Piervincenzi E, Patel A, Kahan B, Rhodes A et al. ( 2021 ) . Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial . The Lancet Respiratory Medicine vol. 9 , ( 11 ) 1221 - 1230 .

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Apea VJ, Wan YI, Dhairyawan R, Puthucheary ZA, Pearse RM, Orkin CM, Prowle JR ( 2021 ) . Ethnicity and outcomes in patients hospitalised with COVID-19 infection in East London: an observational cohort study . BMJ Open vol. 11 , ( 1 )

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Wan YI, Apea VJ, Dhairyawan R, Puthucheary ZA, Pearse RM, Orkin CM, Prowle JR ( 2021 ) . Ethnic disparities in hospitalisation and hospital-outcomes during the second wave of COVID-19 infection in east London .

Bulamba F, Hewitt-Smith A, Stephens T, Uddin R, Patel A, Pearse R ( 2021 ) . Failure to rescue in postpartum haemorrhage: a mixed-methods study to determining why mainstream, evidence-based treatments fail . ANESTHESIA AND ANALGESIA . vol. 133 , 1038 - 1038 .

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Wan Y, Apea V, Dhairyawan R, Orkin C, Pearse RM, Prowle JR ( 2020 ) . ETHICAL: Ethnic Disparities In COVID-19 Admissions in east London .

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Abbott TEF, Pearse RM, Chew MS ( 2020 ) . Prevention of postoperative pulmonary complications in the hypoxaemic patient - gathering the evidence for noninvasive respiratory support . European Journal of Anaesthesiology vol. 37 , ( 4 ) 263 - 264 .

Donnelly D, Pearse RM, Silversides JA ( 2020 ) . Sugammadex to prevent postoperative pulmonary complications: a practice survey . British Journal of Anaesthesia vol. 124 , ( 4 ) e206 - e207 .

Ackland GL, Abbott TEF, Jones TF, Leuwer M, Pearse RM, Investigators FTV-U, Pearse R, Niebrzegowska E et al. ( 2020 ) . Early elevation in plasma high-sensitivity troponin T and morbidity after elective noncardiac surgery: prospective multicentre observational cohort study . British Journal of Anaesthesia vol. 124 , ( 5 ) 535 - 543 .

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Delisle M, Pradarelli JC, Panda N, Koritsanszky L, Sonnay Y, Lipsitz S, Pearse R, Harrison EM et al. ( 2020 ) . Variation in global uptake of the Surgical Safety Checklist . British Journal of Surgery vol. 107 , ( 2 ) e151 - e160 .

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Wan Y, McGuckin D, Fowler A, Prowle J, Pearse R, Moonesinghe R ( 2020 ) . Socioeconomic deprivation and surgical outcomes: ISOS and VISION-UK sub-study (Statistical Analysis Plan) .

Bien Z, Fowler AJ, Robbins AJ, Pearse RM, Prowle J, Wan YI ( 2020 ) . Trends in Hospital Admissions Associated With an Acute Kidney Injury in England 1998-2020: A Repeated Cross-Sectional Study .

Duceppe E, Patel A, Chan MTV, Berwanger O, Ackland G, Kavsak PA, Rodseth R, Biccard B et al. ( 2019 ) . Preoperative N-Terminal Pro-B-Type Natriuretic Peptide and Cardiovascular Events After Noncardiac Surgery: A Cohort Study . Annals of Internal Medicine vol. 172 , ( 2 ) 96 - 104 .

Wijeysundera DN, Beattie WS, Hillis GS, Abbott TEF, Shulman MA, Ackland GL, Mazer CD, Myles PS et al. ( 2019 ) . Integration of the Duke Activity Status Index into preoperative risk evaluation: a multicentre prospective cohort study . British Journal of Anaesthesia vol. 124 , ( 3 ) 261 - 270 .

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MacDonald N, Pearse RM, Murray PT, Inzitari R, Doran P, Prowle JR ( 2019 ) . The role of goal-directed therapy in the prevention of acute kidney injury after major gastrointestinal surgery: Substudy of the OPTIMISE trial . European Journal of Anaesthesiology vol. 36 , ( 12 ) 924 - 932 .

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Biccard BM, Bishop D, Dyer RA, Pearse RM ( 2019 ) . Anaesthesia providers and maternal mortality in Africa – Authors' reply . The Lancet Global Health vol. 7 , ( 10 )

Cashmore RMJ, Fowler AJ, Pearse RM ( 2019 ) . Post-operative intensive care: is it really necessary? . Intensive Care Medicine vol. 45 , ( 12 ) 1799 - 1801 .

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Stephens TJ, Peden CJ, Haines R, Grocott MPW, Murray D, Cromwell D, Johnston C, Hare S et al. ( 2019 ) . Hospital-level evaluation of the effect of a national quality improvement programme: time-series analysis of registry data . BMJ Quality & Safety vol. 29 , ( 8 ) 623 - 635 .

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Miller TE, Pearse RM ( 2019 ) . Perioperative fluid management: moving toward more answers than questions—a commentary on the RELIEF study . Perioperative Medicine vol. 8 , ( 1 )

Stephens T, Pearse RM ( 2019 ) . Learning from the EPOCH trial (Editorial). What we have learnt from a trial of an intervention to improve survival following emergency laparotomy . Anaesthesia Critical Care & Pain Medicine vol. 38 , ( 4 ) 321 - 322 .

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Edwards MR, Forbes G, MacDonald N, Berdunov V, Mihaylova B, Dias P, Thomson A, Grocott MP et al. ( 2019 ) . Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial: study protocol for a multicentre international trial of cardiac output-guided fluid therapy with low-dose inotrope infusion compared with usual care in patients undergoing major elective gastrointestinal surgery . BMJ Open vol. 9 , ( 1 ) e023455 - e023455 .

Ryan EG, Harrison EM, Pearse RM, Gates S ( 2019 ) . Perioperative haemodynamic therapy for major gastrointestinal surgery: the effect of a Bayesian approach to interpreting the findings of a randomised controlled trial . BMJ Open vol. 9 , ( 3 )

Manou-Stathopoulou V, Abbott TEF, May SM, Cuthbertson BH, Wijeysundera DN, Pearse RM, Ackland GL ( 2019 ) . Perioperative plasma cortisol levels and myocardial injury after non-cardiac surgery . British Journal of Anaesthesia . vol. 122 , e45 - e46 .

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Kocman D, Stöckelová T, Pearse R, Martin G ( 2019 ) . Neither magic bullet nor a mere tool: negotiating multiple logics of the checklist in healthcare quality improvement . Sociology of Health & Illness vol. 41 , ( 4 ) 755 - 771 .

Abbott TEF, Pearse RM ( 2019 ) . Depth of Anesthesia and Postoperative Delirium . JAMA: The Journal of the American Medical Association vol. 321 , ( 5 ) 459 - 460 .

Scheeren TWL, Bakker J, De Backer D, Annane D, Asfar P, Boerma EC, Cecconi M, Dubin A et al. ( 2019 ) . Current use of vasopressors in septic shock . Annals of Intensive Care vol. 9 , ( 1 )

Pearse RM ( 2019 ) . Fools rush in where angels fear to tread . Southern African Journal of Anaesthesia and Analgesia vol. 25 , ( 1 )

Du Toit L, Kluyts H-L, Gobin V, Sani C, Zoumenou E, Omigbodun A, Amanor-Boadu S, Zié S et al. ( 2019 ) . The African Surgical OutcomeS-2 (ASOS-2) Pilot Trial, a mixed-methods implementation study . Southern African Journal of Anaesthesia and Analgesia14 - 23 .

Biais M, Pearse R ( 2019 ) . Perioperative haemodynamic therapy: Why are recommendations not being adopted? . Anaesthesia Critical Care & Pain Medicine vol. 38 , ( 1 ) 5 - 7 .

Abbott TEF, Greaves KE, Patel A, Ahmad T, Haddow J, Futier E, Biais M, Slim K et al. ( 2019 ) . Prospective observational cohort study on grading the severity of postoperative complications in global surgery research . British Journal of Surgery vol. 106 , ( 2 ) e73 - e80 .

Wan Y, Patel A, Achary C, Hewson R, Phull M, Pearse R ( 2019 ) . International Surgical Outcomes Study (ISOS) sub-study: post-operative infection (Statistical Analysis Plan) .

Edwards MR, Pearse RM ( 2019 ) . Perioperative Haemodynamic Optimisation . Hemodynamic Monitoring , Springer Nature

Liu KD, Burkhardt DH, Pearse RM ( 2019 ) . Renal Pathophysiology and Treatment for Perioperative Ischemia and Nephrotoxic Injury . Miller S Anesthesia 2 Volume Set , vol. 1-2 ,

Abbott TEF, Pearse RM, Cuthbertson BH, Wijeysundera DN, Ackland GL, investigators MS ( 2018 ) . Cardiac vagal dysfunction and myocardial injury after non-cardiac surgery: a planned secondary analysis of the measurement of Exercise Tolerance before surgery study . British Journal of Anaesthesia vol. 122 , ( 2 ) 188 - 197 .

Stephens TJ, Peden CJ, Pearse RM, Shaw SE, Abbott TEF, Jones EL, Kocman D, Martin G ( 2018 ) . Correction to: Improving care at scale: process evaluation of a multi-component quality improvement intervention to reduce mortality after emergency abdominal surgery (EPOCH trial) . Implementation Science vol. 13 , ( 1 )

Stephens TJ, Peden CJ, Pearse RM, Shaw SE, Abbott TEF, Jones EL, Kocman D, Martin G ( 2018 ) . Improving care at scale: process evaluation of a multi-component quality improvement intervention to reduce mortality after emergency abdominal surgery (EPOCH trial) . Implementation Science vol. 13 , ( 1 )

de Nadal M, Pérez-Hoyos S, Montejo-González JC, Pearse R, Aldecoa C, Spain OBOTESOSI ( 2018 ) . Intensive care admission and hospital mortality in the elderly after non-cardiac surgery . Medicina Intensiva (English Edition) vol. 42 , ( 8 ) 463 - 472 .

Fowler AJ, Ahmad T, Abbott TEF, Torrance HD, Wouters PF, De Hert S, Lobo SM, Rasmussen LS et al. ( 2018 ) . Association of preoperative anaemia with postoperative morbidity and mortality: an observational cohort study in low-, middle-, and high-income countries . British Journal of Anaesthesia vol. 121 , ( 6 ) 1227 - 1235 .

Bloom B, Thomas S, Ahrensberg JM, Weaver R, Fowler A, Bestwick J, Harris T, Pearse R ( 2018 ) . A systematic review and meta-analysis of return to work after mild Traumatic brain injury . Brain Injury vol. 32 , ( 13-14 ) 1623 - 1636 .

Shulman MA, Cuthbertson BH, Wijeysundera DN, Pearse RM, Thompson B, Torres E, Ambosta A, Wallace S et al. ( 2018 ) . Using the 6-minute walk test to predict disability-free survival after major surgery . British Journal of Anaesthesia vol. 122 , ( 1 ) 111 - 119 .

Ackland GL, Abbott TEF, Cain D, Edwards MR, Sultan P, Karmali SN, Fowler AJ, Whittle JR et al. ( 2018 ) . Preoperative systemic inflammation and perioperative myocardial injury: prospective observational multicentre cohort study of patients undergoing non-cardiac surgery . British Journal of Anaesthesia vol. 122 , ( 2 ) 180 - 187 .

Kluyts H-L, le Manach Y, Munlemvo DM, Madzimbamuto F, Basenero A, Coulibaly Y, Rakotoarison S, Gobin V et al. ( 2018 ) . The ASOS Surgical Risk Calculator: development and validation of a tool for identifying African surgical patients at risk of severe postoperative complications . British Journal of Anaesthesia vol. 121 , ( 6 ) 1357 - 1363 .

Torrance HDT, Longbottom ER, Vivian ME, Lalabekyan B, Abbott TEF, Ackland GL, Hinds CJ, Pearse RM et al. ( 2018 ) . Post-operative immune suppression is mediated via reversible, Interleukin-10 dependent pathways in circulating monocytes following major abdominal surgery . PLOS ONE vol. 13 , ( 9 )

Hewitt-Smith A, Bulamba F, Olupot C, Musana F, Ochieng J, Lipnick, Pearse R ( 2018 ) . Surgical outcomes in eastern Uganda: a one-year cohort study . Southern African Journal of Anaesthesia and Analgesia vol. 24 , ( 5 ) 1 - 6 .

Neto AS, da Costa LGV, Hemmes SNT, Canet J, Hedenstierna G, Jaber S, Hiesmayr M, Hollmann MW et al. ( 2018 ) . The LAS VEGAS risk score for prediction of postoperative pulmonary complications . European Journal of Anaesthesiology vol. 35 , ( 9 ) 691 - 701 .

Ackland GL, Abbott TF, Pearse RM, Investigators VEIN-CSPCE-U ( 2018 ) . Preoperative systemic inflammation and myocardial injury in non-cardiac surgery . British Journal of Anaesthesia . vol. 121 , e20 - e21 .

Gillies MA, Pearse R, Chew MS ( 2018 ) . Peri-operative goal-directed therapy . European Journal of Anaesthesiology vol. 35 , ( 7 ) 467 - 468 .

Walker SLM, Abbott TEF, Brown K, Pearse RM, Ackland GL ( 2018 ) . Perioperative management of angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers: a survey of perioperative medicine practitioners . PeerJ vol. 6 ,

Stephens T, ABBOTT TEF, Pearse RM ( 2018 ) . Process Evaluation for the PRISM and OPTIMISE II trials: study protocol . Notes: Study protocol process review document ,

Greenberg L, Jairath V, Pearse R, Kahan BC ( 2018 ) . Pre-specification of statistical analysis approaches in published clinical trial protocols was inadequate . Journal of Clinical Epidemiology vol. 101 , 53 - 60 .

Wijeysundera DN, Pearse RM, Shulman MA, Abbott TEF, Torres E, Ambosta A, Croal BL, Granton JT et al. ( 2018 ) . Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study . The Lancet vol. 391 , ( 10140 ) 2631 - 2640 .

Buse GL, Manns B, Lamy A, Guyatt G, Polanczyk CA, Chan MTV, Wang CY, Villar JC et al. ( 2018 ) . Troponin T monitoring to detect myocardial injury after noncardiac surgery: a cost–consequence analysis . Canadian Journal of Surgery vol. 61 , ( 3 ) 185 - 194 .

Pearse RM, Hopkins PM ( 2018 ) . Where audit meets science: role of reporting and recommendations guidelines in service evaluations . British Journal of Anaesthesia vol. 121 , ( 1 ) 118 - 120 .

Walker S, Abbott T, Brown K, Pearse R, Ackland G ( 2018 ) . Contemporary perioperative management of ACE-inhibitors and angiotensin receptor blockers . British Journal of Anaesthesia . vol. 120 , e24 - e25 .

Buggy DJ, Freeman J, Johnson MZ, Leslie K, Riedel B, Sessler DI, Kurz A, Gottumukkala V et al. ( 2018 ) . Systematic review and consensus definitions for standardised endpoints in perioperative medicine: postoperative cancer outcomes . British Journal of Anaesthesia vol. 121 , ( 1 ) 38 - 44 .

( 2018 ) . Abstracts of Posters presented at the International Anesthesia Research Society 2018 Annual Meeting and International Science Symposium . Anesthesia & Analgesia . vol. 126 , 1 - 795 .

Abbott TEF, Fowler AJ, Pelosi P, de Abreu MG, Møller AM, Canet J, Creagh-Brown B, Mythen M et al. ( 2018 ) . A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications . British Journal of Anaesthesia vol. 120 , ( 5 ) 1066 - 1079 .

Yeung J, Gillies MA, Pearse RM ( 2018 ) . Pragmatic trials in peri-operative medicine: why, when and how? . Anaesthesia

Simonis FD, Barbas CSV, Artigas-Raventós A, Canet J, Determann RM, Anstey J, Hedenstierna G, Hemmes SNT et al. ( 2018 ) . Potentially modifiable respiratory variables contributing to outcome in ICU patients without ARDS: a secondary analysis of PRoVENT . Annals of Intensive Care vol. 8 , ( 1 )

de Nadal M, Pérez-Hoyos S, Montejo-González JC, Pearse R, Aldecoa C, Spain OBOTESOSI ( 2018 ) . Intensive care admission and hospital mortality in the elderly after non-cardiac surgery . Medicina Intensiva (English Edition) vol. 42 , ( 8 ) 463 - 472 .

Haines RW, Lin S-P, Hewson R, Kirwan CJ, Torrance HD, O’Dwyer MJ, West A, Brohi K et al. ( 2018 ) . Acute Kidney Injury in Trauma Patients Admitted to Critical Care: Development and Validation of a Diagnostic Prediction Model . Scientific Reports vol. 8 , ( 1 )

Vincent J-L, Einav S, Pearse R, Jaber S, Kranke P, Overdyk FJ, Whitaker DK, Gordo F et al. ( 2018 ) . Improving detection of patient deterioration in the general hospital ward environment . European Journal of Anaesthesiology vol. 35 , ( 5 ) 325 - 333 .

Kahan BC, Morris TP, Harris E, Pearse R, Hooper R, Eldridge S ( 2018 ) . Re-randomization increased recruitment and provided similar treatment estimates as parallel designs in trials of febrile neutropenia . Journal of Clinical Epidemiology vol. 97 , 14 - 19 .

Biccard BM, Madiba TE, Kluyts H-L, Munlemvo DM, Madzimbamuto FD, Basenero A, Gordon CS, Youssouf C et al. ( 2018 ) . Perioperative patient outcomes in the African Surgical Outcomes Study: a 7-day prospective observational cohort study . The Lancet vol. 391 , ( 10130 ) 1589 - 1598 .

MacDonald N, Pearse RM ( 2017 ) . Are we close to the ideal intravenous fluid? . British Journal of Anaesthesia vol. 119 , ( suppl_1 ) i63 - i71 .

Moppett IK, Pearse RM ( 2017 ) . Evidence-based medicine: the clue is in the name . British Journal of Anaesthesia vol. 119 , ( 6 ) 1084 - 1086 .

Abbott TEF, Ahmad T, Phull MK, Fowler AJ, Hewson R, Biccard BM, Chew MS, Gillies M et al. ( 2017 ) . The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis . British Journal of Anaesthesia vol. 120 , ( 1 ) 146 - 155 .

Ackland GL, Abbott TEF, Pearse RM, Karmali SN, Whittle J, Minto G, Investigators P-HS, Minto G et al. ( 2017 ) . Arterial pulse pressure and postoperative morbidity in high-risk surgical patients . British Journal of Anaesthesia vol. 120 , ( 1 ) 94 - 100 .

Abbott TEF, Pearse RM, Archbold RA, Ahmad T, Niebrzegowska E, Wragg A, Rodseth RN, Devereaux PJ et al. ( 2017 ) . A Prospective International Multicentre Cohort Study of Intraoperative Heart Rate and Systolic Blood Pressure and Myocardial Injury After Noncardiac Surgery . Anesthesia & Analgesia vol. 126 , ( 6 ) 1936 - 1945 .

Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, van der Voort PHJ et al. ( 2017 ) . Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis . Critical Care vol. 21 , ( 1 )

Ghaffar S, Pearse RM, Gillies MA ( 2017 ) . ICU admission after surgery . Current Opinion in Critical Care vol. 23 , ( 5 ) 424 - 429 .

( 2017 ) . Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries . British Journal of Anaesthesia vol. 119 , ( 3 )

Szakmany T, Ditai J, Kirov M, Protsenko D, Osinaike B, Venara A, Demartines N, Hubner M et al. ( 2017 ) . In-hospital clinical outcomes after upper gastrointestinal surgery: Data from an international observational study . European Journal of Surgical Oncology vol. 43 , ( 12 ) 2324 - 2332 .

Abbott TEF, Fowler AJ, Dobbs TD, Harrison EM, Gillies MA, Pearse RM ( 2017 ) . Frequency of surgical treatment and related hospital procedures in the UK: a national ecological study using hospital episode statistics . British Journal of Anaesthesia vol. 119 , ( 2 ) 249 - 257 .

Chaudery H, MacDonald N, Pearse RM, Prowle JR ( 2017 ) . Global Incidence and Associations of Acute Kidney Injury in the International Surgical Outcomes Study (ISOS) . vol. 119 , is. 2 , pp. E28 - E28 .

Ahmad T, Bouwman RA, Grigoras I, Aldecoa C, Hofer C, Hoeft A, Holt P, Fleisher LA et al. ( 2017 ) . Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: a 7-day cohort study of elective surgery . British Journal of Anaesthesia vol. 119 , ( 2 ) 258 - 266 .

Abbott TEF, Pearse RM, Archbold RA, Wragg A, Kam E, Ahmad T, Khan AW, Niebrzegowska E et al. ( 2017 ) . Association between preoperative pulse pressure and perioperative myocardial injury: an international observational cohort study of patients undergoing non-cardiac surgery . British Journal of Anaesthesia vol. 119 , ( 1 ) 78 - 86 .

Abbott TEF, Minto G, Lee AM, Pearse RM, Ackland GL, for the POM-HR P-OAOSG ( 2017 ) . Elevated preoperative heart rate is associated with cardiopulmonary and autonomic impairment in high-risk surgical patients . British Journal of Anaesthesia vol. 119 , ( 1 ) 87 - 94 .

Martin GP, Kocman D, Stephens T, Peden CJ, Pearse RM, This study was carried out as part of a wider randomised controlled trial, EPOCH ( 2017 ) . Pathways to professionalism? Quality improvement, care pathways, and the interplay of standardisation and clinical autonomy . Sociol Health Illn

( 2017 ) . Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications . European Journal of Anaesthesiology vol. 34 , ( 8 ) 492 - 507 .

Gillies MA, Sander M, Shaw A, Wijeysundera DN, Myburgh J, Aldecoa C, Jammer I, Lobo SM et al. ( 2017 ) . Current research priorities in perioperative intensive care medicine . Intensive Care Medicine vol. 43 , ( 9 ) 1173 - 1186 .

Writing Committee for the VISION Study Investigators, Devereaux PJ, Biccard BM, Sigamani A, Xavier D, Chan MTV, Srinathan SK, Walsh M et al. ( 2017 ) . Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery . JAMA vol. 317 , ( 16 ) 1642 - 1651 .

Kahan BC, Koulenti D, Arvaniti K, Beavis V, Campbell D, Chan M, Moreno R, Pearse RM et al. ( 2017 ) . Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries . Intensive Care Medicine vol. 43 , ( 7 ) 971 - 979 .

Skinner DL, de Vasconcellos K, Wise R, Esterhuizen TM, Fourie C, Mahomed AG, Gopalan PD, Joubert I et al. ( 2017 ) . Critical care admission of South African (SA) surgical patients: Results of the SA Surgical Outcomes Study . South African Medical Journal vol. 107 , ( 5 ) 411 - 419 .

Gillies MA, Lone NI, Pearse RM, Haddow C, Smyth L, Parks RW, Walsh TS, Harrison EM ( 2017 ) . Effect of day of the week on short- and long-term mortality after emergency general surgery . British Journal of Surgery vol. 104 , ( 7 ) 936 - 945 .

O'Connor ME, Hewson RW, Kirwan CJ, Ackland GL, Pearse RM, Prowle JR ( 2017 ) . Acute kidney injury and mortality 1 year after major non-cardiac surgery . British Journal of Surgery vol. 104 , ( 7 ) 868 - 876 .

Bloom BM, Kinsella K, Pott J, Patel HC, Harris T, Lecky F, Pearse R ( 2017 ) . Short-term neurocognitive and symptomatic outcomes following mild traumatic brain injury: A prospective multi-centre observational cohort study . Brain Inj vol. 31 , ( 3 ) 304 - 311 .

Abbott TEF, Pearse RM ( 2017 ) . Saving money: An ideal driver for improved perioperative care? . Anaesthesia Critical Care & Pain Medicine vol. 36 , ( 3 ) 147 - 148 .

Davenport RA, Guerreiro M, Frith D, Rourke C, Platton S, Cohen M, Pearse R, Thiemermann C et al. ( 2017 ) . Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy . Anesthesiology vol. 126 , ( 1 ) 115 - 127 .

Gillies MA, Harrison EM, Pearse RM, Garrioch S, Haddow C, Smyth L, Parks R, Walsh TS et al. ( 2017 ) . Intensive care utilization and outcomes after high-risk surgery in Scotland: a population-based cohort study . British Journal of Anaesthesia vol. 118 , ( 1 ) 123 - 131 .

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Pearse RM, Abbott TE, Haslop R, Ahmad T, Kahan BC, Filipini C, Rhodes A, Ranieri M ( 2016 ) . The Prevention of Respiratory Insufficiency after Surgical Management (PRISM) Trial. Report of the protocol for a pragmatic randomized controlled trial of CPAP to prevent respiratory complications and improve survival following major abdominal surgery . Minerva Anestesiologica vol. 83 , ( 2 ) 175 - 182 .

Neto AS, Barbas CSV, Simonis FD, Artigas-Raventós A, Canet J, Determann RM, Anstey J, Hedenstierna G et al. ( 2016 ) . Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study . The Lancet Respiratory Medicine vol. 4 , ( 11 ) 882 - 893 .

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Longbottom ER, Torrance HDT, Owen HC, Fragkou PC, Hinds CJ, Pearse RM, O’Dwyer MJ ( 2016 ) . Features of Postoperative Immune Suppression Are Reversible With Interferon Gamma and Independent of Interleukin-6 Pathways . Annals of Surgery vol. 264 , ( 2 ) 370 - 377 .

Abbott TEF, Ackland GL, Archbold RA, Wragg A, Kam E, Ahmad T, Khan AW, Niebrzegowska E et al. ( 2016 ) . Preoperative heart rate and myocardial injury after non-cardiac surgery: results of a predefined secondary analysis of the VISION study . British Journal of Anaesthesia vol. 117 , ( 2 ) 172 - 181 .

Prowle JR, Kam EPY, Ahmad T, Smith NCE, Protopapa K, Pearse RM ( 2016 ) . Preoperative renal dysfunction and mortality after non-cardiac surgery . British Journal of Surgery vol. 103 , ( 10 ) 1316 - 1325 .

Collaborative S, Drake TM, Chapman SJ, Chapman SJ, Glasbey JC, Khatri C, Claireaux HA, Bath MF et al. ( 2016 ) . Multicentre prospective cohort study of body mass index and postoperative complications following gastrointestinal surgery . British Journal of Surgery vol. 103 , ( 9 ) 1157 - 1172 .

Torrance HDT, Pearse RM, O’Dwyer MJ ( 2016 ) . Does major surgery induce immune suppression and increase the risk of postoperative infection? . Current Opinion in Anaesthesiology vol. 29 , ( 3 ) 376 - 383 .

Jawad M, Baigi A, Oldner A, Pearse RM, Rhodes A, Seeman-Lodding H, Chew MS ( 2016 ) . Swedish surgical outcomes study (SweSOS) . European Journal of Anaesthesiology vol. 33 , ( 5 ) 317 - 325 .

Wijeysundera DN, Pearse RM, Shulman MA ( 2016 ) . Correction . BMJ Open vol. 6 , ( 4 )

Gillies MA, Pearse RM ( 2016 ) . Intensive Care after High-risk Surgery . Anesthesiology vol. 124 , ( 4 ) 761 - 762 .

Wijeysundera DN, Pearse RM, Shulman MA, Abbott TEF, Torres E, Croal BL, Granton JT, Thorpe KE et al. ( 2016 ) . Measurement of Exercise Tolerance before Surgery (METS) study: a protocol for an international multicentre prospective cohort study of cardiopulmonary exercise testing prior to major non-cardiac surgery . BMJ Open vol. 6 , ( 3 )

Ozdemir BA, Sinha S, Karthikesalingam A, Poloniecki JD, Pearse RM, Grocott MPW, Thompson MM, Holt PJE ( 2016 ) . Mortality of emergency general surgical patients and associations with hospital structures and processes . British Journal of Anaesthesia vol. 116 , ( 1 ) 54 - 62 .

Cecconi M, Hochrieser H, Chew M, Grocott M, Hoeft A, Hoste A, Jammer I, Posch M et al. ( 2016 ) . Preoperative abnormalities in serum sodium concentrations are associated with higher in-hospital mortality in patients undergoing major surgery . British Journal of Anaesthesia vol. 116 , ( 1 ) 63 - 69 .

Garrioch S, Lone N, Walsh T, Parks R, Pearse R, Smyth L, Haddow C, Gillies M ( 2016 ) . Short and long term outcome, critical care usage and predictors of mortality following emergency laparotomy in Scotland . ANAESTHESIA . vol. 71 , 64 - 64 .

Sadique Z, Harrison DA, Grieve R, Rowan KM, Pearse RM, for the OPTIMISE study group ( 2015 ) . Cost-effectiveness of a cardiac output-guided haemodynamic therapy algorithm in high-risk patients undergoing major gastrointestinal surgery . Perioperative Medicine vol. 4 , ( 1 )

Abbott T, Ackland GL, Wragg A, Rodseth R, Archbold A, Pearse RM ( 2015 ) . Association between intraoperative heart rate and postoperative myocardial injury in patients following non-cardiac surgery . Intensive Care Med Exp vol. 3 , ( Suppl 1 ) A751 - A751 .

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Jammer I, Ahmad T, Aldecoa C, Koulenti D, Goranovic T, Grigoras I, Mazul-Sunko B, Matas R et al. ( 2015 ) . Point Prevalence of Surgical Checklist Use in Europe . Survey of Anesthesiology vol. 59 , ( 6 ) 298 - 299 .

O’Connor ME, Kirwan CJ, Pearse RM, Prowle JR ( 2015 ) . Incidence and associations of acute kidney injury after major abdominal surgery . Intensive Care Medicine vol. 42 , ( 4 ) 521 - 530 .

Owen HC, Torrance HDT, Jones TF, Pearse RM, Hinds CJ, Brohi K, O’Dwyer MJ ( 2015 ) . Epigenetic regulatory pathways involving microRNAs may modulate the host immune response following major trauma . Journal of Trauma and Acute Care Surgery vol. 79 , ( 5 ) 766 - 772 .

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Raja M, Torrance H, Longbottom E, Stroud A, Vivian M, Zolfaghari P, Pearse R, Hinds C et al. ( 2015 ) . Long-Term Follow-Up of Sepsis Induced Immunoparalysis . Intensive Care Medicine Experimental vol. 3 , ( Suppl 1 )

Longbottom E, Torrance H, Owen H, Hinds C, Pearse R, O'Dwyer M ( 2015 ) . Post-operative immune suppression is reversible with interferon gamma and independent of IL-6 pathways . Intensive Care Medicine Experimental vol. 3 , ( Suppl 1 )

Ahmad T, Beilstein CM, Aldecoa C, Moreno RP, Molnár Z, Novak-Jankovic V, Hofer CK, Sander M et al. ( 2015 ) . Variation in haemodynamic monitoring for major surgery in European nations: secondary analysis of the EuSOS dataset . Perioperative Medicine vol. 4 , ( 1 )

Fowler AJ, Ahmad T, Phull MK, Allard S, Gillies MA, Pearse RM ( 2015 ) . Meta-analysis of the association between preoperative anaemia and mortality after surgery . British Journal of Surgery vol. 102 , ( 11 ) 1314 - 1324 .

Pearse RM, Wijeysundera DN ( 2015 ) . Steroids for cardiac surgery: has the story finally ended? . The Lancet vol. 386 , ( 10000 ) 1215 - 1216 .

Gillies MA, Shah AS, Mullenheim J, Tricklebank S, Owen T, Antonelli J, Strachan F, Mills NL et al. ( 2015 ) . Perioperative myocardial injury in patients receiving cardiac output-guided haemodynamic therapy: a substudy of the OPTIMISE Trial . British journal of anaesthesia vol. 115 , ( 2 ) 227 - 233 .

Gillies MA, Power GS, Harrison DA, Fleming A, Cook B, Walsh TS, Pearse RM, Rowan KM ( 2015 ) . Regional variation in critical care provision and outcome after high-risk surgery . Intensive Care Medicine vol. 41 , ( 10 ) 1809 - 1816 .

Baron DM, Hochrieser H, Posch M, Metnitz B, Rhodes A, Moreno RP, Pearse RM, Metnitz P ( 2015 ) . Preoperative Anaemia Is Associated With Poor Clinical Outcome in Non-cardiac Surgery Patients . Survey of Anesthesiology vol. 59 , ( 3 )

van Zaane B, van Klei WA, Buhre WF, Bauer P, Boerma EC, Hoeft A, Metnitz P, Moreno RP et al. ( 2015 ) . Nonelective surgery at night and in-hospital mortality: Prospective observational data from the European Surgical Outcomes Study . European journal of anaesthesiology vol. 32 , ( 7 ) 477 - 485 .

Vincent J-L, Pelosi P, Pearse R, Payen D, Perel A, Hoeft A, Romagnoli S, Ranieri VM et al. ( 2015 ) . Perioperative cardiovascular monitoring of high-risk patients: a consensus of 12 . CRITICAL CARE vol. 19 , Article ARTN 224 ,

Bloom BM, Maimaris C, Lecky F, Pearse R ( 2015 ) . Letter in response to 'Classification algorithms for the identification of structural injury in TBI using brain electrical activity' . Computers in biology and medicine

Freund Y, Bloom B, Bokobza J, Baarir N, Laribi S, Harris T, Navarro V, Bernard M et al. ( 2015 ) . Predictive value of S100-B and copeptin for outcomes following seizure: the BISTRO International Cohort Study . PloS one vol. 10 , ( 4 ) e0122405 - e0122405 .

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O'Dwyer MJ ( 2015 ) . Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients . Annals of Surgery vol. 261 , ( 4 ) 751 - 759 .

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, OʼDwyer MJ ( 2015 ) . Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients . Ann Surg vol. 261 , ( 4 ) 751 - 759 .

Ackland GL, Cecconi M, Pearse RM ( 2015 ) . Individualised targeted haemodynamic therapy in high-risk surgical patients - authors' reply . The Lancet. Respiratory medicine vol. 3 , ( 4 ) e14 - e15 .

Torrance HDT, Vivian ME, Brohi K, Prowle JR, Pearse RM, Owen HC, Hinds CJ, O’Dwyer MJ ( 2015 ) . Changes in gene expression following trauma are related to the age of transfused packed red blood cells . Journal of Trauma and Acute Care Surgery vol. 78 , ( 3 ) 535 - 542 .

Jammer I, Wickboldt N, Sander M, Smith A, Schultz MJ, Pelosi P, Leva B, Rhodes A et al. ( 2015 ) . Standards for definitions and use of outcome measures for clinical effectiveness research in perioperative medicine: European Perioperative Clinical Outcome (EPCO) definitions: a statement from the ESA-ESICM joint taskforce on perioperative outcome measures . Eur J Anaesthesiol vol. 32 , ( 2 ) 88 - 105 .

Jammer I, Ahmad T, Aldecoa C, Koulenti D, Goranović T, Grigoras I, Mazul-Sunko B, Matos R et al. ( 2015 ) . Point prevalence of surgical checklist use in Europe: relationship with hospital mortality . British Journal of Anaesthesia vol. 114 , ( 5 ) 801 - 807 .

Al-Khafaji A, Elder M, Lebovitz DJ, Murugan R, Souter M, Stuart S, Wahed AS, Keebler B et al. ( 2015 ) . Protocolized fluid therapy in brain-dead donors: the multicenter randomized MOnIToR trial . Intensive Care Medicine vol. 41 , ( 3 ) 418 - 426 .

Ackland GL, Igbal S, Paredes LG, Toner A, Lyness C, Jenkins N, Bodger P, Karmali S et al. ( 2015 ) . Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial . LANCET RESPIRATORY MEDICINE vol. 3 , ( 1 ) 33 - 41 .

Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Machado FR et al. ( 2015 ) . International Study on Microcirculatory Shock Occurrence in Acutely Ill Patients* . Critical Care Medicine vol. 43 , ( 1 ) 48 - 56 .

Moreno RP, Pearse R, Rhodes A ( 2015 ) . O escore da American Society of Anesthesiologists: ainda útil após 60 anos? Resultados do estudo EuSOS . Revista Brasileira de Terapia Intensiva vol. 27 , ( 2 ) 105 - 112 .

Pearse RM ( 2015 ) . The whole truth and nothing but the truth: the need for full reporting of randomised trials . Perioperative medicine (London, England) vol. 4 , 7 - 7 .

Ackland GL, Iqbal S, Paredes LG, Toner A, Lyness C, Jenkins N, Bodger P, Karmali S et al. ( 2014 ) . Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial . The Lancet Respiratory Medicine vol. 3 , ( 1 ) 33 - 41 .

MacDonald N, Ahmad T, Mohr O, Kirk-Bayley J, Moppett I, Hinds CJ, Pearse RM ( 2014 ) . Dynamic preload markers to predict fluid responsiveness during and after major gastrointestinal surgery: an observational substudy of the OPTIMISE trial . British Journal of Anaesthesia vol. 114 , ( 4 ) 598 - 604 .

Pearse RM, MacDonald N, Grocott MPW, OPTIMISE Study Group ( 2014 ) . Use of hemodynamic algorithm after gastrointestinal surgery--reply . JAMA vol. 312 , ( 14 )

Freund Y, Blooom B, Bokobza J, Baarir N, Laribi S, Harris T, Navarro V, Pearse R et al. ( 2014 ) . 19 Short Term Recurrence and Severe Outcome Following Emergency Department Visit for Seizure: Results from the BISTRO International Prospective Trial . Annals of Emergency Medicine vol. 64 , ( 4 )

Fragkou PC, Torrance HD, Pearse RM, Ackland GL, Prowle JR, Owen HC, Hinds CJ, O’Dwyer MJ ( 2014 ) . Perioperative blood transfusion is associated with a gene transcription profile characteristic of immunosuppression: a prospective cohort study . Critical Care vol. 18 , ( 5 )

Edison E, Rhodes A ( 2014 ) . Goal directed therapy in the perioperative setting: what is the evidence? . Perioperative Hemodynamic Monitoring and Goal Directed Therapy , Cambridge University Press (CUP)

Kam E, Pearse R ( 2014 ) . Patient outcome following major surgery . Perioperative Hemodynamic Monitoring and Goal Directed Therapy , Cambridge University Press (CUP)

Carter A, Pearse R ( 2014 ) . ScvO2 monitoring . Perioperative Hemodynamic Monitoring and Goal Directed Therapy , Cambridge University Press (CUP)

Baron DM, Hochrieser H, Posch M, Metnitz B, Rhodes A, Moreno RP, Pearse RM, Metnitz P et al. ( 2014 ) . Preoperative anaemia is associated with poor clinical outcome in non-cardiac surgery patients . Br J Anaesth vol. 113 , ( 3 ) 416 - 423 .

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O’Dwyer MJ ( 2014 ) . Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine . vol. 22 ,

Prowle JR, Kolic I, Purdell-Lewis J, Taylor R, Pearse RM, Kirwan CJ ( 2014 ) . Serum creatinine changes associated with critical illness and detection of persistent renal dysfunction after AKI . Clin J Am Soc Nephrol vol. 9 , ( 6 ) 1015 - 1023 .

Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MPW, Ahern A et al. ( 2014 ) . Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review . JAMA vol. 311 , ( 21 ) 2181 - 2190 .

Hemmes SNT, Gama de Abreu M, Pelosi P, Schultz MJ ( 2014 ) . High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial . The Lancet vol. 384 , ( 9942 ) 495 - 503 .

Fragkou P, Torrance H, Ackland G, Hinds C, Pearse R, O'Dwyer MJ ( 2014 ) . Major gastrointestinal surgery is associated with a specific gene expression profile that is quantitatively associated with infectious complications . European Journal of Anaesthesiology . vol. 31 ,

Fragkou P, Prowle J, Ackland G, Hinds C, Pearse R, O'Dwyer MJ ( 2014 ) . Perioperative blood transfusion is associated with a characteristic immune response, excess infectious complications and death in patients undergoing scheduled major gastrointestinal surgery . European Journal of Anaesthesiology . vol. 31 ,

Jawad M, Pearse R, Rhodes A, SeemanLodding H, Baigi A, Chew MS ( 2014 ) . Swedish Surgical Outcome Study (SweSOS), a sub study of the European Surgical Outcomes Study (EuSOS). Characteristics and outcome of the Swedish subset of EuSOS to identify the predictors of short- and long-term mortality in Sweden. Analytical, descriptive and prospective cohort study . European Journal of Anaesthesiology . vol. 31 , 248 - 249 .

Reynolds TE, Pearse RM ( 2014 ) . Cardiac troponins in sepsis: an indication for echocardiography?* . Crit Care Med vol. 42 , ( 4 ) 975 - 976 .

James S, Jhanji S, Smith A, O'Brien G, Fitzgibbon M, Pearse RM ( 2014 ) . Comparison of the prognostic accuracy of scoring systems, cardiopulmonary exercise testing, and plasma biomarkers: a single-centre observational pilot study . Br J Anaesth vol. 112 , ( 3 ) 491 - 497 .

Botto F, Alonso-Coello P, Chan MTV, Villar JC, Xavier D, Srinathan S, Guyatt G, Cruz P et al. ( 2014 ) . Myocardial Injury after Noncardiac Surgery . Anesthesiology vol. 120 , ( 3 ) 564 - 578 .

Chappell D, Jacob M ( 2014 ) . A rational approach to fluid and volume management . Perioperative Hemodynamic Monitoring and Goal Directed Therapy , Cambridge University Press (CUP)

Torrance HDT, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O’Dwyer MJ ( 2014 ) . Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients . Scandinavian journal of trauma, resuscitation and emergency medicine vol. 22 , ( Suppl 1 ) O7 - O7 .

Pearse RM ( 2014 ) . Effect of a Perioperative, Cardiac Output-Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery: A Randomized Clinical Trial and Systematic Review (vol 311, pg 2181, 2014) . JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION vol. 312 , ( 14 ) 1473 - 1473 .

Macdonald N, Pearse R ( 2014 ) . Effect of a perioperative haemodynamic therapy algorithm on outcomes after major gastrointestinal surgery: a multi-centre randomized controlled trial . BRITISH JOURNAL OF ANAESTHESIA . vol. 112 , 190P - 190P .

Dreyer G, Tucker AT, Harwood SM, Pearse RM, Raftery MJ, Yaqoob MM ( 2014 ) . Ergocalciferol and microcirculatory function in chronic kidney disease and concomitant vitamin d deficiency: an exploratory, double blind, randomised controlled trial . PLoS One vol. 9 , ( 7 )

Gillies MA, Habicher M, Jhanji S, Sander M, Mythen M, Hamilton M, Pearse RM ( 2014 ) . Incidence of postoperative death and acute kidney injury associated with i.v. 6 hydroxyethyl starch use: systematic review and meta-analysis . BRITISH JOURNAL OF ANAESTHESIA vol. 112 , ( 1 ) 25 - 34 .

Kam E, Pearse R ( 2014 ) . Patient outcome following major surgery . Paradise Lost and the Cosmological Revolution ,

Cannesson M, Pearse R ( 2014 ) . Perioperative hemodynamic monitoring and goal directed therapy: From theory to practice .

Vivian M, Torrance HDT, Pearse R, Brohi K, Hinds CJ, O'Dwyer MJ ( 2014 ) . THE AGE OF TRANSFUSED PACKED RED BLOOD CELLS CORRELATES WITH THE DEGREE OF IMMUNOSUPPRESSION AS ASSESSED BY GENE EXPRESSION PATTERNS IN SEVERELY INJURED TRAUMA PATIENTS . INTENSIVE CARE MEDICINE . vol. 40 , S20 - S20 .

Pearse R, Hoeft A, Moreno RP, Pelosi P, Rhodes A ( 2013 ) . Mortality after surgery in Ireland - Authors' reply . Lancet vol. 382 , ( 9910 ) 2063 - 2064 .

Al-Khafaji A, Murugan R, Wahed AS, Lebovitz DJ, Souter MJ, Kellum JA ( 2013 ) . Monitoring Organ Donors to Improve Transplantation Results (MOnIToR) trial methodology . Critical Care and Resuscitation vol. 15 , ( 3 ) 234 - 240 .

Cullen, Jhanji S, Pearse R, Fitzgibbon M ( 2013 ) . Neutrophil gelatinase-associated lipocalin and albuminuria as predictors of acute kidney injury in patients treated with goal-directed haemodynamic therapy after major abdominal surgery . Annals of Clinical Biochemistry International Journal of Laboratory Medicine vol. 51 , ( 3 ) 392 - 399 .

Walsh TS, Boyd JA, Watson D, Hope D, Lewis S, Krishan A, Forbes JF, Ramsay P et al. ( 2013 ) . Restrictive Versus Liberal Transfusion Strategies for Older Mechanically Ventilated Critically Ill Patients . Critical Care Medicine vol. 41 , ( 10 ) 2354 - 2363 .

Lee GR, Jhanji S, Tarrant H, James S, Pearse RM, Fitzgibbon M ( 2013 ) . Peri-operative troponin monitoring using a prototype high-sensitivity cardiac troponin I (hs-cTnI) assay: comparisons with hs-cTnT and contemporary cTnI assays . Annals of Clinical Biochemistry International Journal of Laboratory Medicine vol. 51 , ( 2 ) 258 - 268 .

Reynolds T, Vivian-Smith A, Jhanji S, Pearse RM ( 2013 ) . Observational study of the effects of age, diabetes mellitus, cirrhosis and chronic kidney disease on sublingual microvascular flow . Perioper Med (Lond) vol. 2 , ( 1 )

Bangash MN, Patel NSA, Benetti E, Collino M, Hinds CJ, Thiemermann C, Pearse RM ( 2013 ) . Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regional microvascular flow . Crit Care vol. 17 , ( 2 )

Prowle JR, Pearse RM ( 2013 ) . Is it the end of the road for synthetic starches in critical illness? . The BMJ vol. 346 , ( mar20 1 )

Reynolds T, Jhanji S, Vivian-Smith A, Pearse R ( 2013 ) . Observational study of the effects of age, diabetes mellitus, cirrhosis and chronic kidney disease on sublingual microvascular flow . Critical Care vol. 17 , ( Suppl 2 )

Pearse R, Moreno RP, Bauer P, Pelosi P, Metnitz P, Spies C, Vallet B, Vincent J-L et al. ( 2013 ) . Mortality after surgery in Europe – Authors' reply . The Lancet vol. 381 , ( 9864 ) 370 - 371 .

Torrance HDT, Brohi K, Pearse RM, Fragkou P, Hinds CJ, O'Dwyer MJ ( 2013 ) . BLOOD TRANSFUSION FOLLOWING SEVERE TRAUMA IS ASSOCIATED WITH THE DEVELOPMENT OF AN EARLY ANTI-INFLAMMATORY RESPONSE . INTENSIVE CARE MEDICINE . vol. 39 , S386 - S387 .

Baron DM, Hochrieser H, Metnitz B, Rhodes A, Moreno RP, Pearse RM, Metnitz P ( 2013 ) . PREOPERATIVE ANEMIA AND POLYCYTHEMIA ARE ASSOCIATED WITH A HIGHER IN-HOSPITAL MORTALITY IN NON-CARDIAC SURGERY PATIENTS . INTENSIVE CARE MEDICINE . vol. 39 , S285 - S285 .

Cecconi M, Hochrieser H, Metnitz B, Moreno R, Pearse R, Metnitz P, Rhodes A ( 2013 ) . PREOPERATVE SERUM SODIUM AND POSTOPERATIVE MORTALITY: A EUSOS SUBSTUDY . INTENSIVE CARE MEDICINE . vol. 39 , S337 - S338 .

Pearse RM, van Zaane B, Moreno RP, Buhre WF, van Klei WA, Rhodes A ( 2013 ) . START TIMES OF EMERGENCY SURGERY AND IN HOSPITAL MORTALITY: A COHORT STUDY ON THE EUSOS DATABASE COMPARING MORTALITY AFTER DAY SHIFT, EVENING SHIFT AND NIGHT SHIFT PROCTDURES . INTENSIVE CARE MEDICINE . vol. 39 , S349 - S349 .

Diogo AC, Iannuccelli F, Rhodes A, Pearse R, Moreno R ( 2013 ) . THE RELATIONSHIP BETWEEN THE ASA SCORE AND OUTCOME FROM SURGERY. RESULTS FROM THE EUSOS STUDY . INTENSIVE CARE MEDICINE . vol. 39 , S349 - S349 .

Retter A, Wyncoll D, Pearse R, Carson D, McKechnie S, Stanworth S, Allard S, Thomas D et al. ( 2012 ) . Guidelines on the management of anaemia and red cell transfusion in adult critically ill patients . British Journal of Haematology vol. 160 , ( 4 ) 445 - 464 .

Ford SR, Pearse RM ( 2012 ) . Do integrated care pathways have a place in critical care? . Curr Opin Crit Care vol. 18 , ( 6 ) 683 - 687 .

Pearse RM, Moreno RP, Bauer P, Pelosi P, Metnitz P, Spies C, Vallet B, Vincent J-L et al. ( 2012 ) . Mortality after surgery in Europe: a 7 day cohort study . Lancet vol. 380 , ( 9847 ) 1059 - 1065 .

Young EL, Huddart S, Pearse RP, Karthikesalingam A, Hinchliffe RJ, Loftus IM, Thompson MM, Holt PJE ( 2012 ) . Reply to ‘Comment on a Systematic Review of the Role of Cardiopulmonary Exercise Testing in Vascular Surgery’ . European Journal of Vascular and Endovascular Surgery vol. 44 , ( 3 ) 350 - 351 .

Pearse RM, Ackland GL ( 2012 ) . [Perioperative fluid therapy] . Praxis (Bern 1994) vol. 101 , ( 17 ) 1113 - 1118 .

McGinley A, Pearse RM ( 2012 ) . A national early warning score for acutely ill patients . The BMJ vol. 345 , ( aug08 1 )

( 2012 ) . Error in Viewpoint in: Statin Therapy for Healthy Men Identified as ‘Increased Risk,’ . JAMA: The Journal of the American Medical Association vol. 307 , ( 24 ) 2590 - 2590 .

( 2012 ) . Incomplete Results Data in: Association Between Postoperative Troponin Levels and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery . JAMA: The Journal of the American Medical Association vol. 307 , ( 24 ) 2590 - 2590 .

Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Bakker J et al. ( 2012 ) . Study Design of the Microcirculatory Shock Occurrence in Acutely Ill Patients (microSOAP): an International Multicenter Observational Study of Sublingual Microcirculatory Alterations in Intensive Care Patients . Critical Care Research and Practice vol. 2012 , ( 1 )

Pearse RM, Ackland GL ( 2012 ) . Perioperative fluid therapy . BMJ vol. 344 ,

Young EL, Karthikesalingam A, Huddart S, Pearse RM, Hinchliffe RJ, Loftus IM, Thompson MM, Holt PJE ( 2012 ) . A Systematic Review of the Role of Cardiopulmonary Exercise Testing in Vascular Surgery . European Journal of Vascular and Endovascular Surgery vol. 44 , ( 1 ) 64 - 71 .

Bangash MN, Kong M-L, Pearse RM ( 2012 ) . Use of inotropes and vasopressor agents in critically ill patients . Br J Pharmacol vol. 165 , ( 7 ) 2015 - 2033 .

Devereaux PJ, Chan MT, Alonso-Coello P, Walsh M, Berwanger O, Villar JC, Wang CY, Garutti RI et al. ( 2012 ) . Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery . JAMA: Journal of the American Medical Association vol. 307 , ( 21 ) 2295 - 2304 .

Frith D, Guerreiro M, Pearse R, Thiemermann C, Brohi K ( 2012 ) . EXPERIMENTAL ACUTE TRAUMATIC COAGULOPATHY IS ASSOCIATED WITH MODERATE IMPAIRMENT OF THROMBIN GENERATION AND DYSFIBRINOGENEMIA . SHOCK . vol. 37 , 34 - 34 .

( 2012 ) . IC . Encyclopedia of Intensive Care Medicine , Springer Nature

Hewson R, Pearse RM ( 2012 ) . Inotropic Therapy . Encyclopedia of Intensive Care Medicine , Springer Nature

Bangash MN, Pearse RM ( 2012 ) . Microcirculation . Encyclopedia of Intensive Care Medicine , Springer Nature

Grocott MPW, Pearse RM ( 2012 ) . Perioperative medicine: the future of anaesthesia? . BRITISH JOURNAL OF ANAESTHESIA vol. 108 , ( 5 ) 723 - 726 .

Terblanche M, Kruger P, di Gangi S, Gearay S, Gilfeather L, Ferguson ND, Pearse R, Beale R et al. ( 2012 ) . Risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study . CRITICAL CARE vol. 16 , ( 2 ) Article ARTN R61 ,

Pearse R, Wort S ( 2011 ) . Acute respiratory distress syndrome (ARDS) . Clinical Intensive Care vol. 15 , ( 1 ) 37 - 42 .

Pearse R, Wort S, Terblanche M, Rhodes A ( 2011 ) . Critical care clinical conundrums . Clinical Intensive Care vol. 14 , ( 3-4 ) 149 - 155 .

Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, Hart D, Pearse R et al. ( 2011 ) . Functional definition and characterization of acute traumatic coagulopathy . Crit Care Med vol. 39 , ( 12 ) 2652 - 2658 .

Pearse R, Holt P, Grocott M ( 2011 ) . Authors' reply to Petros and colleagues . BMJ Online vol. 343 , ( 7833 )

Pearse RM, Holt PJE, Grocott MPW ( 2011 ) . Managing perioperative risk in patients undergoing elective non-cardiac surgery . BMJ vol. 343 ,

MacDonald N, Pearse RM ( 2011 ) . Peri-operative hemodynamic therapy: only large clinical trials can resolve our uncertainty . Crit Care vol. 15 , ( 3 )

Pearse RM, Rhodes A, Moreno R, Pelosi P, Spies C, Vallet B, Metnitz P, Bauer P et al. ( 2011 ) . EuSOS: European surgical outcomes study . Eur J Anaesthesiol vol. 28 , ( 6 ) 454 - 456 .

Kavsak PA, Walsh M, Srinathan S, Thorlacius L, Buse GL, Botto F, Pettit S, McQueen MJ et al. ( 2011 ) . High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study . Clinical Biochemistry vol. 44 , ( 12 ) 1021 - 1024 .

Correa T, Kindler R, Brandt S, Gorrasi J, Regueira T, Bracht H, Porta F, Takala J et al. ( 2011 ) . Impact of hepatic venous oxygen efflux and carotid blood flow on the difference between mixed and central venous oxygen saturation . Critical Care vol. 15 , ( Suppl 1 )

Pearse R, Holt P, Grocott M ( 2011 ) . Authors' reply to Petros and colleagues . BMJ vol. 343 ,

Frith D, Baptista ML, Cohen MJ, Pearse R, Thiemermann C, Brohi K ( 2011 ) . EXPERIMENTAL ACUTE TRAUMATIC COAGULOPATHY: INITIATED BY HYPOPERFUSION, MODULATED BY THE PROTEIN C PATHWAY . SHOCK vol. 36 , 16 - 17 .

Frith D, Baptista ML, Cohen M, Pearse R, Thiemermann C, Brohi K ( 2011 ) . Experimental acute traumatic coagulopathy is due to systemic activation of protein c during hypoperfusion . JOURNAL OF THROMBOSIS AND HAEMOSTASIS vol. 9 , 481 - 481 .

Davenport R, Curry N, Manson J, De'Ath H, Coates A, Rourke C, Pearse R, Stanworth S et al. ( 2011 ) . Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1:2 . J Trauma vol. 70 , ( 1 ) 90 - 95 .

James S, Jhanji S, Niebrzegowska E, Tarrell T, Smith AV, Pearse R ( 2011 ) . PERI-OPERATIVE MICROVASCULAR FLOW AND CARDIO-PULMONARY EXERCISE TESTLNG IN HIGH RISK SURGICAL PATIENTS . INTENSIVE CARE MEDICINE . vol. 37 , S132 - S132 .

Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, Hart D, Pearse R et al. ( 2011 ) . Point of care diagnostics for the rapid identification of acute traumatic coagulopathy and prediction of massive trauma haemorrhage . BRITISH JOURNAL OF SURGERY . vol. 98 , 7 - 7 .

Martin-Loeches I, Lisboa T, Rhodes A, Moreno RP, Silva E, Sprung C, Chiche JD, Barahona D et al. ( 2010 ) . Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection . Intensive Care Medicine vol. 37 , ( 2 ) 272 - 283 .

Grocott MPW, Pearse RM ( 2010 ) . Prognostic studies of perioperative risk: robust methodology is needed . British Journal of Anaesthesia vol. 105 , ( 3 ) 243 - 245 .

Pearse RM ( 2010 ) . Another inconvenient truth: meeting the challenge of preventing poor surgical outcomes . Current Opinion in Critical Care vol. 16 , ( 4 ) 337 - 338 .

( 2010 ) . Editorial introductions . Current Opinion in Critical Care vol. 16 , ( 4 )

Rampal T, Jhanji S, Pearse RM ( 2010 ) . Using oxygen delivery targets to optimize resuscitation in critically ill patients . Curr Opin Crit Care vol. 16 , ( 3 ) 244 - 249 .

Spanos A, Jhanji S, Vivian-Smith A, Harris T, Pearse RM ( 2010 ) . EARLY MICROVASCULAR CHANGES IN SEPSIS AND SEVERE SEPSIS . SHOCK vol. 33 , ( 4 ) 387 - 391 .

Pearse RM ( 2010 ) . Water, taken in moderation, cannot hurt anybody (Mark Twain 1835-1910) . J PHYSIOL-LONDON vol. 588 , ( 2 ) 281 - 282 .

Frith D, Stanworth S, Gaarder C, Maegele M, Goslings C, Johansson P, Allard S, Cohen M et al. ( 2010 ) . Acute traumatic coagulopathy is dependent upon injury load and shock . BRITISH JOURNAL OF SURGERY vol. 97 , 39 - 40 .

Jhanji S, Vivian-Smith A, Lucena-Amaro S, Watson D, Hinds CJ, Pearse RM ( 2010 ) . Haemodynamic optimisation improves tissue microvascular flow and oxygenation after major surgery: a randomised controlled trial . Crit Care vol. 14 , ( 4 )

Frith D, Cohen M, Pearse R, Thiemermann C, Brohi K ( 2010 ) . Rodent coagulation responses to trauma and haemorrhagic shock . INFLAMMATION RESEARCH . vol. 59 , S26 - S27 .

Martin-Loeches I, Lisboa T, Rhodes A, Moreno R, Silva E, Sprung C, Chiche J, Barahona D et al. ( 2010 ) . USE OF CORTICOSTEROID THERAPY IN PATIENTS AFFECTED BY SEVERE PANDEMIC (H1N1)V INFLUENZA A INFECTION . INTENSIVE CARE MEDICINE . vol. 36 , S319 - S319 .

Pearse R, Bennett D, Hinds C ( 2009 ) . Dopexamine and survival: areas of consistency . Anaesthesia vol. 64 , ( 11 ) 1258 - 1258 .

Jhanji S, Vivian-Smith A, Lucena-Amaro S, Watson D, Hinds CJ, Pearse RM ( 2009 ) . A RANDOMISED CONTROLLED TRIAL OF THE EFFECTS OF POST-OPERATIVE HAEMODYNAMIC OPTIMISATION ON MICROVASCULAR FLOW, TISSUE OXYGENATION AND INFLAMMATORY MARKERS AFTER MAJOR ABDOMINAL SURGERY . INTENSIVE CARE MEDICINE . vol. 35 , 213 - 213 .

Shepherd SJ, Pearse RM ( 2009 ) . Role of Central and Mixed Venous Oxygen Saturation Measurement in Perioperative Care . ANESTHESIOLOGY vol. 111 , ( 3 ) 649 - 656 .

Jhanji S, Pearse RM ( 2009 ) . The use of early intervention to prevent postoperative complications . Curr Opin Crit Care vol. 15 , ( 4 ) 349 - 354 .

Powell-Tuck J, Gosling P, Lobo DN, Carlson GL, Allison SP, Gore M, Lewington AJ, Pearse RL et al. ( 2009 ) . Authors of guideline respond . The BMJ vol. 339 , ( jul28 3 )

Jhanji S, Stirling S, Patel N, Hinds CJ, Pearse RM ( 2009 ) . The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock . Crit Care Med vol. 37 , ( 6 ) 1961 - 1966 .

Jhanji S, Lee C, Watson D, Hinds C, Pearse RM ( 2009 ) . Microvascular flow and tissue oxygenation after major abdominal surgery: association with post-operative complications . Intensive Care Med vol. 35 , ( 4 ) 671 - 677 .

Frith D, Chesebro B, Pittet JF, Cohen MJ, Thiemermann C, Pearse R, Brohi K ( 2009 ) . ACUTE TRAUMATIC COAGULOPATHY IS DRIVEN BY SYSTEMIC HYPOPERFUSION INDEPENDENT OF HYPOTENSION AND HAEMORRHAGE VOLUME . SHOCK . vol. 32 , 9 - 9 .

Maddison B, Wolff C, Findlay G, Radermacher P, Hinds C, Pearse RM ( 2009 ) . Comparison of three methods of extravascular lung water volume measurement in patients after cardiac surgery . Crit Care vol. 13 , ( 4 )

Jhanji S, Stirling S, Patel NSA, Hinds CJ, Pearse RM ( 2009 ) . EFFECT OF INCREASING DOSES OF NOREPINEPHRINE ON TISSUE OXYGENATION AND MICROVASCULAR PERFUSION IN SEPTIC SHOCK . SHOCK . vol. 32 , 2 - 2 .

Pearse RM ( 2009 ) . Extending the role of lactate measurement into the prehospital environment . Crit Care vol. 13 , ( 1 )

Morris CG, Pearse RM ( 2009 ) . Pro-Con Debate: We should not Measure Cardiac output in Critical Care . Journal of the Intensive Care Society vol. 10 , ( 1 ) 8 - 12 .

Powell-Tuck J, Allison SP, Gosling P, Lobo DN, Carlson GL, Gore M, Lewington AJ, Pearse RM et al. ( 2009 ) . Summary of the British Consensus Guidelines on Intravenous Fluid Therapy for Adult Surgical Patients (GIFTASUP) – For Comment . Journal of the Intensive Care Society vol. 10 , ( 1 ) 13 - 15 .

Davenport R, Coates A, Allard S, Pasi J, MacCallum P, Stanworth S, Thiemermann C, Pearse R et al. ( 2009 ) . TRAUMA HAEMORRHAGE: EVOLVING ROLE OF ROTEM FOR PREDICTING TRANSFUSION REQUIREMENTS . SHOCK . vol. 32 , 15 - 15 .

Maddison B, Giudici R, Calzia E, Wolff C, Hinds C, Radermacher P, Pearse RM ( 2008 ) . Extravascular lung water volume measurement by a novel lithium-thermal indicator dilution method: comparison of three techniques to post-mortem gravimetry . Intensive Care Med vol. 34 , ( 11 ) 2106 - 2111 .

Pearse R ( 2008 ) . Inadequate pre‐operative evaluation and preparation 1 . Anaesthesia vol. 56 , ( 4 ) 374 - 374 .

Nourse S, Hurding A, McGinley A, Mandersloot G, Pearse R ( 2008 ) . Association between Cardiac Index and Mortality in Patients Assessed on the Ward by a Nurse-Led Critical Care Outreach Team . Journal of the Intensive Care Society vol. 9 , ( 2 ) 118 - 123 .

Jhanji S, Thomas B, Ely A, Watson D, Hinds CJ, Pearse RM ( 2008 ) . Mortality and utilisation of critical care resources amongst high-risk surgical patients in a large NHS trust . Anaesthesia vol. 63 , ( 7 ) 695 - 700 .

Pearse RM, Belsey JD, Cole JN, Bennett ED ( 2008 ) . Effect of dopexamine infusion on mortality following major surgery: Individual patient data meta-regression analysis of published clinical trials . CRIT CARE MED vol. 36 , ( 4 ) 1323 - 1329 .

Maddison B, Wolff C, Findlay G, Calzia E, Hinds C, Pearse R ( 2008 ) . Intrathoracic blood volume measurement: comparison of transpulmonary lithium indicator dilution with indocyanine green indicator dilution . Critical Care vol. 12 , ( Suppl 2 )

Jhanji S, Dawson J, Pearse RM ( 2008 ) . Cardiac output monitoring: basic science and clinical application . Anaesthesia vol. 63 , ( 2 ) 172 - 181 .

Maddison B, Findlay G, Radermacher P, Hinds C, Pearse RM ( 2008 ) . Intrathoracic blood volume measurement: A comparison of transpulmonary lithium indicator dilution with indocyanine green indicator dilution . SHOCK . vol. 29 , 63 - 63 .

Pearse RM, Langford RM ( 2008 ) . Perioperative management of the high-risk surgical patient . Bailey Love S Short Practice of Surgery ,

Jhanji S, Lee C, Watson D, Hinds CJ, Pearse RM ( 2008 ) . Tissue oxygenation and microvascular flow after major abdominal surgery . SHOCK . vol. 29 , 64 - 64 .

Frith D, Chesebro B, Patel N, Thiemermann C, Brohi K, Cohen M, Pearse R ( 2008 ) . Towards a mouse model for acute coagulopathy of trauma/shock . SHOCK . vol. 29 , 6 - 6 .

McGinley A, Pearse RM ( 2007 ) . DeVita MA, Hillman K, Bellomo R (Eds): Medical Emergency Teams: Implementation and Outcome Measurement,1st edition. New York: Springer . Critical Care vol. 11 , ( 2 )

Pearse RM, Young JD ( 2007 ) . Steroids to prevent postextubation laryngeal oedema . Lancet vol. 369 , ( 9567 ) 1060 - 1061 .

Belsey J, Pearse R, Cole J, Bennet D ( 2007 ) . An individual patient meta-analysis of clinical trials using dopexamine to increase oxygen delivery in high-risk surgical patients . Critical Care vol. 11 , ( Suppl 2 )

Maddison B, Best T, Wolff C, Jones P, Hinds C, Pearse R ( 2007 ) . Transpulmonary lithium indicator dilution: a new method of intrathoracic blood volume measurement . Critical Care vol. 11 , ( Suppl 2 )

Pearse RM, Dawson D, Fawcett J, Rhodes A, Grounds RM, Bennett D ( 2007 ) . The incidence of myocardial injury following post-operative Goal Directed Therapy . BMC Cardiovasc Disord vol. 7 ,

Maddison B, Best T, Pearse RM ( 2007 ) . Extravascular Lung Water Measurement . Intensive Care Medicine , Springer Nature

Pearse RM, Harrison DA, James P, Watson D, Hinds C, Rhodes A, Grounds RM, Bennett ED ( 2006 ) . Identification and characterisation of the high-risk surgical population in the United Kingdom . Crit Care vol. 10 , ( 3 )

Collinson PO, Wort S, Bruce H, Rhodes A, Pearse R, Bennett ED ( 2006 ) . Plasma DNA concentration as a predictor of mortality and sepsis in general intensive care patients . CLINICAL CHEMISTRY . vol. 52 , A12 - A12 .

Pearse RM, Hinds CJ ( 2006 ) . Should we use central venous saturation to guide management in high-risk surgical patients? . Crit Care vol. 10 , ( 6 )

Pearse R, Dawson D, Fawcett J, Rhodes A, Grounds RM, Bennett ED ( 2005 ) . Changes in central venous saturation after major surgery, and association with outcome . Critical Care vol. 9 , ( 6 )

Pearse R, Dawson D, Fawcett J, Rhodes A, Grounds RM, Bennett ED ( 2005 ) . Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445] . Critical Care vol. 9 , ( 6 )

Bates CJ, Pearse R ( 2005 ) . Use of hydrogen peroxide vapour for environmental control during a Serratia outbreak in a neonatal intensive care unit . Journal of Hospital Infection vol. 61 , ( 4 ) 364 - 366 .

Pearse R, Dawson D, Fawcett J, Rhodes A, Grounds M, Bennnett D ( 2005 ) . Early goal directed therapy reduces morbidity and length of hospital stay following high-risk surgery . Critical Care vol. 9 , ( Suppl 1 )

Jin DK, Young LM, Vincent L, Gelbshtein U, Pekle K, Lam G, Shido K, Cho HJ et al. ( 2005 ) . Multimodular analysis of angiogenic biomarkers in the primary treatment of multiple myeloma: Correlative studies of the BiRD trial . BLOOD . vol. 106 , 972A - 972A .

Wort SJ, Rhodes A, Thomas H, Pearse R, Collinson P, Bennett ED ( 2005 ) . The role of plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients . THORAX . vol. 60 , II116 - II116 .

Pearse RM, Rhodes A, Grounds R ( 2004 ) . Clinical review: How to optimize management of high-risk surgical patients . Critical Care vol. 8 , ( 6 )

Pearse RM ( 2004 ) . Equipment review . Critical Care vol. 8 , ( 3 ) 193 - 195 .

Pearse RM, Ikram K, Barry J ( 2004 ) . Equipment review: An appraisal of the LiDCO™plus method of measuring cardiac output . Critical Care vol. 8 , ( 3 )

Pearse RM, Rhodes A ( 2004 ) . Haemodynamic monitoring and management of the circulation in intensive care . Surgery (Oxford) vol. 22 , ( 4 ) 88 - 93 .

Wort S, Rhodes A, Thomas H, Pearse R, Collinson P ( 2004 ) . Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients . Critical Care vol. 8 , ( Suppl 1 )

Pearse R, Dawson D, Fawcett J, Wort S, Rhodes A, Grounds R ( 2004 ) . The relationship between central venous saturation and outcome following high-risk surgery . Critical Care vol. 8 , ( Suppl 1 )

Pearse R, Wort S ( 2004 ) . Acute respiratory distress syndrome (ARDS) . Clinical Intensive Care vol. 15 , ( 1 ) 37 - 42 .

Pearse RM, Draper A, Grounds RM ( 2003 ) . Non-invasive ventilation to avoid tracheal intubation in a patient with Guillain-Barré syndrome . British Journal of Anaesthesia vol. 91 , ( 6 ) 913 - 916 .

R P, SJ W, M T, A R ( 2003 ) . Critical care clinical conundrums . Clinical Intensive Care vol. 14 , ( 3-4 ) 149 - 155 .

Pearse RM, Dawson D, Rhodes A, Grounds RM, Bennett ED ( 2003 ) . Low central venous saturation predicts post-operative mortality . INTENSIVE CARE MEDICINE . vol. 29 , S15 - S15 .

Dawson D, Pearse R, Rhodes A, Bennett D ( 2003 ) . Reliability of venous blood gas measurements in the recognition of the acutely ill patient . INTENSIVE CARE MEDICINE . vol. 29 , S178 - S178 .

Pearse RM, Dana EC, Lanigan CJ, Pook JAR ( 2002 ) . Organisational failures in urgent and emergency surgeryA potential peri‐operative risk factor . Anaesthesia vol. 56 , ( 7 ) 684 - 689 .

Pearse R, Rajakulendran Y ( 2001 ) . Pre‐operative fasting and administration of regular medications in adult patients presenting for elective surgery. Has the new evidence changed practice? . European Journal of Anaesthesiology vol. 16 , ( 8 ) 565 - 568 .

Pearse RM, Mitra AV, Heymann TD ( 1999 ) . What the SHO Really Does . Clinical Medicine vol. 33 , ( 6 ) 553 - 556 .

Pearse R, Rajakulendran Y ( 1999 ) . Pre-operative fasting and administration of regular medications in adult patients presenting for elective surgery. Has the new evidence changed practice? . European Journal of Anaesthesiology vol. 16 , ( 8 ) 565 - 568 .

Lee CN, Vasilakis C, Kearney D, Pearse R, Millard PH ( 1998 ) . An analysis of admission, discharge and bed occupancy of stroke patients aged 65 and over in English hospitals . Health Care Management Science vol. 1 , ( 2 ) 151 - 157 .

Cottee MA, Lee CN, Pearse R, MacKinnon A, Millard PH ( 1998 ) . The Value of Albert's Test and Line Bisection in Geriatric Patients . Age and Ageing vol. 27 , ( suppl_2 )

Kelly RI, Pearse R, Bull RH, Leveque J-L, de Rigal J, Mortimer PS ( 1995 ) . The effects of aging on the cutaneous microvasculature . Journal of the American Academy of Dermatology vol. 33 , ( 5 ) 749 - 756 .

Pearse R, MacMillan RL ( 1947 ) . Congenital Arteriovenous Aneurysm of the Renal Artery11Read at annual meeting, Western New York and Ontario Urological Society of the Central Section, American Urological Association, Alexandria Bay, N. Y., September 14, 1946 . Journal of Urology vol. 58 , ( 4 ) 235 - 238 .

PEARSE R ( 1945 ) . The problem of acidosis in urological patients . Transactions of the American Association of Genito-Urinary Surgeons vol. 37 , 283 - 289 .

Davies TW, Kelly E, Gassel RJV, de Poll MV, Gunst J, Casaer MP, Christopher KB, Preiser JC et al. . A systematic review and meta-analysis of the clinimetric properties of the core outcome measurement instruments for clinical effectiveness trials of nutritional and metabolic interventions in critical illness (CONCISE) .

Torrance HD, Zhang P, Longbottom ER, Mi Y, Whalley JP, Allcock A, Kwok AJ, Cano-Gamez E et al. . A transcriptomic approach to understand patient susceptibility to pneumonia after abdominal surgery .

McNelly A, Langan A, Bear DE, Page A, Martin T, Seidu F, Santos F, Rooney K et al. . Alternative Substrates in the Critically Ill Subject (ASICS): Safety, Feasibility, Tolerability and Metabolic Profiling of a Novel Ketogenic Feed .

Wan YI, Smuk M, Pearse RM, Paparini S, Apea VJ, Orkin CM . Clinical academics in the NHS: a cross-section study of research engagement during the monkeypox pandemic .

Davies T, Gassel RV, de Poll MV, Gunst J, Casaer M, Christopher K, Preiser JC, Hill A et al. . Core Outcome Measures for Clinical Effectiveness Trials of Nutritional and Metabolic Interventions in Critical Illness: An International Modified Delphi Consensus Study Evaluation (CONCISE) .

Davies T, Watson N, Pilkington J, McClelland T, Azzopardi G, Pearse R, Prowle J, Puthucheary Z . Creatine supplementation for optimisation of physical function in the patient at risk of functional disability: A systematic review and meta-analysis .

Yohannes T, Belachew FK, Derso D, Daniel S, Demelash A, Kifle K, Nora WT, Teko EB et al. . Critical care capacity in Africa: Post-pandemic ICU capacity, service readiness, and patient profiles across public and private hospitals in Ethiopia .

Savic LC, Dias P, Variale J, Begum S, Khan K, Fowler AJ, Kaura V, Watson S-L et al. . Drug allergy labels and complications after surgery: a prospective multi-centre cohort study .

Hewitt-Smith A, Bulamba F, Nanimambi J, Adong LR, Emacu B, Kabaleta M, Khanyalano J, Hussein MA et al. . Family supplemented patient monitoring after surgery (SMARTER): process evaluation of a complex intervention in Uganda .

Wan YI, Pearse RM, Prowle JR . Impact of acute hospitalisation on development of long-term disease and health inequality: a longitudinal population study .

Wan YI, Pearse RM, Prowle JR . Inequality in healthy lifespan following surgery: a longitudinal population study .

Nazeer S, Fowler AJ, Ahmad A, Stephens TJ, Wan YI, Sanders J, Prowle J, Pearse R et al. . Intersectional Influences on Non-Engagement Among Critical Care Survivors: A Prospective Cohort Study .

Nazeer S, Fowler AJ, Ahmed A, Stephens T, Wan Y, Sanders J, Prowle J, Pearse R et al. . Intersectional factors associated with non-engagement in follow-up care among critical care survivors: A retrospective cohort study .

Mazzinari G, Neto AS, Hemmes S, Hedenstierna G, Jaber S, Hiesmayr M, Hollmann M, Mills G et al. . Intraoperative Driving Pressure and Postoperative Pulmonary Complications After Abdominal Surgery – A Posthoc Propensity Score–Weighted Cohort Analysis of the LAS VEGAS Study Comparing Open to Closed Surgery .

Bloom BM, Maimaris C, Lecky F, Pearse R . Letter in Response to 'Classification of Traumatic Brain Injury Severity Using Informed Data Reduction in a Series of Binary Classifier Algorithms' . IEEE Trans Neural Syst Rehabil Eng vol. 24 , ( 5 ) 616 - 616 .

Fowler A, Prowle J, Abbott T, Harrison E, Gillies M, Cromwell D, Pearse R, Fowler A . Long-term outcomes for high-risk surgical patients in the UK: An epidemiological study . The Lancet Public Health

Investigators ACIOS, Bedwell GJ, Parker R, Madden VJ, Scribante J, Elhadi M, Ademuyiwa AO, Osinaike B et al. . One in seven has severe pain: A point-prevalence study of hospitalised patients across Africa .

Shaw SE, Hughes GL, Pearse R, Avagliano E, Day JR, Edsell ME, Edwards JA, Everest L et al. . Opportunities for shared decision-making about major surgery: findings from a multi-method qualitative study of decision-making about orthopaedic, colorectal and cardio thoracic surgery with high risk patients .

McClelland TJ, Fowler AJ, Davies T, Pearse R, Prowle J, Puthucheary Z . Pioglitazone for optimisation of clinical nutrition therapy in the critically ill patient: A Systematic Review .

del Arroyo AG, Abbott TEF, Patel A, Begum S, Dias P, Brealey D, Pearse RM, Kapil V et al. . Preoperative activation of the Renin–Angiotensin system and myocardial injury in noncardiac surgery: Post Hoc Analysis of the SPACE randomised controlled Trial .

Yeung J, Jhanji S, Braun J, Dunn J, Eggleston L, Frempong S, Hiller L, Jacques C et al. . Volatile vs Total intravenous Anaesthesia for major non-cardiac surgery: A pragmatic randomised triaL (VITAL) .

Ludwiczak A, Stephens T, Prowle J, Pearse R, Osman M . ‘Doing nothing’ is simply not an option: why framing of choices matters in surgical shared decision-making .