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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: DR Hong Wan

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( 2023 ) . Comparative Transcriptome Analysis Identifies Desmoglein-3 as a Potential Oncogene in Oral Cancer Cells . Cells vol. 12 , ( 23 ) 2710 - 2710 .
( 2023 ) . Comparative Transcriptome Analysis Identifies Desmoglein-3 as a Potential Oncogene in ORAL Cancer .
( 2022 ) . The Regulation of the Hippo Pathway by Intercellular Junction Proteins . Life vol. 12 , ( 11 ) 1792 - 1792 .
( 2022 ) . Extracellular Prostaglandins E1 and E2 and Inflammatory Cytokines Are Regulated by the Senescence Program in Potentially Premalignant Oral Keratinocytes . Cancers vol. 14 , ( 11 ) 2636 - 2636 .
( 2022 ) . YAP Inhibition by Verteporfin Causes Downregulation of Desmosomal Genes and Proteins Leading to the Disintegration of Intercellular Junctions . Life vol. 12 , ( 6 ) 792 - 792 .
( 2022 ) . Extracellular prostaglandins E1 and E2 and inflammatory cytokines are regulated by the senescence program in potentially premalignant oral keratinocytes .
( 2022 ) . Desmoglein‐3 induces YAP phosphorylation and inactivation during collective migration of oral carcinoma cells . Molecular Oncology vol. 16 , ( 8 ) 1625 - 1649 .
( 2022 ) . Oxidative stress-mediated yes-associated protein dysregulation contributes to the pathogenesis of pemphigus vulgaris . BRITISH JOURNAL OF DERMATOLOGY . vol. 187 , E43 - E44 .
( 2021 ) . Evolving Mechanisms in the Pathophysiology of Pemphigus Vulgaris: A Review Emphasizing the Role of Desmoglein 3 in Regulating p53 and the Yes-Associated Protein . Life vol. 11 , ( 7 ) 621 - 621 .
( 2021 ) . Oxidative Stress-Mediated YAP Dysregulation Contributes to the Pathogenesis of Pemphigus Vulgaris . Frontiers in Immunology vol. 12 , Article 649502 ,
( 2021 ) . The role of YAP in the control of the metastatic potential of oral cancer . Oncology Research vol. 29 , ( 6 ) 377 - 391 .
( 2020 ) . A novel regulatory pathway of Desmoglein-3 in keratinocyte stress response . Journal of Cellular Signaling vol. 1 , ( 4 ) 169 - 179 .
( 2020 ) . Induction of p53 in keratinocyte cultures treated with Behçet's patient sera . Journal of Oral Pathology & Medicine vol. 49 , ( 5 ) 435 - 442 .
( 2019 ) . Evidence for the Desmosomal Cadherin Desmoglein-3 in Regulating YAP and Phospho-YAP in Keratinocyte Responses to Mechanical Forces . International Journal of Molecular Sciences vol. 20 , ( 24 ) 6221 - 6221 .
( 2019 ) . Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells . Mechanisms of Ageing and Development vol. 184 , Article 111174 , 111174 - 111174 .
( 2019 ) . The desmosomal cadherin Desmoglein-3 regulates YAP and phospho-YAP in keratinocyte responses to mechanical forces .
( 2019 ) . The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53 . Cell Death & Disease vol. 10 , ( 10 ) Article 750 ,
( 2018 ) . Desmoglein 3 – Influence on oral carcinoma cell migration and invasion . Experimental Cell Research vol. 370 , ( 2 ) 353 - 364 .
( 2018 ) . The <i>Pemphigus Vulgaris</i> antigen desmoglein-3 suppresses p53 function via the YAP-Hippo pathway .
( 2018 ) . D2 . Encyclopedia of Signaling Molecules , Springer International Publishing
( 2018 ) . Desmoglein-3 . Encyclopedia of Signaling Molecules , Springer International Publishing
( 2018 ) . 1347 Desmoglein-3 acts as an anti-stress protein via suppression of p53 . Journal of Investigative Dermatology vol. 138 , ( 5 ) S229 - S229 .
( 2018 ) . 858 Desmoglein 3 acts as a mechanosensor in keratinocytes . Journal of Investigative Dermatology . vol. 138 , S146 - S146 .
( 2018 ) . Anchoring Junctions in the Oral Mucosa: Adherens Junctions and Desmosomes . Oral Mucosa in Health and Disease , Springer International Publishing
( 2018 ) . Cell-Cell Interactions in the Oral Mucosa: Tight Junctions and Gap Junctions . Oral Mucosa in Health and Disease , Springer International Publishing
( 2018 ) . Desmoglein-3 acts as an anti-stress protein via suppression of p53 . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 138 , S229 - S229 .
( 2018 ) . Evidence for desmoglein 3 as a mechanosensor in keratinocytes . BRITISH JOURNAL OF DERMATOLOGY . vol. 178 , E406 - E407 .
( 2018 ) . Novel role of desmoglein-3 acting as a negative regulator of p53 . BRITISH JOURNAL OF DERMATOLOGY . vol. 178 , E417 - E418 .
( 2016 ) . Desmoglein-3 . Encyclopedia of Signaling Molecules , Springer New York
( 2016 ) . Independent evaluation of a FOXM1-based quantitative malignancy diagnostic system (qMIDS) on head and neck squamous cell carcinomas . Oncotarget vol. 7 , ( 34 ) 54555 - 54563 .
( 2016 ) . Desmoglein 3 regulates membrane trafficking of cadherins, an implication in cell-cell adhesion . Cell Adhesion &amp; Migration vol. 11 , ( 3 ) 211 - 232 .
( 2016 ) . Evidence for Dsg3 in regulating Src signaling by competing with it for binding to caveolin-1 . Data in Brief vol. 6 , 124 - 134 .
( 2016 ) . Desmoglein 3 acts as a potential oncogene in promoting cancer cell migration and invasion through regulating AP-1 and PKC dependent-Ezrin activation . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 65 - 66 .
( 2015 ) . Desmoglein 3: A Help or a Hindrance in Cancer Progression? . Cancers vol. 7 , ( 1 ) 266 - 286 .
( 2015 ) . Desmoglein 3: a help or a hindrance in cancer progression? . Cancers vol. Cancers 2015 , ( 7 ) 266 - 286 .
( 2014 ) . DESMOGLEIN 3 ACTS AS A MECHANOSENSOR IN RESPONSE TO ENVIRONMENTAL MECHANICAL PROPERTY . ANTICANCER RESEARCH vol. 34 , ( 10 ) 6238 - 6238 .
( 2014 ) . Role for Desmoglein 3 in regulating E-cadherin trafficking . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 134 , S29 - S29 .
( 2013 ) . Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation . Oncogene vol. 33 , ( 18 ) 2363 - 2374 .
( 2012 ) . Desmoglein 3 acting as an upstream regulator of Rho GTPases, Rac-1/Cdc42 in the regulation of actin organisation and dynamics . Experimental Cell Research vol. 318 , ( 18 ) 2269 - 2283 .
( 2012 ) . Exploiting FOXM1‐orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis . International Journal of Cancer vol. 132 , ( 9 ) 2095 - 2106 .
( 2012 ) . 187 Desmoglein 3 Regulates Cancer Cell Migration Through PKC Dependent-ezrin Activation . European Journal of Cancer . vol. 48 , S45 - S46 .
( 2012 ) . Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling . PLoS ONE vol. 7 , ( 6 ) e38599 - e38599 .
( 2012 ) . Non‐junctional human desmoglein 3 acts as an upstream regulator of Src in E‐cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris . The Journal of Pathology vol. 227 , ( 1 ) 81 - 93 .
( 2012 ) . Desmoglein 3 regulates cancer cell migration through Protein Kinase C dependent-ezrin activation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S37 - S37 .
( 2011 ) . RNAi-mediated inhibition of the desmosomal cadherin (desmoglein 3) impairs epithelial cell proliferation . Cell Proliferation vol. 44 , ( 4 ) 301 - 310 .
( 2011 ) . Correction: Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1 . Cancer Research vol. 71 , ( 1 ) 290 - 290 .
( 2011 ) . A molecular study of desmosomes identifies a desmoglein isoform switch in head and neck squamous cell carcinoma . J ORAL PATHOL MED vol. 40 , ( 1 ) 67 - 76 .
( 2010 ) . Desmoglein 3, via an Interaction with E-cadherin, Is Associated with Activation of Src . PLOS ONE vol. 5 , ( 12 ) Article e14211 ,
( 2010 ) . Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1 . CANCER RES vol. 70 , ( 22 ) 9515 - 9526 .
( 2010 ) . Identification and characterization of DSPIa, a novel isoform of human desmoplakin . Cell and Tissue Research vol. 341 , ( 1 ) 121 - 129 .
( 2010 ) . Identification and characterisation of DSPla, a novel isoform of human desmoplakin . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 130 , S16 - S16 .
( 2010 ) . Novel role for human desmoglein 3 in regulating E-cadherin mediated adherens junctions through Src family kinase activation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 130 , S33 - S33 .
( 2009 ) . FOXM1 Upregulation Is an Early Event in Human Squamous Cell Carcinoma and it Is Enhanced by Nicotine during Malignant Transformation . PLOS ONE vol. 4 , ( 3 ) Article e4849 ,
( 2009 ) . Class specific inhibition of house dust mite proteinases which cleave cell adhesion, induce cell death and which increase the permeability of lung epithelium . British Journal of Pharmacology vol. 124 , ( 6 ) 1048 - 1059 .
( 2008 ) . The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of <i>Dermatophagoides pteronyssinus</i> . Clinical &amp; Experimental Allergy vol. 31 , ( 2 ) 279 - 294 .
( 2007 ) . Increased keratinocyte proliferation initiated through downregulation of desmoplakin by RNA interference . EXP CELL RES vol. 313 , ( 11 ) 2336 - 2344 .
( 2007 ) . Stem/progenitor cell-like properties of Desmoglein 3dim cells in primary and immortalized keratinocyte lines . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 127 , S66 - S66 .
( 2007 ) . Stem/progenitor cell-like properties of desmoglein 3(dim) cells in primary and immortalized keratinocyte lines . STEM CELLS vol. 25 , ( 5 ) 1286 - 1297 .
( 2005 ) . Specific downregulation of Desmoglein 3 by RNA interference in HaCaT keratinocyte cells causes decreased cell proliferation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 124 , A29 - A29 .
( 2005 ) . Downregulation of desmoplakin by RNA interference in HaCaT cells results in increased cellular proliferation . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 834 - 834 .
( 2005 ) . Generation of stable knockdown in keratinocyte cell lines using retrovirus-mediated RNA interference . BRITISH JOURNAL OF DERMATOLOGY . vol. 152 , 846 - 846 .
( 2004 ) . Striate palmoplantar keratoderma arising from desmoplakin and desmoglein 1 mutations is associated with contrasting perturbations of desmosomes and the keratin filament network . British Journal of Dermatology vol. 150 , ( 5 ) 878 - 891 .
( 2004 ) . Striate palmoplantar keratoderma arising from desmoplakin and desmoglein 1 mutations is associated with contrasting perturbations of desmosomes and the keratin filament network . BRITISH JOURNAL OF DERMATOLOGY vol. 150 , ( 5 ) 878 - 891 .
( 2003 ) . Desmosomal proteins, including desmoglein 3, serve as novel negative markers for epidermal stem cell-containing population of keratinocytes . Journal of Cell Science vol. 116 , ( 20 ) 4239 - 4248 .
( 2003 ) . Desmosomes exhibit site‐specific features in human palm skin . Experimental Dermatology vol. 12 , ( 4 ) 378 - 388 .
( 2003 ) . Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability . Journal of Cell Science vol. 116 , ( 16 ) 3303 - 3314 .
( 2002 ) . Frameshift Mutation in the V2 Domain of Human Keratin 1 Results in Striate Palmoplantar Keratoderma . Journal of Investigative Dermatology vol. 118 , ( 5 ) 838 - 844 .
( 2002 ) . Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1) . Human Molecular Genetics vol. 11 , ( 7 ) 833 - 840 .
( 2002 ) . Compound Heterozygosity for Non-Sense and Mis-Sense Mutations in Desmoplakin Underlies Skin Fragility/Woolly Hair Syndrome . Journal of Investigative Dermatology vol. 118 , ( 2 ) 232 - 238 .
( 2002 ) . Diversity of desmoplakin expression in basal palm keratinocytes: A possible clue to the identification of epidermal stem cells . JOURNAL OF INVESTIGATIVE DERMATOLOGY vol. 119 , ( 3 ) 714 - 714 .
( 2002 ) . Lack of plakophilin-1 reduces calcium stability of membrane bound desmosomal components . JOURNAL OF INVESTIGATIVE DERMATOLOGY vol. 119 , ( 1 ) 226 - 226 .
( 2001 ) . Epithelial repair in asthma. Do the benefits of house dust mite avoidance result from proteinase avoidance? . Clinical &amp; Experimental Allergy vol. 28 , ( 5 ) 530 - 533 .
( 2001 ) . Quantitative structural and biochemical analyses of tight junction dynamics following exposure of epithelial cells to house dust mite allergen Der p 1 . Clinical &amp; Experimental Allergy vol. 30 , ( 5 ) 685 - 698 .
( 2001 ) . Response by Robinson, Wan and Winton . Clinical & Experimental Allergy vol. 29 , ( 2 ) 281 - 282 .
( 2001 ) . The 18‐kDa form of cat allergen <i>Felis domesticus</i> 1 (Fel d 1) is associated with gelatin‐ and fibronectin‐degrading activity . Clinical &amp; Experimental Allergy vol. 30 , ( 8 ) 1085 - 1096 .
( 2001 ) . Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli . Nature Medicine vol. 7 , ( 7 ) 801 - 806 .
( 2001 ) . Desmosomes exhibit site-specific features in human palm skin . JOURNAL OF INVESTIGATIVE DERMATOLOGY vol. 117 , ( 3 ) 789 - 789 .
( 2001 ) . Frameshift mutation in the V2 domain of keratin I causes the striate form of palmoplantar keratoderma . JOURNAL OF INVESTIGATIVE DERMATOLOGY vol. 117 , ( 3 ) 766 - 766 .
( 2000 ) . Tight junction properties of the immortalized human bronchial epithelial cell lines Calu‐3 and 16HBE14o‐ . European Respiratory Journal vol. 15 , ( 6 ) 1058 - 1058 .
( 1999 ) . Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions . J CLIN INVEST vol. 104 , ( 1 ) 123 - 133 .
( 1999 ) . Cleavage of occludin by Der P 1 facilitates transepithelial permeation of allergen . AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE vol. 159 , ( 3 ) A856 - A856 .
( 1999 ) . Proteinase Allergens of House Dust Mites: Molecular Biology, Biochemistry and Possible Functional Significance of Their Enzyme Activity . Molecular Biology of the Lung , Birkhäuser Basel
( 1998 ) . Cell lines of pulmonary and non-pulmonary origin as tools to study the effects of house dust mite proteinases on the regulation of epithelial permeability . CLIN EXP ALLERGY vol. 28 , ( 10 ) 1273 - 1285 .
( 1998 ) . Quantitative Immunocytochemistry of Proteins Using 2- Photon Microscopy and Digital Image Analysis . Microscopy and Microanalysis vol. 4 , ( S2 ) 416 - 417 .
( 1997 ) . A study of cell behaviour on the surfaces of multifilament materials . J MATER SCI-MATER M vol. 8 , ( 1 ) 45 - 51 .
( 1994 ) . THE CYTOTOXICITY EVALUATION OF KEVLAR AND SILICON-CARBIDE BY MTT ASSAY . JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE vol. 5 , ( 6-7 ) 441 - 445 .
( 1994 ) . A study of the reproducibility of the MTT test . Journal of Materials Science: Materials in Medicine vol. 5 , ( 3 ) 154 - 159 .
. Desmoglein 3 regulation of E-cadherin adhesion through Src . Journal of Investigative Dermatology .
. Evidence of a novel role for human desmoglein 3 in the regulation of actin organisation through activation of ezrin-Thr 567 .
. House-Dust Mite Protei Nase Allergens and Their Interaction with the Bronchial Epithelium . Asthma and Rhinitis , Blackwell Science Ltd
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