Publications: PROF Daniel Pennington

Patel A, Sumaria N, Thomson J, Peleva E, Qamar M, Taggart E, Pennington D, Harwood C et al. ( 2025 ) . 386 Single cell and spatial transcriptomics analyses reveal immune mechanisms associated with progression and metastasis in cutaneous squamous cell carcinoma . Journal of Investigative Dermatology vol. 145 , ( 12 )

Sánchez-Lanzas R, Jiménez-Pompa A, Smith E, Sumaria N, Kalampalika F, Barclay J, Pennington D, Efremova M et al. ( 2025 ) . 3208 – CELL-TO-CELL INTERACTION RECORDING AND IDENTIFICATION OF CELLULAR INTERACTOMES THAT SUPPORT T CELLS IN THE THYMUS . Experimental Hematology vol. 151 ,

Gelmetti M, Tomas I, Ragazzini R, Cautela M, Campinoti S, Torre M, Bonfanti P ( 2024 ) . 010 Keratin 76 expression in Thymic Epithelial Cells is Necessary for Skin T cell Tolerance . Journal of Investigative Dermatology vol. 144 , ( 12 )

Wiesheu R, Edwards SC, Hedley A, Hall H, Tosolini M, Fares da Silva MGF, Sumaria N, Castenmiller SM et al. ( 2024 ) . IL-27 maintains cytotoxic Ly6C+ γδ T cells that arise from immature precursors . The EMBO Journal vol. 43 , ( 14 ) 2878 - 2907 .

Sumaria N, Fiala GJ, Inácio D, Curado-Avelar M, Cachucho A, Pinheiro R, Wiesheu R, Kimura S et al. ( 2024 ) . Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R–STAT5B-driven neoplasms . Nature Immunology vol. 25 , ( 7 ) 1207 - 1217 .

Hirani P, McDermott J, Rajeeve V, Cutillas PR, Jones JL, Pennington DJ, Wight TN, Santamaria S et al. ( 2024 ) . Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate . Cancer Research Communications vol. 4 , ( 4 ) 970 - 985 .

Murtough S, Babu D, Webb CM, Picard HLD, McGinty LA, Pink R, Silver AR, Smart HL et al. ( 2023 ) . Investigating iRHOM2-Associated Transcriptional Changes in Tylosis With Esophageal Cancer . Gastro Hep Advances vol. 3 , ( 3 ) 385 - 395 .

Hindle S, Taggart E, Blowes L, Pennington D, Singh B, Caley M, Connelly J ( 2023 ) . 1035 Understanding dynamic immune responses within a 3D microfluidic model of human skin . Journal of Investigative Dermatology vol. 143 , ( 5 )

Mann BT, Sanz M, Ryan P, Bosque A, Pennington D, Hackstein H, Soriano-Sarabia N ( 2023 ) . Deep Characterization of Human γδ T Cell Subsets Defines Lineage-Specific Traits . The Journal of Immunology vol. 210 , ( Supplement_1 ) 167.15 - 167.15 .

Hirani P, Alonge KM, Pennington DJ, Cutillas PR, Wight TN, Pearce OM ( 2023 ) . Abstract 5841: Exploring the role of versican in immune exclusion within triple negative breast cancer . Cancer Research vol. 83 , ( 7_Supplement ) 5841 - 5841 .

Sanz M, Mann BT, Ryan PL, Bosque A, Pennington DJ, Hackstein H, Soriano-Sarabia N ( 2023 ) . Deep characterization of human γδ T cell subsets defines shared and lineage-specific traits . Frontiers in Immunology vol. 14 ,

Hindle S, Taggart E, Blowes L, Pennington D, Singh B, Caley M, Connelly J ( 2023 ) . Understanding dynamic immune responses within a 3D microfluidic model of human skin . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 143 , S177 - S177 .

Murtough S, Ramos Del Caño L, Delaney P, Webb C, Colom B, Jones P, Kelsell D ( 2022 ) . ESDR173 - A Model to Unravel Pathways Underpinning Palmoplantar Homeostasis and Disease .

Anene CA, Taggart E, Harwood CA, Pennington DJ, Wang J ( 2022 ) . Decosus: An R Framework for Universal Integration of Cell Proportion Estimation Methods . Frontiers in Genetics vol. 13 ,

Sumaria N, Martin S ( 2021 ) . Constrained TCRγδ-associated Syk activity engages PI3K to facilitate thymic development of IL-17A–secreting γδ T cells . Science Signaling vol. 14 , ( 692 )

Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Zaman N, Tsisanova E, Mastroianni G et al. ( 2021 ) . Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy . Cell and Tissue Research vol. 386 , ( 1 ) 79 - 98 .

Park JE, JebaMercy G, Pazhanchamy K, Guo X, Ngan SC, Liou KCK, Lynn SE, Ng SS et al. ( 2021 ) . Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis . Atherosclerosis vol. 324 , 58 - 68 .

Lopes N, McIntyre C, Martin S, Raverdeau M, Sumaria N, Kohlgruber AC, Agudelo LZ, Dyck L et al. ( 2021 ) . Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments . Nature Immunology vol. 22 , ( 2 ) 179 - 192 .

Sumaria N, Martin S, Pennington DJ ( 2021 ) . PI3K inhibition reveals a novel gamma delta T cell-associated transcriptional program during thymic development . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 51 , 176 - 176 .

Galson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK et al. ( 2020 ) . Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures . Frontiers in Immunology vol. 11 ,

Clohosey ML, Mann BT, Ryan PL, Apanasovich TV, Maggirwar SB, Pennington DJ, Soriano-Sarabia N ( 2020 ) . Comparable Vδ2 Cell Functional Characteristics in Virally Suppressed People Living with HIV and Uninfected Individuals . Cells vol. 9 , ( 12 )

Chao-Chu J, Murtough S, Zaman N, Pennington DJ, Blaydon DC ( 2020 ) . iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral Susceptibility . Journal of Investigative Dermatology vol. 141 , ( 4 ) 722 - 726 .

Galson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK et al. ( 2020 ) . Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures .

Edelblum K, Gustafsson K, Pennington DJ, Willcox BE ( 2019 ) . Bordeaux 2018: Wine, Cheese, and γδ T Cells . Frontiers in Immunology vol. 10 ,

Murtough S, Webb CM, Chikh A, Picard HLD, Pink R, Wang J, Fitzgerald R, Risk J et al. ( 2019 ) . 423 Type 2 Immunity Linked to iRhom2 and Tylosis with Oesophageal Cancer . Journal of Investigative Dermatology . vol. 139 ,

Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al. ( 2019 ) . 454 iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus . Journal of Investigative Dermatology vol. 139 , ( 5 )

Sumaria N, Martin S ( 2019 ) . Developmental origins of murine γδ T‐cell subsets . Immunology vol. 156 , ( 4 ) 299 - 304 .

Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al. ( 2019 ) . iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 139 , S78 - S78 .

Grandjean CL, Martin S, Pennington DJ ( 2017 ) . Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ(+)CD8αα(+) intraepithelial lymphocytes . Scientific Reports vol. 7 , ( 1 )

Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB et al. ( 2017 ) . Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study . PLOS Medicine vol. 14 , ( 7 )

Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB et al. ( 2017 ) . Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study . PLoS Med vol. 14 , ( 7 )

Sumaria N, Grandjean CL ( 2017 ) . Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells . Cell Reports vol. 19 , ( 12 ) 2469 - 2476 .

Muñoz-Ruiz M, Sumaria N, Pennington DJ ( 2017 ) . Thymic Determinants of γδ T Cell Differentiation . Trends in Immunology vol. 38 , ( 5 ) 336 - 344 .

Fechter K, Dorronsoro A, Jakobsson E, Ferrin I, Lang V, Sepulveda P, Pennington DJ, Trigueros C ( 2017 ) . IFNγ Regulates Activated Vδ2+ T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells . PLOS ONE vol. 12 , ( 1 )

Ryan PL, Sumaria N, Holland CJ, Bradford CM, Izotova N, Grandjean CL, Jawad AS, Bergmeier LA et al. ( 2016 ) . Heterogeneous yet stable Vδ2(+) T-cell profiles define distinct cytotoxic effector potentials in healthy human individuals . Proceedings of the National Academy of Sciences of the United States of America vol. 113 , ( 50 ) 14378 - 14383 .

Manson J, Cole E, De’Ath HD, Vulliamy P, Meier U, Pennington D, Brohi K ( 2016 ) . Early changes within the lymphocyte population are associated with the development of multiple organ dysfunction syndrome in trauma patients . Critical Care vol. 20 , ( 1 )

Muñoz-Ruiz M, Ribot JC, Grosso AR, Gonçalves-Sousa N, Pamplona A, Pennington DJ, Regueiro JR, Fernández-Malavé E et al. ( 2016 ) . TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets . Nature Immunology vol. 17 , ( 6 ) 721 - 727 .

Stoenchev KV ( 2016 ) . Structure and Function of TCRγδ Receptors . Encyclopedia of Immunobiology , Elsevier

Escorcio-Correia M, Provan A ( 2015 ) . Immune Profiling of Immune Thrombocytopenia (ITP) Patients: Evidence for CD8 T Cell Involvement in the Disease . Blood . vol. 126 ,

Torrance H, Brohi K, Warnes G, Owen H, Hinds C, Pennington D, O'Dwyer M ( 2015 ) . T-helper cell polarisation following severe polytrauma . Intensive Care Medicine Experimental vol. 3 , ( Suppl 1 )

Rei M, Pennington DJ ( 2015 ) . The Emerging Protumor Role of γδ T Lymphocytes: Implications for Cancer Immunotherapy . Cancer Research vol. 75 , ( 5 ) 798 - 802 .

Leslie RD, Dang MA, Hawa MI, Cunningham S, Bradford CM, Lowe R, Paul DM, Lernmark A et al. ( 2015 ) . DNA Methylation Variation in Type 1 Diabetes Mellitus . DIABETES . vol. 64 , A81 - A81 .

Turner MD, Nedjai B, Hurst T ( 2014 ) . Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease . Biochim Biophys Acta vol. 1843 , ( 11 ) 2563 - 2582 .

Rei M, Gonçalves-Sousa N, Lança T, Thompson RG, Mensurado S, Kulbe H ( 2014 ) . Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages . Proc Natl Acad Sci U S A vol. 111 , ( 34 ) E3562 - E3570 .

Dorronsoro A, Ferrin I, Salcedo JM, Fernández-Rueda J, Lang V, Fechter K ( 2014 ) . Human mesenchymal stromal cells modulate T-cell responses through TNF-α-mediated activation of NF-κB . Eur J Immunol vol. 44 , ( 2 ) 480 - 488 .

Sumaria N, Grandjean CLA, Pang DJ, Neves JF, Silva-Santos B ( 2014 ) . A requirement for PI3K in gamma delta T-cell development . IMMUNOLOGY . vol. 143 , 53 - 53 .

Schmolka N, Serre K, Grosso AR, Rei M, Silva-Santos B ( 2013 ) . Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets . Nat Immunol vol. 14 , ( 10 ) 1093 - 1100 .

Prinz I, Pennington DJ ( 2013 ) . Functional development of γδ T cells . Eur J Immunol vol. 43 , ( 8 ) 1988 - 1994 .

Coquet JM, Ribot JC, Bąbała N, van der Horst G, Xiao Y, Neves JF, Fonseca-Pereira D, Borst J ( 2013 ) . Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway . J Exp Med vol. 210 , ( 4 ) 715 - 728 .

Michel M-L, Pang DJ, Haque SFY, Potocnik AJ ( 2012 ) . Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells . Proc Natl Acad Sci U S A vol. 109 , ( 43 ) 17549 - 17554 .

Pang DJ, Neves JF, Sumaria N ( 2012 ) . Understanding the complexity of γδ T-cell subsets in mouse and human . Immunology vol. 136 , ( 3 ) 283 - 290 .

Ribot JC, Coquet JM, Middendorp S, van der Horst G, Babala N, Neves JF, Pennington DJ ( 2012 ) . CD70-CD27 interactions promote CD4<SUP>+</SUP>Foxp3<SUP>+</SUP> regulatory T cell development in the thymic medulla . IMMUNOLOGY . vol. 137 , 37 - 37 .

Sumaria N, Pang DJ, Neves JF, Stoenchev KV ( 2012 ) . TCR requirements for gamma delta T cell development . IMMUNOLOGY . vol. 137 , 402 - 403 .

Grandjean CLA, Mahtani-Patching J, Pang DJ ( 2012 ) . The role of pTalpha isoforms in alpha beta T cell development . IMMUNOLOGY . vol. 137 , 369 - 369 .

Turchinovich G, Pennington DJ ( 2011 ) . T cell receptor signalling in γδ cell development: strength isn't everything . Trends Immunol vol. 32 , ( 12 ) 567 - 573 .

Mahtani-Patching J, Neves JF, Pang DJ, Aguirre-Blanco AM ( 2011 ) . PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization . Sci Signal vol. 4 , ( 182 )

Cárcamo-Orive I, Delgado J, Dorronsoro A, Fernández-Rueda J, Pennington DJ ( 2010 ) . Regulation of human bone marrow stromal cell proliferation and differentiation capacity by glucocorticoid receptor and AP-1 crosstalk . J Bone Miner Res vol. 25 , ( 10 ) 2115 - 2125 .

Afifi A, Raja SG, Pennington DJ ( 2010 ) . For neonates undergoing cardiac surgery does thymectomy as opposed to thymic preservation have any adverse immunological consequences? . Interact Cardiovasc Thorac Surg vol. 11 , ( 3 ) 287 - 291 .

Sengupta N, MacFie TS, MacDonald TT, Pennington D ( 2010 ) . Cancer immunoediting and "spontaneous" tumor regression . Pathol Res Pract vol. 206 , ( 1 ) 1 - 8 .

Ribot JC, deBarros A, Pang DJ, Neves JF, Peperzak V, Roberts SJ, Girardi M, Borst J ( 2009 ) . CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets . Nat Immunol vol. 10 , ( 4 ) 427 - 436 .

McKnight A, Pennington DJ ( 2009 ) . HIV Vaccine Approaches . Encyclopedia of Life Sciences , John Wiley & Sons, Ltd: Chichester.

Sancho D, Mourão-Sá D, Joffre OP, Rogers NC, Carlyle JR ( 2008 ) . Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin . J Clin Invest vol. 118 , ( 6 ) 2098 - 2110 .

Hunt KA, Zhernakova A, Turner G, Heap GAR, Franke L, Bruinenberg M, Romanos J, Dinesen LC et al. ( 2008 ) . Newly identified genetic risk variants for celiac disease related to the immune response . Nat Genet vol. 40 , ( 4 ) 395 - 402 .

Hayday AC ( 2007 ) . Key factors in the organized chaos of early T cell development . Nat Immunol vol. 8 , ( 2 ) 137 - 144 .

Pennington DJ, Silva-Santos B, Silberzahn T, Escorcio-Correia M, Woodward MJ, Dyson PJ ( 2006 ) . Early events in the thymus affect the balance of effector and regulatory T cells . NATURE vol. 444 , ( 7122 ) 1073 - 1077 .

Pennington DJ, Silva-Santos B, Hayday AC ( 2005 ) . The regulation of gamma delta cell functional potential by alpha alpha beta T cell progenitors in the thymus . IMMUNOLOGY vol. 116 , 88 - 88 .

Pennington DJ, Silva-Santos B ( 2005 ) . Gammadelta T cell development--having the strength to get there . Curr Opin Immunol vol. 17 , ( 2 ) 108 - 115 .

Silva-Santos B, Pennington DJ ( 2005 ) . Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors . Science vol. 307 , ( 5711 ) 925 - 928 .

Pennington DJ, Vermijlen D, Clarke SL, Tigelaar RE ( 2005 ) . The integration of conventional and unconventional T cells that characterizes cell-mediated responses . Adv Immunol vol. 87 , 27 - 59 .

Comalada M, Valledor AF, López-López C ( 2003 ) . PKC epsilon is involved in JNK activation that mediates LPS-induced TNF-alpha, which induces apoptosis in macrophages . Am J Physiol Cell Physiol vol. 285 , ( 5 ) C1235 - C1245 .

Pennington DJ, Silva-Santos B, Shires J, Theodoridis E, Pollitt C, Owen MJ ( 2003 ) . The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells . Nat Immunol vol. 4 , ( 10 ) 991 - 998 .

Hayday AC, Pennington DJ ( 2003 ) . Genomics and immunology . Semin Immunol vol. 15 , ( 4 ) 201 - 208 .

Trigueros C, Hozumi K, Silva-Santos B, Bruno L, Hayday AC ( 2003 ) . Pre-TCR signaling regulates IL-7 receptor alpha expression promoting thymocyte survival at the transition from the double-negative to double-positive stage . Eur J Immunol vol. 33 , ( 7 ) 1968 - 1977 .

Aliberti J, Schulz O, Pennington DJ, Reis e Sousa C, Ozato K, Sher A ( 2003 ) . Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells . Blood vol. 101 , ( 1 ) 305 - 310 .

Saurin AT, Pennington DJ, Raat NJH, Latchman DS, Owen MJ ( 2002 ) . Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts . Cardiovasc Res vol. 55 , ( 3 ) 672 - 680 .

Leask A, Abraham DJ, Finlay DR, Holmes A, Pennington D, Shi-Wen X, Chen Y, Venstrom K et al. ( 2002 ) . Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts . Arthritis Rheum vol. 46 , ( 7 ) 1857 - 1865 .

Schulz O, Pennington DJ, Hodivala-Dilke K, Febbraio M ( 2002 ) . CD36 or alphavbeta3 and alphavbeta5 integrins are not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ murine dendritic cells . J Immunol vol. 168 , ( 12 ) 6057 - 6065 .

Holmes A, Shi-Wen X, Ponticos M, Rajkumar V, Mukerjee D, Abraham DJ ( 2002 ) . CONNECTIVE TISSUE GROWTH FACTOR PRODUCED BY LUNG FIBROBLASTS IN RESPONSE TO INJURY MEDIATES EXTRACELLULAR MATRIX DEPOSITION IN BLEOMYCIN-INDUCED LUNG FIBROSIS . RHEUMATOLOGY vol. 41 , 58 - 58 .

Castrillo A, Pennington DJ, Parker PJ, Owen MJ ( 2001 ) . Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection . J Exp Med vol. 194 , ( 9 ) 1231 - 1242 .

Saurin AT, Pennington DJ, Owen MJ ( 2000 ) . Ischemic preconditioning in isolated mouse hearts - An essential role for PKC-epsilon . CIRCULATION vol. 102 , ( 18 ) 155 - 155 .

Shi-wen X, Pennington D, Holmes A, Leask A, Bradham D, Beauchamp JR, Martin GR ( 2000 ) . Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis . Exp Cell Res vol. 259 , ( 1 ) 213 - 224 .

Buckland J, Pennington DJ, Bruno L ( 2000 ) . Correction: Co-ordination of the expression of the protein tyrosine kinase p56(lck) with the pre-T cell receptor during thymocyte development (European Journal of Immunology) (2000) 30, 1 (8-18)) . European Journal of Immunology vol. 30 , ( 3 )

Buckland J, Pennington DJ ( 2000 ) . Co-ordination of the expression of the protein tyrosine kinase p56(lck) with the pre-T cell receptor during thymocyte development . Eur J Immunol vol. 30 , ( 1 ) 8 - 18 .

Holmes A, Fonseca C, Pennington D, Rajkumar V, Black C ( 1999 ) . Identification of over expressed genes involved in the maintance of fibrosis: representational difference analysis of scleroderma fibroblasts . ARTHRITIS RHEUM vol. 42 , ( 9 ) S203 - S203 .

Pennington DJ, Jenkins SA, Brady HJ, Miles CG ( 1997 ) . HIV- I Nef severely impairs thymocyte development and peripheral T-cell function by a CD4-independent mechanism . Genes Funct vol. 1 , ( 5-6 ) 321 - 335 .

Brady HJ, Abraham DJ, Pennington DJ, Miles CG, Dzierzak EA ( 1995 ) . Altered cytokine expression in T lymphocytes from human immunodeficiency virus Tat transgenic mice . J Virol vol. 69 , ( 12 ) 7622 - 7629 .

ABRAHAM D, PENNINGTON D, MILES C, JENKINS S ( 1995 ) . T-CELLS FROM HIV-1 TAT TRANSGENIC MICE SHOW ALTERED CYTOKINE EXPRESSION . J CELL BIOCHEM200 - 200 .

Brady HJ, Pennington DJ ( 1994 ) . Transgenic mice as models of human immunodeficiency virus expression and related cellular effects . J Gen Virol vol. 75 ( Pt 10) , 2549 - 2558 .

Brady HJ, Miles CG ( 1994 ) . Specific ablation of human immunodeficiency virus Tat-expressing cells by conditionally toxic retroviruses . Proc Natl Acad Sci U S A vol. 91 , ( 1 ) 365 - 369 .

Brady HJ, Pennington DJ, Miles CG ( 1993 ) . CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration . EMBO J vol. 12 , ( 13 ) 4923 - 4932 .

Brady HJ, Miles CG, Pennington DJ ( 1993 ) . Studies of HIV-2 promoter activity and cell specific ablation . Leukemia vol. 7 Suppl 2 , S61 - S65 .

DZIERZAK EA, MILES C, BRADY HJM ( 1993 ) . SPECIFIC ABLATION OF HIV-TAT EXPRESSING CELLS BY CONDITIONALLY TOXIC RETROVIRUSES . J CELL BIOCHEM249 - 249 .

Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Tsisanova E, Walker SLM, Westaby JD et al. . Early cardiac inflammation as a driver of murine model of Arrhythmogenic Cardiomyopathy .

Gisby JS, Purcell R, Withnell I, Cabrera CP, Watson DS, Masarone S, Hernández Mir G, Savage E et al. . Human-porcine transcriptomics reveals resuscitation-responsive pathways in trauma shock .

Wiesheu R, Edwards SC, Hedley A, Tosolini M, da Silva MGFF, Sumaria N, Optaczy Y, Hill DG et al. . IL-27 maintains cytotoxic Ly6C+ γδ T cells that arise from immature precursors .

da Silva MGFF, Agerholm R, Sumaria N, Rizk J, Fiske J, Catafál-Tardos E, Baglioni MV, Secci D et al. . Multi-level orchestration of γδ T cell development and central nervous system inflammation by retinoic acid .

Pennington D, Sumaria N . Perinatal thymic-derived CD8alphabeta-expressing gammadelta T cells are innate interferon-gamma producers that expand in IL-7R/STAT5B-driven neoplasms . Nature Immunology

Aries JA, Charrot S, Theocharidis S, Meena M, Lee W-YJ, Correia ME, Pennington DJ, Cavenagh J et al. . Single-cell mass cytometry maps the evolution of immune cell signatures predictive of acute graft-versus-host disease .

Masarone S, Hernández Mir G, Ross J, Pott J, Brohi K, Barnes MR, Pennington DJ . The hyperacute plasma proteome reports injury severity and defines distinct trauma endotypes .