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  1. Queen Mary University of London
  2. Research
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Publications: P Ahmad Waseem

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Usman S, You Y, Waseem A ( 2025 ) . Exploring the Healing Powers of Histatins: From Oral Health to Therapeutics . International Journal of Molecular Sciences vol. 26 , ( 11 ) 5019 - 5019 .
Usman S, Waseem A, Teh MT, Tummala H, Ghaloum F, Yeudall WA ( 2024 ) . A single cysteine residue in vimentin regulates long non-coding RNA XIST to suppress epithelial-mesenchymal transition and stemness in breast cancer . eLife vol. 623301 ,
Jamal A, Usman S, Teh M-T, Waseem A ( 2024 ) . Preparation and Use of shRNA for Knocking Down Specific Genes . 55 - 72 .
Usman S, Bushaala A, Teh MT, Waseem A ( 2024 ) . Site-Directed Mutagenesis to Mutate Multiple Residues in a Single Reaction . 123 - 133 .
Khera N, Rajkumar AS, Abdulkader M Alkurdi K, Liu Z, Ma H, Waseem A, Teh M-T ( 2023 ) . Identification of multidrug chemoresistant genes in head and neck squamous cell carcinoma cells . Molecular Cancer vol. 22 , ( 1 ) Article 146 ,
Usman S, Jamal A, Bushaala A, Waseem NH, Al-Dehlawi H, Yeudall WA, Teh M-T, Tummala H et al. ( 2022 ) . Transcriptome Analysis Reveals Vimentin-Induced Disruption of Cell–Cell Associations Augments Breast Cancer Cell Migration . Cells vol. 11 , ( 24 ) 4035 - 4035 .
Usman S, Jamal A, Bushaala A, Waseem NH, Al-Dehlawi H, Yeudall A, Teh M-T, Tummala H et al. ( 2022 ) . Transcriptome analysis reveals vimentin-induced disruption of cell-cell associations augments cancer cell migration .
Usman S, Teh MT, Waseem A ( 2022 ) . Vimentin Mediated Downregulation of Intercelluar Associations Augments Cancer Cell Migration . https://www.per-iadr2020.com/docs/Abstract_Book.pdf . Conference: PER-IADR Oral Health Congress 2022 from: 17/09/2022 to: 15/09/2022 , 160 - 160 .
Usman S, Aldehlawi H, Nguyen TKN, Teh M-T, Waseem A ( 2022 ) . Impact of N-Terminal Tags on De Novo Vimentin Intermediate Filament Assembly . International Journal of Molecular Sciences vol. 23 , ( 11 ) 6349 - 6349 .
Teh M-T, Ma H, Liang Y-Y, Solomon MC, Chaurasia A, Patil R, Tekade SA, Mishra D et al. ( 2022 ) . Molecular Signatures of Tumour and Its Microenvironment for Precise Quantitative Diagnosis of Oral Squamous Cell Carcinoma: An International Multi-Cohort Diagnostic Validation Study . Cancers vol. 14 , ( 6 ) 1389 - 1389 .
Teh M-T, Ma H, Liang Y-Y, Solomon MC, Chaurasia A, Patil R, Tekade SA, Mishra D et al. ( 2022 ) . Molecular Signatures of Tumour and Its Microenvironment for Precise Quantitative Diagnosis of Oral Squamous Cell Carcinoma: An International Multi-Cohort Diagnostic Validation Study . CANCERS vol. 14 , ( 6 ) Article ARTN 1389 ,
Usman S, Teh MT, Waseem A ( 2021 ) . Free Head Domain of Vimentin Is Crucial For Filament Assembly . Conference: Cell Bio Virtual 2021 EMBO Meeting American Society of Cell Biology from: 10/12/2021 to: 01/12/2021 ,
Usman S, Waseem NH, Nguyen TKN, Mohsin S, Jamal A, Teh M-T, Waseem A ( 2021 ) . Vimentin Is at the Heart of Epithelial Mesenchymal Transition (EMT) Mediated Metastasis . Cancers vol. 13 , ( 19 ) 4985 - 4985 .
Laly AC, Sliogeryte K, Pundel OJ, Ross R, Keeling MC, Avisetti D, Waseem A, Gavara N et al. ( 2021 ) . The keratin network of intermediate filaments regulates keratinocyte rigidity sensing and nuclear mechanotransduction . Science Advances vol. 7 , ( 5 ) Article eabd6187 ,
Usman S, Jamal A, Teh M-T, Waseem A ( 2021 ) . Major Molecular Signaling Pathways in Oral Cancer Associated With Therapeutic Resistance . Frontiers in Oral Health vol. 1 , Article 603160 ,
Lalli A, Aldehlawi H, Buchanan JAG, Seoudi N, Fortune F, Waseem A ( 2021 ) . Screening for oral cancer utilising risk-factor analysis is ineffective in high-risk populations . British Journal of Oral and Maxillofacial Surgery vol. 59 , ( 1 ) e17 - e22 .
Waseem NH, Low S, Shah AZ, Avisetti D, Ostergaard P, Simpson M, Niemiec KA, Martin-Martin B et al. ( 2020 ) . Mutations in SPATA13/ASEF2 cause primary angle closure glaucoma . PLOS Genetics vol. 16 , ( 4 ) e1008721 - e1008721 .
Aldehlawi H, Usman S, Lalli A, Ahmad F, Williams G, Teh M-T, Waseem A ( 2020 ) . Serum lipids, retinoic acid and phenol red differentially regulate expression of keratins K1, K10 and K2 in cultured keratinocytes . Scientific Reports vol. 10 , ( 1 ) Article 4829 ,
Haider A, Waseem A, Karpukhina N, Mohsin S ( 2020 ) . Strontium- and Zinc-Containing Bioactive Glass and Alginates Scaffolds . Bioengineering vol. 7 , ( 1 ) 10 - 10 .
Stephanie Yeung J-Y, Teh M-T, Hutchison I, Waseem A ( 2019 ) . qMIDS: A Digital Diagnostic Test for Oral Cancer . British Journal of Oral and Maxillofacial Surgery vol. 57 , ( 10 ) e86 - e87 .
Qadir F, Lalli A, Dar HH, Hwang S, Aldehlawi H, Ma H, Dai H, Waseem A et al. ( 2019 ) . Clinical correlation of opposing molecular signatures in head and neck squamous cell carcinoma . BMC Cancer vol. 19 , ( 1 ) Article 830 ,
Aldehlawi H, Niemiec KA, Avisetti DR, Lalli A, Teh M-T, Waseem A ( 2019 ) . The monoclonal antibody EPR1614Y against the stem cell biomarker keratin K15 lacks specificity and reacts with other keratins . Scientific Reports vol. 9 , ( 1 ) Article 1943 ,
Qadir F, Aziz MA, Sari CP, Ma H, Dai H, Wang X, Raithatha D, Da Silva LGL et al. ( 2018 ) . Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation . MOLECULAR CANCER vol. 17 , Article ARTN 97 ,
Maruthappu T, Chikh A, Fell B, Delaney PJ, Brooke MA, Levet C, Moncada-Pazos A, Ishida-Yamamoto A et al. ( 2017 ) . Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16 . Nature Communications vol. 8 , ( 1 ) Article 14174 ,
Nguyen NT, Mackenzie I, Teh M, Waseem A ( 2015 ) . HOXA7 suppresses keratinocyte differentiation via PKC/AP-1 pathway . MOLECULAR BIOLOGY OF THE CELL . vol. 26 ,
Hwang S, Mahadevan S, Qadir F, Hutchison IL, Costea DE, Neppelberg E, Liavaag PG, Waseem A et al. ( 2013 ) . Identification of FOXM1‐induced epigenetic markers for head and neck squamous cell carcinomas . Cancer vol. 119 , ( 24 ) 4249 - 4258 .
Bose A, Teh M-T, Mackenzie I, Waseem A ( 2013 ) . Keratin K15 as a Biomarker of Epidermal Stem Cells . International Journal of Molecular Sciences vol. 14 , ( 10 ) 19385 - 19398 .
( 2013 ) . Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation . Oncogene vol. 33 , ( 18 ) 2363 - 2374 .
( 2012 ) . Exploiting FOXM1‐orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis . International Journal of Cancer vol. 132 , ( 9 ) 2095 - 2106 .
( 2012 ) . Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling . PLoS ONE vol. 7 , ( 6 ) e38599 - e38599 .
Teh M-T, Gemenetzidis E, Patel D, Tariq R, Nadir A, Bahta AW, Waseem A, Hutchison IL ( 2012 ) . FOXM1 Induces a Global Methylation Signature That Mimics the Cancer Epigenome in Head and Neck Squamous Cell Carcinoma . PLoS ONE vol. 7 , ( 3 ) e34329 - e34329 .
Pitiyage GN, Lim KP, Gemenitzidis E, Teh M, Waseem A, Prime SS, Tilakaratne WM, Fortune F et al. ( 2012 ) . Increased secretion of tissue inhibitors of metalloproteinases 1 and 2 (TIMPs ‐1 and ‐2) in fibroblasts are early indictors of oral sub‐mucous fibrosis and ageing . Journal of Oral Pathology & Medicine vol. 41 , ( 6 ) 454 - 462 .
( 2011 ) . Correction: Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1 . Cancer Research vol. 71 , ( 1 ) 290 - 290 .
( 2010 ) . Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1 . CANCER RES vol. 70 , ( 22 ) 9515 - 9526 .
Waseem A, Ali M, Odell EW, Fortune F, Teh MT ( 2010 ) . Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma . ORAL ONCOL vol. 46 , ( 7 ) 536 - 542 .
Waseem A, Leigh IM ( 2010 ) . The Skin . Wiley
Collier J, Waseem A, Farthing P ( 2009 ) . The chemokine receptor CXCR4 demonstrates several features of a cancer stem cell marker in OSCC . British Journal of Oral and Maxillofacial Surgery vol. 47 , ( 7 ) e68 - e68 .
( 2009 ) . FOXM1 Upregulation Is an Early Event in Human Squamous Cell Carcinoma and it Is Enhanced by Nicotine during Malignant Transformation . PLOS ONE vol. 4 , ( 3 ) Article e4849 ,
Paccione RJ, Miyazaki H, Patel V, Waseem A, Gutkind JS, Zehner ZE, Yeudall WA ( 2008 ) . Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility . Molecular Cancer Therapeutics vol. 7 , ( 9 ) 2894 - 2903 .
Teh MT, Tilakaratne WM, Chaplin T, Young BD, Ariyawardana A, Pitiyage G, Lalli A, Stewart JE et al. ( 2008 ) . Fingerprinting genomic instability in oral submucous fibrosis . J ORAL PATHOL MED vol. 37 , ( 7 ) 430 - 436 .
Tilakaratne WM, Iqbal Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Stewart JE, Hagi-Pavli E et al. ( 2008 ) . Upregulation of HIF-1 alpha in malignant transformation of oral submucous fibrosis . J ORAL PATHOL MED vol. 37 , ( 6 ) 372 - 377 .
Lalli A, Tilakaratne WM, Ariyawardana A, Fitchett C, Leigh IM, Hagi-Pavli E, Cruchley AT, Parkinson EK et al. ( 2008 ) . An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity . J ORAL PATHOL MED vol. 37 , ( 4 ) 211 - 220 .
KÖSE O, WASEEM A ( 2008 ) . Keloids and Hypertrophic Scars . Dermatologic Surgery vol. 34 , ( 3 ) 336 - 346 .
Kose O, Waseem A ( 2008 ) . Keloids and hypertrophic scars: Are they two different sides of the same coin? . DERMATOL SURG vol. 34 , ( 3 ) 336 - 346 .
Fu L, Suen CKM, Waseem A, White KN ( 2008 ) . Variable requirement for splicing signals for nucleocytoplasmic export of mRNAs . IUBMB Life vol. 42 , ( 2 ) 329 - 337 .
Kose O, Stewart J, Waseem A, Lalli A, Fortune F ( 2007 ) . Expression of cytokeratins, adhesion and activation molecules in oral ulcers of Behçet's disease . Clinical and Experimental Dermatology vol. 0 , ( 0 ) 071106211831010 - ??? .
Collier JM, Waseem A, Farthing P ( 2007 ) . Characterisation of chemokine receptor expression by oral squamous cell carcinoma cells in vitro . British Journal of Oral and Maxillofacial Surgery vol. 45 , ( 7 ) e3 - e3 .
Collier JM, Waseem A, Farthing P ( 2007 ) . Overexpression of the chemokine receptor CXCR4 is associated with lymph node metastasis in patients with HNSCC . British Journal of Oral and Maxillofacial Surgery vol. 45 , ( 7 ) e60 - e60 .
Collier JM, Waseem A, Adegun O, Farthing P ( 2007 ) . Overexpression of the chemokine receptor CXCR4 results in an aggressive OSCC tumour phenotype in vitro . British Journal of Oral and Maxillofacial Surgery vol. 45 , ( 7 ) e3 - e3 .
Tilakaratne W, Iqbal Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Hagi-Pavli E, Lalli A et al. ( 2007 ) . P245 Up regulation of HIF-1a in the progression and malignant transformation of oral submucous fibrosis . Oral Oncology Supplement vol. 2 , ( 1 ) 204 - 205 .
Köse O, Lalli A, Kutulola AO, Odell EW, Waseem A ( 2007 ) . Changes in the expression of stem cell markers in oral lichen planus and hyperkeratotic lesions . Journal of Oral Science vol. 49 , ( 2 ) 133 - 139 .
Tilakaratne W, Iqball Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Hagi-Pavli E, Lalli A et al. ( 2007 ) . Up regulation of HIF-1α in the progression and malignant transformation of oral submucous fibrosis . ORAL ONCOLOGY . 204 - 205 .
Su L, Morgan PR, Harrison DL, Waseem A, Lane EB ( 2005 ) . Expression of keratin mRNAS and proteins in normal salivary epithelia and pleomorphic adenomas . The Journal of Pathology vol. 171 , ( 3 ) 173 - 181 .
WASEEM A, PALFREY HC ( 2005 ) . Erythrocyte adducin . European Journal of Biochemistry vol. 178 , ( 2 ) 563 - 573 .
Radoja N, Stojadinovic O, Waseem A, Tomic-Canic M, Milisavljevic V, Teebor S, Blumenberg M ( 2004 ) . Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription . MOL CELL BIOL vol. 24 , ( 8 ) 3168 - 3179 .
Waseem A, Karsten U, Leigh IM, Purkis P, Waseem NH, Lane EB ( 2004 ) . Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability . BIOCHEMISTRY-US vol. 43 , ( 5 ) 1283 - 1295 .
Bowen SL, Bloor BK, Leigh IM, Waseem A ( 2003 ) . Adducin expression in cutaneous and oral lesions: alpha- and beta-adducin transcripts down-regulate with keratinocyte differentiation in stratified epithelia . J PATHOL vol. 201 , ( 1 ) 119 - 126 .
Bloor BK, Tidman N, Leigh IM, Odell E, Dogan B, Wollina U, Ghali L, Waseem A ( 2003 ) . Expression of keratin K2e in cutaneous and oral lesions - Association with keratinocyte activation, proliferation, and keratinization . AM J PATHOL vol. 162 , ( 3 ) 963 - 975 .
Bloor BK, Tidman N, Leigh IM, Odell E, Dogan B, Wollina U, Ghali L, Waseem A ( 2003 ) . Expression of keratin K2e in cutaneous and oral lesions: Association with keratinocyte activation, proliferation, and keratinization . American Journal of Pathology vol. 162 , ( 3 ) 963 - 975 .
Ditzel HJ, Strik MCM, Larsen MK, Willis AC, Waseem A, Kejling K, Jensenius JC ( 2002 ) . Cancer-associated cleavage of cytokeratin 8/18 heterotypic complexes exposes a neoepitope in human adenocarcinomas . J BIOL CHEM vol. 277 , ( 24 ) 21712 - 21722 .
Ola A, Waga S, Ellison V, Stillman B, McGurk M, Leigh IM, Waseem NH, Waseem A ( 2001 ) . Human-Saccharomyces cerevisiae proliferating cell nuclear antigen hybrids - Oligomeric structure and functional characterization using in vitro DNA replication . J BIOL CHEM vol. 276 , ( 13 ) 10168 - 10177 .
Waseem A, Alam Y, Lalli A, Dogan B, Tidman N, Purkis P, Jackson S, Machesney M et al. ( 1999 ) . Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes . Journal of Investigative Dermatology vol. 112 , ( 3 ) 362 - 369 .
( 1998 ) . Erratum . Gene vol. 221 , ( 2 ) 287 - 287 .
Waseem A, Alam Y, Dogan B, White KN, Leigh IM, Waseem NH ( 1998 ) . Isolation, sequence and expression of the gene encoding human keratin 13 . Gene vol. 215 , ( 2 ) 269 - 279 .
Machesney M, Tidman N, Waseem A, Kirby L, Leigh I ( 1998 ) . Activated keratinocytes in the epidermis of hypertrophic scars . American Journal of Pathology vol. 152 , ( 5 ) 1133 - 1141 .
Waseem A, White K, Waseem NH ( 1997 ) . Identification of a novel keratin epitope: Evidence for association between non-helical sub-domains L12 during filament assembly . The International Journal of Biochemistry & Cell Biology vol. 29 , ( 7 ) 971 - 983 .
Waseem A, Lane EB, Harrison D, Waseem N ( 1996 ) . A Keratin Antibody Recognizing a Heterotypic Complex: Epitope Mapping to Complementary Locations on Both Components of the Complex . Experimental Cell Research vol. 223 , ( 2 ) 203 - 214 .
Waseem A, Alexander CM, Steel JB, Lane EB ( 1990 ) . Embryonic simple epithelial keratins 8 and 18: Chromosomal location emphasizes difference from other keratin pairs . New Biologist vol. 2 , ( 5 ) 464 - 478 .
Waseem A, Gough AC, Spurr NK, Lane EB ( 1990 ) . Localization of the gene for human simple epithelial keratin 18 to chromosome 12 using polymerase chain reaction . Genomics vol. 7 , ( 2 ) 188 - 194 .
Waseem A, Palfrey HC ( 1990 ) . Identification and protein kinase c-dependent phosphorylation of <i>α</i>-adducin in human fibroblasts . Journal of Cell Science vol. 96 , ( 1 ) 93 - 98 .
Rogalski AA, Steck TL, Waseem A ( 1989 ) . Association of Glyceraldehyde-3-phosphate Dehydrogenase with the Plasma Membrane of the Intact Human Red Blood Cell . Journal of Biological Chemistry vol. 264 , ( 11 ) 6438 - 6446 .
Waseem A, Steck TL ( 1989 ) . [33] Protein associations with band 3 at cytoplasmic surface of human erythrocyte membrane . 513 - 519 .
Palfrey HC, Waseem A ( 1988 ) . Protein kinase C and its associated substrates in the human erythrocyte . Society of General Physiologists Series vol. 43 , 357 - 369 .
Waseem A, Anwar K ( 1987 ) . Glycoprotein - concanavalin A interaction: Role of protein conformation in the specific interaction of glycoprotein with concanavalin A . Biomedica Biochimica Acta vol. 46 , ( 1 ) 23 - 32 .
Palfrey HC, Waseem A ( 1985 ) . Protein kinase C in the human erythrocyte. Translocation to the plasma membrane and phosphorylation of bands 4.1 and 4.9 and other membrane proteins . Journal of Biological Chemistry vol. 260 , ( 29 ) 16021 - 16029 .
Salahuddin A, Waseem A ( 1984 ) . Functional properties of divalent derivatives of concanavalin A . Indian Journal of Biochemistry and Biophysics vol. 21 , ( 2 ) 93 - 98 .
Waseem A, Salahuddin A ( 1983 ) . Relevance of hydrophobic interactions in specific binding of multivalent ligands to Concanavalin A--effect of organic solvents . Indian Journal of Biochemistry and Biophysics vol. 20 , ( 5 ) 253 - 258 .
Waseem A, Salahuddin A ( 1983 ) . Anomalous temperature-dependence of the specific interaction of concanavalin A with a multivalent ligand-dextran . Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology vol. 746 , ( 1-2 ) 65 - 71 .
Salahuddin A, Waseem A, Khan MY, Qasim MA, Sibghatullah ( 1983 ) . A possible relation between the salting-out behaviour of proteins & their surface hydrophobicity . Indian Journal of Biochemistry and Biophysics vol. 20 , ( 3 ) 127 - 131 .
Bano B, Garg M, Waseem A ( 1983 ) . Solubility of buffalo fibrinogen in concentrated ammonium sulphate solution . Indian Journal of Biochemistry and Biophysics vol. 20 , ( 1 ) 43 - 45 .
Waseem A, Salahuddin A ( 1980 ) . Influence of ionic strength on the interaction of concanavalin A with dextran . Indian Journal of Biochemistry and Biophysics vol. 17 , ( 4 )
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